• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-2491
HMOX2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Heme oxygenase
Gene Name: HMOX2
Ensembl Gene: ENSOCUG00000006018.2
Ensembl Protein: ENSOCUP00000005212.2
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOCUT00000006018.2ENSOCUP00000005212.2
UniProtG1SQ54, G1SQ54_RABIT

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSAEVETSEG  VDEPEEKNFG  ENHIRSPNRM  ADLSELLKEG  TKEAHDRAEN  TKFVKDFLKG  60
61    NIKKEIFKLA  TTALYFTYSA  LEEEMDRNKD  HPAFAPLYFP  MELHRKEALT  KDMEYFFGEN  120
121   WEEQVQCSEA  AQKYVERIHY  IGQNEPELLV  AHAYTRYMGD  LSGGQVLKKV  AQRALKLPST  180
181   GEGTQFYLFE  NVDNAQQFKQ  FYRARMNALD  LNLKTKERIV  EEANKAFEYN  MQIFSELDQA  240
241   GSAPASETVE  DRIPVHDGKG  DVRKCPYYAA  GQVNGALEGS  SCPFRAAMAV  LRKPSLQLVL  300
301   AAAVALAAGL  LAWYYM  316
Nucleotide CDS Sequence (FASTA)
1     ATGTCAGCGG  AAGTGGAGAC  CTCCGAGGGG  GTAGACGAGC  CGGAGGAAAA  GAACTTTGGG  60
61    GAAAATCACA  TCAGATCTCC  CAACAGAATG  GCTGATCTCT  CTGAGCTCCT  GAAGGAAGGG  120
121   ACCAAGGAAG  CACATGACCG  GGCAGAAAAT  ACCAAGTTTG  TCAAGGACTT  CTTGAAAGGC  180
181   AACATTAAGA  AGGAGATATT  TAAGCTGGCC  ACCACCGCAC  TTTACTTCAC  ATATTCAGCC  240
241   TTGGAGGAAG  AAATGGACCG  CAATAAGGAC  CACCCAGCCT  TTGCCCCCTT  GTACTTCCCC  300
301   ATGGAGCTGC  ACCGGAAGGA  GGCACTGACC  AAGGACATGG  AGTACTTCTT  TGGTGAGAAC  360
361   TGGGAGGAGC  AGGTGCAGTG  CTCTGAGGCT  GCCCAGAAGT  ACGTAGAGCG  GATCCACTAC  420
421   ATAGGGCAGA  ATGAGCCAGA  GCTGCTGGTG  GCCCATGCGT  ACACCCGCTA  CATGGGGGAC  480
481   CTCTCAGGGG  GCCAAGTGCT  GAAGAAGGTG  GCCCAGCGGG  CACTGAAGCT  CCCCAGCACA  540
541   GGAGAAGGGA  CCCAGTTCTA  CCTGTTTGAG  AACGTGGACA  ATGCCCAGCA  GTTCAAGCAG  600
601   TTCTACCGGG  CCAGGATGAA  TGCTCTGGAC  CTGAACCTGA  AGACCAAAGA  GAGGATCGTG  660
661   GAGGAGGCCA  ACAAGGCATT  TGAATATAAT  ATGCAGATAT  TCAGTGAACT  GGACCAGGCT  720
721   GGCTCTGCAC  CGGCCAGTGA  GACTGTGGAG  GACAGGATCC  CCGTGCACGA  CGGCAAAGGA  780
781   GATGTGCGCA  AATGCCCCTA  CTATGCTGCT  GGGCAAGTCA  ACGGTGCCCT  GGAGGGCAGC  840
841   AGCTGCCCTT  TCCGAGCAGC  CATGGCTGTG  CTGAGGAAGC  CCAGCCTCCA  GTTGGTCCTG  900
901   GCCGCCGCTG  TGGCCTTGGC  TGCAGGACTC  TTGGCCTGGT  ACTACATGTG  A  951

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Heme
Iron
Membrane
Metal-binding
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Molecular Function
Heme oxygenase (decyclizing) activity
Molecular Function
Metal ion binding
Biological Process
Heme oxidation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Maf-4149Macaca fascicularis90.940.0 515
LLPS-Pap-2248Pan paniscus89.240.0 548
LLPS-Pat-1886Pan troglodytes89.240.0 548
LLPS-Hos-3264Homo sapiens89.240.0 549
LLPS-Poa-3793Pongo abelii88.920.0 545
LLPS-Gog-4610Gorilla gorilla88.610.0 544
LLPS-Cea-1749Cercocebus atys88.290.0 546
LLPS-Mal-0641Mandrillus leucophaeus88.290.0 546
LLPS-Paa-2840Papio anubis88.290.0 545
LLPS-Mam-4698Macaca mulatta88.290.0 545
LLPS-Cas-1595Carlito syrichta88.290.0 549
LLPS-Nol-1752Nomascus leucogenys88.290.0 541
LLPS-Rhb-0579Rhinopithecus bieti87.660.0 546
LLPS-Man-0755Macaca nemestrina87.460.0 515
LLPS-Tut-1451Tursiops truncatus87.030.0 541
LLPS-Mea-2150Mesocricetus auratus86.710.0 536
LLPS-Aon-3406Aotus nancymaae86.710.0 531
LLPS-Dio-2612Dipodomys ordii86.710.0 538
LLPS-Urm-1606Ursus maritimus86.390.0 539
LLPS-Mup-3581Mustela putorius furo86.080.0 537
LLPS-Aim-1052Ailuropoda melanoleuca86.080.0 535
LLPS-Otg-3183Otolemur garnettii86.080.0 544
LLPS-Cap-3544Cavia porcellus85.940.0 532
LLPS-Ran-4843Rattus norvegicus85.890.0 532
LLPS-Caj-4307Callithrix jacchus85.760.0 527
LLPS-Fec-4575Felis catus85.760.0 539
LLPS-Eqc-4651Equus caballus85.760.0 535
LLPS-Caf-1822Canis familiaris85.440.0 536
LLPS-Fud-0790Fukomys damarensis85.310.0 529
LLPS-Loa-4532Loxodonta africana85.130.0 525
LLPS-Mum-1629Mus musculus84.950.0 528
LLPS-Sus-4681Sus scrofa84.490.0 529
LLPS-Myl-1377Myotis lucifugus83.860.0 519
LLPS-Ict-4325Ictidomys tridecemlineatus80.381e-167 476
LLPS-Meg-3278Meleagris gallopavo79.239e-122 355
LLPS-Sah-3678Sarcophilus harrisii78.231e-173 491
LLPS-Bot-4880Bos taurus78.145e-177 501
LLPS-Ova-4032Ovis aries76.953e-173 493
LLPS-Mod-3299Monodelphis domestica76.179e-166 471
LLPS-Tag-1433Taeniopygia guttata73.681e-144 417
LLPS-Fia-0311Ficedula albicollis72.281e-143 415
LLPS-Ora-2256Ornithorhynchus anatinus72.197e-151 433
LLPS-Pes-3404Pelodiscus sinensis71.157e-154 441
LLPS-Anp-3052Anas platyrhynchos69.814e-148 426
LLPS-Gaga-2838Gallus gallus68.242e-147 424
LLPS-Leo-0834Lepisosteus oculatus65.991e-132 387
LLPS-Xet-1959Xenopus tropicalis65.282e-122 360
LLPS-Lac-2380Latimeria chalumnae64.048e-139 403
LLPS-Scf-0675Scleropages formosus61.895e-121 358
LLPS-Gaa-3403Gasterosteus aculeatus60.141e-121 359
LLPS-Asm-3730Astyanax mexicanus60.076e-116 345
LLPS-Icp-0835Ictalurus punctatus60.05e-116 345
LLPS-Scm-1770Scophthalmus maximus59.251e-114 341
LLPS-Pof-1878Poecilia formosa58.192e-113 338
LLPS-Orn-0068Oreochromis niloticus58.134e-114 340
LLPS-Ten-3168Tetraodon nigroviridis57.693e-114 339
LLPS-Dar-4142Danio rerio56.383e-108 325
LLPS-Tar-3819Takifugu rubripes56.154e-118 350
LLPS-Orl-3479Oryzias latipes55.528e-116 344
LLPS-Xim-2053Xiphophorus maculatus53.542e-110 330
LLPS-Chc-0312Chondrus crispus48.084e-66 214
LLPS-Usm-1544Ustilago maydis41.821e-1683.6
LLPS-Abg-1687Absidia glauca37.953e-45 165
LLPS-Crn-0858Cryptococcus neoformans28.782e-1785.1
LLPS-Miv-0623Microbotryum violaceum28.528e-24 104