LLPS-Pof-1064
LZTS2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Leucine zipper putative tumor suppressor 2 homolog; Protein LAPSER1 |
| Gene Name: | LZTS2, LAPSER1 |
| Ensembl Gene: | ENSPFOG00000004153.2 |
| Ensembl Protein: | ENSPFOP00000004056.2 |
| Organism: | Poecilia formosa |
| Taxa ID: | 48698 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPFOT00000004064.2 | ENSPFOP00000004056.2 |
| UniProt | A0A087XE53, A0A087XE53_POEFO | |
| GeneBank | AYCK01011216 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALVQALPVS DHPNPGLDLH QCRPLSPHSP SDPCSGPCGA CSADAAMGSV SSLISGRTYQ 60 61 ERHCRAGSEF ANKPRRSTPA TSCFRLQDKS LRSGSSLEQL LVNSNHSGGG MAAGAAGGGT 120 121 NANFGYVSEE AVLGDWNDNL VLTVASPCSD PEDQKDSGTV NGNIGGPPPK LVPVSGQLEK 180 181 NMEKVLIRPT AFKPVVPKNR HSVQYLSPRP GGSSLSESQA SLNVLLPLAA PNGTSSTNGN 240 241 ICSSSSEGKT NSCGGRNARS SQSCSMSDSG RNSLSSLPTH SSTGYSLAPS EGSSSGSGSG 300 301 GSVEPVSALV RNTSGGSGGH GHSNSDSGRS SFSKSTGSGS LSGRGQPLSD SGSCGHSPPP 360 361 VEGYEVVVKE LEEKLRERDL ELQQLRENLD ENEAAICQVY EEKQRRCERE MEELRQSCAV 420 421 KMKQTSQKAQ RAQQVLQLQV FQLQQEKKKL QEDFSSLLQD RETLERKCAT IQREQTQLGP 480 481 RLEETKWEVC QKSGEISLLK QQLKEIQSEL TQKAGDIVVL KAQLREARSE LQASQGRTQE 540 541 AQTALRTRSL ELEVCENELQ RRKSEAELLR EKVSRLEDES GRIRDTLSNH SGNAPKKGLG 600 601 VSLSFQQGRV VMGRGGPSPC MYRDGEDGYL VWGGESDEAK AQRQNAETLM GLRQQQVDRL 660 661 KAELMYERRT GEEQRSRFEE ERRVWHEEKE KVVIRYQKQL QQNYIQMYRR NRDLERVMRE 720 721 LSLELENRDM EDYEVRSGSN DIHFEEITAT EI 752 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTCTGG TCCAGGCACT CCCTGTGAGT GACCATCCCA ATCCAGGTCT TGACCTCCAC 60 61 CAGTGCCGGC CACTGTCACC CCACTCCCCC TCGGACCCTT GCTCCGGTCC TTGTGGGGCC 120 121 TGCAGCGCCG ACGCAGCCAT GGGTTCAGTC AGCAGTCTCA TATCAGGCAG GACGTATCAA 180 181 GAGAGGCACT GCAGGGCTGG CAGCGAATTC GCCAACAAAC CACGTCGCTC CACGCCGGCC 240 241 ACCAGCTGCT TCCGGCTGCA GGACAAAAGC CTCCGCAGCG GGAGCTCCCT GGAGCAGCTG 300 301 CTGGTCAACA GCAACCACAG TGGGGGTGGA ATGGCTGCTG GAGCAGCCGG AGGTGGAACC 360 361 AACGCAAACT TTGGATACGT AAGCGAAGAG GCGGTTCTCG GAGACTGGAA CGACAACCTG 420 421 GTGCTGACCG TCGCCAGTCC CTGCAGCGAC CCGGAGGACC AAAAGGACAG CGGGACTGTG 480 481 AACGGCAACA TCGGCGGGCC TCCTCCCAAA CTCGTCCCCG TGTCTGGACA GCTGGAGAAG 540 541 AACATGGAGA AAGTCTTGAT TCGTCCCACG GCTTTCAAAC CTGTCGTCCC CAAGAACCGT 600 601 CACTCGGTGC AGTACCTGTC TCCGCGGCCA GGAGGCAGCA GTCTGTCCGA GAGCCAGGCC 660 661 AGCCTGAACG TCCTGTTGCC CCTCGCCGCC CCCAACGGCA CGAGCAGCAC AAACGGCAAC 720 721 ATTTGCAGCT CCAGCTCCGA GGGGAAAACC AACTCGTGCG GAGGCCGTAA CGCTCGCAGC 780 781 AGCCAGTCCT GCTCCATGTC CGACTCGGGG AGGAACTCCC TCTCCAGCCT CCCCACTCAC 840 841 AGCAGCACGG GCTACAGTTT GGCCCCCAGC GAGGGATCCA GCTCGGGGTC TGGTTCCGGG 900 901 GGCTCGGTGG AGCCGGTGTC GGCTCTGGTT CGCAACACTT CAGGGGGAAG CGGCGGCCAC 960 961 GGTCACAGCA ATTCGGACAG CGGACGATCC TCCTTCAGCA AAAGCACAGG CTCGGGGTCG 1020 1021 CTGAGCGGGC GCGGGCAGCC CCTCTCCGAC AGCGGGTCCT GTGGGCACTC GCCGCCGCCT 1080 1081 GTGGAGGGAT ACGAAGTGGT GGTGAAGGAG CTGGAGGAGA AGCTGAGGGA GCGAGACCTG 1140 1141 GAGCTCCAAC AGCTCCGGGA AAACCTGGAC GAGAACGAGG CGGCCATCTG CCAGGTGTAT 1200 1201 GAAGAGAAGC AGCGACGGTG TGAGAGAGAG ATGGAGGAGT TGAGGCAGAG CTGTGCAGTC 1260 1261 AAGATGAAAC AGACGTCTCA GAAAGCTCAG AGAGCACAGC AGGTGCTGCA GTTACAGGTA 1320 1321 TTCCAGCTGC AGCAGGAGAA AAAGAAGCTG CAGGAGGATT TCTCATCCCT GCTGCAGGAC 1380 1381 AGAGAAACAC TAGAAAGAAA GTGTGCCACC ATCCAGAGGG AGCAGACGCA GCTGGGGCCC 1440 1441 CGTCTGGAGG AGACGAAGTG GGAGGTTTGT CAGAAGTCGG GAGAGATCTC GCTCCTGAAG 1500 1501 CAGCAGCTGA AAGAAATCCA GTCTGAGCTC ACCCAGAAAG CGGGCGACAT TGTGGTGCTC 1560 1561 AAGGCCCAGC TCAGGGAAGC TCGCTCCGAG CTGCAAGCGA GCCAGGGCCG AACCCAAGAG 1620 1621 GCCCAGACGG CCCTGCGGAC GCGATCCCTG GAGCTGGAGG TCTGCGAGAA CGAACTCCAA 1680 1681 AGACGCAAGA GCGAAGCCGA GCTGCTGCGT GAAAAGGTCA GCCGTCTCGA GGACGAATCG 1740 1741 GGTCGGATCC GCGACACGCT GTCCAATCAC AGCGGGAACG CGCCCAAGAA GGGGCTCGGC 1800 1801 GTGAGCCTGT CGTTTCAACA GGGAAGAGTT GTGATGGGAA GGGGAGGCCC CAGCCCCTGC 1860 1861 ATGTACCGTG ATGGAGAGGA CGGTTACCTG GTGTGGGGCG GAGAGAGCGA CGAAGCCAAG 1920 1921 GCTCAGAGGC AGAATGCAGA AACGCTAATG GGACTCAGAC AGCAGCAGGT GGATCGACTG 1980 1981 AAAGCCGAGC TCATGTATGA GAGAAGAACT GGCGAGGAGC AGCGGTCACG ATTTGAGGAA 2040 2041 GAGAGGAGGG TCTGGCACGA GGAGAAAGAG AAAGTAGTAA TCCGCTACCA AAAGCAGCTG 2100 2101 CAGCAGAACT ACATCCAGAT GTATCGCCGC AACCGTGATC TGGAGCGCGT GATGAGGGAG 2160 2161 CTGAGTCTGG AGCTGGAGAA CAGGGACATG GAGGACTACG AGGTCCGCAG CGGCAGCAAC 2220 2221 GACATCCACT TTGAGGAAAT CACTGCCACT GAGATCTAG 2259 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule | |
Cellular Component | Midbody | |
Molecular Function | Beta-catenin binding | |
Biological Process | Cell migration involved in gastrulation | |
Biological Process | Convergent extension | |
Biological Process | Dorsal/ventral pattern formation | |
Biological Process | Microtubule severing | |
Biological Process | Mitotic cytokinesis | |
Biological Process | Negative regulation of canonical Wnt signaling pathway | |
Biological Process | Nuclear export | |
Biological Process | Positive regulation of BMP signaling pathway | |
Biological Process | Spindle midzone assembly | |
Biological Process | Wnt signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Xim-2218 | Xiphophorus maculatus | 90.0 | 0.0 | 1102 |
| LLPS-Scm-2890 | Scophthalmus maximus | 79.79 | 0.0 | 908 |
| LLPS-Orl-3224 | Oryzias latipes | 79.21 | 0.0 | 867 |
| LLPS-Tar-1476 | Takifugu rubripes | 78.47 | 0.0 | 885 |
| LLPS-Gaa-1768 | Gasterosteus aculeatus | 74.86 | 0.0 | 790 |
| LLPS-Meg-2324 | Meleagris gallopavo | 74.1 | 3e-36 | 147 |
| LLPS-Ten-0843 | Tetraodon nigroviridis | 73.57 | 0.0 | 772 |
| LLPS-Orn-0052 | Oreochromis niloticus | 71.45 | 0.0 | 725 |
| LLPS-Asm-0665 | Astyanax mexicanus | 70.73 | 1e-130 | 410 |
| LLPS-Leo-2468 | Lepisosteus oculatus | 68.29 | 1e-112 | 363 |
| LLPS-Dar-3635 | Danio rerio | 66.74 | 1e-127 | 404 |
| LLPS-Scf-3779 | Scleropages formosus | 65.44 | 2e-102 | 332 |
| LLPS-Lac-0481 | Latimeria chalumnae | 65.27 | 4e-105 | 343 |
| LLPS-Icp-0022 | Ictalurus punctatus | 60.79 | 0.0 | 669 |
| LLPS-Xet-3884 | Xenopus tropicalis | 59.11 | 3e-97 | 323 |
| LLPS-Anc-2092 | Anolis carolinensis | 58.48 | 1e-84 | 287 |
| LLPS-Mod-4275 | Monodelphis domestica | 56.27 | 2e-76 | 266 |
| LLPS-Loa-3202 | Loxodonta africana | 54.06 | 9e-70 | 248 |
| LLPS-Gaga-0577 | Gallus gallus | 53.35 | 4e-72 | 254 |
| LLPS-Ere-0915 | Erinaceus europaeus | 52.11 | 3e-46 | 177 |
| LLPS-Mum-3092 | Mus musculus | 52.09 | 7e-65 | 234 |
| LLPS-Ran-2091 | Rattus norvegicus | 52.09 | 1e-67 | 241 |
| LLPS-Caf-0262 | Canis familiaris | 51.58 | 1e-44 | 174 |
| LLPS-Mea-2171 | Mesocricetus auratus | 50.98 | 3e-63 | 229 |
| LLPS-Ict-2999 | Ictidomys tridecemlineatus | 50.14 | 7e-65 | 234 |
| LLPS-Ora-3210 | Ornithorhynchus anatinus | 49.44 | 1e-69 | 246 |
| LLPS-Caj-4404 | Callithrix jacchus | 48.75 | 2e-69 | 247 |
| LLPS-Myl-0451 | Myotis lucifugus | 48.74 | 5e-68 | 243 |
| LLPS-Pap-0982 | Pan paniscus | 48.47 | 2e-68 | 244 |
| LLPS-Dio-1876 | Dipodomys ordii | 48.33 | 5e-59 | 216 |
| LLPS-Orc-4271 | Oryctolagus cuniculus | 48.33 | 2e-59 | 219 |
| LLPS-Cap-3363 | Cavia porcellus | 48.19 | 5e-62 | 226 |
| LLPS-Bot-3222 | Bos taurus | 47.62 | 8e-65 | 234 |
| LLPS-Sus-4051 | Sus scrofa | 46.5 | 7e-66 | 237 |
| LLPS-Aon-0636 | Aotus nancymaae | 45.96 | 2e-64 | 231 |
| LLPS-Pat-0238 | Pan troglodytes | 45.96 | 7e-65 | 234 |
| LLPS-Hos-0636 | Homo sapiens | 45.96 | 7e-65 | 234 |
| LLPS-Nol-0961 | Nomascus leucogenys | 45.96 | 7e-65 | 234 |
| LLPS-Tut-1259 | Tursiops truncatus | 45.94 | 3e-62 | 226 |
| LLPS-Eqc-4576 | Equus caballus | 45.94 | 1e-63 | 230 |
| LLPS-Gog-1903 | Gorilla gorilla | 45.68 | 2e-63 | 229 |
| LLPS-Maf-4444 | Macaca fascicularis | 45.68 | 1e-64 | 233 |
| LLPS-Chs-1032 | Chlorocebus sabaeus | 45.68 | 2e-64 | 233 |
| LLPS-Cea-2527 | Cercocebus atys | 45.68 | 1e-64 | 233 |
| LLPS-Paa-3830 | Papio anubis | 45.68 | 2e-64 | 233 |
| LLPS-Mal-3195 | Mandrillus leucophaeus | 45.68 | 2e-64 | 233 |
| LLPS-Rhb-2960 | Rhinopithecus bieti | 45.68 | 1e-64 | 233 |
| LLPS-Man-1881 | Macaca nemestrina | 45.68 | 2e-64 | 233 |
| LLPS-Mam-4162 | Macaca mulatta | 45.68 | 1e-64 | 233 |
| LLPS-Poa-2316 | Pongo abelii | 45.4 | 8e-64 | 231 |
| LLPS-Aim-0147 | Ailuropoda melanoleuca | 45.38 | 3e-63 | 229 |
| LLPS-Fud-3097 | Fukomys damarensis | 45.33 | 8e-59 | 214 |
| LLPS-Otg-3889 | Otolemur garnettii | 45.13 | 2e-64 | 233 |
| LLPS-Fec-3040 | Felis catus | 45.1 | 1e-61 | 225 |
| LLPS-Mup-2989 | Mustela putorius furo | 44.66 | 3e-61 | 223 |
| LLPS-Cis-2088 | Ciona savignyi | 40.66 | 2e-08 | 59.7 |