• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
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  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-2116
IPPK

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Inositol-pentakisphosphate 2-kinase
Gene Name: IPPK
Ensembl Gene: ENSOCUG00000007241.3
Ensembl Protein: ENSOCUP00000006261.3
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOCUT00000007241.3ENSOCUP00000006261.3
UniProtG1SSM9, G1SSM9_RABIT
GeneBankAAGW02048249

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEAVGGVASG  GPRLRVAAAG  SGASSGCQAL  LPDGCDWCRA  RQAAPNLSPR  VPARRAPGPC  60
61    RGMDEEKMDE  NEWKYHGEGN  KSLVVAHAQR  CVVLRFLKFP  PNRKKTSEEI  FRHLQNIVDF  120
121   GKNVMKEFLG  ENYVHCGEVV  QLPLEFVKQL  CVRIQSERPE  SRCDKDLDTL  SGYAMCLPNL  180
181   TRLQTYHFAE  LRPILCVEIK  PKCGFIPFSS  DVTHEMKHKV  CRYCMHQHLK  VATGKWKQIS  240
241   KYCPLDLYSG  NKQRMHFALK  SLLQETQNNL  KIFKNGELIY  GCSDARSPVA  DWSELAHHLK  300
301   PFFFPSNGLA  AGPHCTRAVI  RELVHVITRV  LLSSTDKGRA  GALRPGPQGP  RVCEASPFGR  360
361   SLRHQGKNTP  ERSGLPKGCL  LYKTLQVQML  DLLDIEGLYP  LYKRVERYLE  EFPEERKTLQ  420
421   IDGPYDEAFY  QKLFDLSTED  DGTVAFALTK  VQQYRVAMTA  KDCSIMIALS  PCLQDASSDQ  480
481   RLVVPSSRSQ  LAFSVSVLDL  DLKPYESIPH  QYKLDGKIVS  FYSKTVHAKD  DTVMSTRFKE  540
541   SEDCTLVLHK  V  551
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCCG  TCGGGGGCGT  GGCTTCCGGA  GGCCCGCGCC  TTCGAGTCGC  CGCGGCGGGG  60
61    TCGGGCGCAA  GCAGCGGCTG  TCAGGCCCTC  CTTCCAGACG  GCTGCGACTG  GTGCCGGGCG  120
121   AGGCAGGCGG  CCCCCAACTT  AAGTCCCCGC  GTCCCGGCCC  GCCGGGCACC  TGGGCCGTGC  180
181   CGGGGCATGG  ACGAGGAGAA  GATGGACGAG  AATGAATGGA  AATATCACGG  CGAGGGCAAC  240
241   AAGAGCCTGG  TGGTGGCCCA  CGCGCAGCGC  TGTGTTGTGC  TGCGTTTCCT  GAAGTTTCCT  300
301   CCGAACAGGA  AGAAGACCTC  GGAAGAGATA  TTTCGGCACC  TGCAGAACAT  AGTGGACTTT  360
361   GGCAAAAATG  TCATGAAGGA  GTTTTTGGGA  GAGAACTATG  TTCACTGTGG  GGAAGTTGTT  420
421   CAGCTGCCTT  TAGAGTTTGT  GAAACAGCTT  TGTGTTAGGA  TACAGTCTGA  AAGACCAGAA  480
481   TCTCGCTGTG  ACAAGGACCT  AGACACTCTC  AGTGGCTACG  CCATGTGCCT  TCCCAACTTA  540
541   ACCAGACTGC  AGACCTACCA  CTTTGCAGAG  CTACGGCCCA  TTCTGTGTGT  GGAGATCAAG  600
601   CCCAAATGCG  GGTTTATTCC  TTTCTCGAGT  GATGTCACGC  ATGAGATGAA  GCATAAGGTG  660
661   TGCCGTTACT  GCATGCACCA  GCATCTCAAG  GTAGCGACTG  GGAAGTGGAA  GCAGATAAGT  720
721   AAATATTGTC  CCCTGGATCT  CTACTCAGGA  AACAAACAAA  GGATGCACTT  TGCACTGAAG  780
781   AGTTTGCTGC  AGGAGACACA  GAACAACTTG  AAGATATTTA  AGAATGGTGA  GCTCATCTAT  840
841   GGTTGCAGCG  ACGCCCGCAG  CCCCGTGGCC  GACTGGAGCG  AGCTCGCCCA  CCACCTGAAG  900
901   CCCTTCTTCT  TCCCTTCCAA  CGGCCTGGCG  GCCGGGCCGC  ACTGCACGAG  GGCCGTGATC  960
961   CGGGAGCTGG  TGCACGTCAT  CACGAGGGTG  CTGCTGAGCA  GCACCGACAA  GGGCCGGGCG  1020
1021  GGTGCGCTGC  GGCCCGGGCC  CCAGGGCCCA  CGGGTCTGCG  AGGCCAGCCC  GTTCGGCAGG  1080
1081  AGCCTGCGCC  ACCAAGGAAA  AAACACCCCA  GAGCGCTCGG  GGTTACCGAA  GGGCTGTCTT  1140
1141  CTGTACAAAA  CCCTCCAGGT  GCAGATGTTG  GACCTGCTGG  ACATCGAAGG  CCTCTACCCT  1200
1201  CTGTACAAGC  GGGTTGAGCG  GTACCTGGAG  GAGTTTCCTG  AGGAGAGAAA  AACGTTACAA  1260
1261  ATAGATGGGC  CTTACGATGA  AGCGTTTTAC  CAGAAGCTGT  TTGACCTCTC  CACGGAGGAC  1320
1321  GACGGGACGG  TGGCCTTCGC  GTTGACAAAG  GTGCAGCAGT  ACCGAGTCGC  CATGACCGCC  1380
1381  AAGGACTGCT  CCATCATGAT  TGCGCTCTCC  CCGTGTCTGC  AGGACGCAAG  CTCTGATCAG  1440
1441  AGGCTCGTGG  TCCCCTCGTC  GAGGTCTCAG  CTCGCTTTCT  CCGTGTCTGT  GCTGGACCTC  1500
1501  GACCTCAAGC  CCTATGAGAG  CATTCCTCAC  CAGTACAAAC  TGGACGGCAA  GATAGTCAGC  1560
1561  TTCTACTCAA  AGACTGTGCA  TGCCAAAGAC  GACACGGTGA  TGTCGACGCG  GTTCAAGGAG  1620
1621  AGCGAGGACT  GCACGCTGGT  TCTCCACAAG  GTCTAA  1656

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Molecular Function
ATP binding
Molecular Function
Inositol pentakisphosphate 2-kinase activity
Molecular Function
Protein-containing complex scaffold activity
Biological Process
Inositol phosphorylation
Biological Process
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-3176Gorilla gorilla94.090.0 957
LLPS-Pat-3183Pan troglodytes94.080.0 953
LLPS-Poa-4479Pongo abelii93.890.0 954
LLPS-Hos-0705Homo sapiens93.890.0 954
LLPS-Aon-0243Aotus nancymaae93.890.0 952
LLPS-Nol-0797Nomascus leucogenys93.690.0 954
LLPS-Mam-1216Macaca mulatta93.690.0 951
LLPS-Paa-4181Papio anubis93.690.0 951
LLPS-Cea-0217Cercocebus atys93.690.0 951
LLPS-Man-4244Macaca nemestrina93.480.0 950
LLPS-Caj-4760Callithrix jacchus93.480.0 947
LLPS-Maf-3819Macaca fascicularis93.480.0 949
LLPS-Chs-0408Chlorocebus sabaeus93.480.0 951
LLPS-Otg-1771Otolemur garnettii93.080.0 948
LLPS-Rhb-3736Rhinopithecus bieti92.870.0 944
LLPS-Ict-3446Ictidomys tridecemlineatus92.430.0 944
LLPS-Ova-0147Ovis aries92.390.0 932
LLPS-Fud-1006Fukomys damarensis92.020.0 932
LLPS-Aim-3162Ailuropoda melanoleuca91.850.0 919
LLPS-Bot-3542Bos taurus91.850.0 936
LLPS-Dio-4271Dipodomys ordii91.210.0 931
LLPS-Fec-1858Felis catus90.840.0 924
LLPS-Pap-3421Pan paniscus90.740.0 900
LLPS-Eqc-1564Equus caballus90.630.0 926
LLPS-Ran-0273Rattus norvegicus90.590.0 922
LLPS-Mea-2863Mesocricetus auratus89.370.0 912
LLPS-Caf-2811Canis familiaris89.210.0 900
LLPS-Mal-3117Mandrillus leucophaeus89.210.0 893
LLPS-Mup-1313Mustela putorius furo89.210.0 910
LLPS-Sus-4665Sus scrofa89.170.0 952
LLPS-Cap-1450Cavia porcellus88.340.0 905
LLPS-Myl-3841Myotis lucifugus88.190.0 902
LLPS-Cas-1019Carlito syrichta86.640.0 814
LLPS-Urm-3249Ursus maritimus85.230.0 764
LLPS-Loa-0385Loxodonta africana84.730.0 866
LLPS-Mum-4791Mus musculus83.690.0 877
LLPS-Gaga-2984Gallus gallus78.210.0 813
LLPS-Ora-2060Ornithorhynchus anatinus77.882e-120 362
LLPS-Meg-1289Meleagris gallopavo77.850.0 764
LLPS-Fia-2455Ficedula albicollis77.80.0 805
LLPS-Anp-3292Anas platyrhynchos77.780.0 761
LLPS-Tag-3155Taeniopygia guttata77.190.0 799
LLPS-Mod-2734Monodelphis domestica74.590.0 544
LLPS-Anc-3851Anolis carolinensis73.730.0 765
LLPS-Xet-1719Xenopus tropicalis67.550.0 701
LLPS-Leo-1476Lepisosteus oculatus61.410.0 626
LLPS-Lac-3172Latimeria chalumnae60.850.0 584
LLPS-Icp-3761Ictalurus punctatus55.150.0 546
LLPS-Dar-2648Danio rerio54.550.0 542
LLPS-Asm-2964Astyanax mexicanus53.440.0 553
LLPS-Scf-3232Scleropages formosus53.060.0 537
LLPS-Pof-4144Poecilia formosa51.82e-162 479
LLPS-Xim-0033Xiphophorus maculatus51.169e-159 469
LLPS-Orn-0020Oreochromis niloticus50.32e-167 492
LLPS-Orl-0768Oryzias latipes49.91e-164 485
LLPS-Gaa-2852Gasterosteus aculeatus49.81e-160 474
LLPS-Scm-2415Scophthalmus maximus49.64e-162 481
LLPS-Tar-2478Takifugu rubripes48.222e-150 448
LLPS-Ten-2244Tetraodon nigroviridis48.111e-147 441
LLPS-Thc-2466Theobroma cacao39.582e-0964.3
LLPS-Mua-2248Musa acuminata37.182e-1067.4
LLPS-Orp-2053Oryza punctata36.651e-23 107
LLPS-Hov-0645Hordeum vulgare36.021e-1893.2
LLPS-Sei-1080Setaria italica35.373e-0757.0
LLPS-Zem-0244Zea mays34.156e-0756.2
LLPS-Orbr-1915Oryza brachyantha34.155e-0653.5
LLPS-Nia-1394Nicotiana attenuata32.21e-22 104
LLPS-Sol-1205Solanum lycopersicum31.582e-0757.4
LLPS-Orb-1984Oryza barthii31.284e-25 112
LLPS-Sot-1884Solanum tuberosum31.063e-21 100
LLPS-Org-0162Oryza glaberrima30.291e-24 110
LLPS-Ors-0053Oryza sativa30.292e-24 110
LLPS-Brd-0038Brachypodium distachyon30.297e-26 114
LLPS-Orgl-1308Oryza glumaepatula30.296e-25 111
LLPS-Orni-2022Oryza nivara30.291e-24 110
LLPS-Ori-0071Oryza indica30.292e-24 110
LLPS-Orr-2255Oryza rufipogon30.161e-23 109
LLPS-Orm-0797Oryza meridionalis30.112e-24 112
LLPS-Sob-0109Sorghum bicolor30.06e-0756.2
LLPS-Tra-0605Triticum aestivum29.962e-2099.4
LLPS-Met-2255Medicago truncatula29.351e-40 157
LLPS-Amt-2121Amborella trichopoda29.273e-38 149
LLPS-Viv-1512Vitis vinifera28.742e-39 154
LLPS-Dac-1647Daucus carota28.571e-35 145
LLPS-Cus-1935Cucumis sativus28.541e-41 160
LLPS-Sem-0350Selaginella moellendorffii28.433e-40 156
LLPS-Prp-2529Prunus persica28.285e-41 159
LLPS-Glm-2256Glycine max28.033e-38 150
LLPS-Brr-2887Brassica rapa27.846e-38 151
LLPS-Hea-2736Helianthus annuus27.711e-35 143
LLPS-Bro-2923Brassica oleracea27.698e-38 149
LLPS-Brn-1838Brassica napus27.697e-38 149
LLPS-Via-1342Vigna angularis27.472e-37 147
LLPS-Art-3066Arabidopsis thaliana27.387e-38 149
LLPS-Usm-1205Ustilago maydis27.349e-1477.8
LLPS-Mae-1203Manihot esculenta26.975e-34 138
LLPS-Vir-0541Vigna radiata26.922e-30 127
LLPS-Phv-0974Phaseolus vulgaris26.852e-37 148
LLPS-Crn-1429Cryptococcus neoformans26.757e-0962.0
LLPS-Arl-1398Arabidopsis lyrata26.732e-37 148
LLPS-Drm-1348Drosophila melanogaster26.562e-1686.7
LLPS-Gor-1231Gossypium raimondii26.557e-32 132
LLPS-Spr-0723Sporisorium reilianum26.516e-1375.1
LLPS-Pot-2385Populus trichocarpa25.667e-30 125
LLPS-Php-1884Physcomitrella patens25.561e-33 137
LLPS-Miv-1306Microbotryum violaceum25.331e-1171.2
LLPS-Abg-0358Absidia glauca25.325e-30 125
LLPS-Coc-1458Corchorus capsularis25.266e-23 106
LLPS-Pug-1027Puccinia graminis24.542e-1377.0