LLPS-Pof-2634
ENY2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transcription and mRNA export factor ENY2; Enhancer of yellow 2 transcription factor homolog |
| Gene Name: | ENY2 |
| Ensembl Gene: | ENSPFOG00000019257.2 |
| Ensembl Protein: | ENSPFOP00000019374.2 |
| Organism: | Poecilia formosa |
| Taxa ID: | 48698 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPFOT00000019396.1 | ENSPFOP00000019374.2 |
| Ensembl | ENSPFOT00000029583.1 | ENSPFOP00000025117.1 |
| UniProt | A0A096M126, A0A096M126_POEFO | |
| GeneBank | AYCK01000145 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 SLKFLPRGLS SKHFVNETYL QPHISVLTNT MNKEARLKAS INQKLTETGE RDRLKELLRA 60 61 KLTECGWKDQ MKAQCKDVIK QKGLEHVTVE DLVVEVTPKG RALVPDSVKK ELLQRIRAFL 120 121 TQHAS 125 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAATAAAG AAGCCAGACT GAAGGCATCA ATAAACCAGA AGCTAACGGA GACAGGAGAA 60 61 AGAGATCGAC TGAAGGAGCT GCTGAGAGCT AAGCTCACAG AGTGTGGGTG GAAGGACCAA 120 121 ATGAAGGCTC AATGCAAAGA CGTCATCAAA CAAAAAGGTC TGGAGCACGT GACGGTGGAG 180 181 GACCTTGTTG TAGAGGTCAC CCCTAAAGGA AGAGCCTTGG TGCCAGACAG CGTTAAGAAG 240 241 GAGCTCCTAC AGAGAATTCG AGCCTTTTTG ACACAGCACG CCTCATAG 288 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | DUBm complex | |
Cellular Component | Nuclear pore | |
Cellular Component | SAGA complex | |
Cellular Component | Transcription export complex 2 | |
Molecular Function | Transcription coactivator activity | |
Biological Process | Histone deubiquitination | |
Biological Process | MRNA export from nucleus | |
Biological Process | Positive regulation of transcription, DNA-templated | |
Biological Process | Transcription elongation from RNA polymerase II promoter |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Xim-0293 | Xiphophorus maculatus | 100.0 | 7e-65 | 199 |
| LLPS-Fia-1177 | Ficedula albicollis | 83.16 | 5e-53 | 168 |
| LLPS-Pes-2713 | Pelodiscus sinensis | 83.16 | 7e-53 | 168 |
| LLPS-Mod-3378 | Monodelphis domestica | 83.16 | 5e-53 | 169 |
| LLPS-Tag-0120 | Taeniopygia guttata | 83.16 | 4e-53 | 169 |
| LLPS-Anc-1209 | Anolis carolinensis | 83.16 | 5e-53 | 168 |
| LLPS-Ten-3576 | Tetraodon nigroviridis | 83.16 | 3e-52 | 166 |
| LLPS-Sah-1993 | Sarcophilus harrisii | 82.47 | 8e-54 | 171 |
| LLPS-Leo-2330 | Lepisosteus oculatus | 82.11 | 6e-52 | 166 |
| LLPS-Xet-2841 | Xenopus tropicalis | 82.11 | 1e-52 | 167 |
| LLPS-Anp-0981 | Anas platyrhynchos | 81.25 | 2e-52 | 167 |
| LLPS-Paa-4075 | Papio anubis | 81.05 | 2e-51 | 164 |
| LLPS-Scm-1418 | Scophthalmus maximus | 81.05 | 8e-52 | 165 |
| LLPS-Lac-1693 | Latimeria chalumnae | 81.05 | 8e-52 | 165 |
| LLPS-Gaga-3113 | Gallus gallus | 81.05 | 6e-52 | 166 |
| LLPS-Loa-0110 | Loxodonta africana | 79.59 | 2e-52 | 167 |
| LLPS-Orc-4064 | Oryctolagus cuniculus | 79.0 | 2e-53 | 169 |
| LLPS-Maf-1362 | Macaca fascicularis | 78.95 | 3e-49 | 159 |
| LLPS-Cas-2693 | Carlito syrichta | 78.79 | 9e-53 | 168 |
| LLPS-Cap-0411 | Cavia porcellus | 78.79 | 1e-52 | 167 |
| LLPS-Tar-0397 | Takifugu rubripes | 78.64 | 1e-52 | 169 |
| LLPS-Fud-3696 | Fukomys damarensis | 78.0 | 2e-53 | 169 |
| LLPS-Gog-1746 | Gorilla gorilla | 78.0 | 1e-52 | 167 |
| LLPS-Sus-2988 | Sus scrofa | 78.0 | 1e-52 | 167 |
| LLPS-Aon-0982 | Aotus nancymaae | 78.0 | 1e-52 | 167 |
| LLPS-Chs-2434 | Chlorocebus sabaeus | 78.0 | 1e-52 | 167 |
| LLPS-Mum-3746 | Mus musculus | 78.0 | 1e-52 | 167 |
| LLPS-Mea-3914 | Mesocricetus auratus | 78.0 | 1e-52 | 167 |
| LLPS-Myl-3510 | Myotis lucifugus | 78.0 | 1e-52 | 167 |
| LLPS-Mup-3598 | Mustela putorius furo | 78.0 | 1e-52 | 167 |
| LLPS-Ran-2514 | Rattus norvegicus | 78.0 | 1e-52 | 167 |
| LLPS-Bot-4859 | Bos taurus | 78.0 | 1e-52 | 167 |
| LLPS-Dio-0067 | Dipodomys ordii | 78.0 | 1e-52 | 167 |
| LLPS-Tut-2311 | Tursiops truncatus | 78.0 | 1e-52 | 167 |
| LLPS-Otg-2769 | Otolemur garnettii | 78.0 | 1e-52 | 167 |
| LLPS-Fec-4074 | Felis catus | 78.0 | 1e-52 | 167 |
| LLPS-Hos-4055 | Homo sapiens | 78.0 | 1e-52 | 167 |
| LLPS-Pap-3134 | Pan paniscus | 78.0 | 1e-52 | 167 |
| LLPS-Nol-0188 | Nomascus leucogenys | 78.0 | 1e-52 | 167 |
| LLPS-Ict-0933 | Ictidomys tridecemlineatus | 78.0 | 1e-52 | 167 |
| LLPS-Mam-4419 | Macaca mulatta | 78.0 | 1e-52 | 167 |
| LLPS-Eqc-1096 | Equus caballus | 78.0 | 1e-52 | 167 |
| LLPS-Poa-0825 | Pongo abelii | 78.0 | 1e-52 | 167 |
| LLPS-Scf-2558 | Scleropages formosus | 77.89 | 1e-48 | 157 |
| LLPS-Caf-4561 | Canis familiaris | 77.78 | 1e-50 | 162 |
| LLPS-Ora-2243 | Ornithorhynchus anatinus | 77.45 | 2e-53 | 171 |
| LLPS-Icp-2558 | Ictalurus punctatus | 76.84 | 9e-49 | 157 |
| LLPS-Dar-3683 | Danio rerio | 76.84 | 3e-48 | 156 |
| LLPS-Caj-3260 | Callithrix jacchus | 76.0 | 7e-44 | 145 |
| LLPS-Urm-0994 | Ursus maritimus | 71.77 | 8e-58 | 183 |
| LLPS-Mae-1916 | Manihot esculenta | 62.37 | 3e-33 | 118 |
| LLPS-Brd-1879 | Brachypodium distachyon | 58.7 | 7e-31 | 112 |
| LLPS-Sem-0942 | Selaginella moellendorffii | 58.62 | 2e-30 | 111 |
| LLPS-Orbr-1807 | Oryza brachyantha | 56.99 | 8e-31 | 112 |
| LLPS-Cii-0500 | Ciona intestinalis | 56.12 | 4e-38 | 130 |
| LLPS-Drm-0801 | Drosophila melanogaster | 48.81 | 1e-23 | 93.6 |
| LLPS-Sac-0493 | Saccharomyces cerevisiae | 32.56 | 1e-06 | 47.8 |
| LLPS-Crn-1242 | Cryptococcus neoformans | 32.32 | 1e-08 | 53.1 |
| LLPS-Asg-1528 | Ashbya gossypii | 32.22 | 3e-07 | 49.3 |
| LLPS-Kop-1506 | Komagataella pastoris | 30.95 | 4e-09 | 54.7 |
| LLPS-Yal-0787 | Yarrowia lipolytica | 28.24 | 5e-06 | 45.8 |