DrLLPS - Data resource of LLPS

LLPS-Paa-1226

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Breast cancer type 1 susceptibility protein homolog
Ensembl Gene:	ENSPANG00000021372.2
Ensembl Protein:	ENSPANP00000027226.1
Organism:	Papio anubis
Taxa ID:	9555
LLPS Type:	LLPS regulator

▼ PROPERTY

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Chromatin, PML nuclear body, Centrosome/Spindle pole body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-1492	P48754	Regulator	Chromatin, PML nuclear body, Centrosome/Spindle pole body	53.72	0.0	1702
Homo sapiens	LLPS-Hos-2552	P38398	Regulator	PML nuclear body, Centrosome/Spindle pole body	91.54	0.0	3179

▼ FUNCTION

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSPANT00000045313.1	ENSPANP00000027226.1
Ensembl	ENSPANT00000012331.2	ENSPANP00000020748.2
Ensembl	ENSPANT00000039264.1	ENSPANP00000042752.1
Ensembl	ENSPANT00000029739.2	ENSPANP00000034328.1
Ensembl	ENSPANT00000034109.1	ENSPANP00000027730.1
Ensembl	ENSPANT00000053705.1	ENSPANP00000027983.1
Ensembl	ENSPANT00000059342.1	ENSPANP00000042124.1
UniProt		A0A2I3LUU0, A0A2I3LUU0_PAPAN
GeneBank	AHZZ02010411, AHZZ02010409, AHZZ02010408, AHZZ02010410

▼ SEQUENCE

Protein Sequence (FASTA)
1 TSPWGYTISK IQNLIKEPVS TKCDHIFCRF CMLKLLNQKK GPSQCPLCKN DITKRSLQES 60 61 TRFSQLVEEL LKIIHAFQLD TGLQFANSYN FAKKENHSPE HLKDEVSIIQ SMGYRNRAKR 120 121 LLQSEPENPS LQETSLSVPL SNLGIVRTLR TKQRIQPQKK SVYIELGSDS SEDTVNKATY 180 181 CSVGDQELLQ ITPQGTRDET SLDSAKKAAC EFSEKDITNT EHHQSSNNDL NTTEKHATER 240 241 HPEKYQGSSV SNLHVEPCGT NTHASSLQHE NSLLLTKDRM NVEKAEFCNK SKQPGLARSQ 300 301 HNRWTGSKET CNDRQTPSTE KKVDLNANAL YERKEWNKQK LPCSENPRDT EDVPWITLNS 360 361 SIQKVNEWFS RSDELLSSDD SHDGGSESNA KVADVLDVLN EVDEYSGSSE KIDLLASDPH 420 421 EPLICKSERV HSSSVEINIK DKIFGKTYRR KANRPNLSHV TENLIIGALV TESEIMQERP 480 481 LTNKLKRKRR TTSGLHPEDF IKKADLAVQK TPEIINQGTN QMEQNGQVMN ITNSAHENKT 540 541 KGDSIQNEKN PNPIESLEEE SAFKTKAEPI SSSINNMELE LNIHNSKAPK KNRLRRKSST 600 601 RHIHALELVV SRNLSPPNCT ELQIDSCSSS EEIKKKNYNQ MPVRHSRNLQ LMEDKESATG 660 661 AKKSNKPNEQ TSKRHASDTF PELKLTKVPG SFTNCSNTSE LKEFVNPSLS REEKEEKLET 720 721 VKVSNNAKDP KDLMLSGERV LQTERSVESS SISLVPGTDY GTQESISLLQ VSTLGKAKTE 780 781 LNKCMSQCAA FENSKELIHG CSEDTRNDTE DSKYPLGREV NHSQETSIEI EESELDTQYL 840 841 QNTFKVSKRQ SFALFSNPGN PEEECATFSA HSRSLKKQSP KVTSECEQKE ENQGKKESNI 900 901 KPVQTVNITA GFSVVCQKDK PVDNAKCSIK GGSRFCLSSQ FRGNETGLIT PNKHGLLQNP 960 961 YHIPPLFPVK SFVKTKCNKN LLEENSEEHS VSPERAVGNE NIIPSTVSTI SHNNIRENAF 1020 1021 KEASWSNINE VGSSTNEVGS SINEVGSSDE NIQAELGRNR GPKLNAVLRL GLLQPEVCKQ 1080 1081 SLPISNCKHP EIKKQEHEEL VQTVNTDFSP CLISDNLEQP MGSSHASEVC SETPDDLLDD 1140 1141 GEIKEDTSFA ENDIKESSAV FSKSVQRGEL SRSPSPFTHT HLAQGYRKGA KKLESSEENL 1200 1201 SSEDEELPCF QHLLFGKVSN IPSQTTRHST VATECLSKNT EENLLSLKNS LTDCSNQVIL 1260 1261 SKASQEHHLS EETKCSGSLF SSQCSELEDL TANTNTQDPF LIGSSKRMRH QSESQGVGLS 1320 1321 DKELVSADEE RGTGLEEDNQ EEQSVDSNLG EAASGYESET SVSEDCSRLS SQSEILTTQQ 1380 1381 RDTMQDNLIK LQQEMAELEA VLEQHGSQPS NSYPSIITDS SALEDLRNPE QSTSEKDSHI 1440 1441 RGQRNNSMFS KRPREHISVL TSQKSSEYPI NQNPEGLSAD KFEVSADSST SKNKEPGVER 1500 1501 SSPSKCQSLE DRWYVHSSSG SLQNGNYPSQ EELIKVVDVE TQQLEKSGPH NLMEPSYLPR 1560 1561 QDLEGTPYLE SGISLFSDDP ESDPSEDRAP ESAHVGSIPS STSALKVPQW QVAESAQSPA 1620 1621 AAHNTNTAGY NAMEESVSRE KPKLTASTER VNERMSLVVS GLTPEEFMLV YKFARRYHIA 1680 1681 LTNLISEETT HVVMKTDAEF VCERTLKYFL GIAGGKWVVS YFWVTQSIKE RKMLNEVNFL 1740 1741 LSIPLCLSLP LFQIFRGLEI CCYGPFTNMP TDQLEWMVQL CGASVVKELS SFTLGTGFHP 1800 1801 IVVVQPDAWT EDNGFHAIGQ MCEAPVVTRE WVLDSVALYQ CQELDTYLIP QIPHSHY 1857
Nucleotide CDS Sequence (FASTA)
1 ACCTCACCAT GGGGTTATAC AATCAGCAAA ATCCAGAATT TGATCAAGGA ACCTGTCTCC 60 61 ACAAAGTGTG ACCACATATT TTGCAGATTT TGCATGCTGA AACTTCTCAA CCAGAAGAAA 120 121 GGGCCTTCAC AGTGTCCTTT GTGTAAGAAT GATATAACCA AAAGAAGCCT ACAAGAAAGT 180 181 ACAAGATTTA GTCAACTTGT TGAAGAGCTA TTGAAAATCA TTCATGCTTT TCAGCTTGAC 240 241 ACAGGTTTGC AGTTTGCAAA CAGTTATAAT TTTGCAAAAA AGGAAAATCA CTCTCCTGAA 300 301 CATCTAAAAG ATGAAGTTTC TATCATCCAA AGTATGGGCT ACAGAAACCG TGCCAAAAGA 360 361 CTTCTACAGA GTGAACCCGA AAATCCTTCC TTGCAGGAAA CCAGTCTCAG TGTCCCACTC 420 421 TCTAACCTTG GAATTGTGAG AACTCTGAGG ACAAAGCAGC GGATACAACC TCAAAAGAAG 480 481 TCTGTCTACA TTGAACTGGG ATCTGATTCT TCTGAAGATA CGGTTAATAA GGCAACTTAT 540 541 TGCAGTGTGG GAGATCAAGA ATTGTTACAA ATCACCCCTC AAGGAACCAG GGATGAAACC 600 601 AGTTTGGATT CTGCAAAAAA GGCTGCTTGT GAATTTTCTG AGAAGGATAT AACAAATACT 660 661 GAACATCATC AGTCCAGTAA TAATGATTTG AACACCACTG AGAAACATGC AACTGAGAGG 720 721 CATCCAGAAA AGTATCAGGG TAGTTCTGTT TCAAACTTGC ATGTGGAGCC ATGTGGCACA 780 781 AATACTCATG CCAGCTCATT ACAGCATGAG AATAGTTTAT TACTCACTAA AGACAGAATG 840 841 AATGTAGAAA AGGCTGAATT CTGTAATAAA AGCAAACAGC CTGGCTTGGC AAGGAGCCAA 900 901 CATAACAGAT GGACTGGAAG TAAGGAAACA TGTAATGATA GGCAGACTCC CAGCACAGAG 960 961 AAAAAGGTAG ATCTGAATGC TAATGCCCTG TATGAGAGAA AAGAATGGAA TAAGCAAAAA 1020 1021 CTGCCATGCT CTGAGAATCC TAGAGACACT GAAGATGTTC CTTGGATAAC ACTAAATAGC 1080 1081 AGCATTCAGA AAGTTAATGA GTGGTTTTCC AGAAGTGATG AACTGTTAAG TTCTGATGAC 1140 1141 TCACATGATG GGGGGTCTGA ATCAAATGCC AAAGTAGCTG ATGTATTGGA CGTTCTAAAT 1200 1201 GAGGTAGATG AATATTCTGG TTCTTCAGAG AAAATAGACT TACTGGCCAG TGATCCTCAT 1260 1261 GAGCCTTTAA TATGTAAAAG TGAAAGAGTT CACTCCAGTT CAGTAGAGAT TAATATTAAA 1320 1321 GACAAAATAT TTGGGAAAAC CTATCGGAGG AAGGCAAACC GTCCCAATTT AAGCCATGTA 1380 1381 ACTGAAAATC TAATTATAGG AGCACTTGTT ACTGAGTCAG AAATAATGCA AGAGCGTCCC 1440 1441 CTCACAAATA AATTAAAGCG TAAAAGGAGA ACTACATCAG GTCTTCATCC TGAGGATTTT 1500 1501 ATAAAGAAAG CAGATTTGGC AGTTCAAAAA ACTCCTGAAA TAATAAATCA GGGAACTAAC 1560 1561 CAAATGGAGC AGAATGGTCA AGTGATGAAT ATTACTAATA GTGCTCATGA GAATAAAACA 1620 1621 AAAGGTGATT CTATTCAGAA TGAGAAAAAT CCTAACCCAA TAGAATCACT GGAAGAAGAA 1680 1681 TCTGCTTTCA AAACTAAAGC TGAACCTATA AGCAGCAGTA TAAACAATAT GGAACTAGAA 1740 1741 TTAAATATCC ACAATTCAAA AGCACCTAAG AAAAATAGGC TGAGGAGGAA GTCTTCTACC 1800 1801 AGGCATATTC ATGCGCTTGA ACTAGTAGTC AGTAGAAATC TAAGCCCACC TAATTGTACT 1860 1861 GAACTACAAA TTGATAGTTG TTCTAGCAGT GAAGAGATAA AGAAAAAAAA TTACAACCAA 1920 1921 ATGCCAGTCA GGCACAGCAG AAACCTACAA CTCATGGAAG ATAAAGAATC TGCAACTGGA 1980 1981 GCCAAGAAGA GTAACAAGCC AAATGAACAG ACAAGTAAAA GACATGCCAG TGATACTTTC 2040 2041 CCAGAACTGA AGTTAACAAA GGTACCTGGT TCTTTTACTA ACTGTTCAAA TACTAGTGAA 2100 2101 CTTAAAGAAT TTGTCAATCC TAGCCTTTCA AGAGAAGAAA AAGAAGAGAA ACTAGAAACA 2160 2161 GTCAAAGTGT CTAATAATGC CAAAGACCCC AAAGATCTCA TGTTAAGTGG AGAAAGGGTT 2220 2221 TTACAAACTG AAAGATCTGT AGAGAGTAGC AGTATTTCAT TGGTACCTGG TACCGATTAT 2280 2281 GGCACTCAGG AAAGTATCTC ATTACTGCAA GTTAGCACTC TAGGGAAGGC AAAAACAGAA 2340 2341 CTAAATAAAT GTATGAGTCA GTGTGCAGCA TTTGAAAACT CCAAGGAACT AATTCATGGT 2400 2401 TGTTCTGAAG ATACTAGAAA TGACACAGAA GACTCTAAGT ATCCATTGGG ACGTGAAGTT 2460 2461 AACCACAGTC AGGAAACAAG CATAGAAATA GAAGAAAGTG AACTTGATAC TCAGTATTTG 2520 2521 CAGAATACAT TCAAGGTTTC AAAGCGCCAG TCCTTTGCTC TGTTTTCAAA TCCAGGAAAT 2580 2581 CCAGAAGAGG AATGTGCAAC ATTCTCTGCC CACTCTAGGT CCTTAAAGAA ACAAAGTCCA 2640 2641 AAAGTTACTT CTGAATGTGA ACAAAAGGAA GAAAATCAAG GAAAGAAAGA GTCTAATATC 2700 2701 AAGCCTGTAC AGACAGTTAA TATCACTGCA GGCTTTTCTG TGGTTTGTCA GAAAGATAAG 2760 2761 CCAGTTGATA ATGCCAAATG TAGTATCAAA GGAGGCTCTA GGTTTTGTCT ATCATCTCAG 2820 2821 TTCAGAGGCA ACGAAACTGG ACTCATTACT CCAAATAAAC ATGGACTTTT ACAAAACCCA 2880 2881 TACCATATAC CACCACTTTT TCCTGTCAAG TCATTTGTTA AAACTAAATG TAACAAAAAC 2940 2941 CTGCTAGAGG AAAACTCTGA GGAACATTCA GTGTCACCTG AAAGAGCAGT GGGAAACGAG 3000 3001 AACATCATTC CAAGTACAGT GAGCACAATT AGCCATAATA ACATTAGAGA AAATGCTTTT 3060 3061 AAAGAAGCCA GCTGGAGCAA TATTAATGAA GTAGGTTCCA GTACTAATGA AGTGGGCTCC 3120 3121 AGTATTAATG AAGTAGGTTC CAGTGATGAA AACATTCAAG CAGAACTAGG TAGAAACAGA 3180 3181 GGGCCAAAAT TGAATGCTGT GCTTAGATTA GGGCTTTTGC AACCTGAGGT CTGTAAACAA 3240 3241 AGTCTTCCTA TAAGTAATTG TAAGCATCCT GAAATAAAAA AGCAAGAACA TGAAGAATTA 3300 3301 GTTCAGACTG TTAATACAGA CTTCTCTCCA TGTCTGATTT CAGATAACCT AGAACAGCCT 3360 3361 ATGGGAAGTA GTCATGCGTC TGAGGTTTGT TCTGAGACTC CTGATGATCT GTTAGATGAT 3420 3421 GGTGAAATAA AGGAAGATAC TAGTTTTGCT GAAAATGACA TTAAGGAGAG TTCTGCTGTT 3480 3481 TTTAGCAAAA GCGTCCAGAG AGGAGAGCTC AGCAGGAGCC CTAGCCCTTT CACCCATACA 3540 3541 CATTTGGCTC AGGGTTACCG AAAAGGGGCC AAGAAATTAG AGTCCTCAGA AGAGAACTTA 3600 3601 TCTAGTGAGG ATGAAGAGCT TCCCTGCTTC CAACACTTGT TATTTGGTAA AGTAAGCAAT 3660 3661 ATACCTTCTC AGACTACTAG GCATAGCACT GTTGCTACCG AGTGTCTGTC TAAGAACACA 3720 3721 GAGGAGAATT TATTATCATT GAAGAATAGC TTAACTGACT GTAGTAACCA GGTAATATTG 3780 3781 TCAAAGGCAT CCCAGGAACA TCACCTTAGT GAGGAAACAA AATGTTCTGG TAGCTTGTTT 3840 3841 TCTTCACAGT GCAGTGAACT GGAAGACTTG ACTGCAAATA CAAATACCCA GGATCCTTTC 3900 3901 TTGATTGGTT CTTCCAAACG AATGAGGCAT CAGTCTGAAA GCCAGGGAGT TGGTCTGAGT 3960 3961 GACAAGGAAT TGGTTTCAGC TGATGAAGAA AGGGGAACAG GCTTGGAAGA AGATAATCAA 4020 4021 GAAGAGCAAA GTGTGGATTC AAACTTAGGT GAAGCAGCAT CCGGGTATGA GAGTGAAACA 4080 4081 AGCGTCTCTG AAGACTGCTC AAGGCTCTCC TCTCAGAGCG AAATTTTAAC CACTCAGCAG 4140 4141 AGGGATACCA TGCAAGATAA CCTAATAAAG CTCCAGCAGG AAATGGCTGA ACTAGAAGCT 4200 4201 GTGTTAGAAC AGCACGGAAG CCAGCCTTCT AACAGCTACC CTTCCATCAT AACTGACTCT 4260 4261 TCTGCCCTTG AGGACCTGCG AAATCCAGAA CAAAGCACAT CAGAAAAAGC AGTATTAACT 4320 4321 TCACAGAAAA GTAGTGAATA TCCTATAAAC CAGAATCCAG AAGGCCTTTC TGCTGACAAG 4380 4381 TTCGAGGTAT CTGCAGATAG TTCTACCAGT AAAAATAAAG AACCAGGAGT GGAAAGGTCA 4440 4441 TCCCCTTCTA AATGCCAGTC ATTAGAGGAT AGGTGGTATG TGCACAGTAG CTCTGGGAGT 4500 4501 CTTCAGAATG GAAATTACCC ATCTCAAGAG GAGCTCATTA AGGTTGTTGA TGTGGAGACG 4560 4561 CAACAACTGG AAAAGTCTGG GCCACACAAT TTGATGGAAC CATCTTACTT GCCAAGGCAA 4620 4621 GATCTAGAGG GAACCCCTTA CCTGGAATCT GGAATCAGTC TCTTCTCTGA TGACCCTGAA 4680 4681 TCTGATCCAT CCGAAGACAG AGCCCCAGAG TCAGCTCATG TTGGCAGCAT ACCATCTTCA 4740 4741 ACCTCTGCAT TGAAAGTACC CCAGTGGCAA GTTGCAGAAT CTGCCCAGAG TCCAGCTGCT 4800 4801 GCTCATAATA CTAATACTGC TGGGTATAAT GCAATGGAAG AAAGTGTGAG CAGGGAGAAG 4860 4861 CCAAAATTGA CAGCTTCAAC AGAAAGGGTC AACGAAAGAA TGTCCTTGGT GGTGTCTGGC 4920 4921 CTGACCCCAG AAGAATTTAT GCTCGTGTAC AAGTTTGCCA GAAGATACCA CATCGCTTTA 4980 4981 ACTAATCTAA TTAGTGAAGA GACTACTCAT GTCGTTATGA AAACAGATGC TGAGTTTGTG 5040 5041 TGTGAACGGA CGCTGAAATA TTTTCTGGGA ATTGCGGGAG GAAAATGGGT AGTTAGCTAT 5100 5101 TTCTGGGTGA CCCAGTCTAT TAAAGAAAGA AAAATGCTGA ATGAGGTAAA TTTCCTTCTC 5160 5161 TCCATTCCCC TGTGCCTCTC TCTTCCTCTC TTCCAGATCT TCAGGGGGCT AGAAATCTGT 5220 5221 TGTTATGGGC CCTTCACCAA CATGCCCACA GATCAACTGG AGTGGATGGT ACAGCTTTGT 5280 5281 GGTGCTTCTG TGGTGAAGGA GCTTTCATCA TTCACCCTTG GCACAGGTTT CCACCCAATT 5340 5341 GTGGTTGTGC AGCCAGATGC CTGGACAGAG GACAATGGCT TCCATGCAAT TGGGCAGATG 5400 5401 TGTGAGGCAC CTGTGGTGAC CCGAGAGTGG GTGTTGGACA GTGTAGCACT CTACCAGTGC 5460 5461 CAGGAGCTGG ACACCTACCT GATACCCCAG ATCCCCCACA GCCACTACTG A 5511

Nucleotide Sequence

>LLPS-Paa-1226|ENSPANG00000021372.2
ACCTCACCATGGGGTTATACAATCAGCAAAATCCAGAATTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAGATTTTGCATGCTGAAACTTCTCAACCAGAAGAAAGGGCCTTCACAGTGTCCTTTGTGTAAGAATGATATAACCAAAAGAAGCCTACAAGAAAGTACAAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCATTCATGCTTTTCAGCTTGACACAGGTTTGCAGTTTGCAAACAGTTATAATTTTGCAAAAAAGGAAAATCACTCTCCTGAACATCTAAAAGATGAAGTTTCTATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCCACTCTCTAACCTTGGAATTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGAAGTCTGTCTACATTGAACTGGGATCTGATTCTTCTGAAGATACGGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAACCAGTTTGGATTCTGCAAAAAAGGCTGCTTGTGAATTTTCTGAGAAGGATATAACAAATACTGAACATCATCAGTCCAGTAATAATGATTTGAACACCACTGAGAAACATGCAACTGAGAGGCATCCAGAAAAGTATCAGGGTAGTTCTGTTTCAAACTTGCATGTGGAGCCATGTGGCACAAATACTCATGCCAGCTCATTACAGCATGAGAATAGTTTATTACTCACTAAAGACAGAATGAATGTAGAAAAGGCTGAATTCTGTAATAAAAGCAAACAGCCTGGCTTGGCAAGGAGCCAACATAACAGATGGACTGGAAGTAAGGAAACATGTAATGATAGGCAGACTCCCAGCACAGAGAAAAAGGTAGATCTGAATGCTAATGCCCTGTATGAGAGAAAAGAATGGAATAAGCAAAAACTGCCATGCTCTGAGAATCCTAGAGACACTGAAGATGTTCCTTGGATAACACTAAATAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTGATGAACTGTTAAGTTCTGATGACTCACATGATGGGGGGTCTGAATCAAATGCCAAAGTAGCTGATGTATTGGACGTTCTAAATGAGGTAGATGAATATTCTGGTTCTTCAGAGAAAATAGACTTACTGGCCAGTGATCCTCATGAGCCTTTAATATGTAAAAGTGAAAGAGTTCACTCCAGTTCAGTAGAGATTAATATTAAAGACAAAATATTTGGGAAAACCTATCGGAGGAAGGCAAACCGTCCCAATTTAAGCCATGTAACTGAAAATCTAATTATAGGAGCACTTGTTACTGAGTCAGAAATAATGCAAGAGCGTCCCCTCACAAATAAATTAAAGCGTAAAAGGAGAACTACATCAGGTCTTCATCCTGAGGATTTTATAAAGAAAGCAGATTTGGCAGTTCAAAAAACTCCTGAAATAATAAATCAGGGAACTAACCAAATGGAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGCTCATGAGAATAAAACAAAAGGTGATTCTATTCAGAATGAGAAAAATCCTAACCCAATAGAATCACTGGAAGAAGAATCTGCTTTCAAAACTAAAGCTGAACCTATAAGCAGCAGTATAAACAATATGGAACTAGAATTAAATATCCACAATTCAAAAGCACCTAAGAAAAATAGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCTTGAACTAGTAGTCAGTAGAAATCTAAGCCCACCTAATTGTACTGAACTACAAATTGATAGTTGTTCTAGCAGTGAAGAGATAAAGAAAAAAAATTACAACCAAATGCCAGTCAGGCACAGCAGAAACCTACAACTCATGGAAGATAAAGAATCTGCAACTGGAGCCAAGAAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGCCAGTGATACTTTCCCAGAACTGAAGTTAACAAAGGTACCTGGTTCTTTTACTAACTGTTCAAATACTAGTGAACTTAAAGAATTTGTCAATCCTAGCCTTTCAAGAGAAGAAAAAGAAGAGAAACTAGAAACAGTCAAAGTGTCTAATAATGCCAAAGACCCCAAAGATCTCATGTTAAGTGGAGAAAGGGTTTTACAAACTGAAAGATCTGTAGAGAGTAGCAGTATTTCATTGGTACCTGGTACCGATTATGGCACTCAGGAAAGTATCTCATTACTGCAAGTTAGCACTCTAGGGAAGGCAAAAACAGAACTAAATAAATGTATGAGTCAGTGTGCAGCATTTGAAAACTCCAAGGAACTAATTCATGGTTGTTCTGAAGATACTAGAAATGACACAGAAGACTCTAAGTATCCATTGGGACGTGAAGTTAACCACAGTCAGGAAACAAGCATAGAAATAGAAGAAAGTGAACTTGATACTCAGTATTTGCAGAATACATTCAAGGTTTCAAAGCGCCAGTCCTTTGCTCTGTTTTCAAATCCAGGAAATCCAGAAGAGGAATGTGCAACATTCTCTGCCCACTCTAGGTCCTTAAAGAAACAAAGTCCAAAAGTTACTTCTGAATGTGAACAAAAGGAAGAAAATCAAGGAAAGAAAGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACTGCAGGCTTTTCTGTGGTTTGTCAGAAAGATAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCTCTAGGTTTTGTCTATCATCTCAGTTCAGAGGCAACGAAACTGGACTCATTACTCCAAATAAACATGGACTTTTACAAAACCCATACCATATACCACCACTTTTTCCTGTCAAGTCATTTGTTAAAACTAAATGTAACAAAAACCTGCTAGAGGAAAACTCTGAGGAACATTCAGTGTCACCTGAAAGAGCAGTGGGAAACGAGAACATCATTCCAAGTACAGTGAGCACAATTAGCCATAATAACATTAGAGAAAATGCTTTTAAAGAAGCCAGCTGGAGCAATATTAATGAAGTAGGTTCCAGTACTAATGAAGTGGGCTCCAGTATTAATGAAGTAGGTTCCAGTGATGAAAACATTCAAGCAGAACTAGGTAGAAACAGAGGGCCAAAATTGAATGCTGTGCTTAGATTAGGGCTTTTGCAACCTGAGGTCTGTAAACAAAGTCTTCCTATAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAACATGAAGAATTAGTTCAGACTGTTAATACAGACTTCTCTCCATGTCTGATTTCAGATAACCTAGAACAGCCTATGGGAAGTAGTCATGCGTCTGAGGTTTGTTCTGAGACTCCTGATGATCTGTTAGATGATGGTGAAATAAAGGAAGATACTAGTTTTGCTGAAAATGACATTAAGGAGAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAGAGGAGAGCTCAGCAGGAGCCCTAGCCCTTTCACCCATACACATTTGGCTCAGGGTTACCGAAAAGGGGCCAAGAAATTAGAGTCCTCAGAAGAGAACTTATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACACTTGTTATTTGGTAAAGTAAGCAATATACCTTCTCAGACTACTAGGCATAGCACTGTTGCTACCGAGTGTCTGTCTAAGAACACAGAGGAGAATTTATTATCATTGAAGAATAGCTTAACTGACTGTAGTAACCAGGTAATATTGTCAAAGGCATCCCAGGAACATCACCTTAGTGAGGAAACAAAATGTTCTGGTAGCTTGTTTTCTTCACAGTGCAGTGAACTGGAAGACTTGACTGCAAATACAAATACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACGAATGAGGCATCAGTCTGAAAGCCAGGGAGTTGGTCTGAGTGACAAGGAATTGGTTTCAGCTGATGAAGAAAGGGGAACAGGCTTGGAAGAAGATAATCAAGAAGAGCAAAGTGTGGATTCAAACTTAGGTGAAGCAGCATCCGGGTATGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAAGGCTCTCCTCTCAGAGCGAAATTTTAACCACTCAGCAGAGGGATACCATGCAAGATAACCTAATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCACGGAAGCCAGCCTTCTAACAGCTACCCTTCCATCATAACTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATATCCTATAAACCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTCGAGGTATCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCTTCTAAATGCCAGTCATTAGAGGATAGGTGGTATGTGCACAGTAGCTCTGGGAGTCTTCAGAATGGAAATTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAGACGCAACAACTGGAAAAGTCTGGGCCACACAATTTGATGGAACCATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAATCTGGAATCAGTCTCTTCTCTGATGACCCTGAATCTGATCCATCCGAAGACAGAGCCCCAGAGTCAGCTCATGTTGGCAGCATACCATCTTCAACCTCTGCATTGAAAGTACCCCAGTGGCAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATAATACTAATACTGCTGGGTATAATGCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAAAATTGACAGCTTCAACAGAAAGGGTCAACGAAAGAATGTCCTTGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAGATACCACATCGCTTTAACTAATCTAATTAGTGAAGAGACTACTCATGTCGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACGCTGAAATATTTTCTGGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGGTAAATTTCCTTCTCTCCATTCCCCTGTGCCTCTCTCTTCCTCTCTTCCAGATCTTCAGGGGGCTAGAAATCTGTTGTTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAGTGGATGGTACAGCTTTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGGTTTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGA

▼ KEYWORD

ID	Family
KW-0131	Cell cycle
KW-0158	Chromosome
KW-0175	Coiled coil
KW-0181	Complete proteome
KW-0227	DNA damage
KW-0233	DNA recombination
KW-0234	DNA repair
KW-0238	DNA-binding
KW-0479	Metal-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0833	Ubl conjugation pathway
KW-0862	Zinc
KW-0863	Zinc-finger

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0070531	Cellular Component	BRCA1-A complex
GO:0031436	Cellular Component	BRCA1-BARD1 complex
GO:0005737	Cellular Component	Cytoplasm
GO:0000800	Cellular Component	Lateral element
GO:0005886	Cellular Component	Plasma membrane
GO:1990904	Cellular Component	Ribonucleoprotein complex
GO:0003684	Molecular Function	Damaged DNA binding
GO:0042802	Molecular Function	Identical protein binding
GO:0003723	Molecular Function	RNA binding
GO:0070063	Molecular Function	RNA polymerase binding
GO:0003713	Molecular Function	Transcription coactivator activity
GO:0044212	Molecular Function	Transcription regulatory region DNA binding
GO:0031625	Molecular Function	Ubiquitin protein ligase binding
GO:0004842	Molecular Function	Ubiquitin-protein transferase activity
GO:0008270	Molecular Function	Zinc ion binding
GO:0071681	Biological Process	Cellular response to indole-3-methanol
GO:0071356	Biological Process	Cellular response to tumor necrosis factor
GO:0007098	Biological Process	Centrosome cycle
GO:0043009	Biological Process	Chordate embryonic development
GO:0007059	Biological Process	Chromosome segregation
GO:0009048	Biological Process	Dosage compensation by inactivation of X chromosome
GO:0000724	Biological Process	Double-strand break repair via homologous recombination
GO:0008630	Biological Process	Intrinsic apoptotic signaling pathway in response to DNA damage
GO:0044818	Biological Process	Mitotic G2/M transition checkpoint
GO:1902042	Biological Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717	Biological Process	Negative regulation of fatty acid biosynthetic process
GO:0035067	Biological Process	Negative regulation of histone acetylation
GO:0051572	Biological Process	Negative regulation of histone H3-K4 methylation
GO:0051573	Biological Process	Negative regulation of histone H3-K9 methylation
GO:0033147	Biological Process	Negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378	Biological Process	Negative regulation of reactive oxygen species metabolic process
GO:0045892	Biological Process	Negative regulation of transcription, DNA-templated
GO:0045766	Biological Process	Positive regulation of angiogenesis
GO:0071158	Biological Process	Positive regulation of cell cycle arrest
GO:0045739	Biological Process	Positive regulation of DNA repair
GO:0051571	Biological Process	Positive regulation of histone H3-K4 methylation
GO:2000617	Biological Process	Positive regulation of histone H3-K9 acetylation
GO:0051574	Biological Process	Positive regulation of histone H3-K9 methylation
GO:2000620	Biological Process	Positive regulation of histone H4-K16 acetylation
GO:0070512	Biological Process	Positive regulation of histone H4-K20 methylation
GO:0031398	Biological Process	Positive regulation of protein ubiquitination
GO:0045944	Biological Process	Positive regulation of transcription by RNA polymerase II
GO:0010575	Biological Process	Positive regulation of vascular endothelial growth factor production
GO:0006301	Biological Process	Postreplication repair
GO:0051865	Biological Process	Protein autoubiquitination
GO:0085020	Biological Process	Protein K6-linked ubiquitination
GO:0044030	Biological Process	Regulation of DNA methylation
GO:0006349	Biological Process	Regulation of gene expression by genetic imprinting
GO:0043627	Biological Process	Response to estrogen
GO:0010212	Biological Process	Response to ionizing radiation
GO:0072425	Biological Process	Signal transduction involved in G2 DNA damage checkpoint

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Maf-0643	Macaca fascicularis	97.41	0.0	3536
LLPS-Mam-3126	Macaca mulatta	97.3	0.0	3535
LLPS-Man-3532	Macaca nemestrina	96.23	0.0	3477
LLPS-Mal-3136	Mandrillus leucophaeus	94.63	0.0	3362
LLPS-Cea-2080	Cercocebus atys	94.53	0.0	3400
LLPS-Chs-2776	Chlorocebus sabaeus	92.31	0.0	690
LLPS-Pap-2477	Pan paniscus	92.2	0.0	3309
LLPS-Pat-1562	Pan troglodytes	92.13	0.0	3332
LLPS-Nol-2709	Nomascus leucogenys	91.54	0.0	3291
LLPS-Hos-2552	Homo sapiens	91.54	0.0	3304
LLPS-Poa-2311	Pongo abelii	90.95	0.0	3267
LLPS-Rhb-1391	Rhinopithecus bieti	90.25	0.0	3169
LLPS-Gog-0694	Gorilla gorilla	87.35	0.0	3086
LLPS-Dio-0957	Dipodomys ordii	86.25	8e-37	140
LLPS-Aon-0442	Aotus nancymaae	86.11	0.0	3065
LLPS-Caj-1140	Callithrix jacchus	84.81	0.0	3005
LLPS-Mup-0672	Mustela putorius furo	78.57	2e-126	422
LLPS-Ora-2928	Ornithorhynchus anatinus	78.18	1e-21	99.8
LLPS-Cas-3558	Carlito syrichta	78.0	2e-19	90.9
LLPS-Fec-4101	Felis catus	77.44	2e-123	413
LLPS-Ict-3217	Ictidomys tridecemlineatus	73.01	5e-164	511
LLPS-Eqc-2341	Equus caballus	72.97	0.0	2510
LLPS-Aim-1582	Ailuropoda melanoleuca	71.99	0.0	2470
LLPS-Tut-0406	Tursiops truncatus	71.87	0.0	2457
LLPS-Loa-3118	Loxodonta africana	71.37	0.0	2434
LLPS-Caf-1549	Canis familiaris	71.33	0.0	2455
LLPS-Sus-3755	Sus scrofa	70.88	0.0	2454
LLPS-Urm-0965	Ursus maritimus	69.15	0.0	2315
LLPS-Myl-1291	Myotis lucifugus	69.01	0.0	2308
LLPS-Cap-0777	Cavia porcellus	68.35	3e-26	110
LLPS-Ova-0836	Ovis aries	68.28	0.0	2328
LLPS-Bot-2159	Bos taurus	68.03	0.0	2303
LLPS-Orc-3653	Oryctolagus cuniculus	66.86	0.0	2265
LLPS-Leo-0756	Lepisosteus oculatus	59.46	1e-20	104
LLPS-Mea-1366	Mesocricetus auratus	56.82	2e-117	410
LLPS-Gaa-0981	Gasterosteus aculeatus	56.76	1e-17	94.4
LLPS-Pof-1514	Poecilia formosa	55.71	2e-14	84.0
LLPS-Scf-0072	Scleropages formosus	55.26	4e-17	92.4
LLPS-Ran-1791	Rattus norvegicus	53.69	0.0	1660
LLPS-Mum-1492	Mus musculus	53.67	0.0	1670
LLPS-Orn-2960	Oreochromis niloticus	52.7	1e-16	91.3
LLPS-Orl-0482	Oryzias latipes	52.7	2e-15	87.0
LLPS-Icp-3646	Ictalurus punctatus	51.43	1e-14	84.3
LLPS-Fud-0326	Fukomys damarensis	50.54	0.0	1587
LLPS-Meg-3162	Meleagris gallopavo	47.17	6e-64	246
LLPS-Scm-1860	Scophthalmus maximus	47.06	1e-15	87.8
LLPS-Tar-2305	Takifugu rubripes	46.51	2e-14	84.0
LLPS-Xim-1453	Xiphophorus maculatus	46.24	1e-14	84.3
LLPS-Anc-1120	Anolis carolinensis	45.87	3e-58	222
LLPS-Fia-0965	Ficedula albicollis	45.59	6e-61	236
LLPS-Xet-1997	Xenopus tropicalis	45.15	2e-43	179
LLPS-Gaga-3615	Gallus gallus	44.93	9e-61	235
LLPS-Mod-3367	Monodelphis domestica	44.74	0.0	1205
LLPS-Tag-2100	Taeniopygia guttata	44.65	7e-59	229
LLPS-Asm-0229	Astyanax mexicanus	44.05	5e-15	85.9
LLPS-Sah-1537	Sarcophilus harrisii	39.4	0.0	688
LLPS-Ten-2093	Tetraodon nigroviridis	37.68	5e-34	147
LLPS-Dac-2247	Daucus carota	35.06	6e-07	57.8
LLPS-Anp-0669	Anas platyrhynchos	34.31	6e-111	396
LLPS-Mae-2035	Manihot esculenta	33.72	3e-07	60.1
LLPS-Pot-1482	Populus trichocarpa	32.95	7e-08	62.0
LLPS-Hea-0185	Helianthus annuus	32.93	3e-07	59.7
LLPS-Lac-1432	Latimeria chalumnae	32.9	4e-76	285
LLPS-Gor-2089	Gossypium raimondii	32.56	4e-09	66.2
LLPS-Vir-2127	Vigna radiata	32.56	1e-06	58.2
LLPS-Prp-1696	Prunus persica	32.14	2e-06	57.0
LLPS-Met-1619	Medicago truncatula	31.82	9e-08	61.6
LLPS-Pes-1743	Pelodiscus sinensis	31.67	1e-55	216
LLPS-Via-2163	Vigna angularis	31.58	4e-07	59.7
LLPS-Glm-2772	Glycine max	31.18	3e-06	57.0
LLPS-Cus-1743	Cucumis sativus	30.48	6e-07	59.3
LLPS-Coc-1642	Corchorus capsularis	30.23	5e-07	59.3
LLPS-Thc-0315	Theobroma cacao	30.23	5e-07	59.3
LLPS-Sol-1744	Solanum lycopersicum	29.0	5e-07	59.3
LLPS-Cis-0528	Ciona savignyi	27.7	6e-19	93.6
LLPS-Phv-1190	Phaseolus vulgaris	26.13	7e-06	55.5
LLPS-Tra-1408	Triticum aestivum	24.66	5e-08	62.8
LLPS-Brr-2943	Brassica rapa	23.94	5e-07	59.3
LLPS-Art-1977	Arabidopsis thaliana	22.75	8e-08	62.0
LLPS-Brn-1344	Brassica napus	20.92	3e-07	60.1

LLPS-Paa-1226

Protein Sequence

Nucleotide Sequence