• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orl-3043
LOC101165911

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pyruvate dehydrogenase E1 component subunit alpha
Gene Name: LOC101165911
Ensembl Gene: ENSORLG00000006582.2
Ensembl Protein: ENSORLP00000008262.2
Organism: Oryzias latipes
Taxa ID: 8090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLTNISSLLR  ACAQKSGAAA  AVSVRSYSDF  TTQATFEIKK  CDLHKLDEAP  ATEVVMTREE  60
61    GLKYYHIMQT  IRRMELKADQ  LYKQKIIRGF  CHLYDGQEAC  AVGIEASINM  SDHLITAYRA  120
121   HGYTYTRGGT  VKKIMAELTG  RRGGIAKGKG  GSMHMYCKNF  YGGNGIVGAQ  VPLGAGVALA  180
181   CKYQGNNELC  VCLYGDGAAN  QGQIFETYNM  ASLWKLPVIF  ICENNRYGMG  TSVERAAAST  240
241   DYYKRGEFIP  GLRVDGMDVL  CVREATRFAA  EHCRSGKGPI  LMELQTYRYH  GHSMSDPGIS  300
301   YRTREEIQEV  RSKSDPISLL  KDRLLSNNMA  SVEELKVIDV  EVRKEIEDAA  QFATTDPEPP  360
361   LDELCNHMFS  NNPPVEVRGT  NPWAKLKSVS  390
Nucleotide CDS Sequence (FASTA)
1     ATGCTGACTA  ATATATCCAG  TCTGTTGAGG  GCTTGCGCTC  AGAAGAGTGG  CGCTGCAGCA  60
61    GCAGTCTCCG  TGCGCTCCTA  TTCAGACTTC  ACAACCCAGG  CTACTTTTGA  AATAAAGAAA  120
121   TGCGACCTCC  ATAAACTGGA  TGAGGCTCCG  GCCACTGAGG  TGGTGATGAC  TCGTGAGGAG  180
181   GGCCTGAAGT  ATTACCATAT  CATGCAGACC  ATCAGGCGGA  TGGAGCTGAA  GGCTGACCAG  240
241   CTGTATAAGC  AGAAGATCAT  CAGAGGGTTC  TGCCACTTGT  ATGATGGCCA  GGAAGCCTGT  300
301   GCTGTTGGTA  TCGAAGCATC  CATTAATATG  AGCGATCACC  TGATCACTGC  GTACCGTGCC  360
361   CACGGCTACA  CCTACACCCG  GGGAGGCACT  GTGAAGAAGA  TTATGGCTGA  ACTCACAGGT  420
421   AGAAGAGGAG  GTATTGCAAA  GGGCAAAGGA  GGTTCTATGC  ACATGTATTG  TAAAAACTTC  480
481   TATGGTGGAA  ACGGAATCGT  TGGAGCTCAG  GTTCCTCTTG  GTGCTGGTGT  GGCGCTGGCC  540
541   TGCAAGTATC  AGGGCAACAA  TGAGCTTTGT  GTCTGTCTGT  ACGGGGATGG  TGCTGCCAAC  600
601   CAGGGTCAGA  TTTTTGAAAC  GTACAACATG  GCATCTCTGT  GGAAGTTGCC  CGTCATCTTC  660
661   ATCTGTGAGA  ACAACAGGTA  CGGCATGGGC  ACATCAGTGG  AGCGAGCTGC  AGCCAGCACA  720
721   GACTACTACA  AGAGAGGAGA  GTTTATTCCT  GGACTTAGGG  TTGATGGGAT  GGATGTTCTT  780
781   TGTGTTCGTG  AAGCAACAAG  GTTTGCAGCC  GAACACTGCC  GGTCTGGCAA  GGGCCCCATT  840
841   CTCATGGAAC  TGCAGACATA  CCGCTATCAC  GGCCACAGCA  TGAGCGATCC  TGGCATCAGC  900
901   TACCGGACCC  GTGAGGAGAT  CCAGGAGGTT  CGCAGTAAGA  GTGACCCCAT  CTCTCTGCTG  960
961   AAGGATCGTC  TCCTCAGCAA  CAACATGGCA  AGCGTGGAAG  AGTTGAAGGT  GATTGATGTG  1020
1021  GAGGTGAGGA  AAGAAATTGA  AGATGCTGCT  CAGTTTGCCA  CCACAGATCC  AGAGCCACCT  1080
1081  CTGGATGAAT  TGTGCAATCA  CATGTTTTCC  AACAATCCAC  CGGTGGAGGT  GCGTGGCACG  1140
1141  AACCCGTGGG  CCAAGCTCAA  GTCTGTTAGC  TAA  1173

▼ KEYWORD

ID
Family
Complete proteome
Oxidoreductase
Pyruvate
Reference proteome
Thiamine pyrophosphate

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Intracellular membrane-bounded organelle
Molecular Function
Pyruvate dehydrogenase (acetyl-transferring) activity
Biological Process
Acetyl-CoA biosynthetic process from pyruvate

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scm-2975Scophthalmus maximus89.740.0 724
LLPS-Tag-0857Taeniopygia guttata89.112e-62 202
LLPS-Gaa-2364Gasterosteus aculeatus88.460.0 715
LLPS-Tar-3822Takifugu rubripes88.460.0 710
LLPS-Ten-0221Tetraodon nigroviridis86.180.0 703
LLPS-Scf-2665Scleropages formosus85.680.0 674
LLPS-Dar-1199Danio rerio85.640.0 695
LLPS-Asm-2302Astyanax mexicanus85.140.0 689
LLPS-Icp-1197Ictalurus punctatus84.890.0 694
LLPS-Leo-0830Lepisosteus oculatus83.910.0 657
LLPS-Otg-3185Otolemur garnettii82.040.0 621
LLPS-Caj-1340Callithrix jacchus81.490.0 617
LLPS-Xet-1836Xenopus tropicalis81.30.0 630
LLPS-Xim-0452Xiphophorus maculatus81.230.0 650
LLPS-Ora-2673Ornithorhynchus anatinus81.220.0 615
LLPS-Cas-0515Carlito syrichta81.220.0 615
LLPS-Anp-1089Anas platyrhynchos81.030.0 628
LLPS-Orn-1305Oreochromis niloticus79.80.0 651
LLPS-Cea-3575Cercocebus atys79.790.0 618
LLPS-Gog-2378Gorilla gorilla79.790.0 618
LLPS-Hos-1031Homo sapiens79.790.0 618
LLPS-Pat-1993Pan troglodytes79.790.0 618
LLPS-Mam-4296Macaca mulatta79.790.0 617
LLPS-Nol-2006Nomascus leucogenys79.790.0 618
LLPS-Pes-2339Pelodiscus sinensis79.560.0 607
LLPS-Man-3836Macaca nemestrina79.520.0 616
LLPS-Aim-0286Ailuropoda melanoleuca78.910.0 619
LLPS-Fia-1189Ficedula albicollis78.80.0 621
LLPS-Fud-3763Fukomys damarensis78.460.0 627
LLPS-Orc-0567Oryctolagus cuniculus78.460.0 627
LLPS-Dio-3942Dipodomys ordii78.210.0 624
LLPS-Myl-1649Myotis lucifugus78.210.0 626
LLPS-Mup-3057Mustela putorius furo78.210.0 620
LLPS-Ere-0625Erinaceus europaeus78.210.0 629
LLPS-Cap-0691Cavia porcellus78.210.0 625
LLPS-Ict-4504Ictidomys tridecemlineatus78.210.0 624
LLPS-Anc-0122Anolis carolinensis78.060.0 627
LLPS-Mum-4676Mus musculus77.950.0 622
LLPS-Fec-3128Felis catus77.950.0 624
LLPS-Eqc-2160Equus caballus77.950.0 624
LLPS-Pof-0701Poecilia formosa77.830.0 647
LLPS-Maf-0137Macaca fascicularis77.690.0 625
LLPS-Bot-1071Bos taurus77.690.0 621
LLPS-Ova-3461Ovis aries77.690.0 621
LLPS-Pap-3024Pan paniscus77.690.0 624
LLPS-Poa-0582Pongo abelii77.690.0 624
LLPS-Sah-3862Sarcophilus harrisii77.550.0 624
LLPS-Mod-4351Monodelphis domestica77.550.0 628
LLPS-Meg-1021Meleagris gallopavo77.460.0 624
LLPS-Sus-3185Sus scrofa77.440.0 624
LLPS-Aon-4581Aotus nancymaae77.440.0 620
LLPS-Mea-3186Mesocricetus auratus77.440.0 620
LLPS-Ran-0802Rattus norvegicus77.440.0 617
LLPS-Caf-2821Canis familiaris77.440.0 622
LLPS-Lac-3750Latimeria chalumnae77.330.0 636
LLPS-Tut-1755Tursiops truncatus77.180.0 618
LLPS-Gaga-3914Gallus gallus76.880.0 626
LLPS-Loa-3946Loxodonta africana75.140.0 574
LLPS-Paa-3781Papio anubis73.90.0 578
LLPS-Mal-0013Mandrillus leucophaeus73.580.0 577
LLPS-Urm-3344Ursus maritimus72.80.0 575
LLPS-Rhb-2988Rhinopithecus bieti72.80.0 570
LLPS-Cis-1386Ciona savignyi61.763e-137 402
LLPS-Cii-0064Ciona intestinalis61.16e-156 452
LLPS-Cae-2028Caenorhabditis elegans60.05e-159 461
LLPS-Ast-1273Aspergillus terreus57.435e-126 376
LLPS-Aso-0479Aspergillus oryzae56.33e-123 368
LLPS-Asf-0825Aspergillus flavus56.32e-122 367
LLPS-Met-1234Medicago truncatula55.565e-116 350
LLPS-Gor-2633Gossypium raimondii54.763e-119 358
LLPS-Dac-0481Daucus carota54.681e-115 350
LLPS-Sem-1609Selaginella moellendorffii54.435e-117 353
LLPS-Sei-0325Setaria italica54.262e-82 260
LLPS-Orr-0889Oryza rufipogon54.12e-114 345
LLPS-Via-1760Vigna angularis53.922e-110 337
LLPS-Phv-0217Phaseolus vulgaris53.927e-109 331
LLPS-Chr-0340Chlamydomonas reinhardtii53.743e-123 369
LLPS-Php-0348Physcomitrella patens53.571e-119 360
LLPS-Mae-2057Manihot esculenta53.271e-114 347
LLPS-Cus-2318Cucumis sativus53.241e-116 352
LLPS-Asni-0796Aspergillus niger53.087e-117 353
LLPS-Nef-1039Neosartorya fischeri52.871e-119 360
LLPS-Drm-1058Drosophila melanogaster52.812e-119 362
LLPS-Mua-0794Musa acuminata52.222e-95 294
LLPS-Coc-0057Corchorus capsularis52.092e-117 354
LLPS-Pot-2806Populus trichocarpa51.993e-118 356
LLPS-Orbr-2205Oryza brachyantha51.972e-117 353
LLPS-Crn-0557Cryptococcus neoformans51.736e-119 358
LLPS-Brn-3001Brassica napus51.73e-116 351
LLPS-Brr-2139Brassica rapa51.77e-116 350
LLPS-Orb-0647Oryza barthii51.689e-118 355
LLPS-Viv-0174Vitis vinifera51.683e-115 348
LLPS-Lep-2180Leersia perrieri51.665e-119 358
LLPS-Ori-0363Oryza indica51.526e-118 355
LLPS-Ors-2238Oryza sativa51.526e-118 355
LLPS-Orni-2110Oryza nivara51.45e-117 353
LLPS-Orgl-1763Oryza glumaepatula51.42e-117 354
LLPS-Tra-2229Triticum aestivum51.253e-119 358
LLPS-Sol-2295Solanum lycopersicum51.232e-113 344
LLPS-Sot-1054Solanum tuberosum51.234e-114 345
LLPS-Glm-2588Glycine max51.13e-112 341
LLPS-Brd-1072Brachypodium distachyon51.064e-122 366
LLPS-Sob-1486Sorghum bicolor50.971e-116 352
LLPS-Bro-2446Brassica oleracea50.681e-115 350
LLPS-Tru-0781Triticum urartu50.581e-56 190
LLPS-Arl-2732Arabidopsis lyrata50.553e-116 351
LLPS-Art-1136Arabidopsis thaliana50.553e-116 351
LLPS-Orm-0585Oryza meridionalis50.531e-118 357
LLPS-Zem-2071Zea mays50.532e-120 362
LLPS-Vir-0336Vigna radiata50.01e-96 302
LLPS-Hea-1630Helianthus annuus49.876e-117 353
LLPS-Hov-0115Hordeum vulgare49.871e-115 353
LLPS-Blg-0670Blumeria graminis49.482e-116 352
LLPS-Nia-2260Nicotiana attenuata49.194e-112 340
LLPS-Asfu-0296Aspergillus fumigatus46.011e-79 255
LLPS-Orp-0849Oryza punctata44.321e-89 281
LLPS-Put-0339Puccinia triticina43.975e-91 286
LLPS-Asc-0275Aspergillus clavatus41.066e-73 238
LLPS-Org-1261Oryza glaberrima38.625e-70 230
LLPS-Gas-1278Galdieria sulphuraria38.32e-60 205
LLPS-Chc-1157Chondrus crispus38.242e-64 216
LLPS-Cym-0832Cyanidioschyzon merolae37.911e-61 207
LLPS-Thc-2353Theobroma cacao37.393e-67 228
LLPS-Amt-1386Amborella trichopoda37.292e-72 239
LLPS-Prp-1284Prunus persica37.143e-71 236
LLPS-Osl-1061Ostreococcus lucimarinus30.382e-36 141