• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-2751
G6PD

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Glucose-6-phosphate 1-dehydrogenase
Gene Name: G6PD
Ensembl Gene: ENSOCUG00000007866.3
Ensembl Protein: ENSOCUP00000006800.3
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOCUT00000007866.3ENSOCUP00000006800.3
UniProtG1STZ4, G1STZ4_RABIT

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGWRGSAPGN  DRAVRGSARG  GRRRRRGADS  NIMAEQVALS  RTQVCGILRE  ELYQGNAFHQ  60
61    ADTHIFIIMG  ASGDLAKKKI  YPTIWWLFRD  GLLPEDTFVV  GYARSRLTVA  DIRRQSEPFF  120
121   RVNPEEKPKL  EEFFARNSYV  AGQYDDPASY  QRLNSHINAL  HQGPQANRLF  YLALPPTVYE  180
181   AVTKNIHETC  MSQTGWNRVI  VEKPFGRDLQ  SSDQLSNHIS  SLFREDQIYR  IDHYLGKEMV  240
241   QNLMVLRFAN  RIFGPIWNRD  NIACVILTFK  EPFGTEGRGG  YFDEFGIIRD  VMQNHLLQML  300
301   CLVAMEKPAS  TDSDDVRDEK  VKVLKCISEV  QADNVVLGQY  VGNPNGEGEA  TKGYLDDPTV  360
361   PRGSTTATFA  AVVLYVENER  WEGVPFILRC  GKALNERKAE  VRLQFRDVAG  DIFHQQCKRN  420
421   ELVIRVQPNE  AVYTKMMTKK  PGMFFNPEES  ELDLTYGNRY  KNVKLPDAYE  RLILDVFCGS  480
481   QMHFVRSDEL  REAWRIFTPL  LHRIERDKPQ  PIPYVLRQPR  PCGGRRADEE  SGLPVRGHLQ  540
541   KEEESGLPLC  PRAPWASNGR  SRKLGTRRRA  HGPQWSSGRT  ALPHGCGQSS  GGKGTHVAT  599
Nucleotide CDS Sequence (FASTA)
1     ATGGGCTGGC  GGGGCTCAGC  CCCCGGAAAC  GACCGTGCAG  TCCGGGGCAG  TGCGCGCGGC  60
61    GGGCGGCGGC  GGCGGCGAGG  CGCAGACAGC  AACATCATGG  CAGAGCAAGT  GGCCCTGAGC  120
121   AGGACCCAAG  TGTGCGGGAT  CCTACGAGAA  GAGCTCTATC  AAGGCAATGC  CTTCCACCAG  180
181   GCGGATACTC  ACATATTCAT  CATCATGGGT  GCATCGGGTG  ACCTGGCCAA  GAAGAAGATC  240
241   TACCCCACCA  TCTGGTGGCT  GTTCCGGGAT  GGCCTTCTGC  CCGAAGACAC  CTTCGTTGTG  300
301   GGATACGCCC  GCTCCCGCCT  CACGGTGGCC  GACATCCGCC  GGCAGAGTGA  GCCCTTCTTC  360
361   AGGGTCAACC  CCGAGGAGAA  GCCCAAACTG  GAAGAGTTCT  TTGCCCGCAA  CTCCTATGTG  420
421   GCTGGCCAGT  ACGATGACCC  TGCCTCCTAC  CAGCGCCTCA  ACAGCCACAT  AAATGCCCTC  480
481   CACCAGGGGC  CACAGGCCAA  CCGCCTCTTC  TACCTGGCCT  TGCCCCCCAC  CGTCTACGAG  540
541   GCCGTCACCA  AGAACATCCA  TGAGACCTGC  ATGAGTCAGA  CAGGCTGGAA  CCGTGTCATT  600
601   GTGGAAAAGC  CCTTCGGGAG  AGACCTGCAG  AGCTCGGACC  AGCTGTCCAA  CCACATCTCC  660
661   TCCCTGTTCC  GCGAGGACCA  GATCTATCGC  ATTGACCACT  ACCTCGGCAA  GGAGATGGTC  720
721   CAGAACCTCA  TGGTGCTGAG  GTTTGCCAAC  AGGATCTTTG  GGCCCATCTG  GAACCGGGAC  780
781   AACATCGCCT  GTGTGATCCT  CACTTTCAAG  GAACCCTTCG  GCACTGAGGG  CCGTGGGGGC  840
841   TATTTTGATG  AATTTGGCAT  CATCCGGGAC  GTGATGCAGA  ACCACCTCCT  GCAGATGCTG  900
901   TGCCTGGTGG  CCATGGAGAA  GCCCGCCTCC  ACTGACTCCG  ATGACGTCCG  CGACGAGAAG  960
961   GTCAAGGTGT  TAAAGTGCAT  CTCAGAAGTG  CAGGCGGACA  ACGTGGTCCT  GGGCCAGTAT  1020
1021  GTAGGGAACC  CCAATGGAGA  GGGGGAGGCC  ACCAAAGGGT  ACCTGGATGA  CCCCACGGTG  1080
1081  CCCCGCGGCT  CCACCACCGC  CACCTTCGCA  GCCGTCGTCC  TCTATGTGGA  GAACGAGAGG  1140
1141  TGGGAAGGGG  TGCCCTTCAT  CCTGCGCTGC  GGCAAAGCCC  TGAACGAGCG  CAAGGCCGAG  1200
1201  GTGCGGCTGC  AGTTCCGGGA  CGTGGCCGGT  GATATCTTCC  ACCAGCAGTG  CAAGCGCAAC  1260
1261  GAGCTGGTGA  TCCGCGTGCA  GCCCAACGAG  GCCGTGTACA  CCAAGATGAT  GACCAAGAAG  1320
1321  CCTGGCATGT  TCTTCAACCC  CGAGGAGTCC  GAGCTGGACC  TGACCTACGG  CAACCGATAC  1380
1381  AAGAACGTGA  AGCTGCCTGA  CGCTTACGAG  CGCCTCATCC  TGGATGTCTT  CTGCGGGAGC  1440
1441  CAGATGCACT  TCGTGCGCAG  TGACGAGCTC  CGGGAGGCCT  GGCGGATCTT  CACCCCTCTG  1500
1501  CTGCACAGGA  TTGAGCGGGA  CAAGCCACAG  CCCATCCCCT  ACGTTTTACG  GCAGCCGAGG  1560
1561  CCCTGCGGAG  GCAGACGAGC  TGATGAAGAG  AGTGGGCTTC  CAGTACGAGG  GCACCTACAA  1620
1621  AAGGAAGAAG  AGAGCGGCCT  GCCTCTCTGC  CCCAGGGCTC  CTTGGGCCAG  TAATGGCCGG  1680
1681  AGCAGGAAGT  TAGGGACACG  GAGGAGAGCC  CATGGGCCTC  AGTGGAGCAG  TGGCCGCACC  1740
1741  GCACTCCCTC  ACGGCTGTGG  GCAATCCTCT  GGTGGGAAGG  GCACGCATGT  GGCCACGTGA  1800

▼ KEYWORD

ID
Family
Carbohydrate metabolism
Complete proteome
Glucose metabolism
NADP
Oxidoreductase
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic side of plasma membrane
Cellular Component
Cytosol
Molecular Function
Glucose binding
Molecular Function
Glucose-6-phosphate dehydrogenase activity
Molecular Function
NADP binding
Molecular Function
Protein homodimerization activity
Biological Process
Cellular response to oxidative stress
Biological Process
Cholesterol biosynthetic process
Biological Process
Erythrocyte maturation
Biological Process
Glucose metabolic process
Biological Process
Glutathione metabolic process
Biological Process
NADPH regeneration
Biological Process
Negative regulation of protein glutathionylation
Biological Process
Pentose biosynthetic process
Biological Process
Pentose-phosphate shunt, oxidative branch
Biological Process
Ribose phosphate biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-1374Ictidomys tridecemlineatus96.480.0 983
LLPS-Loa-4220Loxodonta africana96.270.0 983
LLPS-Aim-0209Ailuropoda melanoleuca95.260.0 975
LLPS-Fec-3760Felis catus95.030.0 969
LLPS-Mup-2762Mustela putorius furo94.850.0 972
LLPS-Mea-0176Mesocricetus auratus94.820.0 968
LLPS-Ran-0350Rattus norvegicus94.820.0 967
LLPS-Bot-4215Bos taurus94.620.0 964
LLPS-Otg-3650Otolemur garnettii94.410.0 964
LLPS-Mum-4727Mus musculus94.20.0 961
LLPS-Sus-3754Sus scrofa94.020.0 961
LLPS-Chs-4411Chlorocebus sabaeus93.580.0 957
LLPS-Cap-4058Cavia porcellus93.370.0 952
LLPS-Ova-0103Ovis aries93.310.0 962
LLPS-Myl-0122Myotis lucifugus92.750.0 944
LLPS-Fud-1990Fukomys damarensis92.580.0 954
LLPS-Dio-1751Dipodomys ordii92.490.0 878
LLPS-Mal-4289Mandrillus leucophaeus92.270.0 879
LLPS-Caf-4315Canis familiaris92.040.0 965
LLPS-Mod-2446Monodelphis domestica91.960.0 941
LLPS-Rhb-2593Rhinopithecus bieti91.460.0 966
LLPS-Poa-1143Pongo abelii91.460.0 961
LLPS-Eqc-1305Equus caballus90.770.0 974
LLPS-Sah-3642Sarcophilus harrisii90.680.0 931
LLPS-Ora-1948Ornithorhynchus anatinus90.040.0 924
LLPS-Mam-1560Macaca mulatta88.760.0 925
LLPS-Caj-3774Callithrix jacchus88.080.0 962
LLPS-Tut-1757Tursiops truncatus87.880.0 940
LLPS-Cas-2065Carlito syrichta87.290.0 945
LLPS-Pap-1219Pan paniscus85.980.0 937
LLPS-Hos-4546Homo sapiens85.820.0 937
LLPS-Gog-1385Gorilla gorilla85.820.0 937
LLPS-Pat-0603Pan troglodytes85.80.0 936
LLPS-Paa-1301Papio anubis85.440.0 934
LLPS-Maf-2473Macaca fascicularis85.420.0 933
LLPS-Aon-1495Aotus nancymaae84.730.0 909
LLPS-Nol-2174Nomascus leucogenys84.211e-33 137
LLPS-Cea-3073Cercocebus atys83.940.0 857
LLPS-Anc-3797Anolis carolinensis83.090.0 857
LLPS-Man-2467Macaca nemestrina82.670.0 882
LLPS-Pes-3792Pelodiscus sinensis81.110.0 842
LLPS-Lac-1033Latimeria chalumnae80.470.0 743
LLPS-Leo-1640Lepisosteus oculatus77.080.0 789
LLPS-Asm-0424Astyanax mexicanus76.680.0 777
LLPS-Ten-0689Tetraodon nigroviridis76.130.0 763
LLPS-Dar-1018Danio rerio75.840.0 749
LLPS-Fia-2501Ficedula albicollis75.790.0 699
LLPS-Tar-2485Takifugu rubripes75.730.0 780
LLPS-Scf-1679Scleropages formosus74.740.0 767
LLPS-Icp-0465Ictalurus punctatus73.940.0 778
LLPS-Orn-1583Oreochromis niloticus73.40.0 756
LLPS-Scm-1623Scophthalmus maximus73.170.0 748
LLPS-Xet-3717Xenopus tropicalis72.990.0 709
LLPS-Pof-2519Poecilia formosa72.960.0 739
LLPS-Xim-4056Xiphophorus maculatus72.750.0 739
LLPS-Gaa-3297Gasterosteus aculeatus71.070.0 726
LLPS-Orl-3626Oryzias latipes68.910.0 733
LLPS-Cis-1244Ciona savignyi67.330.0 662
LLPS-Cii-1323Ciona intestinalis65.960.0 670
LLPS-Drm-1237Drosophila melanogaster62.730.0 644
LLPS-Cae-1872Caenorhabditis elegans57.260.0 580
LLPS-Ors-1099Oryza sativa55.511e-177 520
LLPS-Orp-2208Oryza punctata55.513e-177 520
LLPS-Orbr-0693Oryza brachyantha55.515e-177 519
LLPS-Zem-1919Zea mays54.66e-174 511
LLPS-Sei-1364Setaria italica54.63e-174 512
LLPS-Aso-1551Aspergillus oryzae54.54e-71 235
LLPS-Tru-1961Triticum urartu54.412e-175 514
LLPS-Brd-0479Brachypodium distachyon54.412e-175 514
LLPS-Tra-2561Triticum aestivum54.419e-176 515
LLPS-Hov-0026Hordeum vulgare54.414e-176 516
LLPS-Vir-1018Vigna radiata54.283e-174 512
LLPS-Php-1177Physcomitrella patens54.239e-177 519
LLPS-Sob-1223Sorghum bicolor54.182e-172 507
LLPS-Ori-0853Oryza indica53.972e-171 505
LLPS-Orm-2002Oryza meridionalis53.771e-170 503
LLPS-Org-1930Oryza glaberrima53.774e-171 504
LLPS-Sot-0028Solanum tuberosum53.683e-173 509
LLPS-Gor-2388Gossypium raimondii53.449e-170 500
LLPS-Coc-0571Corchorus capsularis53.442e-172 507
LLPS-Thc-2225Theobroma cacao53.432e-169 499
LLPS-Bro-0542Brassica oleracea53.45e-174 511
LLPS-Art-2869Arabidopsis thaliana53.392e-174 513
LLPS-Orni-2327Oryza nivara53.396e-166 490
LLPS-Arl-1776Arabidopsis lyrata53.395e-175 514
LLPS-Mua-0480Musa acuminata53.363e-170 502
LLPS-Via-1143Vigna angularis53.326e-174 511
LLPS-Phv-2506Phaseolus vulgaris53.225e-174 511
LLPS-Lep-2138Leersia perrieri53.195e-178 522
LLPS-Viv-1929Vitis vinifera53.145e-169 498
LLPS-Sem-0729Selaginella moellendorffii53.126e-170 501
LLPS-Pot-1908Populus trichocarpa53.055e-169 498
LLPS-Brr-1491Brassica rapa52.988e-172 506
LLPS-Glm-1342Glycine max52.814e-170 501
LLPS-Hea-2691Helianthus annuus52.77e-166 490
LLPS-Amt-0724Amborella trichopoda52.53e-170 502
LLPS-Abg-1738Absidia glauca52.463e-167 494
LLPS-Dac-0391Daucus carota52.46e-170 502
LLPS-Prp-1170Prunus persica52.344e-172 506
LLPS-Mae-1285Manihot esculenta52.096e-171 503
LLPS-Mel-0922Melampsora laricipopulina51.977e-163 482
LLPS-Brn-0593Brassica napus51.716e-169 499
LLPS-Pug-1478Puccinia graminis51.625e-164 485
LLPS-Orgl-1372Oryza glumaepatula51.585e-159 473
LLPS-Met-0391Medicago truncatula51.572e-168 497
LLPS-Phn-0092Phaeosphaeria nodorum51.41e-165 489
LLPS-Lem-1067Leptosphaeria maculans51.46e-165 488
LLPS-Miv-0822Microbotryum violaceum51.32e-165 489
LLPS-Orr-2321Oryza rufipogon51.22e-166 493
LLPS-Tum-1020Tuber melanosporum51.26e-165 488
LLPS-Orb-0836Oryza barthii51.14e-167 494
LLPS-Sol-1966Solanum lycopersicum51.022e-163 484
LLPS-Dos-1415Dothistroma septosporum50.872e-163 484
LLPS-Fuo-1423Fusarium oxysporum50.761e-162 482
LLPS-Fuv-1561Fusarium verticillioides50.761e-162 482
LLPS-Gag-0357Gaeumannomyces graminis50.656e-163 483
LLPS-Blg-0969Blumeria graminis50.652e-162 481
LLPS-Nec-0724Neurospora crassa50.644e-165 488
LLPS-Pytr-1541Pyrenophora triticirepentis50.534e-164 486
LLPS-Coo-1033Colletotrichum orbiculare50.431e-162 482
LLPS-Trr-1417Trichoderma reesei50.332e-162 481
LLPS-Fus-0735Fusarium solani50.331e-161 479
LLPS-Spr-1404Sporisorium reilianum50.332e-152 456
LLPS-Mao-1075Magnaporthe oryzae50.321e-161 479
LLPS-Pyt-1131Pyrenophora teres50.321e-163 484
LLPS-Cog-0551Colletotrichum gloeosporioides50.227e-163 482
LLPS-Cogr-0336Colletotrichum graminicola50.221e-162 482
LLPS-Beb-1630Beauveria bassiana50.211e-162 482
LLPS-Map-1351Magnaporthe poae50.111e-161 479
LLPS-Asf-1521Aspergillus flavus50.111e-160 476
LLPS-Chr-0155Chlamydomonas reinhardtii50.03e-157 471
LLPS-Ved-1313Verticillium dahliae49.797e-164 485
LLPS-Trv-1653Trichoderma virens49.682e-163 484
LLPS-Asc-1543Aspergillus clavatus49.689e-163 482
LLPS-Scj-1551Schizosaccharomyces japonicus49.565e-153 457
LLPS-Usm-1080Ustilago maydis49.452e-151 452
LLPS-Scc-0056Schizosaccharomyces cryophilus49.453e-152 455
LLPS-Nef-1666Neosartorya fischeri49.367e-162 479
LLPS-Asfu-0859Aspergillus fumigatus49.366e-162 480
LLPS-Osl-0183Ostreococcus lucimarinus49.364e-157 467
LLPS-Crn-0559Cryptococcus neoformans49.353e-157 468
LLPS-Zyt-1512Zymoseptoria tritici49.261e-162 482
LLPS-Sac-0418Saccharomyces cerevisiae49.032e-149 448
LLPS-Asni-0551Aspergillus niger48.841e-159 474
LLPS-Scp-1026Schizosaccharomyces pombe48.573e-148 444
LLPS-Ast-1347Aspergillus terreus48.421e-157 469
LLPS-Chc-0785Chondrus crispus48.235e-154 460
LLPS-Asn-1430Aspergillus nidulans48.04e-157 468
LLPS-Yal-1513Yarrowia lipolytica47.745e-149 446
LLPS-Asg-1099Ashbya gossypii47.74e-148 445
LLPS-Gas-0242Galdieria sulphuraria47.252e-147 446
LLPS-Kop-1180Komagataella pastoris47.13e-148 445
LLPS-Cus-0688Cucumis sativus46.631e-150 454
LLPS-Nia-0815Nicotiana attenuata45.425e-147 444
LLPS-Cym-0538Cyanidioschyzon merolae45.32e-132 407
LLPS-Put-0810Puccinia triticina40.877e-94 299
LLPS-Anp-0349Anas platyrhynchos32.443e-66 236
LLPS-Gaga-0470Gallus gallus32.243e-66 236
LLPS-Meg-2691Meleagris gallopavo31.783e-60 219
LLPS-Tag-1479Taeniopygia guttata31.441e-64 232
LLPS-Urm-1886Ursus maritimus30.748e-60 219