LLPS-Nec-1540
paa-1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Polyadenylation factor subunit 2 |
| Gene Name: | paa-1, pfs2, NCU00037 |
| Ensembl Gene: | NCU00037 |
| Ensembl Protein: | ESA43240 |
| Organism: | Neurospora crassa |
| Taxa ID: | 367110 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ESA43240 | ESA43240 |
| Ensembl | ESA43241 | ESA43241 |
| UniProt | Q7RY68, PFS2_NEUCR, U9W884 | |
| GeneBank | CM002238 | ESA43240.1 |
| RefSeq | XM_011395431.1 | XP_011393733.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAWTSPTTIQ SITLTLALLT LSSLLVHPFL LSTAIISHHH LWLFCPVTDY GASVVHYMRH 60 61 RQPRYRGSYA GEVERPSPSY IVDMLPPYAR VTNPADSVPS RHLHSSLNKI KHPINVVRWT 120 121 PEGRRLLTAS SSGEFTLWNG TGFNFETIMQ AHDSAIRALV YSHSDDWLVS ADHDGIIKYW 180 181 QPNFNNVESI RGHTDPIRDL AFSPNDTKFV TASDDQTLKV FDFAGGSTDM TLTGHGWDAK 240 241 SCDWHPSRGL IVSGSKDHLV KLWDPRTGRC LTTLHGHKNT ITKTLFERVQ GNCLATSARD 300 301 QTARVFDLRM MRDIALLRGH EKDISTLTWH PVHSNLLSTG GSDGSLFHYL LDEPNTAPDG 360 361 SVMPIPAVYD TADPSSAPAQ PIYPAHKIPY AHDFAIWSLD WHPLGHILAS GSNDRITRFW 420 421 SRARPGEAPE SFNDRYHIGE AAAEAQGTWD RRGGRHMRQV EEEQELEDEM DGLVDQKMPI 480 481 KGQPGVGGGG MMPGLSFPSI PGLPLQQVPS SGPGGSGFIP PPPIIPGVGG ATGVPPPLPF 540 541 PIPGMPGLPA GVVPPPLPGL DLKNPPDFSA LAEMMKKAGY QPPPPPGSAG APMPPPGILP 600 601 PGLIPPPGAA GFPMPPPGFA PPPLIPGAGG PPGGATHPDG GNDQYDSSGR RRAPLPSQEE 660 661 SLRMEQSKGN YTRVR 675 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTGGA CATCACCGAC GACAATACAA TCGATCACGT TGACACTCGC CCTCCTCACT 60 61 TTATCCTCAC TTCTCGTTCA CCCGTTCCTG CTTAGCACCG CCATCATCTC ACATCACCAT 120 121 CTCTGGCTGT TCTGCCCCGT CACCGACTAT GGTGCTTCAG TAGTTCACTA CATGCGCCAC 180 181 AGGCAACCGA GATACCGGGG ATCGTATGCT GGTGAAGTTG AAAGGCCCAG CCCGAGTTAC 240 241 ATTGTTGATA TGTTACCACC ATACGCCCGA GTCACCAATC CAGCAGACTC CGTACCATCA 300 301 AGGCATCTTC ACTCTTCCCT CAACAAAATC AAACACCCCA TCAATGTGGT ACGATGGACG 360 361 CCAGAAGGAC GAAGGCTGTT AACGGCCAGT AGCAGTGGAG AGTTTACGCT CTGGAACGGC 420 421 ACAGGATTCA ATTTCGAAAC GATCATGCAA GCCCACGATT CCGCCATTCG TGCTCTAGTA 480 481 TATTCGCACA GCGACGACTG GCTCGTCTCA GCCGATCATG ACGGTATCAT CAAATATTGG 540 541 CAGCCAAACT TCAACAATGT CGAGAGCATT AGGGGCCATA CTGATCCCAT CCGCGACCTT 600 601 GCCTTCAGCC CCAACGACAC CAAATTTGTC ACGGCTTCAG ATGATCAGAC ACTCAAAGTC 660 661 TTTGACTTTG CTGGCGGCTC AACGGACATG ACTCTGACAG GGCACGGATG GGACGCAAAG 720 721 AGTTGCGATT GGCATCCCAG CAGAGGCCTG ATTGTCTCTG GTTCGAAAGA TCATCTGGTC 780 781 AAGCTGTGGG ATCCAAGGAC GGGTAGATGC CTGACCACGC TTCATGGGCA CAAAAACACC 840 841 ATCACCAAAA CGCTCTTCGA GAGAGTACAG GGAAACTGTT TGGCAACATC AGCTAGAGAT 900 901 CAGACAGCTC GCGTGTTCGA CCTTCGAATG ATGCGAGACA TCGCCCTCCT CAGGGGCCAC 960 961 GAAAAGGACA TATCGACATT GACGTGGCAC CCAGTCCACT CCAACCTCCT AAGCACCGGC 1020 1021 GGCTCGGACG GCTCGCTATT CCACTACCTC TTGGACGAGC CGAACACCGC GCCCGACGGC 1080 1081 TCAGTCATGC CGATCCCGGC AGTTTACGAC ACCGCCGATC CTTCGTCCGC ACCTGCCCAA 1140 1141 CCCATCTACC CAGCCCACAA GATCCCCTAT GCCCACGACT TCGCCATCTG GTCGCTCGAC 1200 1201 TGGCACCCGC TCGGCCACAT CCTCGCCTCG GGATCCAACG ATCGCATCAC ACGTTTCTGG 1260 1261 TCTCGCGCAA GACCTGGCGA GGCTCCCGAG TCCTTCAACG ACCGGTATCA CATCGGCGAG 1320 1321 GCAGCAGCCG AAGCTCAAGG CACCTGGGAT CGCCGCGGCG GCCGTCACAT GCGGCAAGTC 1380 1381 GAGGAGGAGC AGGAGCTGGA GGACGAGATG GACGGCCTGG TGGATCAAAA GATGCCCATC 1440 1441 AAGGGGCAGC CCGGCGTTGG CGGCGGCGGA ATGATGCCTG GTCTTTCCTT CCCCAGCATT 1500 1501 CCCGGCCTTC CTCTCCAGCA GGTTCCCAGC TCTGGCCCTG GCGGCAGCGG TTTTATACCG 1560 1561 CCACCACCCA TCATCCCCGG CGTCGGCGGT GCCACCGGTG TCCCGCCTCC TCTCCCCTTC 1620 1621 CCTATCCCCG GCATGCCCGG TCTGCCTGCC GGTGTCGTCC CGCCGCCCCT TCCGGGTTTA 1680 1681 GATCTGAAGA ACCCGCCCGA CTTTAGCGCG CTCGCTGAAA TGATGAAGAA GGCCGGTTAT 1740 1741 CAACCGCCGC CGCCGCCAGG CTCGGCTGGC GCACCGATGC CCCCTCCCGG CATCCTGCCC 1800 1801 CCTGGCCTAA TCCCCCCGCC GGGCGCGGCG GGCTTCCCTA TGCCCCCTCC TGGGTTTGCG 1860 1861 CCTCCGCCGC TGATTCCTGG TGCTGGTGGT CCGCCGGGAG GAGCCACTCA CCCCGATGGT 1920 1921 GGGAATGATC AGTATGATTC GTCAGGGAGG AGACGCGCGC CGTTGCCTAG TCAGGAGGAG 1980 1981 AGTCTTAGGA TGGAGCAGAG CAAGGGCAAT TATACGCGCG TGAGATAG 2028 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | MRNA cleavage and polyadenylation specificity factor complex | |
Biological Process | Chromosome segregation | |
Biological Process | MRNA polyadenylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cogr-1104 | Colletotrichum graminicola | 80.71 | 0.0 | 678 |
| LLPS-Coo-1005 | Colletotrichum orbiculare | 80.32 | 0.0 | 691 |
| LLPS-Fuv-0210 | Fusarium verticillioides | 79.58 | 0.0 | 690 |
| LLPS-Fuo-1186 | Fusarium oxysporum | 79.35 | 0.0 | 688 |
| LLPS-Fus-0153 | Fusarium solani | 79.35 | 0.0 | 691 |
| LLPS-Trr-0170 | Trichoderma reesei | 78.89 | 0.0 | 690 |
| LLPS-Beb-0444 | Beauveria bassiana | 78.89 | 0.0 | 697 |
| LLPS-Trv-1381 | Trichoderma virens | 78.65 | 0.0 | 686 |
| LLPS-Mao-0478 | Magnaporthe oryzae | 77.78 | 0.0 | 692 |
| LLPS-Blg-0770 | Blumeria graminis | 75.97 | 0.0 | 696 |
| LLPS-Gag-0756 | Gaeumannomyces graminis | 75.0 | 0.0 | 665 |
| LLPS-Map-0187 | Magnaporthe poae | 74.54 | 9e-149 | 445 |
| LLPS-Ved-0643 | Verticillium dahliae | 72.33 | 0.0 | 658 |
| LLPS-Lem-0668 | Leptosphaeria maculans | 69.21 | 0.0 | 584 |
| LLPS-Pytr-0842 | Pyrenophora triticirepentis | 68.97 | 0.0 | 584 |
| LLPS-Pyt-0611 | Pyrenophora teres | 67.98 | 0.0 | 612 |
| LLPS-Asc-0559 | Aspergillus clavatus | 67.2 | 0.0 | 582 |
| LLPS-Nef-0118 | Neosartorya fischeri | 66.92 | 0.0 | 533 |
| LLPS-Phn-0624 | Phaeosphaeria nodorum | 66.59 | 0.0 | 596 |
| LLPS-Asni-0842 | Aspergillus niger | 66.56 | 4e-145 | 433 |
| LLPS-Ast-0290 | Aspergillus terreus | 66.28 | 0.0 | 579 |
| LLPS-Aso-0371 | Aspergillus oryzae | 66.06 | 0.0 | 574 |
| LLPS-Asf-0214 | Aspergillus flavus | 65.65 | 0.0 | 557 |
| LLPS-Tum-0188 | Tuber melanosporum | 65.45 | 2e-179 | 531 |
| LLPS-Asfu-0832 | Aspergillus fumigatus | 65.32 | 2e-171 | 507 |
| LLPS-Asn-0316 | Aspergillus nidulans | 64.35 | 0.0 | 545 |
| LLPS-Zyt-1201 | Zymoseptoria tritici | 62.56 | 0.0 | 551 |
| LLPS-Dos-0756 | Dothistroma septosporum | 59.66 | 3e-179 | 531 |
| LLPS-Scp-1532 | Schizosaccharomyces pombe | 53.1 | 5e-147 | 444 |
| LLPS-Scj-1467 | Schizosaccharomyces japonicus | 52.1 | 2e-141 | 429 |
| LLPS-Kop-0460 | Komagataella pastoris | 51.72 | 5e-131 | 401 |
| LLPS-Miv-1413 | Microbotryum violaceum | 50.13 | 7e-125 | 390 |
| LLPS-Pug-0407 | Puccinia graminis | 49.47 | 3e-127 | 400 |
| LLPS-Spr-0864 | Sporisorium reilianum | 49.32 | 3e-109 | 350 |
| LLPS-Put-1009 | Puccinia triticina | 49.25 | 4e-109 | 352 |
| LLPS-Gaga-1895 | Gallus gallus | 48.41 | 2e-44 | 166 |
| LLPS-Usm-1167 | Ustilago maydis | 47.8 | 3e-105 | 340 |
| LLPS-Asg-0017 | Ashbya gossypii | 47.14 | 1e-110 | 348 |
| LLPS-Yal-0839 | Yarrowia lipolytica | 46.98 | 3e-115 | 363 |
| LLPS-Abg-0925 | Absidia glauca | 46.87 | 2e-124 | 391 |
| LLPS-Art-2827 | Arabidopsis thaliana | 46.63 | 4e-109 | 351 |
| LLPS-Sac-1127 | Saccharomyces cerevisiae | 46.45 | 5e-108 | 342 |
| LLPS-Asm-1572 | Astyanax mexicanus | 46.37 | 1e-103 | 346 |
| LLPS-Mup-0977 | Mustela putorius furo | 46.15 | 3e-100 | 339 |
| LLPS-Arl-0952 | Arabidopsis lyrata | 46.09 | 6e-112 | 358 |
| LLPS-Prp-2057 | Prunus persica | 45.82 | 4e-115 | 369 |
| LLPS-Php-2533 | Physcomitrella patens | 45.81 | 7e-115 | 367 |
| LLPS-Ora-1459 | Ornithorhynchus anatinus | 45.78 | 3e-104 | 350 |
| LLPS-Gas-1341 | Galdieria sulphuraria | 45.75 | 5e-112 | 350 |
| LLPS-Sem-1759 | Selaginella moellendorffii | 45.66 | 4e-118 | 367 |
| LLPS-Thc-0977 | Theobroma cacao | 45.57 | 7e-114 | 365 |
| LLPS-Brn-1400 | Brassica napus | 45.57 | 6e-114 | 363 |
| LLPS-Brr-0795 | Brassica rapa | 45.57 | 5e-114 | 363 |
| LLPS-Cap-1075 | Cavia porcellus | 45.5 | 1e-103 | 349 |
| LLPS-Met-1306 | Medicago truncatula | 45.43 | 6e-113 | 363 |
| LLPS-Gor-0321 | Gossypium raimondii | 45.32 | 4e-111 | 358 |
| LLPS-Bro-0139 | Brassica oleracea | 45.31 | 8e-114 | 363 |
| LLPS-Glm-1440 | Glycine max | 45.18 | 9e-114 | 365 |
| LLPS-Viv-1366 | Vitis vinifera | 45.18 | 5e-113 | 364 |
| LLPS-Dac-0458 | Daucus carota | 45.16 | 1e-76 | 256 |
| LLPS-Cus-1721 | Cucumis sativus | 44.8 | 2e-112 | 360 |
| LLPS-Hea-0832 | Helianthus annuus | 44.76 | 5e-109 | 350 |
| LLPS-Phv-1707 | Phaseolus vulgaris | 44.63 | 4e-113 | 363 |
| LLPS-Mae-0521 | Manihot esculenta | 44.56 | 1e-111 | 360 |
| LLPS-Via-0057 | Vigna angularis | 44.39 | 1e-112 | 362 |
| LLPS-Coc-1780 | Corchorus capsularis | 44.3 | 3e-110 | 361 |
| LLPS-Amt-0524 | Amborella trichopoda | 44.09 | 3e-106 | 344 |
| LLPS-Icp-2196 | Ictalurus punctatus | 44.08 | 2e-105 | 351 |
| LLPS-Ran-3295 | Rattus norvegicus | 44.05 | 6e-105 | 353 |
| LLPS-Paa-0487 | Papio anubis | 44.05 | 4e-105 | 354 |
| LLPS-Mal-0710 | Mandrillus leucophaeus | 44.05 | 5e-105 | 353 |
| LLPS-Aim-2597 | Ailuropoda melanoleuca | 44.05 | 6e-105 | 354 |
| LLPS-Myl-0335 | Myotis lucifugus | 44.05 | 3e-105 | 354 |
| LLPS-Ova-2604 | Ovis aries | 44.05 | 4e-105 | 354 |
| LLPS-Dio-3357 | Dipodomys ordii | 44.05 | 2e-105 | 355 |
| LLPS-Bot-0577 | Bos taurus | 44.05 | 4e-105 | 354 |
| LLPS-Gog-3555 | Gorilla gorilla | 44.05 | 4e-105 | 354 |
| LLPS-Fud-0154 | Fukomys damarensis | 44.05 | 3e-105 | 354 |
| LLPS-Caj-1509 | Callithrix jacchus | 44.05 | 5e-105 | 353 |
| LLPS-Maf-1897 | Macaca fascicularis | 44.05 | 4e-105 | 354 |
| LLPS-Mum-1825 | Mus musculus | 44.05 | 3e-105 | 354 |
| LLPS-Mea-4009 | Mesocricetus auratus | 44.05 | 5e-105 | 354 |
| LLPS-Sus-3270 | Sus scrofa | 44.05 | 5e-105 | 353 |
| LLPS-Aon-2888 | Aotus nancymaae | 44.05 | 3e-105 | 354 |
| LLPS-Cea-2021 | Cercocebus atys | 44.05 | 4e-105 | 354 |
| LLPS-Xet-1103 | Xenopus tropicalis | 44.05 | 3e-104 | 353 |
| LLPS-Cas-3820 | Carlito syrichta | 44.05 | 3e-105 | 354 |
| LLPS-Anc-1898 | Anolis carolinensis | 44.05 | 3e-105 | 354 |
| LLPS-Nol-4232 | Nomascus leucogenys | 44.05 | 5e-105 | 354 |
| LLPS-Ict-2046 | Ictidomys tridecemlineatus | 44.05 | 3e-105 | 354 |
| LLPS-Tag-3508 | Taeniopygia guttata | 44.05 | 6e-105 | 353 |
| LLPS-Poa-1821 | Pongo abelii | 44.05 | 5e-105 | 354 |
| LLPS-Caf-3279 | Canis familiaris | 44.05 | 5e-105 | 353 |
| LLPS-Eqc-3656 | Equus caballus | 44.05 | 4e-105 | 354 |
| LLPS-Mam-2046 | Macaca mulatta | 44.05 | 4e-105 | 354 |
| LLPS-Otg-0109 | Otolemur garnettii | 44.05 | 5e-105 | 353 |
| LLPS-Pes-1959 | Pelodiscus sinensis | 44.05 | 8e-105 | 353 |
| LLPS-Orc-0502 | Oryctolagus cuniculus | 44.05 | 3e-105 | 354 |
| LLPS-Hos-1371 | Homo sapiens | 44.05 | 4e-105 | 354 |
| LLPS-Meg-1935 | Meleagris gallopavo | 44.05 | 5e-105 | 353 |
| LLPS-Pat-2382 | Pan troglodytes | 44.05 | 4e-105 | 354 |
| LLPS-Pap-0113 | Pan paniscus | 44.05 | 5e-105 | 354 |
| LLPS-Urm-3266 | Ursus maritimus | 44.05 | 3e-105 | 354 |
| LLPS-Mod-2178 | Monodelphis domestica | 44.05 | 6e-105 | 353 |
| LLPS-Fec-0819 | Felis catus | 44.05 | 3e-105 | 354 |
| LLPS-Man-2020 | Macaca nemestrina | 44.05 | 5e-105 | 354 |
| LLPS-Loa-0441 | Loxodonta africana | 44.05 | 4e-105 | 354 |
| LLPS-Xim-2685 | Xiphophorus maculatus | 43.83 | 1e-106 | 351 |
| LLPS-Orl-2655 | Oryzias latipes | 43.83 | 1e-104 | 349 |
| LLPS-Ten-1404 | Tetraodon nigroviridis | 43.83 | 5e-105 | 350 |
| LLPS-Anp-2705 | Anas platyrhynchos | 43.83 | 4e-103 | 348 |
| LLPS-Mua-1131 | Musa acuminata | 43.8 | 4e-112 | 360 |
| LLPS-Chs-1553 | Chlorocebus sabaeus | 43.8 | 1e-104 | 353 |
| LLPS-Sah-0221 | Sarcophilus harrisii | 43.69 | 2e-104 | 352 |
| LLPS-Cis-1574 | Ciona savignyi | 43.6 | 2e-97 | 314 |
| LLPS-Lac-0694 | Latimeria chalumnae | 43.54 | 4e-103 | 348 |
| LLPS-Pot-0088 | Populus trichocarpa | 43.54 | 5e-109 | 352 |
| LLPS-Pof-0801 | Poecilia formosa | 43.47 | 2e-103 | 344 |
| LLPS-Crn-1520 | Cryptococcus neoformans | 43.35 | 2e-99 | 327 |
| LLPS-Gaa-0694 | Gasterosteus aculeatus | 43.32 | 3e-102 | 342 |
| LLPS-Leo-0858 | Lepisosteus oculatus | 43.32 | 3e-103 | 348 |
| LLPS-Orn-0652 | Oreochromis niloticus | 43.32 | 6e-104 | 347 |
| LLPS-Dar-2747 | Danio rerio | 43.29 | 3e-105 | 352 |
| LLPS-Sol-0356 | Solanum lycopersicum | 43.07 | 2e-110 | 358 |
| LLPS-Sei-1814 | Setaria italica | 43.04 | 3e-107 | 348 |
| LLPS-Brd-0602 | Brachypodium distachyon | 43.04 | 4e-107 | 348 |
| LLPS-Zem-0719 | Zea mays | 43.04 | 2e-107 | 348 |
| LLPS-Sob-1809 | Sorghum bicolor | 42.82 | 2e-105 | 343 |
| LLPS-Drm-0669 | Drosophila melanogaster | 42.79 | 8e-106 | 346 |
| LLPS-Ori-0395 | Oryza indica | 42.78 | 7e-108 | 349 |
| LLPS-Orbr-1050 | Oryza brachyantha | 42.78 | 2e-108 | 348 |
| LLPS-Chc-0068 | Chondrus crispus | 42.58 | 1e-108 | 340 |
| LLPS-Tra-1469 | Triticum aestivum | 42.03 | 3e-105 | 342 |
| LLPS-Osl-0859 | Ostreococcus lucimarinus | 41.88 | 2e-103 | 327 |
| LLPS-Hov-0315 | Hordeum vulgare | 41.77 | 7e-104 | 340 |
| LLPS-Cae-0537 | Caenorhabditis elegans | 41.75 | 3e-100 | 332 |
| LLPS-Org-1143 | Oryza glaberrima | 41.5 | 1e-76 | 261 |
| LLPS-Cii-0561 | Ciona intestinalis | 39.77 | 5e-95 | 316 |
| LLPS-Orgl-0216 | Oryza glumaepatula | 39.24 | 5e-91 | 304 |
| LLPS-Orni-1210 | Oryza nivara | 39.24 | 6e-91 | 304 |
| LLPS-Orb-2280 | Oryza barthii | 39.24 | 7e-91 | 304 |
| LLPS-Orr-0446 | Oryza rufipogon | 39.24 | 7e-91 | 304 |
| LLPS-Orm-1404 | Oryza meridionalis | 38.99 | 7e-90 | 301 |
| LLPS-Orp-1357 | Oryza punctata | 38.99 | 6e-88 | 296 |
| LLPS-Lep-0789 | Leersia perrieri | 38.73 | 3e-87 | 294 |
| LLPS-Rhb-1850 | Rhinopithecus bieti | 38.58 | 1e-80 | 283 |
| LLPS-Chr-0550 | Chlamydomonas reinhardtii | 38.36 | 6e-77 | 268 |
| LLPS-Scm-2813 | Scophthalmus maximus | 35.54 | 1e-24 | 110 |
| LLPS-Tar-2694 | Takifugu rubripes | 34.94 | 4e-24 | 108 |
| LLPS-Scf-0095 | Scleropages formosus | 34.94 | 4e-24 | 108 |
| LLPS-Fia-1323 | Ficedula albicollis | 34.94 | 3e-24 | 108 |
| LLPS-Vir-0902 | Vigna radiata | 30.75 | 1e-57 | 213 |