DrLLPS - Data resource of LLPS

LLPS-Otg-0791
TP53

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Cellular tumor antigen p53
Gene Name:	TP53
Ensembl Gene:	ENSOGAG00000016871.2
Ensembl Protein:	ENSOGAP00000015106.2
Organism:	Otolemur garnettii
Taxa ID:	30611
LLPS Type:	Scaffold

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Cajal body, Chromatin, Histone locus body, Nucleolus, Paraspeckle, PML nuclear body, Centrosome/Spindle pole body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1770	P04637	Scaffold	Paraspeckle, PML nuclear body, Centrosome/Spindle pole body	83.43	4e-178	509
Mus musculus	LLPS-Mum-2526	P02340	Scaffold	Cajal body, Chromatin, Histone locus body, Nucleolus, PML nuclear body	73.03	0.0	531

▼ FUNCTION

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSOGAT00000016874.2	ENSOGAP00000015106.2
UniProt		H0XGB0, H0XGB0_OTOGA
GeneBank	AAQR03080642, AAQR03080643

▼ SEQUENCE

Protein Sequence (FASTA)
1 MEETQSDLTI EPPLSQETFS DLWKLLPENN VLSSSLSPPV DDLMLSPDIV NWFDEGPDEA 60 61 LRTLEDPAPV ASTTAALTPA ASAPVTGWPL SSCVPSQTTY PGSYGFRLGF LNSGTAKSVT 120 121 CTYSPVLNKM FCQLAKTCPV QLWFDSTPPP GSRIRAMAIY KQSQHMTEVV RRCPHHERCS 180 181 ESDGLAPPQH LIRVEGNLRV EYLDDKNTFR HSVVVPYEPP EVGSDCTTIH YNYMCNSSCM 240 241 GGMNRRPILT IITLEDSRLG SGNLLGRNSF EVRVCACPGR DRRTEEENSR KKGETCSEPS 300 301 LGSTKRSLPT STSSSPQPKK KLLEGEYFTL KIRGRERYEM FRELNEALEI KDAQAEKESD 360 361 GNRAHSSQPK SKKEQSTSRH KKLMFKREGP DSD 393
Nucleotide CDS Sequence (FASTA)
1 ATGGAGGAGA CACAATCGGA CCTCACCATT GAGCCCCCTC TGAGTCAAGA GACATTTTCA 60 61 GACTTATGGA AACTACTTCC TGAAAACAAT GTTCTGTCCT CCTCACTGTC CCCACCAGTG 120 121 GATGATCTGA TGCTGTCCCC AGACATTGTA AACTGGTTTG ATGAAGGTCC AGATGAAGCG 180 181 CTCAGAACGT TAGAGGATCC TGCACCAGTG GCTTCCACAA CAGCTGCCCT TACACCAGCA 240 241 GCCTCTGCAC CAGTCACCGG CTGGCCTCTG TCATCCTGTG TCCCTTCTCA GACAACTTAC 300 301 CCTGGCAGCT ACGGTTTCCG CCTCGGCTTC TTGAATTCTG GCACAGCCAA GTCTGTCACC 360 361 TGCACGTATT CTCCTGTCCT GAACAAGATG TTTTGCCAGC TGGCGAAGAC CTGCCCTGTA 420 421 CAGCTGTGGT TCGACTCCAC ACCCCCACCA GGCAGTCGCA TCCGTGCCAT GGCCATCTAT 480 481 AAGCAATCAC AACACATGAC AGAAGTGGTG AGGCGCTGCC CCCACCATGA GCGCTGCTCA 540 541 GAAAGTGATG GTCTGGCCCC TCCTCAGCAT CTCATCCGGG TGGAAGGAAA TTTGCGTGTG 600 601 GAGTATTTGG ATGATAAAAA CACTTTTCGA CACAGTGTGG TGGTGCCCTA TGAACCTCCT 660 661 GAGGTCGGCT CTGACTGTAC CACCATCCAC TACAACTACA TGTGTAACAG TTCCTGCATG 720 721 GGGGGCATGA ACCGTCGACC CATCCTCACC ATCATCACAC TGGAAGACTC TAGGCTTGGT 780 781 AGTGGTAACC TGCTGGGACG GAACAGCTTT GAGGTGCGTG TTTGTGCCTG TCCTGGGAGA 840 841 GACCGCCGCA CAGAGGAAGA AAATTCCCGC AAGAAAGGGG AGACTTGTTC TGAGCCATCC 900 901 CTTGGGAGCA CCAAGCGATC ACTGCCCACC AGTACCAGCT CCTCTCCACA GCCAAAGAAG 960 961 AAACTGCTGG AAGGAGAATA TTTTACCCTC AAGATTCGCG GGCGTGAACG TTATGAAATG 1020 1021 TTCCGAGAGC TGAATGAGGC CCTGGAAATC AAGGATGCCC AGGCTGAGAA GGAGTCAGAT 1080 1081 GGGAACAGGG CTCATTCCAG CCAACCGAAG TCCAAGAAGG AGCAATCTAC CTCCCGTCAT 1140 1141 AAAAAATTAA TGTTCAAGAG AGAGGGACCT GACTCCGACT GA 1182

▼ KEYWORD

ID	Family
KW-0010	Activator
KW-0053	Apoptosis
KW-0131	Cell cycle
KW-0175	Coiled coil
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0238	DNA-binding
KW-0479	Metal-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0804	Transcription
KW-0805	Transcription regulation
KW-0862	Zinc

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0005739	Cellular Component	Mitochondrion
GO:0000790	Cellular Component	Nuclear chromatin
GO:0016363	Cellular Component	Nuclear matrix
GO:0005730	Cellular Component	Nucleolus
GO:0016605	Cellular Component	PML body
GO:0005669	Cellular Component	Transcription factor TFIID complex
GO:0005524	Molecular Function	ATP binding
GO:0051087	Molecular Function	Chaperone binding
GO:0005507	Molecular Function	Copper ion binding
GO:0001046	Molecular Function	Core promoter sequence-specific DNA binding
GO:0097718	Molecular Function	Disordered domain specific binding
GO:0001228	Molecular Function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0035035	Molecular Function	Histone acetyltransferase binding
GO:0042826	Molecular Function	Histone deacetylase binding
GO:0042802	Molecular Function	Identical protein binding
GO:0003730	Molecular Function	MRNA 3'-UTR binding
GO:0002039	Molecular Function	P53 binding
GO:1990841	Molecular Function	Promoter-specific chromatin binding
GO:0002020	Molecular Function	Protease binding
GO:0046982	Molecular Function	Protein heterodimerization activity
GO:0047485	Molecular Function	Protein N-terminus binding
GO:0051721	Molecular Function	Protein phosphatase 2A binding
GO:0043621	Molecular Function	Protein self-association
GO:0030971	Molecular Function	Receptor tyrosine kinase binding
GO:0000978	Molecular Function	RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001085	Molecular Function	RNA polymerase II transcription factor binding
GO:0001094	Molecular Function	TFIID-class transcription factor complex binding
GO:0031625	Molecular Function	Ubiquitin protein ligase binding
GO:0006914	Biological Process	Autophagy
GO:0007050	Biological Process	Cell cycle arrest
GO:0072717	Biological Process	Cellular response to actinomycin D
GO:0035690	Biological Process	Cellular response to drug
GO:0071480	Biological Process	Cellular response to gamma radiation
GO:0042149	Biological Process	Cellular response to glucose starvation
GO:0071456	Biological Process	Cellular response to hypoxia
GO:0034644	Biological Process	Cellular response to UV
GO:0031497	Biological Process	Chromatin assembly
GO:0006977	Biological Process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978	Biological Process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000733	Biological Process	DNA strand renaturation
GO:0006983	Biological Process	ER overload response
GO:0042771	Biological Process	Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0009299	Biological Process	MRNA transcription
GO:0007275	Biological Process	Multicellular organism development
GO:0043066	Biological Process	Negative regulation of apoptotic process
GO:0030308	Biological Process	Negative regulation of cell growth
GO:0048147	Biological Process	Negative regulation of fibroblast proliferation
GO:0051974	Biological Process	Negative regulation of telomerase activity
GO:0045892	Biological Process	Negative regulation of transcription, DNA-templated
GO:0006289	Biological Process	Nucleotide-excision repair
GO:0097252	Biological Process	Oligodendrocyte apoptotic process
GO:0090403	Biological Process	Oxidative stress-induced premature senescence
GO:1900119	Biological Process	Positive regulation of execution phase of apoptosis
GO:2001244	Biological Process	Positive regulation of intrinsic apoptotic signaling pathway
GO:1902895	Biological Process	Positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903800	Biological Process	Positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:0032461	Biological Process	Positive regulation of protein oligomerization
GO:2000379	Biological Process	Positive regulation of reactive oxygen species metabolic process
GO:0090200	Biological Process	Positive regulation of release of cytochrome c from mitochondria
GO:0045899	Biological Process	Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0051289	Biological Process	Protein homotetramerization
GO:0008104	Biological Process	Protein localization
GO:0007265	Biological Process	Ras protein signal transduction
GO:0090399	Biological Process	Replicative senescence
GO:0051123	Biological Process	RNA polymerase II preinitiation complex assembly
GO:0016032	Biological Process	Viral process

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-3234	Rattus norvegicus	86.74	1e-150	434
LLPS-Hos-1770	Homo sapiens	83.59	3e-166	479
LLPS-Rhb-0707	Rhinopithecus bieti	83.33	0.0	555
LLPS-Gog-2759	Gorilla gorilla	83.23	1e-163	473
LLPS-Chs-3109	Chlorocebus sabaeus	83.08	0.0	553
LLPS-Pat-2287	Pan troglodytes	83.08	0.0	553
LLPS-Pap-1901	Pan paniscus	83.08	0.0	553
LLPS-Maf-4033	Macaca fascicularis	82.83	0.0	552
LLPS-Poa-0730	Pongo abelii	82.58	0.0	548
LLPS-Ict-3099	Ictidomys tridecemlineatus	81.98	0.0	543
LLPS-Cas-1063	Carlito syrichta	81.47	0.0	560
LLPS-Caj-2951	Callithrix jacchus	81.16	0.0	543
LLPS-Eqc-0097	Equus caballus	79.44	0.0	529
LLPS-Sus-0826	Sus scrofa	78.9	8e-174	500
LLPS-Caf-0841	Canis familiaris	75.89	1e-175	502
LLPS-Urm-1337	Ursus maritimus	75.89	0.0	516
LLPS-Fud-1141	Fukomys damarensis	75.83	0.0	534
LLPS-Bot-3076	Bos taurus	75.38	1e-175	502
LLPS-Paa-1329	Papio anubis	75.31	0.0	527
LLPS-Cea-1132	Cercocebus atys	75.31	0.0	527
LLPS-Ova-1677	Ovis aries	75.19	2e-176	504
LLPS-Mal-0198	Mandrillus leucophaeus	75.06	0.0	527
LLPS-Cap-3698	Cavia porcellus	74.86	5e-164	474
LLPS-Mam-4165	Macaca mulatta	74.81	0.0	526
LLPS-Nol-3919	Nomascus leucogenys	74.49	1e-152	443
LLPS-Dio-2670	Dipodomys ordii	74.22	1e-162	468
LLPS-Mup-2360	Mustela putorius furo	72.59	1e-162	469
LLPS-Mum-2526	Mus musculus	72.26	4e-172	493
LLPS-Mea-2176	Mesocricetus auratus	71.68	4e-174	499
LLPS-Loa-0774	Loxodonta africana	70.82	7e-157	455
LLPS-Man-3642	Macaca nemestrina	67.95	5e-90	280
LLPS-Fec-4041	Felis catus	67.61	6e-166	483
LLPS-Orc-1442	Oryctolagus cuniculus	67.01	6e-147	429
LLPS-Myl-2447	Myotis lucifugus	66.67	5e-128	381
LLPS-Aon-2287	Aotus nancymaae	62.96	3e-131	387
LLPS-Mod-3469	Monodelphis domestica	61.11	5e-36	134
LLPS-Lac-3159	Latimeria chalumnae	56.44	1e-113	345
LLPS-Leo-0269	Lepisosteus oculatus	56.35	1e-102	316
LLPS-Dar-2314	Danio rerio	55.97	5e-108	329
LLPS-Pes-0370	Pelodiscus sinensis	55.45	9e-108	329
LLPS-Icp-2831	Ictalurus punctatus	54.97	3e-101	312
LLPS-Orn-2924	Oreochromis niloticus	54.37	7e-88	277
LLPS-Pof-1860	Poecilia formosa	52.08	1e-77	259
LLPS-Xet-1599	Xenopus tropicalis	51.58	4e-94	293
LLPS-Xim-0802	Xiphophorus maculatus	51.15	3e-78	261
LLPS-Scf-1274	Scleropages formosus	51.02	5e-109	335
LLPS-Gaa-0220	Gasterosteus aculeatus	50.76	1e-80	259
LLPS-Orl-0340	Oryzias latipes	50.76	2e-77	259
LLPS-Ten-1025	Tetraodon nigroviridis	50.57	2e-77	258
LLPS-Tar-1766	Takifugu rubripes	50.38	2e-78	259
LLPS-Asm-2943	Astyanax mexicanus	50.38	3e-76	256
LLPS-Scm-1886	Scophthalmus maximus	50.38	7e-78	259
LLPS-Aim-2920	Ailuropoda melanoleuca	48.68	6e-76	254
LLPS-Tut-1687	Tursiops truncatus	48.68	6e-76	255
LLPS-Ora-0488	Ornithorhynchus anatinus	48.68	9e-76	254
LLPS-Tag-0775	Taeniopygia guttata	48.68	7e-76	254
LLPS-Gaga-2471	Gallus gallus	48.68	7e-76	254
LLPS-Fia-0453	Ficedula albicollis	48.68	8e-76	254
LLPS-Anp-2081	Anas platyrhynchos	48.68	6e-76	254
LLPS-Meg-0131	Meleagris gallopavo	48.68	4e-76	254
LLPS-Anc-1449	Anolis carolinensis	41.01	4e-29	115
LLPS-Cii-1707	Ciona intestinalis	35.89	1e-51	186
LLPS-Cis-0319	Ciona savignyi	35.06	4e-50	181

LLPS-Otg-0791TP53

Protein Sequence

Nucleotide Sequence

LLPS-Otg-0791
TP53