LLPS-Pat-1422
TMEM97
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transmembrane protein 97 |
| Gene Name: | TMEM97 |
| Ensembl Gene: | ENSPTRG00000008909.6 |
| Ensembl Protein: | ENSPTRP00000069848.1 |
| Organism: | Pan troglodytes |
| Taxa ID: | 9598 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPTRT00000090236.1 | ENSPTRP00000069848.1 |
| Ensembl | ENSPTRT00000016433.6 | ENSPTRP00000015206.6 |
| UniProt | H2QCG8, H2QCG8_PANTR | |
| GeneBank | AACZ04041509 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGAPATRRCV EWLLGLYFLS HIPITLFVDL QAVLPRELYP VEFRNLLKWY AKEFKDPLLQ 60 61 EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA IIYSVHTMTT LIPILSTFLF 120 121 EDFSKASGFK GQRPETLHER LTLVSVYAPY LLIPFVLLIF MLRKKKKKMK ETTTDPG 177 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGGCTC CGGCAACCAG GCGCTGCGTG GAGTGGCTGC TGGGCCTCTA CTTCCTCAGC 60 61 CACATCCCCA TCACCCTGTT CGTGGACCTG CAGGCGGTGC TGCCGCGCGA GCTCTACCCA 120 121 GTCGAGTTTA GAAACCTGCT GAAGTGGTAT GCTAAGGAGT TCAAAGACCC GCTGCTACAG 180 181 GAGCCCCCAG CCTGGTTTAA GTCCTTTCTG TTTTGCGAGC TTGTGTTTCA GCTGCCTTTC 240 241 TTTCCCATTG CAACGTATGC CTTCCTCAAA GGAAGCTGCA AGTGGATTCG AACTCCTGCA 300 301 ATCATCTACT CTGTTCACAC CATGACAACC TTAATTCCGA TACTCTCCAC ATTTCTGTTT 360 361 GAGGATTTCT CCAAAGCCAG TGGTTTCAAG GGACAAAGAC CTGAGACTTT GCATGAACGG 420 421 TTAACCCTTG TGTCTGTCTA TGCCCCCTAC TTACTCATCC CATTTGTACT TTTAATTTTC 480 481 ATGTTGCGGA AAAAGAAAAA AAAAATGAAG GAAACAACCA CTGACCCAGG GTAG 534 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Integral component of membrane | |
Cellular Component | Lysosome | |
Cellular Component | Nuclear membrane | |
Cellular Component | Plasma membrane | |
Cellular Component | Rough endoplasmic reticulum membrane | |
Biological Process | Cholesterol homeostasis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-2913 | Pongo abelii | 98.77 | 5e-113 | 328 |
| LLPS-Nol-0535 | Nomascus leucogenys | 98.77 | 8e-113 | 325 |
| LLPS-Hos-4643 | Homo sapiens | 98.77 | 2e-113 | 327 |
| LLPS-Gog-4745 | Gorilla gorilla | 98.31 | 9e-116 | 333 |
| LLPS-Paa-3468 | Papio anubis | 97.55 | 3e-112 | 324 |
| LLPS-Mal-4463 | Mandrillus leucophaeus | 97.55 | 3e-112 | 324 |
| LLPS-Cea-4105 | Cercocebus atys | 97.55 | 3e-112 | 324 |
| LLPS-Chs-4600 | Chlorocebus sabaeus | 97.55 | 3e-112 | 324 |
| LLPS-Mam-2828 | Macaca mulatta | 96.93 | 5e-112 | 323 |
| LLPS-Rhb-2606 | Rhinopithecus bieti | 96.93 | 7e-111 | 320 |
| LLPS-Maf-0243 | Macaca fascicularis | 96.93 | 5e-112 | 323 |
| LLPS-Man-3578 | Macaca nemestrina | 96.32 | 2e-111 | 322 |
| LLPS-Caj-4058 | Callithrix jacchus | 96.32 | 3e-110 | 319 |
| LLPS-Aon-1450 | Aotus nancymaae | 95.71 | 2e-109 | 318 |
| LLPS-Pap-0604 | Pan paniscus | 93.22 | 3e-113 | 329 |
| LLPS-Cas-2570 | Carlito syrichta | 87.73 | 1e-100 | 295 |
| LLPS-Otg-0223 | Otolemur garnettii | 85.28 | 5e-89 | 265 |
| LLPS-Myl-4294 | Myotis lucifugus | 84.66 | 1e-95 | 282 |
| LLPS-Fec-1633 | Felis catus | 84.05 | 2e-96 | 283 |
| LLPS-Mup-2399 | Mustela putorius furo | 81.6 | 1e-92 | 275 |
| LLPS-Loa-1247 | Loxodonta africana | 80.98 | 1e-91 | 271 |
| LLPS-Tut-2019 | Tursiops truncatus | 79.75 | 2e-89 | 266 |
| LLPS-Sus-4524 | Sus scrofa | 78.53 | 5e-88 | 263 |
| LLPS-Orc-2721 | Oryctolagus cuniculus | 77.3 | 1e-81 | 246 |
| LLPS-Cap-1957 | Cavia porcellus | 74.23 | 3e-85 | 255 |
| LLPS-Ict-2494 | Ictidomys tridecemlineatus | 72.22 | 2e-83 | 252 |
| LLPS-Asm-3280 | Astyanax mexicanus | 63.23 | 1e-62 | 198 |
| LLPS-Xet-3558 | Xenopus tropicalis | 58.74 | 5e-53 | 173 |
| LLPS-Fia-0867 | Ficedula albicollis | 56.52 | 1e-46 | 157 |
| LLPS-Chr-1295 | Chlamydomonas reinhardtii | 42.07 | 9e-31 | 115 |
| LLPS-Osl-0898 | Ostreococcus lucimarinus | 40.14 | 3e-26 | 102 |
| LLPS-Sem-1175 | Selaginella moellendorffii | 35.48 | 7e-23 | 94.7 |
| LLPS-Asg-1140 | Ashbya gossypii | 34.97 | 2e-12 | 65.9 |
| LLPS-Kop-1317 | Komagataella pastoris | 34.94 | 3e-07 | 51.2 |
| LLPS-Miv-1573 | Microbotryum violaceum | 30.46 | 1e-10 | 60.8 |
| LLPS-Sac-0655 | Saccharomyces cerevisiae | 29.61 | 7e-08 | 52.8 |
| LLPS-Yal-0870 | Yarrowia lipolytica | 28.31 | 2e-08 | 55.1 |