LLPS-Ran-0460
Fbp1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Fructose-1,6-bisphosphatase 1
Gene Name: Fbp1, Fbp
Ensembl Gene: ENSRNOG00000017597.6
Ensembl Protein: ENSRNOP00000023685.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVDHAPFETD  ISTLTRFVLE  EGRKAGGTGE  MTQLLNSLCT  AIKAISSAVR  QAGIAQLYGI  60
61    AGSTNVTGDQ  VKKLDILSND  LVINMLKSSY  ATCVLVSEED  THAIIIEPEK  RGKYVVCFDP  120
121   LDGSSNIDCL  ASIGTIFGIY  RKTSANEPSE  KDALQPGRNL  VAAGYALYGS  ATMLVLAMNC  180
181   GVNCFMLDPS  IGEFILVDRD  VKIKKKGNIY  SINEGYAKDF  DPAINEYIQR  KKFPPDNSLP  240
241   YGARYVGSMV  ADVHRTLVYG  GIFLNPANKK  NPSGKLRLLY  ECNPIAYVME  KAGGLATTGN  300
301   EDILDIVPTE  IHQKAPVIMG  STEDVQEFLE  IYNKDKAKSR  PSLPLPQSRA  RESPVHSICD  360
361   ELF  363
Nucleotide CDS Sequence (FASTA)
1     ATGGTGGACC  ATGCGCCCTT  CGAAACGGAT  ATCAGCACCC  TGACCCGCTT  CGTCCTGGAG  60
61    GAGGGCAGGA  AGGCTGGGGG  CACGGGCGAG  ATGACCCAGC  TGCTGAATTC  GCTCTGCACC  120
121   GCGATCAAAG  CCATCTCGTC  AGCGGTGCGC  CAGGCCGGCA  TCGCTCAGCT  CTATGGCATC  180
181   GCTGGCTCAA  CCAATGTGAC  TGGGGATCAA  GTGAAGAAGC  TGGACATACT  TTCCAATGAC  240
241   CTGGTGATCA  ATATGCTGAA  GTCGTCCTAT  GCTACCTGTG  TCCTTGTGTC  GGAAGAAGAT  300
301   ACACACGCCA  TCATAATAGA  GCCCGAGAAG  AGGGGCAAAT  ATGTTGTCTG  TTTTGATCCC  360
361   CTCGATGGCT  CATCCAACAT  CGACTGCCTC  GCGTCCATCG  GAACCATCTT  TGGCATTTAC  420
421   AGAAAGACAT  CTGCTAATGA  GCCTTCGGAG  AAAGATGCTC  TGCAGCCAGG  CAGGAACCTG  480
481   GTGGCAGCAG  GCTATGCACT  CTATGGCAGC  GCCACCATGT  TGGTCCTGGC  CATGAATTGT  540
541   GGCGTCAACT  GCTTCATGCT  GGACCCGTCC  ATTGGAGAAT  TCATTTTGGT  GGACAGGGAT  600
601   GTGAAGATCA  AGAAGAAAGG  TAACATCTAC  AGCATTAATG  AGGGCTATGC  TAAGGACTTT  660
661   GACCCTGCCA  TCAATGAGTA  TATCCAGAGG  AAAAAGTTCC  CTCCGGATAA  TTCACTCCCC  720
721   TATGGTGCCC  GGTATGTGGG  GTCCATGGTG  GCTGATGTTC  ACCGCACTCT  GGTGTATGGA  780
781   GGGATCTTCT  TAAACCCTGC  CAACAAGAAA  AATCCATCTG  GAAAGCTGCG  GCTGCTGTAC  840
841   GAGTGCAATC  CCATCGCTTA  CGTCATGGAG  AAGGCCGGTG  GACTTGCCAC  GACGGGGAAT  900
901   GAAGACATAT  TAGACATCGT  CCCCACTGAG  ATCCACCAGA  AGGCACCAGT  TATCATGGGG  960
961   TCCACCGAAG  ACGTGCAGGA  GTTCCTGGAG  ATCTACAATA  AGGACAAAGC  CAAATCAAGG  1020
1021  CCGTCCCTGC  CCCTGCCCCA  GAGCAGAGCT  CGAGAGTCAC  CGGTCCATTC  TATCTGTGAC  1080
1081  GAACTTTTCT  AG  1092

▼ KEYWORD

ID
Family
Acetylation
Allosteric enzyme
Carbohydrate metabolism
Complete proteome
Direct protein sequencing
Gluconeogenesis
Hydrolase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Molecular Function
AMP binding
Molecular Function
Fructose 1,6-bisphosphate 1-phosphatase activity
Molecular Function
Metal ion binding
Molecular Function
Monosaccharide binding
Biological Process
Carbohydrate metabolic process
Biological Process
Cellular response to drug
Biological Process
Cellular response to insulin stimulus
Biological Process
Cellular response to magnesium ion
Biological Process
Dephosphorylation
Biological Process
Fructose 1,6-bisphosphate metabolic process
Biological Process
Fructose 6-phosphate metabolic process
Biological Process
Fructose metabolic process
Biological Process
Gluconeogenesis
Biological Process
Negative regulation of cell growth
Biological Process
Negative regulation of glycolytic process
Biological Process
Negative regulation of Ras protein signal transduction
Biological Process
Protein homotetramerization
Biological Process
Regulation of gluconeogenesis
Biological Process
Sucrose biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4459Mus musculus91.420.0 645
LLPS-Loa-3159Loxodonta africana86.980.0 620
LLPS-Fec-2970Felis catus86.390.0 617
LLPS-Fud-4201Fukomys damarensis86.310.0 591
LLPS-Ict-1879Ictidomys tridecemlineatus86.090.0 612
LLPS-Sus-2199Sus scrofa86.090.0 607
LLPS-Caf-3194Canis familiaris85.80.0 611
LLPS-Orc-3952Oryctolagus cuniculus85.80.0 612
LLPS-Ere-0078Erinaceus europaeus85.80.0 588
LLPS-Nol-1901Nomascus leucogenys85.771e-171 487
LLPS-Dio-0495Dipodomys ordii85.510.0 615
LLPS-Mam-4559Macaca mulatta85.50.0 588
LLPS-Pap-3862Pan paniscus85.50.0 589
LLPS-Pat-4937Pan troglodytes85.50.0 589
LLPS-Paa-3247Papio anubis85.50.0 587
LLPS-Mup-3596Mustela putorius furo85.50.0 583
LLPS-Chs-2847Chlorocebus sabaeus85.50.0 587
LLPS-Cas-0124Carlito syrichta85.350.0 634
LLPS-Man-4015Macaca nemestrina85.290.0 590
LLPS-Poa-4041Pongo abelii85.210.0 587
LLPS-Gog-3975Gorilla gorilla85.210.0 587
LLPS-Cea-2566Cercocebus atys85.210.0 585
LLPS-Aon-1995Aotus nancymaae84.910.0 587
LLPS-Maf-0776Macaca fascicularis84.710.0 588
LLPS-Hos-4537Homo sapiens84.620.0 586
LLPS-Mod-3790Monodelphis domestica84.620.0 605
LLPS-Caj-3127Callithrix jacchus84.620.0 584
LLPS-Tut-2403Tursiops truncatus84.345e-174 493
LLPS-Ova-1086Ovis aries84.320.0 604
LLPS-Bot-1567Bos taurus84.320.0 605
LLPS-Ora-3045Ornithorhynchus anatinus84.235e-124 363
LLPS-Otg-1176Otolemur garnettii84.020.0 606
LLPS-Aim-3220Ailuropoda melanoleuca84.020.0 571
LLPS-Sah-3897Sarcophilus harrisii83.630.0 599
LLPS-Cap-1549Cavia porcellus79.820.0 555
LLPS-Scf-4091Scleropages formosus78.740.0 559
LLPS-Icp-3744Ictalurus punctatus77.540.0 542
LLPS-Leo-2773Lepisosteus oculatus77.540.0 548
LLPS-Lac-0117Latimeria chalumnae77.220.0 556
LLPS-Fia-1962Ficedula albicollis76.990.0 551
LLPS-Ten-3366Tetraodon nigroviridis76.350.0 545
LLPS-Dar-2413Danio rerio76.350.0 543
LLPS-Tar-0280Takifugu rubripes76.350.0 546
LLPS-Pof-0592Poecilia formosa75.750.0 541
LLPS-Gaa-1453Gasterosteus aculeatus75.750.0 541
LLPS-Orl-3100Oryzias latipes75.750.0 541
LLPS-Scm-0071Scophthalmus maximus75.450.0 540
LLPS-Asm-2230Astyanax mexicanus75.450.0 537
LLPS-Xim-3455Xiphophorus maculatus75.150.0 539
LLPS-Anc-3853Anolis carolinensis74.930.0 530
LLPS-Orn-1568Oreochromis niloticus74.850.0 540
LLPS-Anp-2795Anas platyrhynchos74.650.0 560
LLPS-Rhb-0743Rhinopithecus bieti74.340.0 513
LLPS-Mal-3833Mandrillus leucophaeus74.340.0 514
LLPS-Myl-3370Myotis lucifugus73.890.0 514
LLPS-Urm-1070Ursus maritimus73.810.0 528
LLPS-Mea-4001Mesocricetus auratus72.70.0 531
LLPS-Tag-3560Taeniopygia guttata71.180.0 520
LLPS-Pes-0773Pelodiscus sinensis70.883e-175 498
LLPS-Gaga-3644Gallus gallus70.294e-180 511
LLPS-Eqc-1422Equus caballus70.142e-180 513
LLPS-Xet-3308Xenopus tropicalis68.873e-179 509
LLPS-Drm-0993Drosophila melanogaster62.842e-140 410
LLPS-Cae-1778Caenorhabditis elegans62.313e-144 419
LLPS-Meg-2291Meleagris gallopavo59.376e-118 351
LLPS-Mae-1893Manihot esculenta56.65e-133 391
LLPS-Sot-1595Solanum tuberosum56.292e-129 382
LLPS-Sol-2025Solanum lycopersicum56.291e-129 382
LLPS-Nia-2073Nicotiana attenuata55.992e-128 379
LLPS-Glm-2403Glycine max55.933e-129 381
LLPS-Via-0653Vigna angularis55.831e-125 372
LLPS-Phv-2336Phaseolus vulgaris55.322e-129 382
LLPS-Bro-2330Brassica oleracea55.094e-125 370
LLPS-Brn-3236Brassica napus55.094e-125 370
LLPS-Viv-0879Vitis vinifera55.087e-126 372
LLPS-Org-1134Oryza glaberrima54.799e-128 377
LLPS-Cus-0773Cucumis sativus54.792e-123 366
LLPS-Ori-1547Oryza indica54.799e-128 377
LLPS-Brr-2725Brassica rapa54.737e-126 372
LLPS-Gas-0765Galdieria sulphuraria54.633e-118 353
LLPS-Amt-0676Amborella trichopoda54.553e-131 387
LLPS-Pot-2640Populus trichocarpa54.497e-125 370
LLPS-Ors-0326Oryza sativa54.492e-126 374
LLPS-Hea-1955Helianthus annuus54.498e-126 372
LLPS-Coc-1937Corchorus capsularis54.418e-127 375
LLPS-Sem-2268Selaginella moellendorffii54.296e-121 360
LLPS-Art-0420Arabidopsis thaliana54.258e-127 375
LLPS-Met-2046Medicago truncatula54.197e-126 372
LLPS-Mua-1971Musa acuminata54.152e-123 367
LLPS-Prp-2583Prunus persica54.121e-126 374
LLPS-Thc-1370Theobroma cacao54.122e-125 374
LLPS-Tru-1056Triticum urartu54.077e-110 336
LLPS-Arl-1308Arabidopsis lyrata53.963e-126 374
LLPS-Sei-0864Setaria italica53.922e-125 372
LLPS-Gor-1265Gossypium raimondii53.826e-126 373
LLPS-Orbr-1386Oryza brachyantha53.732e-123 367
LLPS-Cym-0442Cyanidioschyzon merolae53.453e-118 353
LLPS-Php-0454Physcomitrella patens53.398e-122 362
LLPS-Zem-2288Zea mays53.373e-124 369
LLPS-Sob-2062Sorghum bicolor53.372e-125 371
LLPS-Brd-1883Brachypodium distachyon53.299e-125 370
LLPS-Tra-1256Triticum aestivum53.089e-124 367
LLPS-Vir-0053Vigna radiata52.871e-120 359
LLPS-Chc-0612Chondrus crispus52.847e-114 343
LLPS-Put-0518Puccinia triticina52.673e-104 316
LLPS-Dac-1626Daucus carota52.26e-122 362
LLPS-Mel-1294Melampsora laricipopulina52.156e-111 334
LLPS-Pug-0731Puccinia graminis51.842e-110 333
LLPS-Miv-0977Microbotryum violaceum51.813e-109 330
LLPS-Hov-0952Hordeum vulgare51.741e-119 357
LLPS-Orp-2123Oryza punctata51.29e-115 343
LLPS-Usm-1052Ustilago maydis50.588e-110 332
LLPS-Spr-1326Sporisorium reilianum50.293e-109 330
LLPS-Crn-1477Cryptococcus neoformans50.291e-107 326
LLPS-Asg-0026Ashbya gossypii49.544e-100 306
LLPS-Abg-1024Absidia glauca49.038e-92 305
LLPS-Orm-1835Oryza meridionalis48.613e-111 336
LLPS-Yal-1114Yarrowia lipolytica47.852e-100 308
LLPS-Orr-2432Oryza rufipogon47.299e-116 349
LLPS-Orgl-2223Oryza glumaepatula47.298e-116 349
LLPS-Orni-2206Oryza nivara47.299e-116 349
LLPS-Orb-2069Oryza barthii47.298e-116 349
LLPS-Zyt-0590Zymoseptoria tritici47.28e-82 258
LLPS-Kop-0617Komagataella pastoris46.992e-97 300
LLPS-Dos-1098Dothistroma septosporum46.811e-96 298
LLPS-Lep-1814Leersia perrieri46.723e-102 312
LLPS-Tum-0929Tuber melanosporum46.691e-95 296
LLPS-Mao-0055Magnaporthe oryzae46.532e-90 282
LLPS-Sac-1628Saccharomyces cerevisiae46.112e-95 295
LLPS-Asf-1008Aspergillus flavus46.062e-98 303
LLPS-Aso-0549Aspergillus oryzae46.062e-98 303
LLPS-Cogr-0031Colletotrichum graminicola45.652e-91 285
LLPS-Cog-0298Colletotrichum gloeosporioides45.655e-94 291
LLPS-Asn-1360Aspergillus nidulans45.543e-93 290
LLPS-Fus-1534Fusarium solani45.292e-92 287
LLPS-Coo-1576Colletotrichum orbiculare45.122e-90 282
LLPS-Gag-1564Gaeumannomyces graminis45.063e-90 281
LLPS-Ved-1190Verticillium dahliae45.034e-89 279
LLPS-Asfu-1441Aspergillus fumigatus45.04e-95 295
LLPS-Map-1359Magnaporthe poae44.923e-90 281
LLPS-Blg-0012Blumeria graminis44.727e-91 283
LLPS-Nef-1425Neosartorya fischeri44.713e-94 292
LLPS-Nec-0220Neurospora crassa44.649e-93 288
LLPS-Ast-1480Aspergillus terreus44.616e-95 294
LLPS-Fuo-0836Fusarium oxysporum44.212e-88 277
LLPS-Fuv-1393Fusarium verticillioides44.212e-89 279
LLPS-Asc-1467Aspergillus clavatus44.182e-90 282
LLPS-Asni-1333Aspergillus niger43.999e-95 293
LLPS-Trv-0538Trichoderma virens43.94e-85 268
LLPS-Beb-1085Beauveria bassiana43.93e-86 271
LLPS-Phn-1457Phaeosphaeria nodorum43.772e-90 282
LLPS-Trr-1273Trichoderma reesei43.65e-85 268
LLPS-Pytr-1211Pyrenophora triticirepentis43.474e-91 284
LLPS-Scp-1332Schizosaccharomyces pombe43.441e-90 282
LLPS-Scc-1572Schizosaccharomyces cryophilus43.323e-88 276
LLPS-Lem-1349Leptosphaeria maculans43.161e-86 276
LLPS-Pyt-1312Pyrenophora teres42.864e-91 284
LLPS-Osl-1378Ostreococcus lucimarinus39.815e-70 229