• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orl-4116
kras1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: GTPase KRas; Ki-Ras; K-ras
Gene Name: kras1
Ensembl Gene: ENSORLG00000024102.1
Ensembl Protein: ENSORLP00000041975.1
Organism: Oryzias latipes
Taxa ID: 8090
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTEYKLVVVG  AGGVGKSALT  IQLIQNHFVD  EYDPTIEDSY  RKQVVIDGET  CLLDILDTAG  60
61    QEEYSAMRDQ  YMRTGEGFLC  VFAINNTKSF  EDIHHYREQI  KRVKDSEDVP  MVLVGNKCDL  120
121   PTRTVDTKQA  QDLARSFGIP  FIETSAKTRQ  RVEDAFYTLV  REIRQYRLSK  LSKEEKTPRC  180
181   VNLKKCVVM  189
Nucleotide CDS Sequence (FASTA)
1     ATGACGGAAT  ATAAGCTGGT  TGTGGTTGGA  GCTGGTGGTG  TTGGCAAGAG  CGCGCTTACC  60
61    ATTCAGCTCA  TCCAAAACCA  TTTTGTGGAT  GAATATGACC  CCACCATTGA  GGACTCCTAC  120
121   AGAAAACAGG  TAGTAATTGA  TGGAGAGACG  TGTCTGCTGG  ACATCCTGGA  CACTGCAGGT  180
181   CAGGAGGAGT  ACAGCGCCAT  GAGGGATCAG  TACATGAGGA  CAGGGGAAGG  CTTCCTCTGT  240
241   GTTTTTGCTA  TCAACAACAC  CAAGTCTTTT  GAAGACATTC  ACCACTATAG  AGAACAGATT  300
301   AAGCGGGTGA  AGGACTCTGA  GGACGTCCCC  ATGGTGTTGG  TGGGAAACAA  GTGTGACCTC  360
361   CCGACCCGGA  CGGTGGACAC  CAAGCAGGCT  CAGGACTTGG  CACGCAGCTT  TGGCATTCCC  420
421   TTTATTGAAA  CCTCTGCCAA  AACCAGACAG  AGAGTGGAAG  ATGCCTTTTA  CACTCTGGTA  480
481   CGGGAGATCA  GGCAGTACCG  GCTCAGTAAG  CTCAGCAAGG  AAGAAAAGAC  TCCACGCTGT  540
541   GTCAACCTTA  AAAAGTGTGT  TGTGATGTGA  570

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Cytoplasm
GTP-binding
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Prenylation
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Extrinsic component of cytoplasmic side of plasma membrane
Molecular Function
GTP binding
Molecular Function
GTPase activity
Biological Process
Positive regulation of cell population proliferation
Biological Process
Signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-3511Astyanax mexicanus97.351e-126 362
LLPS-Tar-2890Takifugu rubripes97.355e-127 362
LLPS-Ten-0310Tetraodon nigroviridis97.355e-127 362
LLPS-Icp-4161Ictalurus punctatus96.833e-126 361
LLPS-Leo-2047Lepisosteus oculatus96.833e-126 360
LLPS-Scm-0828Scophthalmus maximus96.833e-125 358
LLPS-Scf-3415Scleropages formosus96.31e-124 357
LLPS-Orn-1371Oreochromis niloticus96.32e-125 358
LLPS-Pof-1793Poecilia formosa96.36e-126 360
LLPS-Ora-3446Ornithorhynchus anatinus95.817e-108 314
LLPS-Sah-0578Sarcophilus harrisii95.814e-108 315
LLPS-Mea-2733Mesocricetus auratus95.774e-125 357
LLPS-Ova-1731Ovis aries95.774e-125 357
LLPS-Tut-0186Tursiops truncatus95.774e-125 357
LLPS-Bot-1220Bos taurus95.774e-125 357
LLPS-Dio-3287Dipodomys ordii95.778e-125 357
LLPS-Orc-1937Oryctolagus cuniculus95.773e-124 357
LLPS-Eqc-4746Equus caballus95.774e-125 357
LLPS-Gog-4790Gorilla gorilla95.247e-125 357
LLPS-Caj-4361Callithrix jacchus95.247e-125 357
LLPS-Chs-4344Chlorocebus sabaeus95.247e-125 357
LLPS-Mum-4379Mus musculus95.242e-124 356
LLPS-Maf-1562Macaca fascicularis95.247e-125 357
LLPS-Cea-3287Cercocebus atys95.247e-125 357
LLPS-Sus-2986Sus scrofa95.247e-125 357
LLPS-Ran-4489Rattus norvegicus95.242e-124 356
LLPS-Myl-4244Myotis lucifugus95.247e-125 357
LLPS-Aim-2603Ailuropoda melanoleuca95.242e-124 356
LLPS-Paa-4028Papio anubis95.247e-125 357
LLPS-Mal-4609Mandrillus leucophaeus95.247e-125 357
LLPS-Xim-3244Xiphophorus maculatus95.242e-123 353
LLPS-Gaa-1214Gasterosteus aculeatus95.245e-124 355
LLPS-Rhb-2611Rhinopithecus bieti95.247e-125 357
LLPS-Lac-2700Latimeria chalumnae95.249e-125 357
LLPS-Fec-4790Felis catus95.242e-124 356
LLPS-Pap-3846Pan paniscus95.247e-125 357
LLPS-Urm-2880Ursus maritimus95.242e-124 356
LLPS-Pat-1076Pan troglodytes95.247e-125 357
LLPS-Hos-1001Homo sapiens95.247e-125 357
LLPS-Loa-2102Loxodonta africana95.243e-124 355
LLPS-Man-2882Macaca nemestrina95.247e-125 357
LLPS-Cas-2324Carlito syrichta95.247e-125 357
LLPS-Ict-3239Ictidomys tridecemlineatus95.242e-124 356
LLPS-Nol-4172Nomascus leucogenys95.247e-125 357
LLPS-Cap-0756Cavia porcellus95.247e-125 357
LLPS-Mam-3806Macaca mulatta95.247e-125 357
LLPS-Fud-3156Fukomys damarensis94.712e-124 356
LLPS-Otg-3372Otolemur garnettii94.713e-123 355
LLPS-Meg-1972Meleagris gallopavo94.717e-124 355
LLPS-Gaga-2188Gallus gallus94.717e-124 355
LLPS-Ere-0844Erinaceus europaeus94.185e-121 347
LLPS-Dar-2094Danio rerio93.126e-121 347
LLPS-Pes-0030Pelodiscus sinensis88.365e-110 321
LLPS-Fia-1672Ficedula albicollis88.365e-110 319
LLPS-Anp-2058Anas platyrhynchos88.365e-110 319
LLPS-Tag-0266Taeniopygia guttata88.365e-110 319
LLPS-Xet-1095Xenopus tropicalis58.438e-56 181
LLPS-Mod-2390Monodelphis domestica58.189e-57 183
LLPS-Anc-0192Anolis carolinensis58.189e-57 183
LLPS-Caf-4228Canis familiaris58.181e-56 183
LLPS-Cis-1589Ciona savignyi57.321e-55 181
LLPS-Abg-0211Absidia glauca56.898e-56 181
LLPS-Cii-1088Ciona intestinalis56.712e-54 178
LLPS-Drm-1471Drosophila melanogaster55.988e-58 186
LLPS-Cae-1426Caenorhabditis elegans54.613e-50 169
LLPS-Yal-0871Yarrowia lipolytica50.915e-47 160