LLPS-Ran-0021
Ctsb

▼ OVERVIEW

Status: Reviewed
Protein Name: Cathepsin B; Cathepsin B1; RSG-2
Gene Name: Ctsb
Ensembl Gene: ENSRNOG00000010331.5
Ensembl Protein: ENSRNOP00000014178.4
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client
PDB: 1CTE (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Chromatoid body
"...Components of the CB."
Round spermatids18787638

▼ FUNCTION

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:1639824). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSRNOT00000014177.5ENSRNOP00000014178.4
UniProtP00787, CATB_RAT
GeneBankX82396, M11305AAA40993.1, CAA57792.1
Entrez64529

▼ SEQUENCE

Protein Sequence (FASTA)
1     MWWSLIPLSC  LLALTSAHDK  PSFHPLSDDM  INYINKQNTT  WQAGRNFYNV  DISYLKKLCG  60
61    TVLGGPKLPE  RVGFSEDINL  PESFDAREQW  SNCPTIAQIR  DQGSCGSCWA  FGAVEAMSDR  120
121   ICIHTNGRVN  VEVSAEDLLT  CCGIQCGDGC  NGGYPSGAWN  FWTRKGLVSG  GVYNSHIGCL  180
181   PYTIPPCEHH  VNGSRPPCTG  EGDTPKCNKM  CEAGYSTSYK  EDKHYGYTSY  SVSDSEKEIM  240
241   AEIYKNGPVE  GAFTVFSDFL  TYKSGVYKHE  AGDVMGGHAI  RILGWGIENG  VPYWLVANSW  300
301   NVDWGDNGFF  KILRGENHCG  IESEIVAGIP  RTQQYWGRF  339
Nucleotide CDS Sequence (FASTA)
1     ATGTGGTGGT  CCTTGATCCC  TCTCTCTTGC  CTGCTGGCAC  TGACCAGTGC  CCATGACAAG  60
61    CCTTCCTTTC  ACCCACTGTC  GGACGACATG  ATTAACTATA  TCAACAAACA  GAATACAACA  120
121   TGGCAGGCTG  GACGCAACTT  CTACAATGTT  GACATAAGCT  ATCTGAAGAA  GCTGTGTGGA  180
181   ACTGTCCTGG  GTGGACCCAA  GCTGCCGGAA  AGGGTTGGGT  TCAGCGAGGA  CATAAATCTA  240
241   CCTGAATCCT  TTGATGCACG  GGAACAGTGG  TCCAATTGCC  CGACCATCGC  ACAGATCAGA  300
301   GACCAGGGGT  CCTGTGGCTC  TTGTTGGGCA  TTTGGGGCAG  TGGAAGCCAT  GTCTGACCGA  360
361   ATCTGCATTC  ACACCAATGG  CCGAGTCAAT  GTGGAGGTGT  CTGCTGAGGA  CCTGCTTACC  420
421   TGCTGTGGTA  TCCAGTGTGG  GGATGGCTGT  AATGGTGGCT  ATCCCTCTGG  AGCATGGAAC  480
481   TTCTGGACTA  GAAAAGGCCT  GGTTTCTGGT  GGAGTATACA  ATTCTCATAT  AGGCTGCTTA  540
541   CCCTACACCA  TCCCTCCCTG  TGAACACCAT  GTCAATGGCT  CCCGTCCCCC  ATGCACTGGA  600
601   GAAGGAGATA  CTCCCAAGTG  CAACAAGATG  TGTGAGGCTG  GCTACTCCAC  ATCCTACAAG  660
661   GAAGATAAGC  ACTATGGGTA  CACTTCCTAC  AGTGTGTCTG  ACAGCGAGAA  GGAGATCATG  720
721   GCGGAAATCT  ACAAAAATGG  CCCAGTGGAG  GGTGCTTTTA  CTGTGTTTTC  TGACTTCTTG  780
781   ACTTACAAAT  CAGGCGTATA  CAAGCATGAA  GCCGGTGATG  TGATGGGAGG  CCATGCCATC  840
841   CGCATTCTGG  GCTGGGGAAT  AGAGAATGGA  GTACCCTACT  GGCTGGTAGC  AAACTCCTGG  900
901   AACGTTGACT  GGGGTGATAA  TGGTTTCTTT  AAAATCCTCA  GAGGAGAGAA  CCACTGTGGA  960
961   ATTGAATCAG  AAATCGTGGC  TGGAATCCCA  CGCACTCAGC  AGTACTGGGG  AAGATTCTAA  1020

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Protease
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical plasma membrane
Cellular Component
Cell surface
Cellular Component
Cytoplasm
Cellular Component
External side of plasma membrane
Cellular Component
Extracellular region
Cellular Component
Extracellular space
Cellular Component
Lysosome
Cellular Component
Melanosome
Cellular Component
Mitochondrion
Cellular Component
Sarcolemma
Molecular Function
Cysteine-type endopeptidase activity
Molecular Function
Endopeptidase activity
Molecular Function
Kininogen binding
Molecular Function
Peptide binding
Molecular Function
Protein self-association
Molecular Function
Protein-containing complex binding
Biological Process
Autophagy
Biological Process
Cellular response to mechanical stimulus
Biological Process
Negative regulation of cell death
Biological Process
Proteolysis
Biological Process
Proteolysis involved in cellular protein catabolic process
Biological Process
Regulation of catalytic activity
Biological Process
Response to amine
Biological Process
Response to cytokine
Biological Process
Response to ethanol
Biological Process
Response to glucose
Biological Process
Response to interleukin-4
Biological Process
Response to mechanical stimulus
Biological Process
Response to organic cyclic compound
Biological Process
Response to peptide hormone
Biological Process
Response to wounding
Biological Process
Skeletal muscle tissue development
Biological Process
Spermatogenesis

▼ ANNOTATION

Disorder
D2P2IUPred2A
Physicochemical
AAindex
Function
RaftProt
Structure
PDBMMDB
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4940Mus musculus92.920.0 645
LLPS-Mea-1475Mesocricetus auratus89.680.0 651
LLPS-Dio-1538Dipodomys ordii85.250.0 614
LLPS-Orc-3213Oryctolagus cuniculus82.140.0 540
LLPS-Cap-1125Cavia porcellus81.180.0 568
LLPS-Maf-4263Macaca fascicularis80.530.0 597
LLPS-Fud-1254Fukomys damarensis80.290.0 587
LLPS-Cea-2705Cercocebus atys80.240.0 593
LLPS-Mal-1331Mandrillus leucophaeus80.240.0 593
LLPS-Paa-1700Papio anubis80.240.0 593
LLPS-Man-3609Macaca nemestrina80.240.0 593
LLPS-Mam-2363Macaca mulatta80.240.0 593
LLPS-Chs-0204Chlorocebus sabaeus79.940.0 591
LLPS-Rhb-3172Rhinopithecus bieti79.940.0 591
LLPS-Caj-0704Callithrix jacchus79.460.0 582
LLPS-Poa-0282Pongo abelii79.350.0 587
LLPS-Bot-2554Bos taurus79.10.0 546
LLPS-Gog-4330Gorilla gorilla79.060.0 586
LLPS-Aon-3062Aotus nancymaae79.060.0 584
LLPS-Otg-2829Otolemur garnettii79.060.0 547
LLPS-Pap-2143Pan paniscus79.060.0 586
LLPS-Urm-3636Ursus maritimus78.953e-103 308
LLPS-Pat-1568Pan troglodytes78.760.0 584
LLPS-Hos-3329Homo sapiens78.760.0 584
LLPS-Sus-1547Sus scrofa78.510.0 572
LLPS-Ova-3601Ovis aries77.610.0 567
LLPS-Tut-2200Tursiops truncatus77.610.0 552
LLPS-Mup-0259Mustela putorius furo77.290.0 557
LLPS-Aim-2385Ailuropoda melanoleuca76.70.0 548
LLPS-Caf-3909Canis familiaris76.40.0 565
LLPS-Fec-0783Felis catus75.520.0 563
LLPS-Loa-1288Loxodonta africana75.150.0 557
LLPS-Nol-2587Nomascus leucogenys74.780.0 536
LLPS-Meg-2331Meleagris gallopavo74.630.0 550
LLPS-Mod-3606Monodelphis domestica74.480.0 542
LLPS-Anp-2955Anas platyrhynchos74.410.0 549
LLPS-Anc-0044Anolis carolinensis74.326e-173 491
LLPS-Tag-0770Taeniopygia guttata74.120.0 548
LLPS-Gaga-3040Gallus gallus74.040.0 548
LLPS-Sah-1353Sarcophilus harrisii73.680.0 546
LLPS-Eqc-1602Equus caballus72.913e-154 446
LLPS-Orn-1874Oreochromis niloticus71.571e-172 490
LLPS-Icp-0530Ictalurus punctatus71.532e-158 455
LLPS-Fia-1988Ficedula albicollis71.260.0 514
LLPS-Orl-3251Oryzias latipes71.258e-173 491
LLPS-Ten-3161Tetraodon nigroviridis71.124e-169 481
LLPS-Cas-2058Carlito syrichta70.81e-158 453
LLPS-Pof-1651Poecilia formosa70.663e-168 479
LLPS-Ora-1275Ornithorhynchus anatinus70.392e-89 275
LLPS-Xet-2710Xenopus tropicalis70.330.0 514
LLPS-Leo-3449Lepisosteus oculatus69.821e-172 490
LLPS-Scf-3829Scleropages formosus69.499e-178 504
LLPS-Asm-1606Astyanax mexicanus69.432e-162 466
LLPS-Dar-3486Danio rerio69.32e-172 489
LLPS-Tar-1622Takifugu rubripes68.484e-167 476
LLPS-Scm-3023Scophthalmus maximus68.379e-165 471
LLPS-Gaa-0060Gasterosteus aculeatus67.551e-174 496
LLPS-Lac-2885Latimeria chalumnae66.371e-166 476
LLPS-Xim-0726Xiphophorus maculatus65.123e-158 454
LLPS-Pes-2328Pelodiscus sinensis62.692e-142 414
LLPS-Cis-0603Ciona savignyi62.542e-135 396
LLPS-Myl-3938Myotis lucifugus60.935e-123 363
LLPS-Drm-1810Drosophila melanogaster56.593e-132 388
LLPS-Cii-2119Ciona intestinalis50.661e-38 142
LLPS-Cae-1971Caenorhabditis elegans49.523e-103 314
LLPS-Brd-2046Brachypodium distachyon48.06e-94 291
LLPS-Via-2247Vigna angularis47.215e-88 276
LLPS-Pot-2467Populus trichocarpa47.176e-87 274
LLPS-Tra-0847Triticum aestivum47.085e-92 285
LLPS-Sot-1254Solanum tuberosum47.032e-67 218
LLPS-Nia-1091Nicotiana attenuata46.984e-90 281
LLPS-Hov-1319Hordeum vulgare46.673e-88 276
LLPS-Vir-1967Vigna radiata46.423e-88 276
LLPS-Gor-2677Gossypium raimondii46.421e-89 280
LLPS-Orbr-1622Oryza brachyantha46.352e-88 276
LLPS-Tru-1918Triticum urartu46.211e-76 245
LLPS-Ori-1742Oryza indica46.061e-87 275
LLPS-Sem-1761Selaginella moellendorffii45.961e-82 261
LLPS-Cus-2120Cucumis sativus45.941e-89 280
LLPS-Orp-1183Oryza punctata45.741e-86 272
LLPS-Amt-0649Amborella trichopoda45.516e-88 275
LLPS-Phv-1972Phaseolus vulgaris45.459e-89 277
LLPS-Art-2536Arabidopsis thaliana45.313e-86 271
LLPS-Sob-2015Sorghum bicolor44.951e-87 275
LLPS-Prp-2103Prunus persica44.838e-83 262
LLPS-Bro-0027Brassica oleracea44.652e-85 268
LLPS-Dac-2443Daucus carota44.622e-85 268
LLPS-Sei-2462Setaria italica44.582e-86 274
LLPS-Arl-2793Arabidopsis lyrata44.415e-86 270
LLPS-Met-2471Medicago truncatula44.341e-85 269
LLPS-Brr-2291Brassica rapa44.348e-85 267
LLPS-Lep-1266Leersia perrieri44.34e-72 240
LLPS-Thc-0646Theobroma cacao44.24e-84 265
LLPS-Brn-1022Brassica napus44.032e-83 263
LLPS-Mua-2192Musa acuminata43.962e-82 261
LLPS-Glm-2281Glycine max43.915e-88 275
LLPS-Mae-1585Manihot esculenta43.074e-87 273
LLPS-Php-2392Physcomitrella patens42.491e-85 269
LLPS-Sol-0896Solanum lycopersicum42.191e-83 265
LLPS-Orgl-1777Oryza glumaepatula40.881e-81 261
LLPS-Coc-1967Corchorus capsularis40.755e-71 231
LLPS-Zem-2505Zea mays39.777e-69 226
LLPS-Viv-2158Vitis vinifera39.491e-73 239
LLPS-Orni-2302Oryza nivara36.236e-62 208
LLPS-Orb-1387Oryza barthii36.236e-62 208
LLPS-Orr-0916Oryza rufipogon36.236e-62 208
LLPS-Osl-1190Ostreococcus lucimarinus35.042e-39 145
LLPS-Hea-2339Helianthus annuus30.07e-1990.9
LLPS-Ere-0455Erinaceus europaeus27.492e-1785.5
LLPS-Org-1925Oryza glaberrima26.757e-1990.9
LLPS-Orm-1343Oryza meridionalis26.432e-1992.8