• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orl-0252
itk

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tyrosine-protein kinase
Gene Name: itk
Ensembl Gene: ENSORLG00000007773.2
Ensembl Protein: ENSORLP00000009739.2
Organism: Oryzias latipes
Taxa ID: 8090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Receptor clusterPredicted from orthologs(View)

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSORLT00000009740.2ENSORLP00000009739.2
UniProtH2LUG2, H2LUG2_ORYLA

▼ SEQUENCE

Protein Sequence (FASTA)
1     MFPRVILKGT  MIKKSQQKKR  TSPCNYKERF  FVLDTQELKY  SERRSGKKPM  LKGCIQLSSI  60
61    KCVEIVCSDI  PIPCQYKYPF  QVLHDNYYLY  IFAPDNDCRM  RWVKALKEET  KYNSLVAKYH  120
121   TNFWMDGKWR  CCLQTDKLAA  GCRVYDPVGC  VTKKPLPQLP  DPEMSLQPST  QGMVIALQDY  180
181   VPMGDDDLPL  QKDQEYLLIN  SSHSEWWAVQ  DDKGKTGFVP  STYVAEKCGK  NFERFQWYNK  240
241   HINRAEAEDL  LMKKGKEGAF  MVRDSRQAGV  YTVSVYTKAS  KGEKNPRVKH  YQIRQEEGGQ  300
301   FYLAEKYLFN  TIPELIHYHQ  HNAAGLITRL  RYPVLPDGYQ  WDILPEELIL  GEEIGSGQFG  360
361   LVLEGRWRET  KVAVKMVREE  CMTDDEFKEE  AKVMMKLSHC  KLVQLFGVCA  QRSPMCLVFE  420
421   YMEKGCLTDY  LLEKRGHLSQ  ETLLGMCLDV  SEGMAYLESS  NFIHRDLAAR  NCLISKNNEV  480
481   KVSDFGMTRY  VLDDQYTSSL  CSKFPVKWSA  PEVIKYSKFS  SKSDVWSFGV  LMWEVYNEGR  540
541   LPYDNRSNSE  VVESLNAGLR  LLKPRLASDA  VYMLMDWCWK  EKPDDRPSFA  LLLHELSELS  600
601   GM  602
Nucleotide CDS Sequence (FASTA)
1     ATGTTTCCTC  GGGTGATTTT  GAAGGGAACC  ATGATCAAAA  AATCTCAGCA  AAAGAAGAGA  60
61    ACGTCACCGT  GTAATTACAA  AGAGAGATTT  TTTGTTTTGG  ACACACAGGA  GCTGAAGTAT  120
121   TCTGAGCGCC  GTTCGGGGAA  GAAGCCCATG  CTAAAAGGTT  GCATTCAACT  GTCCAGTATT  180
181   AAGTGTGTGG  AAATTGTGTG  TAGTGACATC  CCCATACCAT  GCCAATACAA  GTACCCATTT  240
241   CAGGTTCTTC  ATGACAACTA  TTACCTCTAC  ATTTTTGCTC  CAGACAACGA  CTGTCGTATG  300
301   AGATGGGTCA  AAGCCCTCAA  GGAGGAGACT  AAATATAACA  GTTTGGTTGC  AAAATACCAC  360
361   ACAAACTTCT  GGATGGATGG  AAAATGGAGA  TGCTGCCTAC  AAACTGACAA  ACTGGCAGCA  420
421   GGTTGTCGTG  TGTATGATCC  AGTGGGTTGT  GTCACTAAGA  AGCCACTTCC  CCAACTCCCA  480
481   GATCCAGAGA  TGTCATTACA  ACCTTCAACA  CAGGGGATGG  TCATAGCTTT  GCAAGATTAT  540
541   GTGCCCATGG  GAGACGACGA  TTTGCCCCTC  CAGAAAGATC  AGGAGTACCT  GTTGATCAAC  600
601   AGCTCCCACT  CTGAGTGGTG  GGCTGTGCAG  GACGACAAGG  GTAAAACTGG  TTTTGTGCCC  660
661   AGTACGTACG  TTGCGGAAAA  ATGTGGCAAA  AACTTTGAGA  GATTTCAATG  GTACAACAAG  720
721   CACATTAACA  GAGCCGAGGC  AGAAGACTTG  TTAATGAAAA  AGGGAAAAGA  AGGTGCATTC  780
781   ATGGTGCGGG  ACTCAAGACA  AGCAGGAGTC  TACACGGTGT  CCGTTTACAC  CAAAGCATCA  840
841   AAAGGTGAAA  AGAATCCCAG  GGTGAAACAT  TATCAGATAA  GGCAGGAGGA  AGGAGGACAG  900
901   TTCTACTTGG  CTGAAAAGTA  TCTGTTCAAC  ACCATTCCTG  AGCTCATCCA  CTATCACCAA  960
961   CACAATGCTG  CTGGTCTGAT  AACACGGCTG  AGATACCCCG  TTTTGCCAGA  TGGATATCAG  1020
1021  TGGGACATCC  TCCCTGAGGA  GCTGATCCTG  GGGGAGGAGA  TAGGCAGCGG  GCAGTTTGGG  1080
1081  CTTGTACTGG  AGGGGAGGTG  GAGGGAGACG  AAGGTGGCGG  TGAAGATGGT  GCGAGAAGAG  1140
1141  TGCATGACCG  ATGACGAGTT  CAAAGAGGAG  GCAAAAGTTA  TGATGAAGTT  GTCTCACTGT  1200
1201  AAACTGGTGC  AGCTCTTTGG  AGTGTGCGCA  CAGCGCTCTC  CCATGTGTCT  GGTGTTTGAG  1260
1261  TACATGGAGA  AAGGGTGTCT  GACAGATTAC  CTGCTGGAGA  AGAGAGGCCA  CTTGTCTCAG  1320
1321  GAAACGCTGC  TGGGAATGTG  TCTGGATGTC  AGCGAAGGGA  TGGCGTACCT  GGAAAGCTCC  1380
1381  AATTTTATCC  ACAGGGATCT  GGCAGCTCGG  AATTGCCTCA  TCTCAAAGAA  TAACGAGGTA  1440
1441  AAGGTGTCAG  ACTTTGGCAT  GACCAGGTAC  GTTCTTGATG  ACCAATACAC  AAGCTCCCTG  1500
1501  TGCTCCAAGT  TTCCTGTGAA  GTGGTCAGCC  CCAGAGGTGA  TCAAATATTC  CAAGTTCAGC  1560
1561  AGCAAGTCTG  ACGTCTGGTC  ATTTGGTGTG  CTTATGTGGG  AGGTGTACAA  CGAGGGCCGT  1620
1621  CTTCCGTACG  ATAACCGTTC  AAACTCAGAA  GTGGTGGAGT  CGCTGAACGC  AGGCCTGAGG  1680
1681  CTCCTAAAAC  CTCGCCTGGC  CTCGGACGCA  GTCTACATGC  TGATGGATTG  GTGCTGGAAG  1740
1741  GAGAAACCCG  ATGACCGTCC  ATCTTTCGCT  CTCCTCTTGC  ATGAACTGTC  CGAGCTTTCT  1800
1801  GGCATGTAA  1809

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-0884Xiphophorus maculatus79.90.01004
LLPS-Pof-3431Poecilia formosa79.160.0 994
LLPS-Scm-3873Scophthalmus maximus77.310.0 976
LLPS-Gaa-0480Gasterosteus aculeatus74.960.0 943
LLPS-Ten-1228Tetraodon nigroviridis71.880.0 849
LLPS-Tar-0989Takifugu rubripes70.280.0 829
LLPS-Icp-0454Ictalurus punctatus66.560.0 817
LLPS-Scf-0544Scleropages formosus65.690.0 828
LLPS-Dar-1781Danio rerio65.420.0 813
LLPS-Eqc-3270Equus caballus60.460.0 734
LLPS-Pap-1023Pan paniscus60.420.0 737
LLPS-Pat-4459Pan troglodytes60.420.0 736
LLPS-Gog-4202Gorilla gorilla60.420.0 734
LLPS-Poa-3133Pongo abelii60.260.0 733
LLPS-Hos-0796Homo sapiens60.260.0 734
LLPS-Pes-2723Pelodiscus sinensis60.130.0 729
LLPS-Mam-2681Macaca mulatta60.10.0 730
LLPS-Nol-3600Nomascus leucogenys60.10.0 731
LLPS-Man-3340Macaca nemestrina60.10.0 730
LLPS-Paa-3017Papio anubis60.10.0 730
LLPS-Mal-2253Mandrillus leucophaeus60.10.0 730
LLPS-Maf-1639Macaca fascicularis60.10.0 730
LLPS-Chs-3108Chlorocebus sabaeus60.10.0 730
LLPS-Cea-3146Cercocebus atys60.10.0 730
LLPS-Aon-3307Aotus nancymaae60.10.0 731
LLPS-Caf-4618Canis familiaris59.970.0 729
LLPS-Urm-3839Ursus maritimus59.970.0 728
LLPS-Mup-3394Mustela putorius furo59.970.0 730
LLPS-Fec-0239Felis catus59.80.0 730
LLPS-Aim-0460Ailuropoda melanoleuca59.80.0 728
LLPS-Mea-1680Mesocricetus auratus59.80.0 722
LLPS-Bot-4386Bos taurus59.770.0 731
LLPS-Ova-2777Ovis aries59.770.0 726
LLPS-Sus-1609Sus scrofa59.770.0 730
LLPS-Cas-2803Carlito syrichta59.640.0 733
LLPS-Ict-3226Ictidomys tridecemlineatus59.640.0 728
LLPS-Ran-1283Rattus norvegicus59.640.0 726
LLPS-Myl-2058Myotis lucifugus59.640.0 731
LLPS-Dio-3178Dipodomys ordii59.480.0 729
LLPS-Sah-1789Sarcophilus harrisii59.480.0 724
LLPS-Fud-1816Fukomys damarensis59.310.0 700
LLPS-Cap-0306Cavia porcellus59.060.0 721
LLPS-Mum-3498Mus musculus59.060.0 710
LLPS-Caj-0731Callithrix jacchus58.870.0 716
LLPS-Meg-1648Meleagris gallopavo58.860.0 731
LLPS-Loa-3057Loxodonta africana58.450.0 665
LLPS-Leo-3097Lepisosteus oculatus58.390.0 696
LLPS-Otg-4700Otolemur garnettii58.350.0 719
LLPS-Anc-3144Anolis carolinensis58.240.0 711
LLPS-Ora-0218Ornithorhynchus anatinus58.160.0 707
LLPS-Mod-3271Monodelphis domestica58.050.0 716
LLPS-Fia-0024Ficedula albicollis57.590.0 724
LLPS-Tag-1684Taeniopygia guttata57.420.0 725
LLPS-Lac-3081Latimeria chalumnae57.230.0 713
LLPS-Rhb-4802Rhinopithecus bieti56.680.0 676
LLPS-Anp-1210Anas platyrhynchos55.020.0 701
LLPS-Xet-0775Xenopus tropicalis53.430.0 622
LLPS-Gaga-3980Gallus gallus39.728e-91 309
LLPS-Asm-3326Astyanax mexicanus39.494e-90 307
LLPS-Orn-4025Oreochromis niloticus39.33e-91 297
LLPS-Cii-0103Ciona intestinalis37.897e-87 284
LLPS-Orc-4252Oryctolagus cuniculus37.612e-86 286
LLPS-Tut-0136Tursiops truncatus37.612e-86 285
LLPS-Drm-1666Drosophila melanogaster37.379e-87 301