• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Poa-1331
DUSP3

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Dual specificity protein phosphatase 3
Gene Name: DUSP3
Ensembl Gene: ENSPPYG00000008353.1
Ensembl Protein: ENSPPYP00000009390.1
Organism: Pongo abelii
Taxa ID: 9601
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MSGSFELSVQ  DLNDLLSDGS  GCYSLPSQPC  NEVTPRIYVG  NASVAQDIPK  LQKLGITHVL  60
61    NAAEGRSFMH  VNTNANFYKD  SGITYLGIKA  NDTQEFNLSA  YFERAADFID  QALAQKNGRV  120
121   LVHCREGYSR  SPTLVIAYLM  MRQKMDVKSA  LSIVRQNREI  GPNDGFLAQL  CQLNDRLAKE  180
181   GKLKP  185
Nucleotide CDS Sequence (FASTA)
1     ATGTCGGGCT  CGTTCGAGCT  CTCGGTGCAG  GATCTCAACG  ACCTGCTCTC  GGACGGCAGC  60
61    GGCTGCTACA  GCCTCCCGAG  CCAGCCCTGC  AACGAGGTCA  CCCCGCGGAT  CTACGTGGGC  120
121   AACGCGTCTG  TGGCTCAGGA  TATCCCCAAG  CTGCAGAAAC  TAGGCATCAC  CCATGTGCTG  180
181   AACGCGGCTG  AGGGCAGGTC  CTTCATGCAC  GTCAACACCA  ATGCCAACTT  CTACAAGGAC  240
241   TCCGGCATCA  CATACCTGGG  CATCAAGGCC  AACGACACAC  AGGAGTTCAA  CCTCAGCGCT  300
301   TACTTTGAAA  GGGCTGCCGA  CTTCATTGAC  CAGGCTTTGG  CTCAAAAGAA  TGGCCGGGTG  360
361   CTCGTCCACT  GCCGGGAAGG  TTACAGCCGC  TCCCCAACGC  TAGTTATCGC  CTACCTCATG  420
421   ATGCGGCAGA  AGATGGACGT  CAAGTCTGCC  CTGAGCATCG  TGAGGCAGAA  CCGTGAGATC  480
481   GGCCCCAACG  ATGGCTTCCT  GGCCCAGCTC  TGCCAACTCA  ATGACAGACT  AGCCAAGGAG  540
541   GGGAAGTTGA  AACCCTAG  558

▼ KEYWORD


ID
Family
Complete proteome
Hydrolase
Nucleus
Protein phosphatase
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Immunological synapse
Cellular Component
Nucleoplasm
Molecular Function
Cytoskeletal protein binding
Molecular Function
MAP kinase phosphatase activity
Molecular Function
Phosphatase activity
Molecular Function
Protein tyrosine phosphatase activity
Molecular Function
Protein tyrosine/serine/threonine phosphatase activity
Molecular Function
Receptor tyrosine kinase binding
Biological Process
Cellular response to epidermal growth factor stimulus
Biological Process
Dephosphorylation
Biological Process
Negative regulation of cell migration
Biological Process
Negative regulation of chemotaxis
Biological Process
Negative regulation of ERK1 and ERK2 cascade
Biological Process
Negative regulation of JNK cascade
Biological Process
Negative regulation of T cell activation
Biological Process
Negative regulation of T cell receptor signaling pathway
Biological Process
Positive regulation of focal adhesion disassembly
Biological Process
Positive regulation of mitotic cell cycle
Biological Process
Regulation of focal adhesion assembly

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hos-2204Homo sapiens100.04e-136 385
LLPS-Pat-2628Pan troglodytes100.04e-136 385
LLPS-Man-0796Macaca nemestrina100.04e-136 385
LLPS-Rhb-0961Rhinopithecus bieti100.04e-136 385
LLPS-Mam-0575Macaca mulatta100.04e-136 385
LLPS-Chs-1755Chlorocebus sabaeus100.04e-136 385
LLPS-Maf-0599Macaca fascicularis100.04e-136 385
LLPS-Cea-0148Cercocebus atys100.04e-136 385
LLPS-Gog-4336Gorilla gorilla100.04e-136 385
LLPS-Paa-0706Papio anubis100.04e-136 385
LLPS-Nol-1890Nomascus leucogenys99.461e-135 384
LLPS-Aon-1780Aotus nancymaae99.462e-135 384
LLPS-Caj-3456Callithrix jacchus99.463e-135 387
LLPS-Ova-3862Ovis aries98.591e-99 292
LLPS-Fec-0387Felis catus98.377e-133 377
LLPS-Eqc-3625Equus caballus97.95e-99 292
LLPS-Ict-1820Ictidomys tridecemlineatus97.834e-131 374
LLPS-Tut-0179Tursiops truncatus97.833e-132 375
LLPS-Caf-0838Canis familiaris97.85e-130 370
LLPS-Myl-2975Myotis lucifugus96.743e-131 373
LLPS-Orc-2148Oryctolagus cuniculus96.456e-117 337
LLPS-Otg-1909Otolemur garnettii96.22e-130 371
LLPS-Sus-0005Sus scrofa96.23e-130 370
LLPS-Loa-0406Loxodonta africana95.082e-127 363
LLPS-Mea-0174Mesocricetus auratus94.571e-126 362
LLPS-Dio-1418Dipodomys ordii94.026e-128 365
LLPS-Ere-0096Erinaceus europaeus94.022e-128 365
LLPS-Mum-0277Mus musculus93.481e-126 362
LLPS-Ran-1917Rattus norvegicus92.864e-125 358
LLPS-Aim-3153Ailuropoda melanoleuca92.117e-99 290
LLPS-Mup-3337Mustela putorius furo91.678e-100 292
LLPS-Cap-1451Cavia porcellus89.674e-120 345
LLPS-Bot-4371Bos taurus89.63e-128 366
LLPS-Mal-2243Mandrillus leucophaeus89.223e-102 299
LLPS-Cas-0698Carlito syrichta87.434e-99 291
LLPS-Fud-1780Fukomys damarensis84.484e-69 213
LLPS-Mod-1020Monodelphis domestica81.973e-110 319
LLPS-Anp-2143Anas platyrhynchos80.282e-81 245
LLPS-Sah-2140Sarcophilus harrisii79.781e-104 305
LLPS-Tag-0567Taeniopygia guttata77.463e-77 234
LLPS-Pes-0596Pelodiscus sinensis77.355e-104 304
LLPS-Anc-1518Anolis carolinensis77.221e-103 303
LLPS-Gaga-1669Gallus gallus76.81e-102 300
LLPS-Urm-0112Ursus maritimus76.442e-86 259
LLPS-Meg-2206Meleagris gallopavo76.352e-81 245
LLPS-Leo-1665Lepisosteus oculatus75.03e-100 295
LLPS-Fia-1152Ficedula albicollis74.57e-79 239
LLPS-Asm-2965Astyanax mexicanus73.224e-98 289
LLPS-Lac-1269Latimeria chalumnae73.033e-96 284
LLPS-Icp-0387Ictalurus punctatus72.936e-95 281
LLPS-Dar-1918Danio rerio71.513e-94 280
LLPS-Scm-2122Scophthalmus maximus69.781e-89 269
LLPS-Orn-1892Oreochromis niloticus69.442e-90 271
LLPS-Xim-3984Xiphophorus maculatus69.448e-89 266
LLPS-Pof-3218Poecilia formosa68.892e-88 265
LLPS-Tar-3577Takifugu rubripes68.893e-89 268
LLPS-Ten-1781Tetraodon nigroviridis67.222e-86 259
LLPS-Xet-0791Xenopus tropicalis66.857e-88 263
LLPS-Orl-2265Oryzias latipes66.674e-85 257
LLPS-Scf-0037Scleropages formosus66.671e-78 239
LLPS-Gaa-0256Gasterosteus aculeatus64.297e-82 248
LLPS-Ora-2170Ornithorhynchus anatinus42.532e-35 129
LLPS-Pap-1509Pan paniscus42.441e-36 132
LLPS-Glm-1149Glycine max41.063e-2093.2
LLPS-Cus-2099Cucumis sativus39.732e-23 102
LLPS-Pot-1156Populus trichocarpa39.043e-2299.0
LLPS-Viv-1231Vitis vinifera38.368e-2194.7
LLPS-Met-1517Medicago truncatula37.672e-2094.0
LLPS-Coc-1897Corchorus capsularis37.584e-2195.9
LLPS-Sob-0240Sorghum bicolor36.991e-1888.2
LLPS-Zem-0963Zea mays36.992e-1887.8
LLPS-Hea-0315Helianthus annuus36.995e-2195.5
LLPS-Php-0591Physcomitrella patens36.592e-2197.1
LLPS-Sol-0283Solanum lycopersicum35.623e-2092.4
LLPS-Sot-1972Solanum tuberosum35.624e-2092.8
LLPS-Abg-0895Absidia glauca35.255e-1987.0
LLPS-Drm-1172Drosophila melanogaster35.155e-1885.5
LLPS-Orp-2372Oryza punctata34.517e-1886.3
LLPS-Orr-1027Oryza rufipogon34.516e-1886.7
LLPS-Orm-0648Oryza meridionalis34.517e-1886.3
LLPS-Orb-1548Oryza barthii34.516e-1886.3
LLPS-Orni-1918Oryza nivara34.516e-1886.7
LLPS-Orgl-0101Oryza glumaepatula34.511e-1785.5