LLPS-Nec-0780
erg-3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Delta(14)-sterol reductase; C-14 sterol reductase; Sterol C14-reductase |
| Gene Name: | erg-3, erg3, B2G14.010, NCU08762 |
| Ensembl Gene: | NCU08762 |
| Ensembl Protein: | EAA26875 |
| Organism: | Neurospora crassa |
| Taxa ID: | 367110 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Nuclear pore complex, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAA26875 | EAA26875 |
| UniProt | P38670, ERG24_NEUCR, Q7RV50 | |
| GeneBank | CM002238, BX284753, X77955 | EAA26875.1, CAA54919.1, CAD70446.1 |
| RefSeq | XM_951018.2 | XP_956111.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGKQNQAAP KKAVAPRQQH YEFGGPIGAF GITFGLPILV HVFNLFCNDI SGCPAPSLLH 60 61 PKSLDLAQLK REIGWPDNGV FGLFSWSATL WTLGYYALSL VQYRFLPGHH VEGTELSTGG 120 121 RLKYKLNAFN SAMCTLAILA AGTIAQGAEF PVWTFISDNF AQIISANILF AFALAIFVYV 180 181 RSFDVKPGNK DMRQLAAGGV TGSLIYDFYI GRELNPRITL PLIGQVDIKE FMEMRPGLLG 240 241 WIILNCAFIA KQYRLYGYVT DSILFITAIQ AFYVFDGIYM EPAVLTTMDI TTDGFGFMLS 300 301 FGDVVWVPFM YSTQTRYLSV HPQQLGAFGL IAVGAVLAAG YSIFRLSNSQ KNNFRTNPED 360 361 PSVKHLTYLQ TKTGSRLITS GWWGIARHIN YLGDWLQSWP YSLPTGIAGY QILSAGSNAP 420 421 GAITMLDGRE VVQGEARGWG IVFTYFYILY FAILLIHRDL RDDEKCSKKY GDDWEKYKKL 480 481 VKWRIVPGIY 490 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGGGA AGCAAAACCA AGCTGCCCCA AAGAAGGCGG TTGCGCCGCG CCAGCAGCAC 60 61 TACGAGTTTG GCGGCCCCAT CGGCGCCTTT GGCATCACCT TTGGCCTCCC CATTCTCGTC 120 121 CACGTCTTCA ACCTTTTCTG CAACGACATC TCGGGCTGCC CCGCGCCCTC GCTCCTCCAC 180 181 CCCAAGTCTC TCGACCTCGC CCAGCTCAAG CGCGAAATCG GCTGGCCTGA CAATGGCGTC 240 241 TTCGGCCTCT TCTCGTGGTC CGCCACGCTG TGGACTTTGG GCTACTACGC TCTCTCGCTC 300 301 GTTCAATACC GCTTTCTCCC CGGCCACCAC GTCGAGGGAA CCGAGTTGAG CACCGGCGGC 360 361 CGGCTCAAGT ACAAGCTGAA CGCTTTCAAC TCGGCCATGT GCACCTTGGC CATCCTGGCT 420 421 GCCGGCACCA TCGCTCAGGG CGCCGAGTTC CCCGTTTGGA CTTTCATTTC CGACAACTTT 480 481 GCCCAGATCA TCAGCGCCAA TATCCTCTTC GCTTTTGCCC TCGCCATCTT CGTCTACGTT 540 541 CGCAGCTTTG ACGTGAAGCC GGGCAACAAG GACATGCGCC AGCTAGCAGC AGGCGGTGTC 600 601 ACCGGCTCCC TCATCTACGA TTTCTACATT GGTCGCGAGC TCAATCCTCG CATCACTCTG 660 661 CCCCTCATCG GCCAAGTAGA CATCAAGGAA TTCATGGAAA TGCGCCCTGG TCTTCTGGGC 720 721 TGGATCATTC TGAACTGCGC CTTCATCGCC AAGCAATACC GCCTTTACGG TTACGTCACC 780 781 GATTCAATTC TCTTCATCAC TGCCATCCAG GCTTTCTATG TCTTTGACGG AATCTACATG 840 841 GAGCCGGCCG TCTTGACTAC GATGGATATC ACTACCGACG GCTTCGGGTT CATGCTGAGT 900 901 TTCGGAGATG TCGTTTGGGT GCCCTTCATG TACTCGACTC AGACTCGCTA CCTTTCCGTC 960 961 CATCCTCAGC AGCTGGGCGC TTTCGGACTG ATTGCTGTTG GTGCTGTCCT GGCTGCTGGT 1020 1021 TATAGCATCT TCCGCCTGTC CAACTCGCAG AAGAACAACT TTCGCACGAA CCCCGAGGAT 1080 1081 CCTAGTGTTA AGCACCTTAC CTACCTCCAG ACCAAGACTG GATCGCGACT CATTACCTCG 1140 1141 GGATGGTGGG GCATCGCTCG CCACATCAAT TATCTCGGTG ACTGGCTTCA GAGCTGGCCC 1200 1201 TATTCTCTCC CGACCGGCAT TGCTGGCTAC CAGATCTTGA GCGCCGGCAG CAACGCCCCT 1260 1261 GGTGCAATTA CCATGCTTGA CGGGCGCGAG GTTGTCCAGG GCGAGGCGAG AGGCTGGGGT 1320 1321 ATCGTTTTCA CTTACTTTTA CATCTTGTAC TTTGCTATTC TCTTGATCCA CCGCGACCTC 1380 1381 AGAGATGACG AGAAGTGCTC CAAGAAGTAT GGTGACGATT GGGAAAAGTA CAAGAAGCTT 1440 1441 GTCAAGTGGA GAATTGTCCC TGGCATCTAC TAG 1473 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Lipid biosynthesis | |
Lipid metabolism | |
Membrane | |
NADP | |
Oxidoreductase | |
Reference proteome | |
Steroid biosynthesis | |
Steroid metabolism | |
Sterol biosynthesis | |
Sterol metabolism | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of endoplasmic reticulum membrane | |
Molecular Function | Delta14-sterol reductase activity | |
Molecular Function | NADP binding | |
Biological Process | Ergosterol biosynthetic process | |
Biological Process | Sterol biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fus-0138 | Fusarium solani | 68.12 | 0.0 | 673 |
| LLPS-Beb-0881 | Beauveria bassiana | 66.81 | 0.0 | 654 |
| LLPS-Fuo-0301 | Fusarium oxysporum | 66.32 | 0.0 | 660 |
| LLPS-Cogr-0737 | Colletotrichum graminicola | 66.19 | 0.0 | 656 |
| LLPS-Trv-0498 | Trichoderma virens | 65.97 | 0.0 | 616 |
| LLPS-Fuv-0225 | Fusarium verticillioides | 65.71 | 0.0 | 664 |
| LLPS-Trr-0207 | Trichoderma reesei | 65.08 | 0.0 | 632 |
| LLPS-Cog-0814 | Colletotrichum gloeosporioides | 63.12 | 0.0 | 598 |
| LLPS-Coo-0871 | Colletotrichum orbiculare | 62.47 | 0.0 | 626 |
| LLPS-Ved-1159 | Verticillium dahliae | 62.22 | 0.0 | 625 |
| LLPS-Gag-1313 | Gaeumannomyces graminis | 61.68 | 0.0 | 577 |
| LLPS-Map-0760 | Magnaporthe poae | 61.47 | 0.0 | 576 |
| LLPS-Mao-0955 | Magnaporthe oryzae | 61.46 | 0.0 | 583 |
| LLPS-Asf-1230 | Aspergillus flavus | 61.09 | 0.0 | 582 |
| LLPS-Aso-1434 | Aspergillus oryzae | 60.88 | 0.0 | 578 |
| LLPS-Asc-0798 | Aspergillus clavatus | 60.16 | 0.0 | 568 |
| LLPS-Asni-0568 | Aspergillus niger | 60.08 | 0.0 | 580 |
| LLPS-Nef-1103 | Neosartorya fischeri | 60.08 | 0.0 | 568 |
| LLPS-Asfu-0541 | Aspergillus fumigatus | 59.79 | 0.0 | 550 |
| LLPS-Pyt-0217 | Pyrenophora teres | 59.06 | 0.0 | 567 |
| LLPS-Lem-0533 | Leptosphaeria maculans | 59.04 | 0.0 | 551 |
| LLPS-Dos-0061 | Dothistroma septosporum | 58.88 | 0.0 | 542 |
| LLPS-Scs-0554 | Sclerotinia sclerotiorum | 58.67 | 0.0 | 598 |
| LLPS-Phn-0891 | Phaeosphaeria nodorum | 58.06 | 0.0 | 553 |
| LLPS-Pytr-0091 | Pyrenophora triticirepentis | 57.23 | 0.0 | 540 |
| LLPS-Asn-0193 | Aspergillus nidulans | 56.51 | 0.0 | 540 |
| LLPS-Blg-0103 | Blumeria graminis | 55.82 | 0.0 | 560 |
| LLPS-Ast-1019 | Aspergillus terreus | 55.51 | 2e-166 | 487 |
| LLPS-Zyt-0058 | Zymoseptoria tritici | 54.81 | 4e-171 | 499 |
| LLPS-Miv-0795 | Microbotryum violaceum | 45.45 | 7e-103 | 320 |
| LLPS-Pug-0087 | Puccinia graminis | 44.38 | 7e-116 | 355 |
| LLPS-Tum-1101 | Tuber melanosporum | 44.35 | 7e-120 | 365 |
| LLPS-Scj-0911 | Schizosaccharomyces japonicus | 44.21 | 8e-116 | 355 |
| LLPS-Aim-1356 | Ailuropoda melanoleuca | 44.18 | 8e-76 | 256 |
| LLPS-Urm-2597 | Ursus maritimus | 43.64 | 3e-75 | 253 |
| LLPS-Osl-0954 | Ostreococcus lucimarinus | 43.49 | 1e-116 | 358 |
| LLPS-Abg-1128 | Absidia glauca | 43.27 | 3e-111 | 344 |
| LLPS-Scp-1371 | Schizosaccharomyces pombe | 42.74 | 1e-110 | 342 |
| LLPS-Mel-0723 | Melampsora laricipopulina | 42.71 | 3e-111 | 343 |
| LLPS-Put-0736 | Puccinia triticina | 42.66 | 1e-69 | 234 |
| LLPS-Leo-1690 | Lepisosteus oculatus | 42.61 | 1e-71 | 244 |
| LLPS-Spr-1492 | Sporisorium reilianum | 42.32 | 2e-106 | 333 |
| LLPS-Dio-2620 | Dipodomys ordii | 41.36 | 3e-83 | 275 |
| LLPS-Fud-2239 | Fukomys damarensis | 41.32 | 3e-83 | 270 |
| LLPS-Xet-2859 | Xenopus tropicalis | 41.19 | 1e-89 | 287 |
| LLPS-Meg-1504 | Meleagris gallopavo | 40.62 | 2e-66 | 229 |
| LLPS-Cap-2389 | Cavia porcellus | 40.51 | 5e-78 | 256 |
| LLPS-Usm-0329 | Ustilago maydis | 40.41 | 1e-96 | 308 |
| LLPS-Chs-2536 | Chlorocebus sabaeus | 40.15 | 3e-84 | 279 |
| LLPS-Chr-0654 | Chlamydomonas reinhardtii | 39.96 | 2e-96 | 305 |
| LLPS-Ict-2385 | Ictidomys tridecemlineatus | 39.9 | 5e-80 | 268 |
| LLPS-Anc-2130 | Anolis carolinensis | 39.69 | 5e-82 | 266 |
| LLPS-Mod-2604 | Monodelphis domestica | 39.58 | 4e-91 | 296 |
| LLPS-Tar-1077 | Takifugu rubripes | 39.51 | 5e-86 | 278 |
| LLPS-Scc-0024 | Schizosaccharomyces cryophilus | 39.34 | 2e-99 | 312 |
| LLPS-Ora-1571 | Ornithorhynchus anatinus | 39.19 | 5e-88 | 288 |
| LLPS-Eqc-0768 | Equus caballus | 39.0 | 3e-85 | 281 |
| LLPS-Yal-0095 | Yarrowia lipolytica | 38.78 | 7e-86 | 278 |
| LLPS-Caj-0056 | Callithrix jacchus | 38.7 | 5e-88 | 288 |
| LLPS-Poa-0942 | Pongo abelii | 38.7 | 2e-88 | 290 |
| LLPS-Pat-2170 | Pan troglodytes | 38.7 | 1e-89 | 293 |
| LLPS-Pap-1514 | Pan paniscus | 38.7 | 1e-89 | 293 |
| LLPS-Fec-0118 | Felis catus | 38.7 | 2e-77 | 260 |
| LLPS-Gaa-2206 | Gasterosteus aculeatus | 38.69 | 1e-81 | 272 |
| LLPS-Bot-0447 | Bos taurus | 38.64 | 6e-80 | 267 |
| LLPS-Ten-0569 | Tetraodon nigroviridis | 38.56 | 2e-82 | 268 |
| LLPS-Sah-1045 | Sarcophilus harrisii | 38.52 | 3e-72 | 247 |
| LLPS-Hos-1217 | Homo sapiens | 38.49 | 1e-88 | 290 |
| LLPS-Gaga-3274 | Gallus gallus | 38.33 | 6e-82 | 273 |
| LLPS-Mal-0406 | Mandrillus leucophaeus | 38.28 | 1e-88 | 290 |
| LLPS-Paa-0506 | Papio anubis | 38.28 | 2e-88 | 290 |
| LLPS-Cea-2968 | Cercocebus atys | 38.28 | 2e-88 | 290 |
| LLPS-Maf-0714 | Macaca fascicularis | 38.28 | 1e-88 | 290 |
| LLPS-Mam-1002 | Macaca mulatta | 38.28 | 1e-88 | 290 |
| LLPS-Otg-1095 | Otolemur garnettii | 38.28 | 5e-76 | 257 |
| LLPS-Man-0323 | Macaca nemestrina | 38.28 | 1e-88 | 290 |
| LLPS-Cas-3079 | Carlito syrichta | 38.27 | 3e-87 | 286 |
| LLPS-Ova-2133 | Ovis aries | 38.14 | 5e-79 | 265 |
| LLPS-Tut-0699 | Tursiops truncatus | 38.14 | 4e-83 | 276 |
| LLPS-Xim-1427 | Xiphophorus maculatus | 38.11 | 2e-77 | 262 |
| LLPS-Gog-2226 | Gorilla gorilla | 38.09 | 4e-88 | 288 |
| LLPS-Tag-0169 | Taeniopygia guttata | 38.02 | 6e-87 | 285 |
| LLPS-Pof-0311 | Poecilia formosa | 37.96 | 8e-84 | 273 |
| LLPS-Dar-2361 | Danio rerio | 37.89 | 3e-76 | 258 |
| LLPS-Lac-2205 | Latimeria chalumnae | 37.89 | 1e-83 | 277 |
| LLPS-Nol-0052 | Nomascus leucogenys | 37.87 | 2e-85 | 281 |
| LLPS-Caf-0267 | Canis familiaris | 37.76 | 3e-77 | 260 |
| LLPS-Mup-1150 | Mustela putorius furo | 37.71 | 3e-80 | 268 |
| LLPS-Icp-2088 | Ictalurus punctatus | 37.65 | 4e-67 | 233 |
| LLPS-Myl-1510 | Myotis lucifugus | 37.63 | 7e-81 | 270 |
| LLPS-Crn-1361 | Cryptococcus neoformans | 37.58 | 2e-84 | 275 |
| LLPS-Scf-2700 | Scleropages formosus | 37.47 | 7e-86 | 283 |
| LLPS-Aon-2177 | Aotus nancymaae | 37.47 | 7e-76 | 256 |
| LLPS-Mum-0468 | Mus musculus | 37.4 | 2e-82 | 274 |
| LLPS-Kop-1026 | Komagataella pastoris | 37.39 | 1e-79 | 261 |
| LLPS-Scm-0700 | Scophthalmus maximus | 37.3 | 3e-82 | 273 |
| LLPS-Asm-1629 | Astyanax mexicanus | 37.11 | 1e-78 | 263 |
| LLPS-Anp-1485 | Anas platyrhynchos | 37.03 | 2e-81 | 271 |
| LLPS-Asg-1295 | Ashbya gossypii | 37.01 | 6e-85 | 275 |
| LLPS-Orc-1554 | Oryctolagus cuniculus | 37.01 | 2e-81 | 271 |
| LLPS-Sus-1782 | Sus scrofa | 36.97 | 1e-79 | 266 |
| LLPS-Mea-2105 | Mesocricetus auratus | 36.9 | 8e-84 | 277 |
| LLPS-Rhb-0721 | Rhinopithecus bieti | 36.53 | 1e-77 | 261 |
| LLPS-Pes-1288 | Pelodiscus sinensis | 36.51 | 3e-83 | 276 |
| LLPS-Loa-2402 | Loxodonta africana | 36.42 | 8e-82 | 272 |
| LLPS-Sac-0911 | Saccharomyces cerevisiae | 36.11 | 1e-84 | 275 |
| LLPS-Fia-2575 | Ficedula albicollis | 35.98 | 4e-81 | 271 |
| LLPS-Orn-1152 | Oreochromis niloticus | 35.9 | 1e-77 | 261 |
| LLPS-Ran-0705 | Rattus norvegicus | 35.55 | 2e-72 | 247 |
| LLPS-Orl-0649 | Oryzias latipes | 35.47 | 2e-70 | 241 |
| LLPS-Tru-0810 | Triticum urartu | 35.17 | 5e-42 | 157 |
| LLPS-Cus-0382 | Cucumis sativus | 35.02 | 2e-42 | 160 |
| LLPS-Hov-0071 | Hordeum vulgare | 34.14 | 1e-39 | 153 |
| LLPS-Orni-0554 | Oryza nivara | 34.14 | 8e-37 | 150 |
| LLPS-Zem-2408 | Zea mays | 33.33 | 2e-40 | 156 |
| LLPS-Sei-0230 | Setaria italica | 32.73 | 1e-44 | 166 |
| LLPS-Nia-1006 | Nicotiana attenuata | 32.27 | 8e-45 | 167 |
| LLPS-Php-0923 | Physcomitrella patens | 32.08 | 4e-53 | 190 |
| LLPS-Amt-1184 | Amborella trichopoda | 32.02 | 1e-46 | 172 |
| LLPS-Hea-1053 | Helianthus annuus | 32.0 | 5e-45 | 167 |
| LLPS-Brd-1079 | Brachypodium distachyon | 31.86 | 1e-41 | 158 |
| LLPS-Viv-1341 | Vitis vinifera | 31.86 | 2e-45 | 168 |
| LLPS-Coc-1569 | Corchorus capsularis | 31.8 | 8e-47 | 172 |
| LLPS-Sob-0302 | Sorghum bicolor | 31.69 | 1e-43 | 164 |
| LLPS-Ori-1245 | Oryza indica | 31.62 | 3e-41 | 160 |
| LLPS-Met-1224 | Medicago truncatula | 31.53 | 1e-49 | 179 |
| LLPS-Tra-0277 | Triticum aestivum | 31.53 | 2e-42 | 160 |
| LLPS-Glm-0649 | Glycine max | 31.53 | 1e-46 | 172 |
| LLPS-Sem-1399 | Selaginella moellendorffii | 31.43 | 2e-46 | 171 |
| LLPS-Orgl-0405 | Oryza glumaepatula | 31.37 | 2e-42 | 160 |
| LLPS-Thc-1474 | Theobroma cacao | 31.37 | 3e-44 | 165 |
| LLPS-Orb-2378 | Oryza barthii | 31.37 | 1e-41 | 157 |
| LLPS-Orr-1056 | Oryza rufipogon | 31.37 | 1e-41 | 158 |
| LLPS-Orbr-0480 | Oryza brachyantha | 31.37 | 1e-40 | 155 |
| LLPS-Orp-1938 | Oryza punctata | 31.37 | 4e-41 | 156 |
| LLPS-Ors-1290 | Oryza sativa | 31.37 | 9e-42 | 158 |
| LLPS-Chc-0815 | Chondrus crispus | 31.34 | 5e-47 | 173 |
| LLPS-Gor-0014 | Gossypium raimondii | 31.31 | 2e-45 | 168 |
| LLPS-Phv-1177 | Phaseolus vulgaris | 31.28 | 6e-48 | 175 |
| LLPS-Orm-1984 | Oryza meridionalis | 31.13 | 2e-40 | 154 |
| LLPS-Org-0757 | Oryza glaberrima | 31.1 | 2e-40 | 154 |
| LLPS-Sot-0058 | Solanum tuberosum | 31.03 | 4e-46 | 170 |
| LLPS-Mua-2202 | Musa acuminata | 30.99 | 5e-46 | 170 |
| LLPS-Pot-1296 | Populus trichocarpa | 30.95 | 3e-43 | 163 |
| LLPS-Gas-0219 | Galdieria sulphuraria | 30.91 | 8e-39 | 150 |
| LLPS-Arl-2153 | Arabidopsis lyrata | 30.73 | 4e-47 | 173 |
| LLPS-Prp-1440 | Prunus persica | 30.56 | 9e-46 | 169 |
| LLPS-Sol-0841 | Solanum lycopersicum | 30.54 | 4e-45 | 167 |
| LLPS-Art-2877 | Arabidopsis thaliana | 30.48 | 2e-45 | 168 |
| LLPS-Brn-1055 | Brassica napus | 30.3 | 4e-45 | 167 |
| LLPS-Brr-0247 | Brassica rapa | 30.3 | 4e-45 | 167 |
| LLPS-Bro-0117 | Brassica oleracea | 30.15 | 6e-46 | 170 |
| LLPS-Cis-0025 | Ciona savignyi | 29.51 | 5e-38 | 150 |
| LLPS-Cym-0606 | Cyanidioschyzon merolae | 29.26 | 8e-37 | 145 |
| LLPS-Cii-0209 | Ciona intestinalis | 27.88 | 1e-46 | 176 |
| LLPS-Drm-0104 | Drosophila melanogaster | 25.05 | 3e-16 | 85.5 |