LLPS-Orc-3225
H3F3A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Histone H3.3 |
| Gene Name: | H3F3A, H3.3A |
| Ensembl Gene: | ENSOCUG00000024644.1 |
| Ensembl Protein: | ENSOCUP00000015809.1 |
| Organism: | Oryctolagus cuniculus |
| Taxa ID: | 9986 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOCUT00000026563.1 | ENSOCUP00000015809.1 |
| UniProt | P84246, H33_RABIT, P06351, P33155, Q9V3W4 | |
| GeneBank | X51897 | CAA36179.1 |
| RefSeq | NM_001171112.1, XM_008268052.2, XM_017347763.1 | NP_001164583.1, XP_008266274.1, XP_017203252.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR EIRRYQKSTE 60 61 LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI 120 121 MPKDIQLARR IRGERA 136 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTCGTA CAAAGCAGAC TGCCCGCAAA TCGACTGGTG GTAAAGCACC CAGGAAGCAA 60 61 CTGGCTACAA AAGCCGCTCG CAAGAGTGCG CCCTCTACTG GAGGGGTGAA GAAACCTCAT 120 121 CGTTACAGGC CCGGTACTGT GGCACTTCGT GAAATCAGAC GTTATCAGAA GTCCACTGAG 180 181 CTTCTGATTC GCAAACTCCC CTTCCAGCGT CTGGTGCGAG AAATCGCTCA GGACTTCAAA 240 241 ACAGATCTGC GCTTCCAGAG CGCAGCTATT GGTGCTTTGC AGGAGGCAAG TGAGGCCTAT 300 301 CTGGTTGGCC TTTTTGAAGA CACCAACCTG TGTGCCATCC ATGCCAAACG TGTAACAATT 360 361 ATGCCAAAAG ACATCCAGCT AGCACGCCGC ATACGTGGAG AACGTGCTTA A 411 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleosome | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | Protein heterodimerization activity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fud-0467 | Fukomys damarensis | 100.0 | 1e-93 | 273 |
| LLPS-Asm-1827 | Astyanax mexicanus | 100.0 | 1e-93 | 273 |
| LLPS-Icp-1918 | Ictalurus punctatus | 100.0 | 1e-93 | 273 |
| LLPS-Caj-3023 | Callithrix jacchus | 100.0 | 1e-93 | 273 |
| LLPS-Gog-1682 | Gorilla gorilla | 100.0 | 1e-93 | 273 |
| LLPS-Orl-0894 | Oryzias latipes | 100.0 | 3e-93 | 273 |
| LLPS-Aon-4077 | Aotus nancymaae | 100.0 | 1e-93 | 273 |
| LLPS-Cis-0591 | Ciona savignyi | 100.0 | 1e-93 | 273 |
| LLPS-Sah-1791 | Sarcophilus harrisii | 100.0 | 1e-93 | 273 |
| LLPS-Cea-2158 | Cercocebus atys | 100.0 | 3e-93 | 273 |
| LLPS-Sus-2316 | Sus scrofa | 100.0 | 1e-93 | 273 |
| LLPS-Leo-1949 | Lepisosteus oculatus | 100.0 | 1e-93 | 273 |
| LLPS-Mea-1087 | Mesocricetus auratus | 100.0 | 1e-93 | 273 |
| LLPS-Mum-1803 | Mus musculus | 100.0 | 1e-93 | 273 |
| LLPS-Cii-2230 | Ciona intestinalis | 100.0 | 1e-93 | 273 |
| LLPS-Maf-2882 | Macaca fascicularis | 100.0 | 1e-93 | 273 |
| LLPS-Chs-0132 | Chlorocebus sabaeus | 100.0 | 1e-93 | 273 |
| LLPS-Ora-1769 | Ornithorhynchus anatinus | 100.0 | 1e-93 | 273 |
| LLPS-Paa-1522 | Papio anubis | 100.0 | 1e-93 | 273 |
| LLPS-Mal-0903 | Mandrillus leucophaeus | 100.0 | 1e-93 | 273 |
| LLPS-Myl-2298 | Myotis lucifugus | 100.0 | 1e-93 | 273 |
| LLPS-Ova-1114 | Ovis aries | 100.0 | 1e-93 | 273 |
| LLPS-Aim-0992 | Ailuropoda melanoleuca | 100.0 | 1e-93 | 273 |
| LLPS-Mup-0402 | Mustela putorius furo | 100.0 | 1e-93 | 273 |
| LLPS-Ran-1401 | Rattus norvegicus | 100.0 | 1e-93 | 273 |
| LLPS-Ere-0196 | Erinaceus europaeus | 100.0 | 1e-93 | 273 |
| LLPS-Gaa-0149 | Gasterosteus aculeatus | 100.0 | 1e-93 | 273 |
| LLPS-Dio-2597 | Dipodomys ordii | 100.0 | 1e-93 | 273 |
| LLPS-Bot-2669 | Bos taurus | 100.0 | 1e-93 | 273 |
| LLPS-Scf-0248 | Scleropages formosus | 100.0 | 1e-93 | 273 |
| LLPS-Drm-0300 | Drosophila melanogaster | 100.0 | 1e-93 | 273 |
| LLPS-Tar-2091 | Takifugu rubripes | 100.0 | 1e-93 | 273 |
| LLPS-Tut-2180 | Tursiops truncatus | 100.0 | 1e-93 | 273 |
| LLPS-Fia-1745 | Ficedula albicollis | 100.0 | 1e-93 | 273 |
| LLPS-Rhb-2860 | Rhinopithecus bieti | 100.0 | 1e-93 | 273 |
| LLPS-Orn-1719 | Oreochromis niloticus | 100.0 | 1e-93 | 273 |
| LLPS-Otg-2365 | Otolemur garnettii | 100.0 | 1e-93 | 273 |
| LLPS-Pes-1793 | Pelodiscus sinensis | 100.0 | 1e-93 | 273 |
| LLPS-Man-0966 | Macaca nemestrina | 100.0 | 1e-93 | 273 |
| LLPS-Loa-1723 | Loxodonta africana | 100.0 | 1e-93 | 273 |
| LLPS-Anp-1019 | Anas platyrhynchos | 100.0 | 1e-93 | 273 |
| LLPS-Pap-2789 | Pan paniscus | 100.0 | 1e-93 | 273 |
| LLPS-Pof-0266 | Poecilia formosa | 100.0 | 1e-93 | 273 |
| LLPS-Pat-1349 | Pan troglodytes | 100.0 | 1e-93 | 273 |
| LLPS-Hos-1594 | Homo sapiens | 100.0 | 1e-93 | 273 |
| LLPS-Meg-1738 | Meleagris gallopavo | 100.0 | 1e-93 | 273 |
| LLPS-Dar-1132 | Danio rerio | 100.0 | 1e-93 | 273 |
| LLPS-Lac-2482 | Latimeria chalumnae | 100.0 | 1e-93 | 273 |
| LLPS-Fec-0468 | Felis catus | 100.0 | 1e-93 | 273 |
| LLPS-Mod-3613 | Monodelphis domestica | 100.0 | 1e-93 | 273 |
| LLPS-Scm-0925 | Scophthalmus maximus | 100.0 | 1e-93 | 273 |
| LLPS-Ict-1067 | Ictidomys tridecemlineatus | 100.0 | 1e-93 | 273 |
| LLPS-Nol-3628 | Nomascus leucogenys | 100.0 | 1e-93 | 273 |
| LLPS-Anc-1047 | Anolis carolinensis | 100.0 | 1e-93 | 273 |
| LLPS-Tag-1328 | Taeniopygia guttata | 100.0 | 1e-93 | 273 |
| LLPS-Cas-0222 | Carlito syrichta | 100.0 | 1e-93 | 273 |
| LLPS-Xet-2240 | Xenopus tropicalis | 100.0 | 1e-93 | 273 |
| LLPS-Gaga-1514 | Gallus gallus | 100.0 | 1e-93 | 273 |
| LLPS-Mam-1296 | Macaca mulatta | 100.0 | 1e-93 | 273 |
| LLPS-Caf-0811 | Canis familiaris | 100.0 | 1e-93 | 273 |
| LLPS-Ten-0087 | Tetraodon nigroviridis | 100.0 | 1e-93 | 273 |
| LLPS-Poa-0909 | Pongo abelii | 100.0 | 1e-93 | 273 |
| LLPS-Eqc-0630 | Equus caballus | 100.0 | 1e-93 | 273 |
| LLPS-Cap-0883 | Cavia porcellus | 100.0 | 1e-93 | 273 |
| LLPS-Cae-1905 | Caenorhabditis elegans | 99.26 | 5e-93 | 272 |
| LLPS-Orbr-2171 | Oryza brachyantha | 97.06 | 3e-91 | 267 |
| LLPS-Tru-0831 | Triticum urartu | 97.06 | 3e-91 | 267 |
| LLPS-Php-0610 | Physcomitrella patens | 96.32 | 1e-90 | 266 |
| LLPS-Urm-0460 | Ursus maritimus | 96.32 | 3e-90 | 265 |
| LLPS-Osl-0104 | Ostreococcus lucimarinus | 96.32 | 2e-90 | 266 |
| LLPS-Thc-0291 | Theobroma cacao | 95.59 | 1e-89 | 263 |
| LLPS-Orni-2352 | Oryza nivara | 95.59 | 1e-89 | 263 |
| LLPS-Dac-2250 | Daucus carota | 95.59 | 1e-89 | 263 |
| LLPS-Orb-0081 | Oryza barthii | 95.59 | 1e-89 | 263 |
| LLPS-Brn-3269 | Brassica napus | 95.59 | 1e-89 | 263 |
| LLPS-Ori-1646 | Oryza indica | 95.59 | 1e-89 | 263 |
| LLPS-Sem-0633 | Selaginella moellendorffii | 95.59 | 1e-89 | 263 |
| LLPS-Sei-1272 | Setaria italica | 95.59 | 1e-89 | 263 |
| LLPS-Cus-0860 | Cucumis sativus | 95.59 | 1e-89 | 263 |
| LLPS-Met-0228 | Medicago truncatula | 95.59 | 1e-89 | 263 |
| LLPS-Hov-0876 | Hordeum vulgare | 95.59 | 1e-89 | 263 |
| LLPS-Brd-1732 | Brachypodium distachyon | 95.59 | 1e-89 | 263 |
| LLPS-Tra-0631 | Triticum aestivum | 95.59 | 1e-89 | 263 |
| LLPS-Sot-1788 | Solanum tuberosum | 95.59 | 1e-89 | 263 |
| LLPS-Orgl-0421 | Oryza glumaepatula | 95.59 | 1e-89 | 263 |
| LLPS-Mae-0634 | Manihot esculenta | 95.59 | 1e-89 | 263 |
| LLPS-Phv-2417 | Phaseolus vulgaris | 95.59 | 1e-89 | 263 |
| LLPS-Nia-0321 | Nicotiana attenuata | 95.59 | 1e-89 | 263 |
| LLPS-Pot-2089 | Populus trichocarpa | 95.59 | 1e-89 | 263 |
| LLPS-Ors-2104 | Oryza sativa | 95.59 | 1e-89 | 263 |
| LLPS-Zem-1042 | Zea mays | 95.59 | 1e-89 | 263 |
| LLPS-Org-1713 | Oryza glaberrima | 95.59 | 1e-89 | 263 |
| LLPS-Bro-0754 | Brassica oleracea | 95.59 | 1e-89 | 263 |
| LLPS-Prp-0855 | Prunus persica | 95.59 | 1e-89 | 263 |
| LLPS-Orr-0917 | Oryza rufipogon | 95.59 | 1e-89 | 263 |
| LLPS-Sol-1065 | Solanum lycopersicum | 94.85 | 5e-90 | 264 |
| LLPS-Glm-0325 | Glycine max | 94.85 | 5e-90 | 265 |
| LLPS-Arl-2509 | Arabidopsis lyrata | 94.85 | 5e-90 | 264 |
| LLPS-Lep-0497 | Leersia perrieri | 94.85 | 5e-90 | 264 |
| LLPS-Via-0879 | Vigna angularis | 94.85 | 5e-90 | 265 |
| LLPS-Amt-1774 | Amborella trichopoda | 94.85 | 5e-90 | 264 |
| LLPS-Sob-1818 | Sorghum bicolor | 94.85 | 5e-90 | 264 |
| LLPS-Orp-1274 | Oryza punctata | 94.85 | 5e-90 | 264 |
| LLPS-Viv-1734 | Vitis vinifera | 94.85 | 5e-90 | 264 |
| LLPS-Art-0058 | Arabidopsis thaliana | 94.85 | 5e-90 | 264 |
| LLPS-Gor-1943 | Gossypium raimondii | 94.85 | 7e-90 | 266 |
| LLPS-Orm-0070 | Oryza meridionalis | 94.85 | 5e-90 | 264 |
| LLPS-Coc-0989 | Corchorus capsularis | 94.85 | 5e-90 | 264 |