LLPS-Ran-0784
Serbp1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Plasminogen activator inhibitor 1 RNA-binding protein; PAI1 RNA-binding protein 1; PAI-RBP1; RDA288; SERPINE1 mRNA-binding protein 1
Gene Name: Serbp1, Pairbp1, Rda288
Ensembl Gene: ENSRNOG00000005890.7
Ensembl Protein: ENSRNOP00000009503.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPGHLQEGFG  CVVTNRFDQL  FDDESDPFEV  LKAAENKKKE  AGGGGVGGPG  AKSAAQAAAQ  60
61    TNSNAAGKQL  RKESQKDRKN  PLPPSVGVAD  KKEETQPPVA  LKKEGIRRVG  RRPDQQLQGD  120
121   GKIIDRRPER  RPPRERRFEK  PLEEKGEGGE  FSVDRPIIER  PIRGRGGLGR  GRGGRGRGMG  180
181   RGDGFDSRGK  REFDRHSGSD  RSSFSHYSGL  KHEDKRGGSG  SHNWGTVKDE  LTDLEQSNVT  240
241   EETPEGEEHP  VADTENKENE  VEEVKEEGPK  EMTLDEWKAI  QNKDRAKVEF  NIRKPNEGAD  300
301   GQWKKGFVLH  KSKSEEAHAE  DSVMDHHFRK  PANDITSQLE  INFGDLGRPG  RGGRGGRGGR  360
361   GRGGRPNRGS  RTDKSSASAP  DVDDPEAFPA  LA  392
Nucleotide CDS Sequence (FASTA)
1     ATGCCTGGGC  ACCTACAGGA  AGGCTTCGGC  TGCGTGGTCA  CCAACCGATT  CGACCAGCTA  60
61    TTTGACGACG  AATCGGACCC  TTTCGAGGTA  CTGAAGGCAG  CAGAGAACAA  GAAAAAAGAA  120
121   GCCGGCGGGG  GCGGCGTTGG  GGGCCCCGGG  GCCAAGAGCG  CGGCTCAGGC  CGCGGCCCAG  180
181   ACCAACTCCA  ACGCGGCAGG  CAAACAGTTG  CGGAAAGAGT  CCCAGAAAGA  CCGCAAGAAC  240
241   CCGCTGCCCC  CCAGCGTCGG  CGTGGCTGAC  AAAAAGGAGG  AGACGCAGCC  GCCGGTGGCG  300
301   CTTAAGAAAG  AAGGAATAAG  GCGAGTTGGA  AGAAGACCTG  ATCAACAACT  TCAGGGTGAT  360
361   GGGAAAATAA  TTGATAGGAG  ACCAGAAAGG  CGACCACCTC  GTGAAAGAAG  ATTTGAAAAG  420
421   CCACTTGAAG  AAAAAGGTGA  AGGAGGTGAA  TTTTCAGTTG  ATAGACCGAT  CATCGAACGG  480
481   CCTATCCGAG  GCCGAGGTGG  TCTTGGAAGG  GGTCGAGGTG  GCCGTGGCCG  TGGAATGGGC  540
541   CGAGGTGATG  GATTTGATTC  TCGTGGCAAG  CGTGAATTTG  ATAGGCATAG  TGGAAGTGAT  600
601   AGATCTTCTT  TTTCACATTA  CAGTGGCCTG  AAGCATGAGG  ACAAACGTGG  AGGTAGCGGA  660
661   TCTCACAACT  GGGGAACTGT  CAAAGATGAA  TTAACTGATT  TGGAGCAATC  AAATGTGACT  720
721   GAGGAAACAC  CCGAAGGTGA  AGAGCACCCA  GTGGCAGACA  CTGAAAATAA  GGAGAACGAA  780
781   GTTGAAGAGG  TTAAGGAAGA  GGGTCCAAAA  GAGATGACTT  TGGATGAGTG  GAAAGCTATT  840
841   CAAAATAAAG  ACCGAGCAAA  AGTAGAATTT  AATATCCGAA  AACCAAATGA  AGGTGCTGAT  900
901   GGACAATGGA  AAAAGGGATT  TGTTCTGCAT  AAATCAAAAA  GTGAAGAGGC  TCATGCGGAA  960
961   GATTCAGTTA  TGGACCATCA  TTTCCGGAAG  CCAGCAAATG  ATATAACGTC  TCAACTGGAG  1020
1021  ATCAATTTTG  GAGACCTAGG  CCGCCCAGGA  CGTGGTGGCA  GAGGAGGACG  TGGTGGACGT  1080
1081  GGGCGTGGTG  GTCGTCCTAA  TCGTGGCAGC  AGGACTGATA  AGTCAAGTGC  TTCTGCTCCT  1140
1141  GATGTAGATG  ACCCAGAGGC  ATTCCCCGCT  CTGGCCTAA  1179

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
RNA-binding
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Plasma membrane
Molecular Function
MRNA 3'-UTR binding
Molecular Function
SUMO binding
Biological Process
PML body organization
Biological Process
Regulation of apoptotic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mup-1019Mustela putorius furo98.723e-172 494
LLPS-Fec-1499Felis catus98.723e-172 494
LLPS-Poa-3178Pongo abelii98.565e-157 455
LLPS-Chs-2367Chlorocebus sabaeus98.471e-170 490
LLPS-Paa-0750Papio anubis98.471e-170 490
LLPS-Urm-0821Ursus maritimus98.471e-171 493
LLPS-Mam-2694Macaca mulatta98.471e-170 490
LLPS-Maf-3443Macaca fascicularis98.221e-169 488
LLPS-Eqc-2776Equus caballus97.71e-170 489
LLPS-Bot-1459Bos taurus97.452e-164 474
LLPS-Otg-1794Otolemur garnettii97.459e-165 474
LLPS-Fia-0240Ficedula albicollis96.671e-1066.6
LLPS-Sah-0168Sarcophilus harrisii96.15e-98 299
LLPS-Mum-2436Mus musculus95.583e-170 489
LLPS-Caj-0978Callithrix jacchus95.348e-168 483
LLPS-Gog-1440Gorilla gorilla95.13e-167 482
LLPS-Hos-1027Homo sapiens95.13e-167 482
LLPS-Pat-1299Pan troglodytes95.13e-167 482
LLPS-Pap-1004Pan paniscus95.13e-167 482
LLPS-Rhb-3778Rhinopithecus bieti95.12e-146 428
LLPS-Sus-3585Sus scrofa95.095e-168 484
LLPS-Tut-2312Tursiops truncatus95.098e-168 483
LLPS-Loa-1620Loxodonta africana95.093e-168 484
LLPS-Orc-0982Oryctolagus cuniculus95.093e-168 484
LLPS-Cea-3708Cercocebus atys94.853e-167 482
LLPS-Mal-2590Mandrillus leucophaeus94.853e-167 482
LLPS-Man-1329Macaca nemestrina94.853e-167 482
LLPS-Dio-4280Dipodomys ordii94.845e-168 484
LLPS-Caf-1461Canis familiaris94.843e-168 484
LLPS-Ict-2357Ictidomys tridecemlineatus94.592e-168 485
LLPS-Aon-2739Aotus nancymaae94.23e-153 446
LLPS-Mea-0254Mesocricetus auratus91.911e-167 483
LLPS-Fud-1925Fukomys damarensis91.391e-111 336
LLPS-Cap-0116Cavia porcellus90.175e-151 440
LLPS-Myl-0168Myotis lucifugus89.179e-138 407
LLPS-Anc-0762Anolis carolinensis88.413e-55 185
LLPS-Ere-1007Erinaceus europaeus88.244e-163 471
LLPS-Ora-1372Ornithorhynchus anatinus84.844e-127 378
LLPS-Mod-1233Monodelphis domestica83.855e-102 312
LLPS-Nol-2131Nomascus leucogenys82.112e-137 404
LLPS-Tag-2281Taeniopygia guttata80.982e-96 297
LLPS-Meg-0064Meleagris gallopavo80.582e-100 307
LLPS-Cas-0534Carlito syrichta74.612e-102 315
LLPS-Scf-0730Scleropages formosus73.795e-71 234
LLPS-Leo-1014Lepisosteus oculatus72.443e-113 343
LLPS-Pes-1906Pelodiscus sinensis71.892e-128 384
LLPS-Xet-0432Xenopus tropicalis69.743e-117 354
LLPS-Gaga-1348Gallus gallus69.131e-120 364
LLPS-Lac-0380Latimeria chalumnae68.631e-115 350
LLPS-Anp-1234Anas platyrhynchos65.92e-59 201
LLPS-Dar-1606Danio rerio63.012e-95 298
LLPS-Xim-3081Xiphophorus maculatus62.776e-59 203
LLPS-Pof-2226Poecilia formosa62.531e-98 306
LLPS-Orn-0498Oreochromis niloticus61.742e-95 297
LLPS-Asm-1906Astyanax mexicanus61.328e-84 269
LLPS-Orl-0905Oryzias latipes60.531e-90 285
LLPS-Tar-3385Takifugu rubripes60.196e-92 289
LLPS-Icp-1295Ictalurus punctatus59.243e-89 281
LLPS-Ten-2432Tetraodon nigroviridis59.021e-84 269
LLPS-Gaa-0822Gasterosteus aculeatus56.061e-93 293
LLPS-Scm-1444Scophthalmus maximus56.062e-89 283
LLPS-Drm-0247Drosophila melanogaster44.123e-1787.4
LLPS-Cii-0313Ciona intestinalis37.422e-1168.6