• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nef-0939
NFIA_078420

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Homoaconitase, mitochondrial; Homoaconitate hydratase
Gene Name: NFIA_078420
Ensembl Gene: NFIA_078420
Ensembl Protein: EAW17902
Organism: Neosartorya fischeri
Taxa ID: 331117
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEAW17902EAW17902
UniProtA1DEU5, A1DEU5_NEOFI
GeneBankDS027696EAW17902.1
RefSeqXM_001259798.1XP_001259799.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MIKRTGSLLL  RCRASRAPVI  GRPLISLSTS  STSLSLSRPR  SFATTSLRRY  AEASSSTTQI  60
61    SPSSSSWPAP  DAAPRVPQTL  TEKIVQAYSL  GLAEGQYVKA  GDYVMLSPHR  CMTHDNSWPT  120
121   ALKFMAIGAS  KVHNPNQIVM  TLDHDVQNKS  EKNLKKYESI  EKFANQHGID  FYPAGHGVGH  180
181   QIMIEEGYAF  PGTVTVASDS  HSNMYGGVGC  LGTPMVRTDA  ATIWATGRTW  WKVPPIAKVQ  240
241   FTGTLPEGVT  GKDVIVALSG  LFNKDEVLNY  AIEFTGSEET  MKSLSVDTRL  TIANMTTEWG  300
301   ALTGLFPIDL  TLEQWLRHKA  ATASRTETAR  RFAEERINEL  FANPTVADRG  AKYAKYLYLD  360
361   LSTLSPYVSG  PNSVKVATPI  DELEKHKLKI  DKAYLVSCTN  SRASDIAAAA  KVFKDAVART  420
421   GGPVTVADGV  EFYVAAASKA  EQKIAEEAGD  WQALMDAGAI  PLPAGCAVCI  GLGAGLLKEG  480
481   EVGISASNRN  FKGRMGSPDA  KAYLASPEVV  AASALNGVIS  GPGIYKRPED  WAGVSIGEGE  540
541   VVESGTRIDT  TLEAMEKFIG  QLDSMIESSS  KAVMPEESTG  SGATEVDIVP  GFPEKIEGEI  600
601   LFLDADNIST  DGIYPGKYTY  QDDVTKDKMA  QVCMENYDPA  FSGIARAGDI  FVSGFNFGCG  660
661   SSREQAATSI  LAKQLPLVVA  GSIGNTFSRN  AVNNALPLLE  MPRLVERLRE  AFGSEKQPTR  720
721   RTGWTFTWNV  RTSQVTVQEG  PGGETWSQSV  PAFPPNLQDI  IAQGGLEKWV  KKEISKA  777
Nucleotide CDS Sequence (FASTA)
1     ATGATCAAAC  GCACCGGATC  TTTGCTGCTT  CGGTGCAGAG  CATCGCGAGC  CCCCGTTATC  60
61    GGTCGACCTT  TGATCTCATT  ATCAACCTCC  TCCACCTCCC  TGTCTCTATC  TCGTCCTCGA  120
121   TCCTTTGCCA  CTACATCCCT  TCGCCGTTAC  GCTGAGGCAT  CCTCCTCCAC  GACACAAATC  180
181   TCTCCTTCGT  CGTCGAGTTG  GCCCGCCCCC  GATGCCGCCC  CCCGCGTCCC  CCAGACCCTT  240
241   ACCGAGAAGA  TCGTCCAGGC  ATATTCTCTG  GGCCTCGCCG  AAGGTCAATA  CGTAAAGGCT  300
301   GGAGACTATG  TCATGCTTAG  CCCTCATCGC  TGCATGACCC  ACGACAACTC  ATGGCCCACC  360
361   GCGCTCAAGT  TTATGGCAAT  TGGCGCATCC  AAGGTCCACA  ACCCCAACCA  GATTGTCATG  420
421   ACCCTAGACC  ACGATGTCCA  GAACAAGAGC  GAGAAGAACC  TAAAGAAATA  CGAATCGATC  480
481   GAGAAGTTTG  CCAACCAACA  TGGCATCGAC  TTCTACCCAG  CTGGTCACGG  CGTCGGCCAT  540
541   CAGATCATGA  TTGAGGAGGG  ATATGCCTTC  CCCGGCACCG  TCACTGTGGC  TAGTGACAGT  600
601   CACTCCAACA  TGTACGGTGG  AGTTGGTTGT  CTCGGTACTC  CCATGGTTCG  TACCGATGCC  660
661   GCGACCATCT  GGGCTACCGG  CCGTACCTGG  TGGAAGGTCC  CCCCTATCGC  AAAGGTGCAG  720
721   TTCACCGGCA  CCCTCCCTGA  GGGTGTCACC  GGAAAGGACG  TCATTGTCGC  TTTGTCGGGT  780
781   CTCTTCAACA  AAGACGAGGT  TCTCAACTAC  GCCATTGAGT  TCACTGGCTC  GGAGGAGACC  840
841   ATGAAGAGTC  TCTCTGTCGA  CACCCGTCTG  ACCATCGCCA  ACATGACCAC  CGAATGGGGT  900
901   GCGCTGACCG  GACTGTTCCC  CATCGACTTG  ACCCTGGAGC  AGTGGCTGCG  ACACAAGGCC  960
961   GCTACCGCAT  CACGGACAGA  GACGGCGCGC  CGATTCGCCG  AGGAGCGTAT  CAACGAGTTG  1020
1021  TTCGCCAACC  CCACCGTCGC  TGACCGTGGC  GCCAAGTACG  CCAAATACCT  ATACCTGGAT  1080
1081  CTGTCGACTT  TGTCGCCCTA  CGTTTCCGGA  CCGAACTCCG  TCAAGGTCGC  CACGCCAATT  1140
1141  GACGAACTGG  AAAAGCACAA  GCTGAAGATC  GACAAAGCCT  ACTTGGTGTC  CTGCACTAAC  1200
1201  TCGCGAGCGT  CGGATATTGC  CGCCGCGGCC  AAGGTGTTCA  AGGACGCCGT  TGCCCGGACG  1260
1261  GGTGGACCTG  TGACGGTCGC  GGACGGCGTC  GAGTTCTACG  TTGCGGCGGC  TTCCAAGGCC  1320
1321  GAACAGAAGA  TTGCAGAGGA  GGCGGGTGAC  TGGCAAGCCC  TGATGGACGC  CGGCGCTATC  1380
1381  CCCCTGCCAG  CGGGGTGCGC  CGTCTGTATT  GGTCTGGGTG  CCGGTCTTCT  CAAGGAGGGC  1440
1441  GAAGTTGGAA  TCTCGGCCAG  TAATCGAAAC  TTCAAAGGCC  GCATGGGTTC  GCCTGATGCC  1500
1501  AAGGCCTATC  TTGCCAGTCC  TGAAGTTGTC  GCGGCCAGTG  CACTGAACGG  TGTTATTAGC  1560
1561  GGACCCGGTA  TCTACAAGCG  CCCCGAAGAC  TGGGCCGGCG  TTTCCATCGG  TGAAGGCGAA  1620
1621  GTTGTCGAGT  CCGGCACTCG  CATCGACACC  ACTTTGGAAG  CAATGGAGAA  GTTCATTGGA  1680
1681  CAGCTGGATA  GCATGATTGA  GTCGTCGAGC  AAGGCCGTGA  TGCCGGAAGA  GTCGACTGGC  1740
1741  TCCGGAGCCA  CTGAAGTCGA  CATCGTCCCC  GGCTTCCCCG  AAAAGATTGA  GGGTGAAATC  1800
1801  CTCTTCCTTG  ATGCTGACAA  CATCAGCACT  GATGGCATCT  ACCCTGGCAA  ATACACATAC  1860
1861  CAGGACGACG  TCACCAAGGA  CAAGATGGCG  CAGGTCTGCA  TGGAGAACTA  CGATCCTGCG  1920
1921  TTCAGCGGCA  TCGCCCGCGC  AGGAGACATC  TTCGTCTCCG  GCTTCAACTT  CGGCTGCGGC  1980
1981  TCCTCCCGCG  AGCAAGCCGC  CACCTCCATC  CTCGCCAAGC  AACTCCCCCT  CGTCGTCGCC  2040
2041  GGCAGCATCG  GCAACACCTT  CAGCCGCAAC  GCCGTCAACA  ACGCCCTTCC  TCTCCTCGAG  2100
2101  ATGCCTCGCC  TCGTCGAGCG  CCTGCGCGAA  GCCTTTGGGA  GCGAAAAGCA  ACCAACCCGT  2160
2161  CGCACGGGAT  GGACCTTCAC  CTGGAACGTG  CGCACCTCCC  AGGTCACTGT  CCAGGAAGGC  2220
2221  CCGGGCGGTG  AAACCTGGAG  CCAGAGCGTC  CCTGCTTTCC  CTCCAAACCT  GCAAGACATC  2280
2281  ATTGCCCAGG  GTGGATTGGA  GAAGTGGGTG  AAGAAGGAGA  TTAGCAAGGC  TTGA  2334

▼ KEYWORD

ID
Family
Amino-acid biosynthesis
Complete proteome
Iron
Iron-sulfur
Lyase
Lysine biosynthesis
Metal-binding
Mitochondrion
Reference proteome
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
Homoaconitate hydratase activity
Molecular Function
Metal ion binding
Biological Process
Lysine biosynthetic process via aminoadipic acid

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asfu-0830Aspergillus fumigatus98.20.01435
LLPS-Asc-0210Aspergillus clavatus89.970.01362
LLPS-Asn-0381Aspergillus nidulans69.570.0 993
LLPS-Asf-1184Aspergillus flavus68.540.0 980
LLPS-Aso-1372Aspergillus oryzae68.540.0 981
LLPS-Ast-1274Aspergillus terreus68.20.0 934
LLPS-Mao-1171Magnaporthe oryzae67.940.0 969
LLPS-Nec-0792Neurospora crassa67.460.0 961
LLPS-Gag-0095Gaeumannomyces graminis66.90.0 966
LLPS-Asni-0094Aspergillus niger66.810.0 958
LLPS-Zyt-0952Zymoseptoria tritici66.480.0 944
LLPS-Map-0398Magnaporthe poae65.930.0 780
LLPS-Cogr-0092Colletotrichum graminicola65.220.0 915
LLPS-Coo-1155Colletotrichum orbiculare64.660.0 898
LLPS-Lem-1037Leptosphaeria maculans64.530.0 844
LLPS-Trv-0945Trichoderma virens62.970.0 879
LLPS-Blg-0320Blumeria graminis62.930.0 907
LLPS-Scs-0810Sclerotinia sclerotiorum62.580.0 951
LLPS-Trr-0714Trichoderma reesei61.610.0 874
LLPS-Dos-1009Dothistroma septosporum61.590.0 945
LLPS-Fuv-1149Fusarium verticillioides61.330.0 860
LLPS-Fuo-0713Fusarium oxysporum61.30.0 851
LLPS-Pytr-1176Pyrenophora triticirepentis61.180.0 947
LLPS-Pyt-1232Pyrenophora teres61.180.0 949
LLPS-Phn-1275Phaeosphaeria nodorum61.030.0 936
LLPS-Cog-0161Colletotrichum gloeosporioides60.330.0 824
LLPS-Beb-0521Beauveria bassiana60.110.0 799
LLPS-Ved-0476Verticillium dahliae58.960.0 840
LLPS-Kop-0490Komagataella pastoris58.720.0 799
LLPS-Tum-0380Tuber melanosporum58.550.0 837
LLPS-Fus-1146Fusarium solani58.190.0 794
LLPS-Yal-0182Yarrowia lipolytica57.610.0 773
LLPS-Sac-0658Saccharomyces cerevisiae56.270.0 740
LLPS-Scj-0180Schizosaccharomyces japonicus55.860.0 753
LLPS-Scp-0576Schizosaccharomyces pombe55.70.0 734
LLPS-Asg-1016Ashbya gossypii55.260.0 692
LLPS-Scc-0255Schizosaccharomyces cryophilus55.060.0 735
LLPS-Abg-1915Absidia glauca52.950.0 689
LLPS-Miv-0341Microbotryum violaceum51.840.0 692
LLPS-Usm-0432Ustilago maydis51.160.0 660
LLPS-Spr-0244Sporisorium reilianum50.890.0 654
LLPS-Crn-0640Cryptococcus neoformans50.470.0 649
LLPS-Mel-0614Melampsora laricipopulina49.80.0 639
LLPS-Pug-0113Puccinia graminis48.530.0 608
LLPS-Put-0171Puccinia triticina46.534e-175 527
LLPS-Nia-2494Nicotiana attenuata29.518e-44 170
LLPS-Prp-0825Prunus persica29.31e-41 163
LLPS-Sot-1038Solanum tuberosum29.39e-44 170
LLPS-Cym-0885Cyanidioschyzon merolae29.269e-43 167
LLPS-Gas-0645Galdieria sulphuraria29.241e-38 157
LLPS-Chc-0049Chondrus crispus29.211e-40 160
LLPS-Amt-0109Amborella trichopoda29.22e-41 162
LLPS-Gor-0374Gossypium raimondii29.094e-41 162
LLPS-Art-1182Arabidopsis thaliana29.092e-41 163
LLPS-Sol-0649Solanum lycopersicum28.943e-42 165
LLPS-Pot-2603Populus trichocarpa28.871e-41 164
LLPS-Thc-1246Theobroma cacao28.871e-40 161
LLPS-Via-0781Vigna angularis28.844e-37 150
LLPS-Sem-1251Selaginella moellendorffii28.782e-38 154
LLPS-Org-2265Oryza glaberrima28.663e-39 156
LLPS-Orm-1649Oryza meridionalis28.664e-39 156
LLPS-Orr-1014Oryza rufipogon28.663e-39 156
LLPS-Pat-4229Pan troglodytes28.661e-32 139
LLPS-Pap-4150Pan paniscus28.661e-32 139
LLPS-Orp-0180Oryza punctata28.664e-39 157
LLPS-Chr-1376Chlamydomonas reinhardtii28.663e-40 159
LLPS-Arl-2081Arabidopsis lyrata28.666e-41 161
LLPS-Orgl-1230Oryza glumaepatula28.664e-39 156
LLPS-Orni-2408Oryza nivara28.665e-39 157
LLPS-Orb-1196Oryza barthii28.664e-39 156
LLPS-Phv-0617Phaseolus vulgaris28.636e-42 164
LLPS-Cus-2395Cucumis sativus28.631e-42 166
LLPS-Glm-2315Glycine max28.631e-38 155
LLPS-Zem-0204Zea mays28.451e-39 157
LLPS-Brr-1526Brassica rapa28.451e-40 160
LLPS-Ors-2415Oryza sativa28.455e-39 156
LLPS-Ori-0791Oryza indica28.455e-39 156
LLPS-Brn-3174Brassica napus28.451e-40 160
LLPS-Coc-2240Corchorus capsularis28.422e-41 162
LLPS-Mae-0400Manihot esculenta28.422e-36 149
LLPS-Tra-2843Triticum aestivum28.423e-39 157
LLPS-Met-1606Medicago truncatula28.427e-38 153
LLPS-Bro-2064Brassica oleracea28.246e-40 159
LLPS-Sob-1206Sorghum bicolor28.244e-38 153
LLPS-Brd-0184Brachypodium distachyon28.211e-39 157
LLPS-Sei-0995Setaria italica28.211e-38 155
LLPS-Hea-1867Helianthus annuus28.01e-42 166
LLPS-Dac-2110Daucus carota27.946e-37 150
LLPS-Viv-0229Vitis vinifera27.81e-38 155
LLPS-Php-2405Physcomitrella patens27.623e-37 151
LLPS-Lep-1835Leersia perrieri26.969e-30 128
LLPS-Vir-1013Vigna radiata26.527e-26 116
LLPS-Tru-0554Triticum urartu26.454e-26 116
LLPS-Otg-4281Otolemur garnettii26.269e-25 114
LLPS-Orbr-1231Oryza brachyantha25.95e-24 112
LLPS-Mua-1568Musa acuminata25.691e-25 117