DrLLPS - Data resource of LLPS

LLPS-Nol-1904
LSM2

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U6 snRNA-associated Sm-like protein LSm2
Gene Name:	LSM2
Ensembl Gene:	ENSNLEG00000035542.1
Ensembl Protein:	ENSNLEP00000033222.1
Organism:	Nomascus leucogenys
Taxa ID:	61853
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Cajal body, Nuclear speckle, Nucleolus, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Arabidopsis thaliana	LLPS-Art-0667	Q1H595	Client	Nucleolus	75.56	4e-44	144
Homo sapiens	LLPS-Hos-0553	Q9Y333	Client	Nucleolus	100.00	3e-64	196
Saccharomyces cerevisiae	LLPS-Sac-0289	P38203	Client	P-body	63.16	1e-37	128
Mus musculus	LLPS-Mum-2432	O35900	Client	Cajal body, Nuclear speckle, Nucleolus	100.00	2e-62	193

▼ FUNCTION

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSNLET00000054657.1	ENSNLEP00000033222.1
Ensembl	ENSNLET00000041930.1	ENSNLEP00000038436.1
Ensembl	ENSNLET00000034877.1	ENSNLEP00000030687.1
UniProt		A0A2I3GHD4, A0A2I3GHD4_NOMLE
GeneBank	ADFV01069384, ADFV01069382, ADFV01069383
RefSeq	XM_003272125.2	XP_003272173.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK YPHMLSVKNC 60 61 FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ 95
Nucleotide CDS Sequence (FASTA)
1 ATGCTCTTCT ATTCTTTTTT CAAGTCCCTT GTGGGCAAGG ATGTGGTCGT GGAACTAAAG 60 61 AATGACCTGA GCATCTGTGG AACCCTCCAT TCTGTGGATC AGTATCTCAA CATCAAACTA 120 121 ACTGACATCA GTGTCACAGA CCCTGAGAAA TATCCTCACA TGCTATCAGT GAAGAACTGC 180 181 TTCATTCGGG GCTCAGTGGT CCGATACGTG CAGCTGCCAG CAGATGAGGT CGACACACAG 240 241 TTGCTACAGG ATGCAGCAAG GAAGGAAGCC CTGCAGCAGA AACAGTGA 288

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0071013	Cellular Component	Catalytic step 2 spliceosome
GO:0120115	Cellular Component	Lsm2-8 complex
GO:0000932	Cellular Component	P-body
GO:0071005	Cellular Component	U2-type precatalytic spliceosome
GO:0046540	Cellular Component	U4/U6 x U5 tri-snRNP complex
GO:0005688	Cellular Component	U6 snRNP
GO:0017160	Molecular Function	Ral GTPase binding
GO:0003723	Molecular Function	RNA binding
GO:0000398	Biological Process	MRNA splicing, via spliceosome

▼ KEGG

nle:100594047

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Tut-1829	Tursiops truncatus	100.0	3e-64	196
LLPS-Bot-2466	Bos taurus	100.0	3e-64	196
LLPS-Dio-1715	Dipodomys ordii	100.0	3e-64	196
LLPS-Ran-0984	Rattus norvegicus	100.0	9e-63	193
LLPS-Ova-1931	Ovis aries	100.0	3e-63	193
LLPS-Aim-0041	Ailuropoda melanoleuca	100.0	3e-63	193
LLPS-Mup-0013	Mustela putorius furo	100.0	5e-64	199
LLPS-Paa-1431	Papio anubis	100.0	3e-64	196
LLPS-Mal-1780	Mandrillus leucophaeus	100.0	3e-64	196
LLPS-Ora-1746	Ornithorhynchus anatinus	100.0	3e-63	193
LLPS-Chs-1551	Chlorocebus sabaeus	100.0	3e-64	196
LLPS-Mea-0454	Mesocricetus auratus	100.0	3e-64	196
LLPS-Mum-2432	Mus musculus	100.0	1e-62	193
LLPS-Maf-1818	Macaca fascicularis	100.0	3e-64	196
LLPS-Aon-0603	Aotus nancymaae	100.0	3e-64	196
LLPS-Cea-0976	Cercocebus atys	100.0	3e-64	196
LLPS-Sus-1961	Sus scrofa	100.0	3e-64	196
LLPS-Gog-2055	Gorilla gorilla	100.0	3e-64	196
LLPS-Caj-1972	Callithrix jacchus	100.0	3e-64	196
LLPS-Fud-0191	Fukomys damarensis	100.0	3e-64	196
LLPS-Eqc-0573	Equus caballus	100.0	2e-63	194
LLPS-Cap-0329	Cavia porcellus	100.0	3e-64	196
LLPS-Poa-1539	Pongo abelii	100.0	4e-64	198
LLPS-Mam-2459	Macaca mulatta	100.0	3e-64	196
LLPS-Cas-0365	Carlito syrichta	100.0	3e-64	196
LLPS-Ict-2039	Ictidomys tridecemlineatus	100.0	3e-64	196
LLPS-Anc-0769	Anolis carolinensis	100.0	4e-63	193
LLPS-Fec-1016	Felis catus	100.0	3e-64	196
LLPS-Pap-1297	Pan paniscus	100.0	3e-64	196
LLPS-Urm-3397	Ursus maritimus	100.0	3e-63	195
LLPS-Pat-0380	Pan troglodytes	100.0	3e-64	196
LLPS-Hos-0553	Homo sapiens	100.0	3e-64	196
LLPS-Loa-0883	Loxodonta africana	100.0	3e-63	193
LLPS-Man-1396	Macaca nemestrina	100.0	3e-64	196
LLPS-Pes-1014	Pelodiscus sinensis	100.0	5e-63	193
LLPS-Rhb-1081	Rhinopithecus bieti	100.0	3e-64	196
LLPS-Orc-2320	Oryctolagus cuniculus	100.0	3e-64	196
LLPS-Scf-0385	Scleropages formosus	98.95	5e-64	195
LLPS-Gaa-0581	Gasterosteus aculeatus	98.95	5e-64	195
LLPS-Leo-0470	Lepisosteus oculatus	98.95	5e-64	195
LLPS-Orl-1691	Oryzias latipes	98.95	5e-64	195
LLPS-Icp-1207	Ictalurus punctatus	98.95	5e-64	195
LLPS-Asm-1262	Astyanax mexicanus	98.95	5e-64	195
LLPS-Xet-0578	Xenopus tropicalis	98.95	9e-64	194
LLPS-Lac-1909	Latimeria chalumnae	98.95	5e-64	195
LLPS-Pof-1557	Poecilia formosa	98.95	5e-64	195
LLPS-Dar-1868	Danio rerio	98.95	2e-63	194
LLPS-Orn-1091	Oreochromis niloticus	98.95	5e-64	195
LLPS-Mod-0048	Monodelphis domestica	98.94	4e-63	192
LLPS-Scm-0202	Scophthalmus maximus	98.94	1e-62	193
LLPS-Tar-0388	Takifugu rubripes	97.87	1e-60	186
LLPS-Xim-0087	Xiphophorus maculatus	97.87	1e-60	186
LLPS-Cii-0742	Ciona intestinalis	95.79	9e-62	189
LLPS-Drm-0921	Drosophila melanogaster	95.6	6e-59	182
LLPS-Ten-1198	Tetraodon nigroviridis	95.45	2e-39	132
LLPS-Cae-0989	Caenorhabditis elegans	84.04	3e-54	171
LLPS-Cus-0642	Cucumis sativus	75.56	1e-44	146
LLPS-Arl-0318	Arabidopsis lyrata	75.56	4e-44	144
LLPS-Hea-2076	Helianthus annuus	75.56	4e-44	144
LLPS-Bro-1565	Brassica oleracea	75.56	1e-43	145
LLPS-Art-0667	Arabidopsis thaliana	75.56	4e-44	144
LLPS-Brn-0290	Brassica napus	75.28	6e-43	142
LLPS-Mua-0932	Musa acuminata	75.0	1e-42	141
LLPS-Sem-0211	Selaginella moellendorffii	74.44	2e-44	145
LLPS-Glm-0807	Glycine max	74.44	1e-44	145
LLPS-Php-0583	Physcomitrella patens	74.44	2e-43	142
LLPS-Prp-0963	Prunus persica	74.44	2e-44	145
LLPS-Gor-1964	Gossypium raimondii	74.44	6e-44	144
LLPS-Brr-1971	Brassica rapa	74.44	2e-43	142
LLPS-Pot-1763	Populus trichocarpa	74.44	3e-43	142
LLPS-Thc-2297	Theobroma cacao	74.16	1e-39	142
LLPS-Coc-1516	Corchorus capsularis	74.16	1e-39	142
LLPS-Abg-0149	Absidia glauca	73.81	6e-39	131
LLPS-Sot-0437	Solanum tuberosum	73.33	3e-43	142
LLPS-Lep-1189	Leersia perrieri	73.33	2e-42	140
LLPS-Brd-0981	Brachypodium distachyon	73.33	2e-42	140
LLPS-Tra-0516	Triticum aestivum	73.33	2e-42	140
LLPS-Met-0356	Medicago truncatula	73.33	2e-43	142
LLPS-Hov-0221	Hordeum vulgare	73.33	2e-42	140
LLPS-Sol-2076	Solanum lycopersicum	73.33	3e-43	142
LLPS-Zem-1539	Zea mays	73.33	2e-42	140
LLPS-Org-0295	Oryza glaberrima	73.33	2e-42	140
LLPS-Ors-0374	Oryza sativa	73.33	2e-42	140
LLPS-Orp-0297	Oryza punctata	73.33	6e-42	139
LLPS-Orbr-1511	Oryza brachyantha	73.33	2e-42	140
LLPS-Sob-1099	Sorghum bicolor	73.33	8e-43	141
LLPS-Nia-0958	Nicotiana attenuata	73.33	5e-43	142
LLPS-Amt-1472	Amborella trichopoda	73.33	2e-42	140
LLPS-Mae-0624	Manihot esculenta	73.33	7e-43	141
LLPS-Phv-1953	Phaseolus vulgaris	73.33	4e-43	143
LLPS-Ori-0804	Oryza indica	73.03	2e-41	139
LLPS-Orm-1714	Oryza meridionalis	73.03	2e-36	135
LLPS-Orr-0230	Oryza rufipogon	73.03	2e-41	138
LLPS-Viv-0390	Vitis vinifera	73.03	2e-42	140
LLPS-Orb-0122	Oryza barthii	72.97	1e-11	59.7
LLPS-Tru-0345	Triticum urartu	72.73	4e-22	87.0
LLPS-Orgl-0386	Oryza glumaepatula	72.22	1e-40	137
LLPS-Via-0175	Vigna angularis	72.22	1e-21	86.3
LLPS-Dac-1008	Daucus carota	72.22	4e-21	84.7
LLPS-Osl-0289	Ostreococcus lucimarinus	71.91	1e-40	137
LLPS-Dos-1392	Dothistroma septosporum	71.74	2e-40	135
LLPS-Zyt-0371	Zymoseptoria tritici	70.65	4e-40	134
LLPS-Sei-0286	Setaria italica	70.49	9e-22	86.7
LLPS-Chr-0552	Chlamydomonas reinhardtii	70.0	1e-41	138
LLPS-Beb-0736	Beauveria bassiana	69.15	8e-41	136
LLPS-Blg-1122	Blumeria graminis	68.82	8e-39	131
LLPS-Coo-0175	Colletotrichum orbiculare	68.82	5e-39	132
LLPS-Trv-0662	Trichoderma virens	68.54	2e-37	127
LLPS-Ved-0056	Verticillium dahliae	68.54	2e-33	127
LLPS-Trr-0798	Trichoderma reesei	68.54	2e-37	127
LLPS-Scs-0028	Sclerotinia sclerotiorum	68.24	1e-33	117
LLPS-Pug-0491	Puccinia graminis	67.78	9e-41	136
LLPS-Miv-0543	Microbotryum violaceum	67.78	6e-40	134
LLPS-Asn-0644	Aspergillus nidulans	67.74	6e-34	119
LLPS-Fuv-1076	Fusarium verticillioides	67.42	1e-36	125
LLPS-Fuo-1114	Fusarium oxysporum	67.42	1e-36	125
LLPS-Put-0259	Puccinia triticina	67.42	8e-40	133
LLPS-Cogr-0491	Colletotrichum graminicola	67.42	2e-36	125
LLPS-Asfu-0806	Aspergillus fumigatus	67.05	2e-32	114
LLPS-Nef-0706	Neosartorya fischeri	67.05	2e-32	114
LLPS-Asf-0124	Aspergillus flavus	66.67	9e-35	120
LLPS-Asc-0288	Aspergillus clavatus	66.67	1e-34	120
LLPS-Mel-0907	Melampsora laricipopulina	66.67	6e-38	130
LLPS-Asni-0154	Aspergillus niger	66.67	1e-34	120
LLPS-Crn-0519	Cryptococcus neoformans	65.26	4e-41	137
LLPS-Mao-0635	Magnaporthe oryzae	64.44	3e-36	124
LLPS-Sac-0289	Saccharomyces cerevisiae	63.16	1e-37	128
LLPS-Nec-0261	Neurospora crassa	62.92	1e-33	118
LLPS-Map-0100	Magnaporthe poae	62.92	1e-34	120
LLPS-Spr-0240	Sporisorium reilianum	62.37	3e-37	127
LLPS-Gag-0517	Gaeumannomyces graminis	61.9	5e-31	111
LLPS-Scp-0317	Schizosaccharomyces pombe	61.05	4e-35	122
LLPS-Scc-0021	Schizosaccharomyces cryophilus	61.05	2e-35	122
LLPS-Asg-0856	Ashbya gossypii	61.05	3e-36	124
LLPS-Usm-0710	Ustilago maydis	61.05	3e-37	127
LLPS-Chc-0420	Chondrus crispus	60.67	2e-32	114
LLPS-Scj-1198	Schizosaccharomyces japonicus	60.0	2e-35	122
LLPS-Lem-0379	Leptosphaeria maculans	58.95	4e-34	119
LLPS-Pyt-0730	Pyrenophora teres	58.95	5e-34	119
LLPS-Pytr-0852	Pyrenophora triticirepentis	58.95	5e-34	119
LLPS-Phn-0108	Phaeosphaeria nodorum	58.95	4e-34	119
LLPS-Gas-0735	Galdieria sulphuraria	58.93	5e-16	72.0
LLPS-Yal-0114	Yarrowia lipolytica	56.99	3e-34	119
LLPS-Cog-0046	Colletotrichum gloeosporioides	50.39	1e-32	116
LLPS-Kop-0186	Komagataella pastoris	48.89	2e-22	89.4
LLPS-Cym-0533	Cyanidioschyzon merolae	45.83	1e-24	95.1
LLPS-Sah-0369	Sarcophilus harrisii	35.0	7e-08	50.8
LLPS-Caf-0348	Canis familiaris	35.0	7e-08	50.8
LLPS-Gaga-0064	Gallus gallus	35.0	7e-08	50.8
LLPS-Cis-0375	Ciona savignyi	34.62	6e-09	53.9
LLPS-Tag-1739	Taeniopygia guttata	32.88	2e-07	49.3
LLPS-Fia-2132	Ficedula albicollis	32.0	2e-07	49.3

LLPS-Nol-1904LSM2

Protein Sequence

Nucleotide Sequence

LLPS-Nol-1904
LSM2