LLPS-Poa-1331
DUSP3
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Dual specificity protein phosphatase 3 |
Gene Name: | DUSP3 |
Ensembl Gene: | ENSPPYG00000008353.1 |
Ensembl Protein: | ENSPPYP00000009390.1 |
Organism: | Pongo abelii |
Taxa ID: | 9601 |
LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Nuclear speckle, Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSPPYT00000009767.1 | ENSPPYP00000009390.1 |
UniProt | Q5RD73, DUS3_PONAB | |
GeneBank | CR858043 | CAH90284.1 |
RefSeq | NM_001131657.1 | NP_001125129.1 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL 60 61 NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV 120 121 LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE 180 181 GKLKP 185 |
Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGGCT CGTTCGAGCT CTCGGTGCAG GATCTCAACG ACCTGCTCTC GGACGGCAGC 60 61 GGCTGCTACA GCCTCCCGAG CCAGCCCTGC AACGAGGTCA CCCCGCGGAT CTACGTGGGC 120 121 AACGCGTCTG TGGCTCAGGA TATCCCCAAG CTGCAGAAAC TAGGCATCAC CCATGTGCTG 180 181 AACGCGGCTG AGGGCAGGTC CTTCATGCAC GTCAACACCA ATGCCAACTT CTACAAGGAC 240 241 TCCGGCATCA CATACCTGGG CATCAAGGCC AACGACACAC AGGAGTTCAA CCTCAGCGCT 300 301 TACTTTGAAA GGGCTGCCGA CTTCATTGAC CAGGCTTTGG CTCAAAAGAA TGGCCGGGTG 360 361 CTCGTCCACT GCCGGGAAGG TTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 420 421 ATGCGGCAGA AGATGGACGT CAAGTCTGCC CTGAGCATCG TGAGGCAGAA CCGTGAGATC 480 481 GGCCCCAACG ATGGCTTCCT GGCCCAGCTC TGCCAACTCA ATGACAGACT AGCCAAGGAG 540 541 GGGAAGTTGA AACCCTAG 558 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Immunological synapse | |
Cellular Component | Nucleoplasm | |
Molecular Function | Cytoskeletal protein binding | |
Molecular Function | MAP kinase phosphatase activity | |
Molecular Function | Phosphatase activity | |
Molecular Function | Protein tyrosine phosphatase activity | |
Molecular Function | Protein tyrosine/serine/threonine phosphatase activity | |
Molecular Function | Receptor tyrosine kinase binding | |
Biological Process | Cellular response to epidermal growth factor stimulus | |
Biological Process | Dephosphorylation | |
Biological Process | Negative regulation of cell migration | |
Biological Process | Negative regulation of chemotaxis | |
Biological Process | Negative regulation of ERK1 and ERK2 cascade | |
Biological Process | Negative regulation of JNK cascade | |
Biological Process | Negative regulation of T cell activation | |
Biological Process | Negative regulation of T cell receptor signaling pathway | |
Biological Process | Positive regulation of focal adhesion disassembly | |
Biological Process | Positive regulation of mitotic cell cycle | |
Biological Process | Regulation of focal adhesion assembly |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Hos-2204 | Homo sapiens | 100.0 | 4e-136 | 385 |
LLPS-Pat-2628 | Pan troglodytes | 100.0 | 4e-136 | 385 |
LLPS-Man-0796 | Macaca nemestrina | 100.0 | 4e-136 | 385 |
LLPS-Rhb-0961 | Rhinopithecus bieti | 100.0 | 4e-136 | 385 |
LLPS-Mam-0575 | Macaca mulatta | 100.0 | 4e-136 | 385 |
LLPS-Chs-1755 | Chlorocebus sabaeus | 100.0 | 4e-136 | 385 |
LLPS-Maf-0599 | Macaca fascicularis | 100.0 | 4e-136 | 385 |
LLPS-Cea-0148 | Cercocebus atys | 100.0 | 4e-136 | 385 |
LLPS-Gog-4336 | Gorilla gorilla | 100.0 | 4e-136 | 385 |
LLPS-Paa-0706 | Papio anubis | 100.0 | 4e-136 | 385 |
LLPS-Nol-1890 | Nomascus leucogenys | 99.46 | 1e-135 | 384 |
LLPS-Aon-1780 | Aotus nancymaae | 99.46 | 2e-135 | 384 |
LLPS-Caj-3456 | Callithrix jacchus | 99.46 | 3e-135 | 387 |
LLPS-Ova-3862 | Ovis aries | 98.59 | 1e-99 | 292 |
LLPS-Fec-0387 | Felis catus | 98.37 | 7e-133 | 377 |
LLPS-Eqc-3625 | Equus caballus | 97.9 | 5e-99 | 292 |
LLPS-Ict-1820 | Ictidomys tridecemlineatus | 97.83 | 4e-131 | 374 |
LLPS-Tut-0179 | Tursiops truncatus | 97.83 | 3e-132 | 375 |
LLPS-Caf-0838 | Canis familiaris | 97.8 | 5e-130 | 370 |
LLPS-Myl-2975 | Myotis lucifugus | 96.74 | 3e-131 | 373 |
LLPS-Orc-2148 | Oryctolagus cuniculus | 96.45 | 6e-117 | 337 |
LLPS-Otg-1909 | Otolemur garnettii | 96.2 | 2e-130 | 371 |
LLPS-Sus-0005 | Sus scrofa | 96.2 | 3e-130 | 370 |
LLPS-Loa-0406 | Loxodonta africana | 95.08 | 2e-127 | 363 |
LLPS-Mea-0174 | Mesocricetus auratus | 94.57 | 1e-126 | 362 |
LLPS-Dio-1418 | Dipodomys ordii | 94.02 | 6e-128 | 365 |
LLPS-Ere-0096 | Erinaceus europaeus | 94.02 | 2e-128 | 365 |
LLPS-Mum-0277 | Mus musculus | 93.48 | 1e-126 | 362 |
LLPS-Ran-1917 | Rattus norvegicus | 92.86 | 4e-125 | 358 |
LLPS-Aim-3153 | Ailuropoda melanoleuca | 92.11 | 7e-99 | 290 |
LLPS-Mup-3337 | Mustela putorius furo | 91.67 | 8e-100 | 292 |
LLPS-Cap-1451 | Cavia porcellus | 89.67 | 4e-120 | 345 |
LLPS-Bot-4371 | Bos taurus | 89.6 | 3e-128 | 366 |
LLPS-Mal-2243 | Mandrillus leucophaeus | 89.22 | 3e-102 | 299 |
LLPS-Cas-0698 | Carlito syrichta | 87.43 | 4e-99 | 291 |
LLPS-Fud-1780 | Fukomys damarensis | 84.48 | 4e-69 | 213 |
LLPS-Mod-1020 | Monodelphis domestica | 81.97 | 3e-110 | 319 |
LLPS-Anp-2143 | Anas platyrhynchos | 80.28 | 2e-81 | 245 |
LLPS-Sah-2140 | Sarcophilus harrisii | 79.78 | 1e-104 | 305 |
LLPS-Tag-0567 | Taeniopygia guttata | 77.46 | 3e-77 | 234 |
LLPS-Pes-0596 | Pelodiscus sinensis | 77.35 | 5e-104 | 304 |
LLPS-Anc-1518 | Anolis carolinensis | 77.22 | 1e-103 | 303 |
LLPS-Gaga-1669 | Gallus gallus | 76.8 | 1e-102 | 300 |
LLPS-Urm-0112 | Ursus maritimus | 76.44 | 2e-86 | 259 |
LLPS-Meg-2206 | Meleagris gallopavo | 76.35 | 2e-81 | 245 |
LLPS-Leo-1665 | Lepisosteus oculatus | 75.0 | 3e-100 | 295 |
LLPS-Fia-1152 | Ficedula albicollis | 74.5 | 7e-79 | 239 |
LLPS-Asm-2965 | Astyanax mexicanus | 73.22 | 4e-98 | 289 |
LLPS-Lac-1269 | Latimeria chalumnae | 73.03 | 3e-96 | 284 |
LLPS-Icp-0387 | Ictalurus punctatus | 72.93 | 6e-95 | 281 |
LLPS-Dar-1918 | Danio rerio | 71.51 | 3e-94 | 280 |
LLPS-Scm-2122 | Scophthalmus maximus | 69.78 | 1e-89 | 269 |
LLPS-Orn-1892 | Oreochromis niloticus | 69.44 | 2e-90 | 271 |
LLPS-Xim-3984 | Xiphophorus maculatus | 69.44 | 8e-89 | 266 |
LLPS-Pof-3218 | Poecilia formosa | 68.89 | 2e-88 | 265 |
LLPS-Tar-3577 | Takifugu rubripes | 68.89 | 3e-89 | 268 |
LLPS-Ten-1781 | Tetraodon nigroviridis | 67.22 | 2e-86 | 259 |
LLPS-Xet-0791 | Xenopus tropicalis | 66.85 | 7e-88 | 263 |
LLPS-Orl-2265 | Oryzias latipes | 66.67 | 4e-85 | 257 |
LLPS-Scf-0037 | Scleropages formosus | 66.67 | 1e-78 | 239 |
LLPS-Gaa-0256 | Gasterosteus aculeatus | 64.29 | 7e-82 | 248 |
LLPS-Ora-2170 | Ornithorhynchus anatinus | 42.53 | 2e-35 | 129 |
LLPS-Pap-1509 | Pan paniscus | 42.44 | 1e-36 | 132 |
LLPS-Glm-1149 | Glycine max | 41.06 | 3e-20 | 93.2 |
LLPS-Cus-2099 | Cucumis sativus | 39.73 | 2e-23 | 102 |
LLPS-Pot-1156 | Populus trichocarpa | 39.04 | 3e-22 | 99.0 |
LLPS-Viv-1231 | Vitis vinifera | 38.36 | 8e-21 | 94.7 |
LLPS-Met-1517 | Medicago truncatula | 37.67 | 2e-20 | 94.0 |
LLPS-Coc-1897 | Corchorus capsularis | 37.58 | 4e-21 | 95.9 |
LLPS-Sob-0240 | Sorghum bicolor | 36.99 | 1e-18 | 88.2 |
LLPS-Zem-0963 | Zea mays | 36.99 | 2e-18 | 87.8 |
LLPS-Hea-0315 | Helianthus annuus | 36.99 | 5e-21 | 95.5 |
LLPS-Php-0591 | Physcomitrella patens | 36.59 | 2e-21 | 97.1 |
LLPS-Sol-0283 | Solanum lycopersicum | 35.62 | 3e-20 | 92.4 |
LLPS-Sot-1972 | Solanum tuberosum | 35.62 | 4e-20 | 92.8 |
LLPS-Abg-0895 | Absidia glauca | 35.25 | 5e-19 | 87.0 |
LLPS-Drm-1172 | Drosophila melanogaster | 35.15 | 5e-18 | 85.5 |
LLPS-Orp-2372 | Oryza punctata | 34.51 | 7e-18 | 86.3 |
LLPS-Orr-1027 | Oryza rufipogon | 34.51 | 6e-18 | 86.7 |
LLPS-Orm-0648 | Oryza meridionalis | 34.51 | 7e-18 | 86.3 |
LLPS-Orb-1548 | Oryza barthii | 34.51 | 6e-18 | 86.3 |
LLPS-Orni-1918 | Oryza nivara | 34.51 | 6e-18 | 86.7 |
LLPS-Orgl-0101 | Oryza glumaepatula | 34.51 | 1e-17 | 85.5 |