• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nia-0419
IRE_1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Non-specific serine/threonine protein kinase
Gene Name: IRE_1, A4A49_22088
Ensembl Gene: A4A49_22088
Ensembl Protein: OIT08376
Organism: Nicotiana attenuata
Taxa ID: 49451
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, P-bodyPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDSARSWFQK  FQPRDRLRSS  TKKKDSTMGS  GREDPQPMSA  EEASNVTKQR  VAAAKQYIEN  60
61    HYKEQMRNLQ  ERKERRMVLE  KKLADGDVSE  EDQNNLLKFH  EKKETEYMRL  QRHKMGADDF  120
121   ELLTMIGKGA  FGEVRVCREK  TTGHVYAMKK  LKKSEMLRRG  QVEHVKAERN  LLAEVDSNCI  180
181   VKLYCSFQDD  EFLYLIMEYL  PGGDMMTLLM  RKDTLTEDEA  RFYVAETVLA  IESIHVHNYI  240
241   HRDIKPDNLL  LDKFGHLRLS  DFGLCKPLDC  STLEEKDFTV  GDSVHGASRN  GSSAPKRTQQ  300
301   EQLQHWQKNR  RTLAYSTVGT  PDYIAPEVLL  KKGYGMECDW  WSLGAIMYEM  LVGYPPFYSD  360
361   DPMSTCRKIV  NWKSHLKFPE  EAKLSPEAKD  LISKLLCNVT  QRLGSNGADE  IKVHPWFKGI  420
421   DWDRIYHTDA  AFIPEVNDEL  DTQNFEKFEE  SESHSQSASR  SGPWRKMLSS  KDINFVGYTY  480
481   KNFEIVNDYQ  VPGMAELKKK  NTKPKRPTIK  ALFEDESEGS  DTTSSQQSQG  SFVNLLPP  538
Nucleotide CDS Sequence (FASTA)
1     ATGGATTCAG  CTAGGAGTTG  GTTCCAGAAG  TTTCAACCAC  GAGATCGTTT  AAGGTCATCG  60
61    ACCAAGAAGA  AAGATTCAAC  AATGGGTAGT  GGAAGAGAAG  ATCCTCAGCC  TATGTCAGCT  120
121   GAAGAGGCCT  CCAATGTTAC  GAAGCAGAGG  GTCGCTGCAG  CAAAGCAATA  CATTGAGAAT  180
181   CATTACAAGG  AGCAAATGAG  AAATTTGCAG  GAGAGAAAGG  AGCGTCGAAT  GGTACTGGAA  240
241   AAGAAGCTTG  CGGATGGTGA  TGTCTCAGAG  GAAGATCAAA  ATAATCTACT  GAAATTTCAT  300
301   GAAAAGAAGG  AAACTGAATA  CATGCGTCTG  CAAAGGCACA  AAATGGGTGC  TGATGATTTT  360
361   GAGTTATTAA  CAATGATTGG  GAAAGGTGCA  TTCGGGGAGG  TTAGAGTTTG  TAGAGAAAAA  420
421   ACAACGGGTC  ATGTATATGC  GATGAAAAAG  CTTAAGAAAT  CAGAAATGCT  TCGTAGAGGA  480
481   CAGGTTGAGC  ATGTAAAAGC  AGAAAGGAAT  CTGCTCGCAG  AGGTGGATAG  TAATTGCATT  540
541   GTCAAACTGT  ATTGTTCTTT  CCAAGATGAT  GAGTTTCTAT  ATCTCATCAT  GGAATATCTA  600
601   CCTGGTGGTG  ATATGATGAC  TCTACTCATG  AGGAAGGATA  CACTAACGGA  AGATGAAGCC  660
661   AGATTTTATG  TTGCTGAGAC  TGTTTTGGCT  ATAGAATCTA  TCCATGTACA  TAACTATATA  720
721   CACAGAGACA  TTAAGCCTGA  TAACTTGCTG  CTGGATAAGT  TTGGTCATTT  GAGACTATCG  780
781   GATTTTGGAC  TTTGTAAGCC  TTTAGACTGC  AGCACCCTGG  AAGAGAAGGA  TTTCACGGTG  840
841   GGTGATAGTG  TCCATGGAGC  TTCCCGGAAT  GGGTCTTCAG  CTCCCAAACG  CACTCAGCAA  900
901   GAACAGTTAC  AACACTGGCA  GAAAAATAGG  CGGACGCTTG  CATATTCTAC  AGTGGGAACA  960
961   CCAGACTATA  TAGCTCCTGA  AGTCCTGCTG  AAGAAAGGTT  ATGGAATGGA  GTGTGACTGG  1020
1021  TGGTCACTTG  GTGCTATTAT  GTATGAAATG  CTAGTGGGTT  ATCCACCTTT  CTATTCTGAT  1080
1081  GATCCCATGT  CAACGTGTCG  CAAGATAGTA  AACTGGAAAT  CGCATTTAAA  GTTCCCAGAG  1140
1141  GAAGCAAAGC  TATCTCCAGA  AGCGAAGGAT  CTCATAAGCA  AACTTCTTTG  CAATGTTACT  1200
1201  CAGAGACTAG  GTTCAAATGG  TGCTGATGAA  ATAAAGGTCC  ACCCGTGGTT  TAAGGGAATA  1260
1261  GACTGGGACA  GAATCTATCA  TACGGATGCT  GCCTTCATTC  CTGAAGTTAA  TGATGAGTTG  1320
1321  GACACCCAAA  ACTTTGAAAA  GTTCGAAGAG  TCCGAATCTC  ATTCTCAGAG  TGCATCAAGA  1380
1381  TCTGGTCCTT  GGAGGAAGAT  GCTCTCATCC  AAGGACATCA  ACTTTGTCGG  TTACACATAC  1440
1441  AAAAACTTTG  AAATCGTGAA  TGATTACCAA  GTGCCTGGGA  TGGCTGAACT  GAAGAAGAAG  1500
1501  AATACCAAGC  CAAAGAGACC  AACAATCAAA  GCACTATTCG  AGGACGAGTC  AGAAGGATCA  1560
1561  GATACAACTA  GTTCTCAGCA  ATCCCAAGGA  AGCTTTGTGA  ATCTCTTGCC  TCCATGA  1617

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Coc-1468Corchorus capsularis86.00.0 861
LLPS-Hea-0071Helianthus annuus85.60.0 886
LLPS-Glm-3004Glycine max84.440.0 911
LLPS-Sot-0511Solanum tuberosum83.850.0 878
LLPS-Sol-2048Solanum lycopersicum83.660.0 877
LLPS-Met-1260Medicago truncatula83.110.0 887
LLPS-Thc-0831Theobroma cacao83.030.0 913
LLPS-Mae-2687Manihot esculenta82.20.0 915
LLPS-Pot-0319Populus trichocarpa81.650.0 902
LLPS-Gor-1985Gossypium raimondii80.920.0 863
LLPS-Amt-1852Amborella trichopoda80.420.0 846
LLPS-Via-2375Vigna angularis80.080.0 847
LLPS-Phv-1020Phaseolus vulgaris80.080.0 835
LLPS-Dac-0125Daucus carota79.890.0 858
LLPS-Mua-0394Musa acuminata79.730.0 842
LLPS-Vir-1439Vigna radiata79.690.0 842
LLPS-Viv-0664Vitis vinifera79.670.0 877
LLPS-Arl-0854Arabidopsis lyrata79.570.0 832
LLPS-Prp-0533Prunus persica79.110.0 857
LLPS-Art-2447Arabidopsis thaliana78.720.0 827
LLPS-Bro-2950Brassica oleracea78.660.0 788
LLPS-Brn-3105Brassica napus78.460.0 789
LLPS-Brr-2614Brassica rapa78.460.0 789
LLPS-Cus-0345Cucumis sativus78.410.0 858
LLPS-Org-1517Oryza glaberrima76.920.0 789
LLPS-Sob-2503Sorghum bicolor76.490.0 788
LLPS-Sei-1922Setaria italica76.480.0 785
LLPS-Zem-1653Zea mays76.290.0 781
LLPS-Lep-1065Leersia perrieri76.250.0 784
LLPS-Orbr-2024Oryza brachyantha76.250.0 784
LLPS-Hov-1453Hordeum vulgare76.20.0 790
LLPS-Tra-1844Triticum aestivum76.20.0 791
LLPS-Brd-0179Brachypodium distachyon76.20.0 803
LLPS-Orb-1320Oryza barthii76.050.0 782
LLPS-Orr-1623Oryza rufipogon76.050.0 782
LLPS-Ori-1954Oryza indica75.770.0 775
LLPS-Orni-1934Oryza nivara75.770.0 776
LLPS-Ors-1612Oryza sativa75.770.0 775
LLPS-Orgl-0794Oryza glumaepatula75.630.0 759
LLPS-Orp-0980Oryza punctata75.480.0 769
LLPS-Sem-0773Selaginella moellendorffii74.380.0 731
LLPS-Php-1987Physcomitrella patens74.20.0 781
LLPS-Orm-0925Oryza meridionalis74.190.0 775
LLPS-Tru-0439Triticum urartu71.40.0 682
LLPS-Osl-0013Ostreococcus lucimarinus59.859e-170 494
LLPS-Poa-0999Pongo abelii52.971e-136 409
LLPS-Orl-0055Oryzias latipes50.242e-137 414
LLPS-Meg-2547Meleagris gallopavo50.123e-142 426
LLPS-Hos-2521Homo sapiens50.113e-145 433
LLPS-Pat-0696Pan troglodytes50.113e-145 433
LLPS-Fia-2778Ficedula albicollis50.111e-145 435
LLPS-Gaga-2395Gallus gallus50.114e-145 434
LLPS-Sus-1087Sus scrofa49.897e-144 430
LLPS-Sah-1050Sarcophilus harrisii49.891e-143 429
LLPS-Cea-4077Cercocebus atys49.897e-145 432
LLPS-Aon-1645Aotus nancymaae49.899e-145 432
LLPS-Maf-3200Macaca fascicularis49.899e-145 432
LLPS-Chs-2168Chlorocebus sabaeus49.897e-145 432
LLPS-Asm-2621Astyanax mexicanus49.891e-142 427
LLPS-Fud-1579Fukomys damarensis49.892e-144 431
LLPS-Caj-2211Callithrix jacchus49.899e-145 432
LLPS-Mal-3520Mandrillus leucophaeus49.899e-145 432
LLPS-Man-4226Macaca nemestrina49.896e-145 432
LLPS-Loa-4461Loxodonta africana49.892e-144 431
LLPS-Mod-1371Monodelphis domestica49.891e-143 429
LLPS-Otg-1327Otolemur garnettii49.899e-145 432
LLPS-Mam-0919Macaca mulatta49.899e-145 432
LLPS-Eqc-4196Equus caballus49.892e-144 431
LLPS-Nol-1775Nomascus leucogenys49.899e-145 432
LLPS-Ict-3729Ictidomys tridecemlineatus49.891e-144 432
LLPS-Cas-3639Carlito syrichta49.894e-144 431
LLPS-Leo-1271Lepisosteus oculatus49.775e-143 428
LLPS-Xet-0190Xenopus tropicalis49.775e-142 425
LLPS-Icp-2774Ictalurus punctatus49.662e-144 432
LLPS-Scf-1391Scleropages formosus49.662e-143 429
LLPS-Paa-3401Papio anubis49.665e-141 426
LLPS-Mup-1874Mustela putorius furo49.661e-142 427
LLPS-Ran-0403Rattus norvegicus49.665e-143 428
LLPS-Urm-1168Ursus maritimus49.661e-142 427
LLPS-Pap-0250Pan paniscus49.661e-142 427
LLPS-Lac-2442Latimeria chalumnae49.662e-144 432
LLPS-Rhb-1240Rhinopithecus bieti49.661e-142 427
LLPS-Aim-0151Ailuropoda melanoleuca49.553e-140 421
LLPS-Mum-1169Mus musculus49.437e-141 422
LLPS-Bot-0800Bos taurus49.432e-141 424
LLPS-Tar-1706Takifugu rubripes49.433e-143 429
LLPS-Caf-0736Canis familiaris49.433e-141 423
LLPS-Fec-1425Felis catus49.421e-138 416
LLPS-Pes-0847Pelodiscus sinensis49.337e-143 427
LLPS-Tag-0812Taeniopygia guttata49.332e-144 431
LLPS-Anc-3418Anolis carolinensis49.246e-146 435
LLPS-Gaa-1380Gasterosteus aculeatus49.218e-141 422
LLPS-Cap-3481Cavia porcellus49.212e-141 424
LLPS-Tut-0515Tursiops truncatus49.115e-135 407
LLPS-Anp-0683Anas platyrhynchos49.114e-144 431
LLPS-Dar-1943Danio rerio49.112e-142 426
LLPS-Orc-3353Oryctolagus cuniculus49.11e-139 423
LLPS-Myl-1381Myotis lucifugus48.871e-139 419
LLPS-Orn-0546Oreochromis niloticus48.871e-142 427
LLPS-Drm-2137Drosophila melanogaster48.832e-143 429
LLPS-Scm-0462Scophthalmus maximus48.557e-142 425
LLPS-Pof-3502Poecilia formosa48.488e-144 430
LLPS-Yal-0600Yarrowia lipolytica48.439e-132 403
LLPS-Ova-3619Ovis aries48.427e-131 397
LLPS-Xim-1772Xiphophorus maculatus47.651e-133 403
LLPS-Scp-0024Schizosaccharomyces pombe47.296e-138 415
LLPS-Cii-1987Ciona intestinalis47.182e-133 403
LLPS-Sac-0434Saccharomyces cerevisiae46.614e-130 404
LLPS-Spr-0331Sporisorium reilianum46.361e-126 393
LLPS-Miv-0258Microbotryum violaceum46.13e-129 397
LLPS-Scj-0050Schizosaccharomyces japonicus46.095e-138 415
LLPS-Tum-0580Tuber melanosporum45.985e-133 405
LLPS-Cae-1163Caenorhabditis elegans45.546e-128 389
LLPS-Pug-0507Puccinia graminis45.311e-128 392
LLPS-Scc-1226Schizosaccharomyces cryophilus45.276e-134 405
LLPS-Kop-1137Komagataella pastoris45.212e-128 397
LLPS-Mel-0807Melampsora laricipopulina44.764e-128 390
LLPS-Asg-0552Ashbya gossypii44.381e-127 397
LLPS-Crn-0726Cryptococcus neoformans43.381e-130 399