LLPS-Ran-0686
Vdac2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Voltage-dependent anion-selective channel protein 2
Gene Name: Vdac2
Ensembl Gene: ENSRNOG00000013505.6
Ensembl Protein: ENSRNOP00000018462.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAECCVPVCQ  RPICIPPPYA  DLGKAARDIF  NKGFGFGLVK  LDVKTKSCSG  VEFSTSGSSN  60
61    TDTGKVSGTL  ETKYKWCEYG  LTFTEKWNTD  NTLGTEIAIE  DQICQGLKLT  FDTTFSPNTG  120
121   KKSGKIKSAY  KRECINLGCD  VDFDFAGPAI  HGSAVFGYEG  WLAGYQMTFD  SAKSKLTRSN  180
181   FAVGYRTGDF  QLHTNVNNGT  EFGGSIYQKV  CEDFDTSVNL  AWTSGTNCTR  FGIAAKYQLD  240
241   PTASISAKVN  NSSLIGVGYT  QTLRPGVKLT  LSALVDGKSF  NAGGHKLGLA  LELEA  295
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGAAT  GTTGTGTACC  GGTATGCCAA  CGGCCAATTT  GTATCCCTCC  ACCCTATGCT  60
61    GACCTTGGCA  AAGCTGCCAG  AGATATTTTC  AACAAAGGAT  TTGGTTTTGG  GTTGGTAAAG  120
121   CTGGATGTGA  AAACGAAGTC  ATGCAGTGGT  GTGGAATTTT  CAACATCTGG  CTCATCTAAT  180
181   ACAGACACTG  GTAAAGTCAG  TGGGACCTTG  GAGACCAAGT  ACAAATGGTG  TGAGTATGGT  240
241   CTGACTTTCA  CAGAGAAATG  GAACACTGAC  AACACTCTGG  GGACGGAGAT  TGCAATTGAA  300
301   GACCAGATTT  GTCAAGGTTT  GAAACTGACC  TTTGACACCA  CGTTTTCACC  AAACACAGGA  360
361   AAGAAAAGTG  GTAAAATCAA  GTCTGCTTAC  AAGAGGGAAT  GTATAAACCT  TGGCTGTGAT  420
421   GTTGATTTTG  ATTTTGCTGG  ACCTGCCATC  CATGGGTCAG  CCGTCTTTGG  TTACGAGGGC  480
481   TGGCTTGCTG  GGTACCAGAT  GACCTTTGAC  AGTGCCAAGT  CAAAGCTGAC  AAGGAGTAAC  540
541   TTCGCAGTTG  GCTACAGGAC  TGGGGACTTC  CAGCTACACA  CAAATGTAAA  TAATGGGACA  600
601   GAATTTGGAG  GATCAATTTA  TCAGAAAGTA  TGTGAAGATT  TTGACACTTC  AGTAAACCTT  660
661   GCTTGGACAT  CAGGTACCAA  CTGCACTCGT  TTTGGCATTG  CAGCTAAATA  CCAGTTGGAC  720
721   CCCACTGCTT  CTATTTCTGC  AAAGGTCAAC  AACTCTAGTT  TAATTGGAGT  GGGCTATACT  780
781   CAGACTCTGA  GGCCTGGTGT  GAAGCTTACA  CTGTCTGCTC  TGGTAGACGG  GAAGAGCTTT  840
841   AATGCTGGAG  GCCACAAACT  TGGGCTTGCC  TTGGAATTGG  AGGCTTAA  888

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Direct protein sequencing
Ion transport
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion outer membrane
NAD
Nucleotide-binding
Phosphoprotein
Porin
Reference proteome
Transmembrane
Transmembrane beta strand
Transport
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Acrosomal vesicle
Cellular Component
Mitochondrial nucleoid
Cellular Component
Mitochondrial outer membrane
Cellular Component
Mitochondrion
Cellular Component
Pore complex
Cellular Component
Synaptic vesicle
Molecular Function
Nucleotide binding
Molecular Function
Porin activity
Molecular Function
Voltage-gated anion channel activity
Biological Process
Binding of sperm to zona pellucida
Biological Process
Negative regulation of intrinsic apoptotic signaling pathway
Biological Process
Negative regulation of protein polymerization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-3348Mus musculus99.320.0 603
LLPS-Mea-1438Mesocricetus auratus97.970.0 593
LLPS-Chs-3149Chlorocebus sabaeus97.542e-174 490
LLPS-Man-1813Macaca nemestrina97.170.0 565
LLPS-Rhb-0662Rhinopithecus bieti97.170.0 565
LLPS-Cas-3068Carlito syrichta97.170.0 564
LLPS-Cea-2722Cercocebus atys97.170.0 565
LLPS-Maf-0144Macaca fascicularis97.170.0 565
LLPS-Caj-0746Callithrix jacchus97.170.0 564
LLPS-Paa-1944Papio anubis97.170.0 565
LLPS-Mal-0338Mandrillus leucophaeus97.170.0 565
LLPS-Pat-2641Pan troglodytes97.016e-167 471
LLPS-Orc-2986Oryctolagus cuniculus96.860.0 573
LLPS-Mam-1647Macaca mulatta96.860.0 573
LLPS-Bot-0214Bos taurus96.860.0 573
LLPS-Myl-1265Myotis lucifugus96.860.0 573
LLPS-Ova-1912Ovis aries96.860.0 573
LLPS-Hos-1750Homo sapiens96.820.0 563
LLPS-Gog-0961Gorilla gorilla96.820.0 563
LLPS-Aim-3228Ailuropoda melanoleuca96.820.0 562
LLPS-Urm-2568Ursus maritimus96.520.0 570
LLPS-Caf-1729Canis familiaris96.520.0 573
LLPS-Cap-0361Cavia porcellus96.520.0 570
LLPS-Sus-2803Sus scrofa96.520.0 572
LLPS-Mup-1851Mustela putorius furo96.520.0 572
LLPS-Tut-0096Tursiops truncatus96.380.0 545
LLPS-Dio-0562Dipodomys ordii96.210.0 573
LLPS-Fud-2351Fukomys damarensis96.190.0 573
LLPS-Fec-0659Felis catus96.170.0 566
LLPS-Otg-1565Otolemur garnettii96.170.0 572
LLPS-Mod-1268Monodelphis domestica95.890.0 572
LLPS-Nol-0932Nomascus leucogenys95.760.0 552
LLPS-Eqc-1807Equus caballus95.530.0 572
LLPS-Sah-1129Sarcophilus harrisii95.140.0 563
LLPS-Ict-1025Ictidomys tridecemlineatus94.140.0 563
LLPS-Loa-1910Loxodonta africana93.920.0 571
LLPS-Ora-1239Ornithorhynchus anatinus93.750.0 553
LLPS-Aon-1072Aotus nancymaae89.930.0 521
LLPS-Pes-1873Pelodiscus sinensis88.030.0 531
LLPS-Anp-0070Anas platyrhynchos87.320.0 520
LLPS-Gaga-2706Gallus gallus86.640.0 530
LLPS-Fia-3533Ficedula albicollis86.10.0 529
LLPS-Tag-2431Taeniopygia guttata85.920.0 517
LLPS-Xet-0855Xenopus tropicalis85.870.0 513
LLPS-Anc-2191Anolis carolinensis84.250.0 523
LLPS-Lac-1246Latimeria chalumnae83.975e-180 506
LLPS-Icp-3550Ictalurus punctatus82.695e-177 498
LLPS-Meg-0300Meleagris gallopavo82.589e-176 495
LLPS-Asm-0035Astyanax mexicanus82.333e-178 501
LLPS-Dar-2855Danio rerio81.982e-176 496
LLPS-Leo-0492Lepisosteus oculatus81.850.0 511
LLPS-Orn-3294Oreochromis niloticus81.633e-175 493
LLPS-Ten-2238Tetraodon nigroviridis81.536e-176 495
LLPS-Orl-3880Oryzias latipes81.274e-174 490
LLPS-Xim-0764Xiphophorus maculatus81.232e-154 441
LLPS-Scf-2673Scleropages formosus80.922e-176 496
LLPS-Gaa-2238Gasterosteus aculeatus79.862e-174 491
LLPS-Scm-1253Scophthalmus maximus79.511e-170 481
LLPS-Pof-2005Poecilia formosa78.81e-168 476
LLPS-Tar-2570Takifugu rubripes78.451e-169 479
LLPS-Poa-1237Pongo abelii72.444e-153 437
LLPS-Pap-1664Pan paniscus72.184e-151 432
LLPS-Drm-1166Drosophila melanogaster61.433e-125 366
LLPS-Cis-0657Ciona savignyi59.366e-119 350
LLPS-Cii-0513Ciona intestinalis58.872e-122 359
LLPS-Cae-1315Caenorhabditis elegans41.641e-71 229
LLPS-Abg-1976Absidia glauca39.348e-2190.5
LLPS-Phn-0213Phaeosphaeria nodorum34.462e-1884.7
LLPS-Asn-0811Aspergillus nidulans34.151e-46 164
LLPS-Nef-0141Neosartorya fischeri33.88e-46 162
LLPS-Asfu-1319Aspergillus fumigatus33.632e-30 122
LLPS-Kop-0934Komagataella pastoris33.452e-39 145
LLPS-Asc-0877Aspergillus clavatus33.335e-31 124
LLPS-Aso-0860Aspergillus oryzae33.337e-32 126
LLPS-Asf-0639Aspergillus flavus33.337e-32 126
LLPS-Miv-0091Microbotryum violaceum33.113e-47 166
LLPS-Crn-1079Cryptococcus neoformans32.992e-46 164
LLPS-Put-1147Puccinia triticina32.889e-49 170
LLPS-Tum-0948Tuber melanosporum32.875e-42 152
LLPS-Trr-0003Trichoderma reesei32.629e-35 133
LLPS-Fus-1358Fusarium solani32.583e-28 116
LLPS-Usm-1193Ustilago maydis32.537e-45 160
LLPS-Spr-0494Sporisorium reilianum32.442e-47 166
LLPS-Pyt-0320Pyrenophora teres32.49e-39 144
LLPS-Gag-1096Gaeumannomyces graminis32.392e-37 140
LLPS-Mel-0772Melampsora laricipopulina32.323e-49 171
LLPS-Lem-0750Leptosphaeria maculans32.291e-38 143
LLPS-Map-0116Magnaporthe poae32.042e-36 137
LLPS-Beb-1211Beauveria bassiana32.032e-36 137
LLPS-Fuo-1335Fusarium oxysporum32.031e-36 137
LLPS-Ved-0911Verticillium dahliae32.032e-37 140
LLPS-Fuv-0963Fusarium verticillioides32.031e-36 137
LLPS-Blg-0300Blumeria graminis31.912e-36 137
LLPS-Pug-0838Puccinia graminis31.867e-48 168
LLPS-Cogr-0588Colletotrichum graminicola31.718e-34 130
LLPS-Nec-1159Neurospora crassa31.694e-35 134
LLPS-Trv-1496Trichoderma virens31.673e-35 134
LLPS-Scc-0749Schizosaccharomyces cryophilus31.311e-41 152
LLPS-Mao-1510Magnaporthe oryzae31.211e-36 138
LLPS-Pytr-0247Pyrenophora triticirepentis31.122e-34 132
LLPS-Scp-0851Schizosaccharomyces pombe30.396e-38 141
LLPS-Scj-1294Schizosaccharomyces japonicus29.687e-37 138
LLPS-Asg-1348Ashbya gossypii29.516e-32 127
LLPS-Yal-0484Yarrowia lipolytica29.335e-40 147
LLPS-Ast-1093Aspergillus terreus29.151e-33 130
LLPS-Amt-1582Amborella trichopoda28.378e-1987.8
LLPS-Zyt-0537Zymoseptoria tritici28.332e-29 119
LLPS-Ors-1679Oryza sativa27.562e-1886.7
LLPS-Orbr-0859Oryza brachyantha27.562e-1886.7
LLPS-Orr-0365Oryza rufipogon27.562e-1886.7
LLPS-Orni-0148Oryza nivara27.562e-1886.7
LLPS-Orgl-1240Oryza glumaepatula27.562e-1886.7
LLPS-Gas-0374Galdieria sulphuraria27.58e-26 109
LLPS-Zem-1618Zea mays26.921e-1887.4
LLPS-Dos-1054Dothistroma septosporum26.851e-27 114
LLPS-Sac-0127Saccharomyces cerevisiae25.771e-24 105
LLPS-Coo-0667Colletotrichum orbiculare25.62e-23 102
LLPS-Chc-0917Chondrus crispus24.376e-1988.2