• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orn-3235
LOC100712415

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin beta chain
Gene Name: LOC100712415
Ensembl Gene: ENSONIG00000020223.1
Ensembl Protein: ENSONIP00000025480.1
Organism: Oreochromis niloticus
Taxa ID: 8128
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREIVHLQAG  QCGNQIGAKF  WEVISDEHGI  DPTGTYHGDS  DLQLDRINVY  YNEASGGKYV  60
61    PRAVLVDLEP  GTMDSVRSGP  FGQVFRPDNF  VFGQSGAGNN  WAKGHYTEGA  ELVDSVLDVV  120
121   RKEAESCDCL  QGFQLTHSLG  GGTGSGMGTL  LISKIREEYP  DRIMNTFSVV  PSPKVSDTVV  180
181   EPYNATLSVH  QLVENTDETY  CIDNEALYDI  CFRTLKLTTP  SYGDLNHLVS  ATMSGVTTCL  240
241   RFPGQLNADL  RKLAVNMVPF  PRLHFFMPGF  APLTSRGSQQ  YRSLTVPELT  QQMFDAKNMM  300
301   AACDPRHGRY  LTVAAIFRGR  MSMKEVDEQM  LNVQNKNSSY  FVEWIPNNVK  TAVCDIPPRG  360
361   LKMAATFIGN  STAIQELFKR  ISEQFTAMFR  RKAFLHWYTG  EGMDEMEFTE  AESNMNDLVS  420
421   EYQQYQDATA  EEEGEFEEEG  EEDLA  445
Nucleotide CDS Sequence (FASTA)
1     ATGAGGGAAA  TTGTCCATCT  TCAGGCCGGC  CAGTGCGGAA  ACCAGATTGG  TGCCAAGTTT  60
61    TGGGAGGTGA  TCAGTGATGA  GCATGGCATT  GACCCAACTG  GCACTTACCA  CGGTGACAGT  120
121   GACCTGCAGC  TGGACAGGAT  CAATGTCTAC  TACAATGAAG  CATCAGGTGG  CAAATATGTG  180
181   CCCCGTGCTG  TCCTTGTGGA  TCTGGAGCCA  GGCACCATGG  ACTCTGTGAG  GTCTGGTCCC  240
241   TTTGGCCAAG  TCTTCAGACC  AGACAACTTC  GTTTTTGGCC  AGAGCGGTGC  TGGTAACAAC  300
301   TGGGCCAAGG  GTCACTACAC  AGAAGGTGCA  GAGCTGGTGG  ACTCTGTCCT  GGATGTGGTG  360
361   AGGAAGGAGG  CAGAGAGCTG  CGACTGCCTG  CAGGGCTTCC  AGCTCACACA  CTCCCTGGGT  420
421   GGCGGTACGG  GATCTGGTAT  GGGCACACTG  CTCATCAGCA  AGATCCGCGA  AGAGTATCCT  480
481   GACCGCATTA  TGAACACCTT  CAGCGTGGTG  CCTTCCCCAA  AAGTATCAGA  CACAGTTGTT  540
541   GAGCCCTACA  ACGCCACATT  ATCGGTTCAT  CAGCTTGTAG  AAAACACAGA  TGAGACCTAC  600
601   TGCATCGACA  ACGAGGCCCT  CTATGACATC  TGCTTCCGCA  CCCTTAAACT  CACAACCCCT  660
661   TCGTATGGTG  ACCTCAACCA  TTTGGTCTCT  GCAACGATGA  GTGGCGTCAC  CACGTGCCTC  720
721   AGGTTCCCTG  GACAGCTCAA  TGCTGACCTG  CGCAAGCTGG  CTGTAAACAT  GGTGCCATTC  780
781   CCTCGTCTGC  ACTTCTTCAT  GCCAGGCTTT  GCTCCTCTCA  CAAGCAGGGG  TAGCCAGCAG  840
841   TACAGATCAC  TCACTGTACC  AGAGCTCACC  CAGCAGATGT  TCGATGCCAA  GAACATGATG  900
901   GCTGCCTGTG  ACCCACGTCA  CGGTCGTTAT  CTGACAGTGG  CTGCCATCTT  CCGTGGGCGC  960
961   ATGTCCATGA  AGGAGGTCGA  CGAGCAGATG  CTGAATGTGC  AGAATAAGAA  CAGCAGCTAC  1020
1021  TTCGTTGAAT  GGATCCCCAA  CAACGTCAAG  ACTGCAGTCT  GCGACATTCC  TCCCAGAGGT  1080
1081  CTCAAGATGG  CTGCCACCTT  TATTGGTAAT  AGCACAGCAA  TCCAAGAGCT  GTTTAAGCGC  1140
1141  ATCTCGGAGC  AGTTCACTGC  CATGTTCAGG  CGTAAAGCTT  TCCTTCACTG  GTACACTGGT  1200
1201  GAGGGTATGG  ATGAGATGGA  GTTCACTGAG  GCAGAAAGCA  ACATGAATGA  CCTGGTGTCA  1260
1261  GAGTACCAGC  AGTACCAGGA  TGCCACTGCT  GAGGAGGAGG  GAGAGTTTGA  GGAGGAAGGT  1320
1321  GAAGAGGACC  TGGCCTAA  1338

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dar-1614Danio rerio100.00.0 862
LLPS-Pof-0256Poecilia formosa100.00.0 863
LLPS-Xim-1769Xiphophorus maculatus100.00.0 863
LLPS-Gaa-1344Gasterosteus aculeatus100.00.0 862
LLPS-Scf-0653Scleropages formosus99.530.0 858
LLPS-Scm-0411Scophthalmus maximus99.10.0 848
LLPS-Icp-1398Ictalurus punctatus99.070.0 857
LLPS-Asm-3759Astyanax mexicanus98.60.0 855
LLPS-Leo-2361Lepisosteus oculatus98.60.0 855
LLPS-Anc-1529Anolis carolinensis98.590.0 850
LLPS-Gaga-0553Gallus gallus98.370.0 853
LLPS-Xet-1448Xenopus tropicalis98.370.0 855
LLPS-Fud-3138Fukomys damarensis98.370.0 853
LLPS-Cii-2095Ciona intestinalis98.370.0 855
LLPS-Cis-0796Ciona savignyi98.370.0 855
LLPS-Hos-2792Homo sapiens98.360.0 849
LLPS-Fec-0114Felis catus98.360.0 849
LLPS-Mod-3852Monodelphis domestica98.360.0 849
LLPS-Lac-4047Latimeria chalumnae98.360.0 849
LLPS-Man-4381Macaca nemestrina98.360.0 849
LLPS-Ict-2948Ictidomys tridecemlineatus98.360.0 849
LLPS-Caf-3592Canis familiaris98.360.0 849
LLPS-Cap-3489Cavia porcellus98.360.0 849
LLPS-Mam-0567Macaca mulatta98.360.0 849
LLPS-Caj-2185Callithrix jacchus98.360.0 849
LLPS-Mum-1755Mus musculus98.360.0 849
LLPS-Mea-3878Mesocricetus auratus98.360.0 849
LLPS-Chs-0448Chlorocebus sabaeus98.360.0 849
LLPS-Sah-3322Sarcophilus harrisii98.360.0 849
LLPS-Bot-4278Bos taurus98.360.0 849
LLPS-Tar-2601Takifugu rubripes98.140.0 855
LLPS-Maf-3352Macaca fascicularis98.130.0 847
LLPS-Paa-2063Papio anubis97.80.0 810
LLPS-Rhb-0035Rhinopithecus bieti97.670.0 848
LLPS-Urm-3705Ursus maritimus97.670.0 848
LLPS-Pat-3341Pan troglodytes97.670.0 848
LLPS-Cas-0144Carlito syrichta97.670.0 848
LLPS-Nol-3585Nomascus leucogenys97.670.0 848
LLPS-Poa-2450Pongo abelii97.670.0 848
LLPS-Gog-0740Gorilla gorilla97.670.0 848
LLPS-Cea-2760Cercocebus atys97.670.0 848
LLPS-Aon-0745Aotus nancymaae97.670.0 848
LLPS-Ran-0387Rattus norvegicus97.670.0 848
LLPS-Mal-0435Mandrillus leucophaeus97.670.0 848
LLPS-Ova-2492Ovis aries97.670.0 848
LLPS-Dio-3081Dipodomys ordii97.670.0 848
LLPS-Eqc-3902Equus caballus97.440.0 840
LLPS-Otg-1654Otolemur garnettii97.420.0 842
LLPS-Orc-3339Oryctolagus cuniculus97.420.0 842
LLPS-Pap-1145Pan paniscus97.420.0 842
LLPS-Ten-2857Tetraodon nigroviridis97.420.0 844
LLPS-Orl-3812Oryzias latipes97.420.0 844
LLPS-Sus-1819Sus scrofa97.420.0 842
LLPS-Myl-2541Myotis lucifugus97.420.0 842
LLPS-Mup-3390Mustela putorius furo97.20.0 846
LLPS-Drm-0325Drosophila melanogaster97.070.0 802
LLPS-Pes-0306Pelodiscus sinensis96.980.0 847
LLPS-Fia-0318Ficedula albicollis96.980.0 847
LLPS-Aim-3912Ailuropoda melanoleuca96.980.0 847
LLPS-Tut-2274Tursiops truncatus96.980.0 847
LLPS-Tag-2634Taeniopygia guttata96.740.0 845
LLPS-Ora-3257Ornithorhynchus anatinus96.740.0 844
LLPS-Ere-0293Erinaceus europaeus96.740.0 840
LLPS-Cae-1271Caenorhabditis elegans96.050.0 837
LLPS-Anp-3174Anas platyrhynchos96.030.0 784
LLPS-Loa-2963Loxodonta africana94.650.0 823
LLPS-Php-1465Physcomitrella patens89.770.0 793
LLPS-Chr-0860Chlamydomonas reinhardtii89.070.0 794
LLPS-Sem-1389Selaginella moellendorffii88.840.0 792
LLPS-Orbr-1685Oryza brachyantha88.60.0 783
LLPS-Ors-0595Oryza sativa88.140.0 779
LLPS-Pot-1361Populus trichocarpa88.140.0 780
LLPS-Sob-2219Sorghum bicolor88.110.0 779