LLPS-Ran-0676
Timm13
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mitochondrial import inner membrane translocase subunit Tim13 |
| Gene Name: | Timm13, Tim13a, Timm13a |
| Ensembl Gene: | ENSRNOG00000019682.3 |
| Ensembl Protein: | ENSRNOP00000026648.2 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000026648.3 | ENSRNOP00000026648.2 |
| UniProt | P62076, TIM13_RAT, Q9UHL8, Q9WTL1 | |
| GeneBank | AF144701 | AAD39952.1 |
| RefSeq | NM_145781.2 | NP_665724.1 |
| Entrez | 252928 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDSGFGSDFG GTGGGKLDPG AIMEQVKVQI AVANAQELLQ RMTDKCFRKC IGKPGGSLDN 60 61 SEQKCIAMCM DRYMDAWNTV SRAYNSRLQR ERANM 95 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACAGCG GATTCGGCTC GGACTTCGGC GGCACGGGTG GTGGGAAGCT GGACCCGGGA 60 61 GCCATTATGG AACAGGTGAA AGTGCAGATC GCCGTGGCCA ATGCGCAGGA GCTGCTACAG 120 121 AGGATGACGG ACAAGTGTTT CCGGAAGTGC ATCGGGAAGC CCGGGGGCTC CTTAGATAAC 180 181 TCGGAGCAGA AATGCATCGC CATGTGCATG GACCGGTACA TGGACGCCTG GAACACCGTG 240 241 TCCCGCGCCT ACAACTCCCG ACTGCAGCGG GAACGAGCCA ACATGTGA 288 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Fibrillar center | |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrial intermembrane space protein transporter complex | |
Cellular Component | Mitochondrion | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein transporter activity | |
Biological Process | Chaperone-mediated protein transport | |
Biological Process | Protein insertion into mitochondrial inner membrane |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Caf-1105 | Canis familiaris | 100.0 | 2e-16 | 72.0 |
| LLPS-Mum-4149 | Mus musculus | 100.0 | 1e-53 | 168 |
| LLPS-Eqc-1198 | Equus caballus | 98.75 | 9e-53 | 166 |
| LLPS-Cap-1863 | Cavia porcellus | 98.75 | 9e-53 | 166 |
| LLPS-Poa-3926 | Pongo abelii | 98.75 | 9e-53 | 166 |
| LLPS-Mam-1918 | Macaca mulatta | 98.75 | 8e-53 | 167 |
| LLPS-Ict-0059 | Ictidomys tridecemlineatus | 98.75 | 9e-53 | 166 |
| LLPS-Fec-0071 | Felis catus | 98.75 | 9e-53 | 166 |
| LLPS-Pap-2918 | Pan paniscus | 98.75 | 9e-53 | 166 |
| LLPS-Pat-3282 | Pan troglodytes | 98.75 | 9e-53 | 166 |
| LLPS-Hos-1447 | Homo sapiens | 98.75 | 9e-53 | 166 |
| LLPS-Loa-0056 | Loxodonta africana | 98.75 | 8e-53 | 167 |
| LLPS-Man-2375 | Macaca nemestrina | 98.75 | 8e-53 | 167 |
| LLPS-Otg-2110 | Otolemur garnettii | 98.75 | 8e-53 | 167 |
| LLPS-Rhb-3548 | Rhinopithecus bieti | 98.75 | 8e-53 | 167 |
| LLPS-Bot-3071 | Bos taurus | 98.75 | 1e-52 | 166 |
| LLPS-Dio-1241 | Dipodomys ordii | 98.75 | 9e-53 | 166 |
| LLPS-Myl-2371 | Myotis lucifugus | 98.75 | 1e-52 | 166 |
| LLPS-Mup-3721 | Mustela putorius furo | 98.75 | 9e-53 | 166 |
| LLPS-Paa-1206 | Papio anubis | 98.75 | 8e-53 | 167 |
| LLPS-Mal-2920 | Mandrillus leucophaeus | 98.75 | 8e-53 | 167 |
| LLPS-Chs-1269 | Chlorocebus sabaeus | 98.75 | 8e-53 | 167 |
| LLPS-Mea-0944 | Mesocricetus auratus | 98.75 | 6e-53 | 167 |
| LLPS-Maf-0707 | Macaca fascicularis | 98.75 | 8e-53 | 167 |
| LLPS-Aon-2370 | Aotus nancymaae | 98.75 | 9e-53 | 166 |
| LLPS-Cea-1594 | Cercocebus atys | 98.75 | 8e-53 | 167 |
| LLPS-Sus-0646 | Sus scrofa | 98.75 | 8e-53 | 167 |
| LLPS-Gog-0253 | Gorilla gorilla | 98.75 | 9e-53 | 166 |
| LLPS-Fud-2187 | Fukomys damarensis | 98.75 | 8e-53 | 166 |
| LLPS-Nol-0240 | Nomascus leucogenys | 97.92 | 9e-27 | 99.4 |
| LLPS-Caj-2226 | Callithrix jacchus | 97.5 | 4e-52 | 165 |
| LLPS-Xet-0063 | Xenopus tropicalis | 96.25 | 3e-51 | 163 |
| LLPS-Gaga-0935 | Gallus gallus | 96.25 | 3e-51 | 162 |
| LLPS-Mod-1218 | Monodelphis domestica | 96.25 | 3e-51 | 162 |
| LLPS-Fia-0157 | Ficedula albicollis | 96.25 | 1e-51 | 164 |
| LLPS-Tut-0825 | Tursiops truncatus | 95.83 | 1e-45 | 148 |
| LLPS-Icp-0613 | Ictalurus punctatus | 93.75 | 1e-49 | 158 |
| LLPS-Pof-2075 | Poecilia formosa | 91.25 | 2e-48 | 155 |
| LLPS-Xim-0906 | Xiphophorus maculatus | 91.25 | 2e-48 | 155 |
| LLPS-Leo-3765 | Lepisosteus oculatus | 91.25 | 7e-49 | 156 |
| LLPS-Scm-2535 | Scophthalmus maximus | 90.0 | 3e-48 | 155 |
| LLPS-Dar-3729 | Danio rerio | 90.0 | 1e-48 | 156 |
| LLPS-Orn-0255 | Oreochromis niloticus | 90.0 | 3e-48 | 155 |
| LLPS-Scf-1519 | Scleropages formosus | 90.0 | 5e-49 | 157 |
| LLPS-Ten-2458 | Tetraodon nigroviridis | 88.75 | 8e-48 | 154 |
| LLPS-Gaa-1176 | Gasterosteus aculeatus | 88.75 | 2e-47 | 153 |
| LLPS-Orl-0855 | Oryzias latipes | 88.75 | 1e-47 | 154 |
| LLPS-Tar-1332 | Takifugu rubripes | 87.5 | 3e-47 | 152 |
| LLPS-Asm-3264 | Astyanax mexicanus | 81.13 | 6e-24 | 93.6 |
| LLPS-Drm-1990 | Drosophila melanogaster | 67.53 | 2e-35 | 122 |
| LLPS-Abg-0131 | Absidia glauca | 57.53 | 2e-27 | 102 |
| LLPS-Miv-1415 | Microbotryum violaceum | 54.79 | 8e-25 | 95.9 |
| LLPS-Ors-1778 | Oryza sativa | 53.85 | 2e-18 | 78.6 |
| LLPS-Orp-0733 | Oryza punctata | 53.85 | 5e-18 | 78.6 |
| LLPS-Ori-0186 | Oryza indica | 53.85 | 2e-18 | 78.6 |
| LLPS-Orbr-1786 | Oryza brachyantha | 53.62 | 2e-18 | 78.6 |
| LLPS-Sob-0210 | Sorghum bicolor | 53.62 | 3e-15 | 70.1 |
| LLPS-Cus-0026 | Cucumis sativus | 53.33 | 7e-11 | 58.5 |
| LLPS-Orb-2096 | Oryza barthii | 53.33 | 7e-16 | 74.3 |
| LLPS-Orni-1410 | Oryza nivara | 53.33 | 2e-16 | 75.1 |
| LLPS-Mae-0285 | Manihot esculenta | 53.23 | 3e-12 | 62.4 |
| LLPS-Zem-1796 | Zea mays | 53.03 | 1e-14 | 68.6 |
| LLPS-Org-1690 | Oryza glaberrima | 53.03 | 3e-13 | 64.7 |
| LLPS-Orgl-0937 | Oryza glumaepatula | 53.03 | 3e-13 | 64.7 |
| LLPS-Orm-2026 | Oryza meridionalis | 52.31 | 4e-17 | 75.1 |
| LLPS-Gor-0061 | Gossypium raimondii | 52.24 | 5e-12 | 61.6 |
| LLPS-Tru-1129 | Triticum urartu | 52.17 | 2e-14 | 67.8 |
| LLPS-Pot-2050 | Populus trichocarpa | 51.67 | 3e-10 | 57.0 |
| LLPS-Thc-1469 | Theobroma cacao | 51.61 | 9e-12 | 60.8 |
| LLPS-Orr-1005 | Oryza rufipogon | 51.43 | 8e-15 | 73.6 |
| LLPS-Tra-0500 | Triticum aestivum | 51.43 | 1e-14 | 68.2 |
| LLPS-Sem-0279 | Selaginella moellendorffii | 50.79 | 4e-11 | 58.9 |
| LLPS-Hea-0813 | Helianthus annuus | 50.75 | 4e-12 | 61.6 |
| LLPS-Lep-1547 | Leersia perrieri | 50.72 | 3e-13 | 65.9 |
| LLPS-Scj-0493 | Schizosaccharomyces japonicus | 50.7 | 4e-22 | 88.2 |
| LLPS-Scp-1169 | Schizosaccharomyces pombe | 50.0 | 2e-23 | 91.7 |
| LLPS-Sot-1123 | Solanum tuberosum | 50.0 | 5e-12 | 61.6 |
| LLPS-Arl-2587 | Arabidopsis lyrata | 50.0 | 2e-12 | 62.8 |
| LLPS-Sol-1100 | Solanum lycopersicum | 50.0 | 5e-12 | 61.6 |
| LLPS-Mua-2137 | Musa acuminata | 50.0 | 2e-17 | 75.9 |
| LLPS-Usm-1108 | Ustilago maydis | 49.32 | 4e-20 | 83.2 |
| LLPS-Hov-1212 | Hordeum vulgare | 49.25 | 4e-13 | 64.7 |
| LLPS-Viv-0659 | Vitis vinifera | 49.23 | 3e-11 | 59.7 |
| LLPS-Cym-0888 | Cyanidioschyzon merolae | 49.09 | 8e-14 | 66.2 |
| LLPS-Spr-0083 | Sporisorium reilianum | 48.61 | 3e-19 | 80.9 |
| LLPS-Brn-0912 | Brassica napus | 48.57 | 2e-14 | 67.8 |
| LLPS-Brd-0597 | Brachypodium distachyon | 48.48 | 4e-12 | 62.0 |
| LLPS-Bro-1610 | Brassica oleracea | 47.95 | 1e-14 | 68.9 |
| LLPS-Prp-0097 | Prunus persica | 47.89 | 2e-12 | 62.8 |
| LLPS-Art-0397 | Arabidopsis thaliana | 47.76 | 2e-12 | 62.4 |
| LLPS-Brr-0487 | Brassica rapa | 47.14 | 4e-14 | 67.4 |
| LLPS-Chr-1497 | Chlamydomonas reinhardtii | 47.06 | 6e-17 | 74.7 |
| LLPS-Nia-1531 | Nicotiana attenuata | 46.97 | 2e-11 | 60.1 |
| LLPS-Pytr-0387 | Pyrenophora triticirepentis | 46.75 | 1e-20 | 84.3 |
| LLPS-Pyt-1251 | Pyrenophora teres | 46.75 | 1e-20 | 84.3 |
| LLPS-Tum-1380 | Tuber melanosporum | 46.67 | 2e-16 | 73.2 |
| LLPS-Yal-0952 | Yarrowia lipolytica | 46.38 | 4e-18 | 77.4 |
| LLPS-Osl-1129 | Ostreococcus lucimarinus | 46.15 | 5e-17 | 74.7 |
| LLPS-Gas-1059 | Galdieria sulphuraria | 46.15 | 7e-16 | 72.0 |
| LLPS-Zyt-0908 | Zymoseptoria tritici | 46.15 | 4e-08 | 51.2 |
| LLPS-Trr-0285 | Trichoderma reesei | 45.95 | 5e-20 | 82.4 |
| LLPS-Php-1520 | Physcomitrella patens | 45.71 | 3e-11 | 59.7 |
| LLPS-Via-0505 | Vigna angularis | 45.59 | 9e-10 | 55.5 |
| LLPS-Cae-0382 | Caenorhabditis elegans | 45.12 | 9e-18 | 77.4 |
| LLPS-Nef-0745 | Neosartorya fischeri | 45.07 | 4e-18 | 78.2 |
| LLPS-Cii-0735 | Ciona intestinalis | 44.74 | 3e-18 | 78.2 |
| LLPS-Trv-1614 | Trichoderma virens | 44.59 | 2e-19 | 81.3 |
| LLPS-Phv-1733 | Phaseolus vulgaris | 44.12 | 1e-09 | 55.5 |
| LLPS-Asfu-0619 | Aspergillus fumigatus | 43.66 | 1e-17 | 77.0 |
| LLPS-Phn-0225 | Phaeosphaeria nodorum | 43.59 | 5e-19 | 80.9 |
| LLPS-Dos-0394 | Dothistroma septosporum | 43.48 | 1e-18 | 79.3 |
| LLPS-Cog-0516 | Colletotrichum gloeosporioides | 43.24 | 1e-17 | 76.3 |
| LLPS-Fus-0227 | Fusarium solani | 43.24 | 8e-19 | 79.3 |
| LLPS-Nec-1391 | Neurospora crassa | 43.24 | 1e-18 | 79.0 |
| LLPS-Coo-0953 | Colletotrichum orbiculare | 43.24 | 1e-17 | 76.6 |
| LLPS-Map-1311 | Magnaporthe poae | 43.24 | 4e-18 | 78.6 |
| LLPS-Cogr-0258 | Colletotrichum graminicola | 42.25 | 6e-17 | 74.7 |
| LLPS-Met-0148 | Medicago truncatula | 42.25 | 8e-11 | 58.5 |
| LLPS-Asf-1188 | Aspergillus flavus | 42.25 | 4e-17 | 75.9 |
| LLPS-Glm-1764 | Glycine max | 42.25 | 2e-09 | 54.7 |
| LLPS-Ved-1561 | Verticillium dahliae | 41.89 | 6e-17 | 74.7 |
| LLPS-Vir-0827 | Vigna radiata | 41.89 | 4e-07 | 48.5 |
| LLPS-Gag-1524 | Gaeumannomyces graminis | 41.89 | 3e-17 | 75.9 |
| LLPS-Beb-1508 | Beauveria bassiana | 41.33 | 2e-16 | 73.2 |
| LLPS-Lem-1190 | Leptosphaeria maculans | 41.33 | 7e-17 | 74.7 |
| LLPS-Kop-1284 | Komagataella pastoris | 41.1 | 7e-18 | 77.8 |
| LLPS-Fuo-0844 | Fusarium oxysporum | 40.79 | 4e-18 | 77.8 |
| LLPS-Fuv-0759 | Fusarium verticillioides | 40.79 | 4e-18 | 77.8 |
| LLPS-Crn-1102 | Cryptococcus neoformans | 40.0 | 6e-13 | 64.3 |
| LLPS-Asn-1281 | Aspergillus nidulans | 39.39 | 2e-14 | 68.6 |
| LLPS-Asg-0309 | Ashbya gossypii | 38.57 | 4e-13 | 64.7 |
| LLPS-Sac-1618 | Saccharomyces cerevisiae | 38.55 | 7e-14 | 67.0 |
| LLPS-Mao-0380 | Magnaporthe oryzae | 38.36 | 3e-15 | 70.9 |
| LLPS-Blg-1501 | Blumeria graminis | 38.03 | 1e-15 | 71.6 |
| LLPS-Asc-0168 | Aspergillus clavatus | 38.03 | 8e-16 | 72.4 |
| LLPS-Asni-1225 | Aspergillus niger | 37.33 | 2e-15 | 71.2 |
| LLPS-Ast-1058 | Aspergillus terreus | 36.62 | 7e-15 | 70.1 |
| LLPS-Ova-4352 | Ovis aries | 35.29 | 7e-07 | 47.8 |
| LLPS-Orc-4353 | Oryctolagus cuniculus | 34.43 | 2e-06 | 45.8 |
| LLPS-Anc-2442 | Anolis carolinensis | 33.33 | 3e-06 | 45.8 |
| LLPS-Ora-0688 | Ornithorhynchus anatinus | 33.33 | 2e-06 | 46.6 |
| LLPS-Lac-1280 | Latimeria chalumnae | 30.51 | 2e-06 | 45.8 |