DrLLPS - Data resource of LLPS

LLPS-Php-0537
PHYPA_018379

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Cyclin-dependent kinases regulatory subunit
Gene Name:	PHYPA_018379, PHYPADRAFT_161852
Ensembl Gene:	Pp3c14_11680
Ensembl Protein:	Pp3c14_11680V3.1
Organism:	Physcomitrella patens
Taxa ID:	3218
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nuclear speckle, Nucleolus, Others	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0137	Q17868	Regulator	P granule	65.15	3e-27	101
Mus musculus	LLPS-Mum-0857	P61025	Client	Nuclear speckle, Nucleolus	70.97	8e-27	99.8

▼ FUNCTION

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	Pp3c14_11680V3.1	Pp3c14_11680V3.1
Ensembl	Pp3c14_11680V3.3	Pp3c14_11680V3.3
Ensembl	Pp3c14_11680V3.2	Pp3c14_11680V3.2
UniProt		A9RYI3, A9RYI3_PHYPA
GeneBank	ABEU02000014, DS544925	EDQ76003.1, PNR40976.1
RefSeq	XM_001759267.1	XP_001759319.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MPQIQYSEKY FDDTYEYRHV VLPPDIAKLL PKNRLLSEAE WRGIGVQQSR GWVHYAIHRP 60 61 EPHIMLFRRP LNYGQPQQAA AVQQQPTGMK A 91
Nucleotide CDS Sequence (FASTA)
1 ATGCCCCAGA TCCAGTACTC GGAGAAGTAC TTCGACGATA CCTACGAGTA TCGGCATGTC 60 61 GTGCTTCCCC CCGACATTGC CAAATTGCTG CCCAAAAACC GACTCCTGTC TGAGGCCGAA 120 121 TGGCGTGGTA TCGGAGTGCA GCAGTCACGT GGGTGGGTTC ACTACGCAAT TCACCGCCCT 180 181 GAGCCACACA TTATGCTCTT CCGTAGACCC CTGAATTACG GTCAACCTCA GCAAGCTGCC 240 241 GCTGTGCAGC AACAACCCAC AGATTCCAGG AATTGA 276

▼ KEYWORD

ID	Family
KW-0131	Cell cycle
KW-0132	Cell division
KW-0181	Complete proteome
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0000307	Cellular Component	Cyclin-dependent protein kinase holoenzyme complex
GO:0019005	Cellular Component	SCF ubiquitin ligase complex
GO:0061575	Molecular Function	Cyclin-dependent protein serine/threonine kinase activator activity
GO:0042393	Molecular Function	Histone binding
GO:0019901	Molecular Function	Protein kinase binding
GO:0043130	Molecular Function	Ubiquitin binding
GO:0007049	Biological Process	Cell cycle
GO:0051301	Biological Process	Cell division
GO:0045737	Biological Process	Positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007346	Biological Process	Regulation of mitotic cell cycle

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Sot-1334	Solanum tuberosum	94.52	2e-45	147
LLPS-Sol-1585	Solanum lycopersicum	94.37	2e-44	159
LLPS-Coc-2334	Corchorus capsularis	93.15	9e-45	145
LLPS-Phv-0578	Phaseolus vulgaris	93.15	9e-45	145
LLPS-Gor-2548	Gossypium raimondii	93.15	8e-45	145
LLPS-Sei-1290	Setaria italica	93.15	2e-44	145
LLPS-Met-1203	Medicago truncatula	93.15	1e-44	145
LLPS-Dac-0082	Daucus carota	93.15	1e-44	145
LLPS-Thc-1955	Theobroma cacao	93.15	1e-44	145
LLPS-Glm-2240	Glycine max	93.15	9e-45	145
LLPS-Orbr-2074	Oryza brachyantha	92.96	4e-43	141
LLPS-Gas-0614	Galdieria sulphuraria	92.65	2e-42	140
LLPS-Org-1643	Oryza glaberrima	91.78	5e-44	144
LLPS-Zem-2117	Zea mays	91.78	4e-44	144
LLPS-Orm-1085	Oryza meridionalis	91.78	5e-44	144
LLPS-Ors-2037	Oryza sativa	91.78	5e-44	144
LLPS-Viv-1064	Vitis vinifera	91.78	1e-43	143
LLPS-Via-1511	Vigna angularis	91.78	2e-44	145
LLPS-Hea-0933	Helianthus annuus	91.78	6e-45	149
LLPS-Orni-1114	Oryza nivara	91.78	5e-44	144
LLPS-Mua-0172	Musa acuminata	91.78	6e-44	144
LLPS-Ori-1968	Oryza indica	91.78	5e-44	144
LLPS-Osl-0885	Ostreococcus lucimarinus	91.43	7e-43	140
LLPS-Bro-2388	Brassica oleracea	90.41	1e-43	143
LLPS-Prp-0230	Prunus persica	90.41	7e-43	140
LLPS-Sob-1385	Sorghum bicolor	90.41	1e-43	143
LLPS-Amt-1979	Amborella trichopoda	90.41	8e-44	143
LLPS-Brr-0175	Brassica rapa	90.41	2e-43	142
LLPS-Cus-2018	Cucumis sativus	90.41	6e-43	141
LLPS-Brn-0436	Brassica napus	90.41	2e-43	142
LLPS-Art-2293	Arabidopsis thaliana	89.04	4e-44	144
LLPS-Pot-1167	Populus trichocarpa	89.04	8e-44	143
LLPS-Arl-2161	Arabidopsis lyrata	89.04	4e-44	144
LLPS-Sem-0810	Selaginella moellendorffii	89.04	4e-43	142
LLPS-Cym-0224	Cyanidioschyzon merolae	88.89	4e-44	144
LLPS-Brd-1508	Brachypodium distachyon	87.67	4e-43	141
LLPS-Tra-1887	Triticum aestivum	87.67	4e-43	141
LLPS-Hov-0655	Hordeum vulgare	87.67	2e-43	144
LLPS-Chr-1303	Chlamydomonas reinhardtii	85.92	1e-39	132
LLPS-Chc-0403	Chondrus crispus	83.33	9e-38	128
LLPS-Lep-0678	Leersia perrieri	79.31	7e-26	97.4
LLPS-Ora-3357	Ornithorhynchus anatinus	75.93	5e-24	92.0
LLPS-Fia-1318	Ficedula albicollis	73.91	1e-31	112
LLPS-Pof-2724	Poecilia formosa	73.91	8e-32	112
LLPS-Xim-2875	Xiphophorus maculatus	73.91	8e-32	112
LLPS-Mam-2629	Macaca mulatta	73.68	1e-25	97.1
LLPS-Anc-1955	Anolis carolinensis	72.86	2e-30	108
LLPS-Gaga-0361	Gallus gallus	72.46	1e-31	112
LLPS-Cas-0641	Carlito syrichta	72.46	1e-31	112
LLPS-Nol-0793	Nomascus leucogenys	72.46	1e-31	112
LLPS-Eqc-0743	Equus caballus	72.46	1e-31	112
LLPS-Cap-1891	Cavia porcellus	72.46	1e-31	112
LLPS-Poa-3238	Pongo abelii	72.46	1e-31	112
LLPS-Otg-3919	Otolemur garnettii	72.46	1e-31	112
LLPS-Rhb-1838	Rhinopithecus bieti	72.46	1e-31	112
LLPS-Orc-3804	Oryctolagus cuniculus	72.46	1e-31	112
LLPS-Mod-4150	Monodelphis domestica	72.46	2e-31	111
LLPS-Fec-4270	Felis catus	72.46	1e-31	112
LLPS-Pat-2409	Pan troglodytes	72.46	1e-31	112
LLPS-Urm-2647	Ursus maritimus	72.46	1e-31	112
LLPS-Pap-3715	Pan paniscus	72.46	1e-31	112
LLPS-Dar-0937	Danio rerio	72.46	2e-31	111
LLPS-Hos-4110	Homo sapiens	72.46	1e-31	112
LLPS-Loa-1932	Loxodonta africana	72.46	1e-31	112
LLPS-Man-1645	Macaca nemestrina	72.46	1e-31	112
LLPS-Ere-0160	Erinaceus europaeus	72.46	1e-31	112
LLPS-Ran-1755	Rattus norvegicus	72.46	1e-31	112
LLPS-Mup-1175	Mustela putorius furo	72.46	1e-31	112
LLPS-Aim-1431	Ailuropoda melanoleuca	72.46	1e-31	112
LLPS-Myl-2159	Myotis lucifugus	72.46	3e-31	111
LLPS-Ova-0233	Ovis aries	72.46	1e-31	112
LLPS-Paa-1073	Papio anubis	72.46	1e-31	112
LLPS-Mal-0910	Mandrillus leucophaeus	72.46	1e-31	112
LLPS-Tut-0043	Tursiops truncatus	72.46	1e-31	112
LLPS-Bot-0795	Bos taurus	72.46	1e-31	112
LLPS-Dio-2114	Dipodomys ordii	72.46	1e-31	112
LLPS-Gaa-1562	Gasterosteus aculeatus	72.46	3e-31	111
LLPS-Gog-0883	Gorilla gorilla	72.46	1e-31	112
LLPS-Caj-2016	Callithrix jacchus	72.46	1e-31	112
LLPS-Fud-1824	Fukomys damarensis	72.46	1e-31	112
LLPS-Mea-1972	Mesocricetus auratus	72.46	1e-31	112
LLPS-Maf-2707	Macaca fascicularis	72.46	1e-31	112
LLPS-Mum-0857	Mus musculus	72.46	1e-31	112
LLPS-Cea-1934	Cercocebus atys	72.46	1e-31	112
LLPS-Aon-2348	Aotus nancymaae	72.46	1e-31	112
LLPS-Tar-0912	Takifugu rubripes	71.43	3e-31	111
LLPS-Xet-1143	Xenopus tropicalis	71.01	4e-31	110
LLPS-Lac-2069	Latimeria chalumnae	71.01	6e-31	110
LLPS-Scm-1319	Scophthalmus maximus	71.01	2e-28	107
LLPS-Icp-1455	Ictalurus punctatus	71.01	9e-31	109
LLPS-Asm-0536	Astyanax mexicanus	71.01	1e-30	109
LLPS-Sah-1958	Sarcophilus harrisii	71.01	9e-31	110
LLPS-Meg-0143	Meleagris gallopavo	70.59	7e-29	105
LLPS-Scf-0748	Scleropages formosus	70.59	2e-30	108
LLPS-Ict-1552	Ictidomys tridecemlineatus	69.57	1e-29	107
LLPS-Caf-1275	Canis familiaris	69.57	1e-29	107
LLPS-Orn-1034	Oreochromis niloticus	69.57	9e-30	107
LLPS-Chs-4398	Chlorocebus sabaeus	69.57	9e-29	107
LLPS-Orl-1207	Oryzias latipes	69.57	5e-31	110
LLPS-Drm-1607	Drosophila melanogaster	68.66	5e-31	110
LLPS-Tag-2325	Taeniopygia guttata	68.12	2e-28	103
LLPS-Cii-0861	Ciona intestinalis	67.65	1e-29	107
LLPS-Anp-0181	Anas platyrhynchos	66.67	4e-20	82.0
LLPS-Sus-0023	Sus scrofa	66.67	6e-29	106
LLPS-Leo-2461	Lepisosteus oculatus	66.67	6e-30	107
LLPS-Cae-0137	Caenorhabditis elegans	65.15	3e-27	101
LLPS-Cis-1222	Ciona savignyi	64.71	7e-28	103
LLPS-Miv-0972	Microbotryum violaceum	57.14	9e-23	90.1
LLPS-Put-0483	Puccinia triticina	56.34	5e-23	91.3
LLPS-Pug-0327	Puccinia graminis	56.34	4e-23	90.9
LLPS-Mel-1338	Melampsora laricipopulina	56.34	2e-23	91.7
LLPS-Map-1341	Magnaporthe poae	54.43	1e-22	90.5
LLPS-Crn-1584	Cryptococcus neoformans	54.43	1e-23	92.4
LLPS-Gag-1541	Gaeumannomyces graminis	54.43	1e-22	90.1
LLPS-Abg-1759	Absidia glauca	53.42	8e-19	81.6
LLPS-Ved-0247	Verticillium dahliae	53.16	1e-21	87.8
LLPS-Trv-0173	Trichoderma virens	53.16	1e-21	87.4
LLPS-Lem-0692	Leptosphaeria maculans	53.16	1e-21	93.6
LLPS-Phn-1287	Phaeosphaeria nodorum	52.56	4e-22	88.6
LLPS-Mao-1198	Magnaporthe oryzae	52.44	1e-22	90.1
LLPS-Yal-1491	Yarrowia lipolytica	52.0	1e-21	87.0
LLPS-Asni-1319	Aspergillus niger	51.9	6e-22	88.2
LLPS-Usm-1522	Ustilago maydis	51.85	2e-22	89.7
LLPS-Trr-1192	Trichoderma reesei	51.35	7e-19	80.1
LLPS-Beb-0634	Beauveria bassiana	50.63	3e-21	86.3
LLPS-Spr-0907	Sporisorium reilianum	50.62	3e-21	86.3
LLPS-Fus-0014	Fusarium solani	49.37	3e-20	83.6
LLPS-Cog-1521	Colletotrichum gloeosporioides	49.35	3e-20	84.3
LLPS-Scj-1148	Schizosaccharomyces japonicus	48.75	1e-20	84.7
LLPS-Asc-1090	Aspergillus clavatus	46.75	4e-18	79.0

LLPS-Php-0537PHYPA_018379

Protein Sequence

Nucleotide Sequence

LLPS-Php-0537
PHYPA_018379