LLPS-Ran-0840
Sst

▼ OVERVIEW

Status: Unreviewed
Protein Name: Somatostatin
Gene Name: Sst, Smst
Ensembl Gene: ENSRNOG00000001837.3
Ensembl Protein: ENSRNOP00000002519.1
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Somatostatin inhibits the release of somatotropin.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLSCRLQCAL  AALCIVLALG  GVTGAPSDPR  LRQFLQKSLA  AATGKQELAK  YFLAELLSEP  60
61    NQTENDALEP  EDLPQAAEQD  EMRLELQRSA  NSNPAMAPRE  RKAGCKNFFW  KTFTSC  116
Nucleotide CDS Sequence (FASTA)
1     ATGCTGTCCT  GCCGTCTCCA  GTGCGCGCTG  GCCGCGCTCT  GCATCGTCCT  GGCTTTGGGC  60
61    GGTGTCACCG  GGGCGCCCTC  GGACCCCAGA  CTCCGTCAGT  TTCTGCAGAA  GTCTCTGGCG  120
121   GCTGCCACCG  GGAAACAGGA  ACTGGCCAAG  TACTTCTTGG  CAGAACTGCT  GTCCGAGCCC  180
181   AACCAGACAG  AGAACGATGC  CCTGGAGCCT  GAGGATTTGC  CCCAGGCAGC  TGAGCAGGAC  240
241   GAGATGAGGC  TGGAGCTGCA  GAGGTCTGCC  AACTCGAACC  CAGCCATGGC  ACCCCGGGAA  300
301   CGCAAAGCTG  GCTGCAAGAA  CTTCTTCTGG  AAGACATTCA  CATCCTGTTA  G  351

▼ KEYWORD

ID
Family
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Hormone
Reference proteome
Secreted
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Extracellular space
Cellular Component
Neuronal cell body
Molecular Function
Hormone activity
Biological Process
Hyperosmotic response
Biological Process
Regulation of cell migration
Biological Process
Response to acidic pH
Biological Process
Response to amino acid
Biological Process
Response to drug
Biological Process
Response to heat
Biological Process
Response to organonitrogen compound
Biological Process
Response to steroid hormone

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4006Mus musculus100.02e-65 200
LLPS-Mea-2492Mesocricetus auratus99.141e-64 198
LLPS-Fud-3133Fukomys damarensis97.878e-60 186
LLPS-Cea-2352Cercocebus atys97.417e-64 196
LLPS-Sus-1794Sus scrofa97.417e-64 196
LLPS-Maf-3026Macaca fascicularis97.417e-64 196
LLPS-Chs-4795Chlorocebus sabaeus97.417e-64 196
LLPS-Gog-3139Gorilla gorilla97.417e-64 196
LLPS-Tut-0766Tursiops truncatus97.417e-64 196
LLPS-Mal-3350Mandrillus leucophaeus97.417e-64 196
LLPS-Paa-4281Papio anubis97.417e-64 196
LLPS-Mup-0434Mustela putorius furo97.417e-64 196
LLPS-Ova-2295Ovis aries97.417e-64 196
LLPS-Man-1787Macaca nemestrina97.417e-64 196
LLPS-Loa-3747Loxodonta africana97.417e-64 196
LLPS-Pat-2466Pan troglodytes97.417e-64 196
LLPS-Urm-3223Ursus maritimus97.417e-64 196
LLPS-Pap-1757Pan paniscus97.417e-64 196
LLPS-Rhb-2281Rhinopithecus bieti97.417e-64 196
LLPS-Mam-2439Macaca mulatta97.417e-64 196
LLPS-Poa-1545Pongo abelii97.417e-64 196
LLPS-Eqc-1234Equus caballus97.417e-64 196
LLPS-Ict-4272Ictidomys tridecemlineatus97.417e-64 196
LLPS-Cas-2323Carlito syrichta97.417e-64 196
LLPS-Aim-4248Ailuropoda melanoleuca96.584e-62 192
LLPS-Dio-3612Dipodomys ordii96.555e-65 199
LLPS-Bot-3362Bos taurus96.552e-63 195
LLPS-Hos-2627Homo sapiens96.558e-64 196
LLPS-Fec-1217Felis catus96.553e-63 195
LLPS-Orc-4124Oryctolagus cuniculus96.552e-63 195
LLPS-Caf-2912Canis familiaris96.552e-62 193
LLPS-Nol-4255Nomascus leucogenys96.552e-63 195
LLPS-Aon-4477Aotus nancymaae95.694e-62 192
LLPS-Ere-0692Erinaceus europaeus95.693e-63 194
LLPS-Caj-2438Callithrix jacchus94.833e-61 189
LLPS-Myl-3339Myotis lucifugus94.836e-63 194
LLPS-Otg-0932Otolemur garnettii94.835e-61 189
LLPS-Cap-3081Cavia porcellus94.833e-62 192
LLPS-Sah-2985Sarcophilus harrisii86.218e-57 178
LLPS-Meg-1593Meleagris gallopavo85.927e-38 129
LLPS-Gaga-0936Gallus gallus85.341e-56 178
LLPS-Ora-3096Ornithorhynchus anatinus84.481e-54 172
LLPS-Mod-2473Monodelphis domestica81.98e-55 173
LLPS-Fia-1665Ficedula albicollis81.93e-51 164
LLPS-Pes-2481Pelodiscus sinensis81.95e-54 171
LLPS-Anc-0571Anolis carolinensis75.633e-44 147
LLPS-Xet-2562Xenopus tropicalis75.08e-51 163
LLPS-Leo-1251Lepisosteus oculatus74.141e-45 150
LLPS-Lac-0707Latimeria chalumnae68.975e-46 151
LLPS-Asm-1105Astyanax mexicanus68.13e-40 136
LLPS-Dar-1685Danio rerio66.383e-31 113
LLPS-Scm-2625Scophthalmus maximus60.984e-1160.5
LLPS-Gaa-2764Gasterosteus aculeatus60.719e-1878.2
LLPS-Icp-1822Ictalurus punctatus58.621e-33 119
LLPS-Tar-3503Takifugu rubripes50.882e-1161.6
LLPS-Orn-2597Oreochromis niloticus46.322e-1879.7
LLPS-Scf-2273Scleropages formosus46.153e-1571.2
LLPS-Pof-4078Poecilia formosa46.158e-1673.2
LLPS-Xim-3714Xiphophorus maculatus46.074e-1776.6
LLPS-Orl-3846Oryzias latipes43.162e-1674.3
LLPS-Ten-0247Tetraodon nigroviridis36.267e-0748.1