• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Nec-0612
apg-5

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Ubiquitin-like modifier-activating enzyme atg7; ATG12-activating enzyme E1 atg7; Autophagy-related protein 7
Gene Name: apg-5, atg7, 100H1.190, NCU06672
Ensembl Gene: NCU06672
Ensembl Protein: ESA42584
Organism: Neurospora crassa
Taxa ID: 367110
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with apg-4/atg5 and apg-6/atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the apg-6/atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MDLKFATFSS  EIELPFYSAL  FSSKLDHDKL  DSSARPVLGL  YEPRSHASPE  ASTRMQILGS  60
61    ALTSDQDESG  PLGMTRAEGY  IKNVNTIEEF  KNTDKNAMIK  KAGEQIWDAI  QDGTIYSCPS  120
121   LLASFRILSY  ADLKKYKFTY  WFAFPALHSE  PQWKRTGPIG  RLTSDESTAL  VERIGTWRYM  180
181   VDRREHGFFL  AKKVRREAAG  PRSSLDDPGV  DIGYRWDIGS  LRDFETGFFN  DAAEEDRYVA  240
241   FVDPSNYPEY  PSWPLRNLLI  LIRQRYRLNK  VQILCYRDTQ  PRRHEARSTI  LPLAMDQVGD  300
301   VELKCMPKVT  GWERNGNGDL  RPRVANLAEY  MDPTRLADQA  VDLNLKLMKW  RLAPNLDLDA  360
361   IKNTKCLLLG  AGTLGSYVSR  NLLGWGVRKI  TFIDYGSVSY  SNPVRQPLFK  FEDCHNGGKP  420
421   KAIQAAEALK  EIYPGVDVEG  YALSVPMLDH  AIHNEAKTKA  DFDKLKELID  SHDAIFLLMD  480
481   TRESRWLPTL  MGKAANKIVM  NAALGFDTYV  VMRHGAAPND  GSEETLGCYF  CNDVVVAADS  540
541   MKDQTLDQQC  TVTRPGVAAI  ASALLVELLT  SILQHPLKQH  APAPVSTGTG  SAVSYERDPP  600
601   DHPLGLVPHQ  VRGFLSNFQN  MVIRGKSYPQ  CSACSKPILD  AYKEGGWEFV  KTALASRDYV  660
661   AELSGLAEVQ  RLAEKAAAEM  QWSEDEEGMD  EEEGEGELI  699
Nucleotide CDS Sequence (FASTA)
1     ATGGATCTCA  AGTTTGCGAC  CTTCTCCTCG  GAGATCGAGC  TGCCCTTCTA  CTCGGCCCTC  60
61    TTCTCATCCA  AACTCGACCA  TGACAAGCTC  GACTCTTCGG  CCCGCCCTGT  CTTGGGCTTA  120
121   TATGAACCTC  GGTCGCACGC  GAGTCCAGAG  GCCAGTACGA  GAATGCAGAT  CTTGGGGAGC  180
181   GCCCTAACAA  GCGACCACGG  GCCCTTGGGC  ATGACGAGAG  CCGAAGGCTA  CATTAAGAAC  240
241   GTCAACACGA  TCGAGGAATT  CAAAAACACG  GACAAAAATG  CGATGATCAA  GAAGGCGGGC  300
301   GAACAGATCT  GGGATGCTAT  TCAAGACGGC  ACGATATACT  CCTGCCCATC  GCTACTTGCC  360
361   TCTTTCCGGA  TCCTGTCATA  CGCCGACCTG  AAGAAGTACA  AGTTTACCTA  CTGGTTCGCA  420
421   TTTCCAGCCC  TACACTCGGA  GCCGCAGTGG  AAGCGAACAG  GACCGATTGG  CCGGTTGACC  480
481   TCGGACGAAA  GCACTGCTTT  GGTCGAGCGC  ATAGGAACAT  GGCGATACAT  GGTTGACAGG  540
541   AGAGAGCACG  GATTCTTCCT  CGCAAAGAAA  GTGCGTCGCG  AGGCCGCAGG  CCCAAGATCC  600
601   TCACTTGATG  ATCCCGGGGT  CGATATCGGC  TACCGTTGGG  ATATTGGATC  TCTCAGAGAC  660
661   TTCGAGACGG  GATTCTTCAA  CGACGCGGCG  GAAGAGGACA  GATATGTTGC  TTTCGTGGAC  720
721   CCATCCAACT  ATCCCGAGTA  CCCTTCCTGG  CCTCTTCGTA  ATCTCCTCAT  CCTTATCCGG  780
781   CAAAGATACC  GCCTCAACAA  GGTCCAAATT  CTCTGCTACC  GCGACACGCA  GCCTAGGAGA  840
841   CATGAAGCGC  GGAGCACCAT  CCTGCCACTG  GCGATGGACC  AAGTTGGCGA  CGTGGAGTTG  900
901   AAGTGTATGC  CCAAGGTTAC  CGGCTGGGAG  AGGAACGGTA  ACGGCGATCT  CAGGCCACGG  960
961   GTCGCGAATC  TGGCAGAGTA  CATGGATCCC  ACTCGACTAG  CAGACCAGGC  AGTGGACTTG  1020
1021  AACTTGAAGC  TGATGAAGTG  GCGGCTCGCG  CCGAATCTTG  ACTTGGACGC  GATCAAGAAT  1080
1081  ACGAAATGCT  TGTTGCTGGG  CGCAGGGACA  CTCGGCAGCT  ATGTCTCGAG  AAACCTGCTA  1140
1141  GGGTGGGGAG  TTCGCAAGAT  CACGTTTATT  GATTATGGGA  GCGTATCTTA  TTCAAACCCA  1200
1201  GTACGGCAGC  CTCTCTTCAA  GTTTGAAGAT  TGTCACAATG  GGGGAAAGCC  GAAGGCTATT  1260
1261  CAAGCTGCCG  AGGCACTTAA  AGAAATTTAT  CCAGGAGTTG  ATGTAGAGGG  CTACGCACTC  1320
1321  TCTGTTCCGA  TGCTGGACCA  CGCGATCCAC  AACGAGGCAA  AAACCAAAGC  AGACTTTGAC  1380
1381  AAGCTGAAGG  AGTTAATCGA  TTCACACGAT  GCGATCTTCC  TCCTCATGGA  CACGCGCGAG  1440
1441  TCCCGATGGC  TGCCCACACT  GATGGGCAAA  GCTGCGAACA  AGATCGTGAT  GAATGCGGCA  1500
1501  CTCGGATTCG  ACACCTACGT  TGTCATGCGA  CATGGTGCGG  CGCCGAACGA  CGGCAGTGAA  1560
1561  GAGACCCTTG  GATGTTATTT  TTGCAACGAC  GTAGTAGTTG  CTGCCGATTC  GATGAAAGAC  1620
1621  CAAACGCTCG  ACCAACAATG  TACCGTCACC  CGTCCCGGCG  TGGCAGCCAT  CGCTTCGGCC  1680
1681  CTCCTCGTCG  AGCTTCTCAC  TAGCATTTTG  CAGCACCCGC  TCAAGCAACA  CGCGCCCGCG  1740
1741  CCCGTCTCAA  CCGGCACCGG  CTCTGCCGTC  TCGTACGAGC  GCGATCCCCC  TGACCATCCC  1800
1801  CTCGGTCTTG  TCCCGCACCA  GGTCCGCGGT  TTCCTATCCA  ACTTCCAGAA  CATGGTTATA  1860
1861  CGCGGCAAGT  CGTACCCGCA  GTGCAGCGCC  TGCAGCAAGC  CCATCCTCGA  CGCATACAAG  1920
1921  GAGGGCGGAT  GGGAGTTTGT  CAAGACGGCG  CTGGCTAGTC  GGGACTATGT  AGCTGAGCTG  1980
1981  AGTGGGCTGG  CTGAGGTGCA  GCGGTTGGCG  GAGAAGGCGG  CTGCGGAGAT  GCAGTGGAGT  2040
2041  GAGGATGAGG  AGGGGATGGA  TGAGGAGGAA  GGCGAGGGAG  AATTGATTTG  A  2091

▼ KEYWORD


ID
Family
Autophagy
Complete proteome
Cytoplasm
Protein transport
Reference proteome
Transport
Ubl conjugation pathway

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Phagophore assembly site
Molecular Function
Atg12 activating enzyme activity
Molecular Function
Atg8 activating enzyme activity
Biological Process
Autophagosome assembly
Biological Process
Autophagy of mitochondrion
Biological Process
C-terminal protein lipidation
Biological Process
Cellular response to nitrogen starvation
Biological Process
Late nucleophagy
Biological Process
Piecemeal microautophagy of the nucleus
Biological Process
Protein modification by small protein conjugation
Biological Process
Protein transport

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fus-1078Fusarium solani72.50.0 967
LLPS-Map-0669Magnaporthe poae71.870.0 979
LLPS-Trr-0102Trichoderma reesei70.910.0 944
LLPS-Gag-1089Gaeumannomyces graminis70.850.0 951
LLPS-Trv-1178Trichoderma virens70.740.0 935
LLPS-Fuo-1037Fusarium oxysporum70.320.0 949
LLPS-Cog-1156Colletotrichum gloeosporioides70.190.0 954
LLPS-Cogr-1399Colletotrichum graminicola70.090.0 955
LLPS-Beb-1608Beauveria bassiana69.550.0 951
LLPS-Mao-0506Magnaporthe oryzae68.370.0 964
LLPS-Fuv-0990Fusarium verticillioides66.277e-89 306
LLPS-Ved-1343Verticillium dahliae65.950.0 905
LLPS-Coo-0675Colletotrichum orbiculare65.940.0 900
LLPS-Scs-1006Sclerotinia sclerotiorum63.860.0 877
LLPS-Asni-1150Aspergillus niger62.43e-90 288
LLPS-Blg-0352Blumeria graminis60.090.0 840
LLPS-Asn-1608Aspergillus nidulans59.570.0 768
LLPS-Lem-0277Leptosphaeria maculans58.620.0 624
LLPS-Asf-0936Aspergillus flavus57.790.0 696
LLPS-Asc-1565Aspergillus clavatus57.730.0 759
LLPS-Zyt-0499Zymoseptoria tritici57.140.0 766
LLPS-Tum-1059Tuber melanosporum56.70.0 719
LLPS-Aso-1417Aspergillus oryzae56.460.0 775
LLPS-Pyt-0028Pyrenophora teres56.450.0 600
LLPS-Nef-1593Neosartorya fischeri54.580.0 730
LLPS-Pytr-0330Pyrenophora triticirepentis54.150.0 705
LLPS-Asfu-1014Aspergillus fumigatus54.030.0 711
LLPS-Sac-1552Saccharomyces cerevisiae53.997e-133 413
LLPS-Ast-1535Aspergillus terreus52.830.0 682
LLPS-Dos-0354Dothistroma septosporum51.570.0 744
LLPS-Phn-1045Phaeosphaeria nodorum51.450.0 618
LLPS-Aon-4511Aotus nancymaae47.142e-124 392
LLPS-Cii-1243Ciona intestinalis44.65e-169 508
LLPS-Scp-0696Schizosaccharomyces pombe44.264e-164 494
LLPS-Orp-1234Oryza punctata44.257e-79 278
LLPS-Anc-1239Anolis carolinensis44.212e-155 470
LLPS-Mae-2356Manihot esculenta44.071e-127 400
LLPS-Orm-0737Oryza meridionalis43.849e-78 275
LLPS-Org-1822Oryza glaberrima43.689e-78 275
LLPS-Coc-1982Corchorus capsularis43.632e-132 412
LLPS-Aim-2089Ailuropoda melanoleuca43.572e-164 494
LLPS-Orbr-1525Oryza brachyantha43.498e-76 269
LLPS-Orr-2250Oryza rufipogon43.392e-77 273
LLPS-Ors-2148Oryza sativa43.396e-77 272
LLPS-Ori-1296Oryza indica43.393e-77 273
LLPS-Orni-2245Oryza nivara43.392e-77 273
LLPS-Lac-1165Latimeria chalumnae43.361e-95 314
LLPS-Yal-0218Yarrowia lipolytica43.121e-149 455
LLPS-Zem-1672Zea mays43.18e-79 277
LLPS-Spr-1435Sporisorium reilianum42.799e-177 530
LLPS-Leo-2563Lepisosteus oculatus42.564e-173 520
LLPS-Orgl-2156Oryza glumaepatula42.461e-74 266
LLPS-Orb-2353Oryza barthii42.466e-75 266
LLPS-Asg-1065Ashbya gossypii42.445e-150 457
LLPS-Usm-1218Ustilago maydis42.393e-175 527
LLPS-Cas-1960Carlito syrichta42.391e-158 480
LLPS-Icp-2476Ictalurus punctatus42.394e-170 512
LLPS-Tru-1436Triticum urartu42.354e-75 267
LLPS-Abg-0665Absidia glauca42.345e-135 417
LLPS-Mea-3802Mesocricetus auratus42.286e-164 497
LLPS-Gaga-2832Gallus gallus42.261e-167 505
LLPS-Chr-1421Chlamydomonas reinhardtii42.231e-110 362
LLPS-Pes-3490Pelodiscus sinensis42.21e-161 488
LLPS-Tra-2469Triticum aestivum42.062e-74 265
LLPS-Mup-2897Mustela putorius furo42.061e-164 500
LLPS-Urm-2552Ursus maritimus42.022e-166 504
LLPS-Kop-1012Komagataella pastoris42.022e-158 479
LLPS-Meg-1439Meleagris gallopavo41.981e-166 503
LLPS-Cap-4590Cavia porcellus41.963e-164 496
LLPS-Ran-4213Rattus norvegicus41.942e-166 502
LLPS-Fud-1708Fukomys damarensis41.922e-165 499
LLPS-Caf-1586Canis familiaris41.894e-165 499
LLPS-Fec-1256Felis catus41.864e-165 499
LLPS-Crn-1440Cryptococcus neoformans41.852e-156 476
LLPS-Sob-0905Sorghum bicolor41.833e-76 270
LLPS-Lep-0994Leersia perrieri41.831e-72 259
LLPS-Mum-0491Mus musculus41.814e-165 500
LLPS-Myl-4103Myotis lucifugus41.789e-164 495
LLPS-Man-0324Macaca nemestrina41.723e-165 499
LLPS-Eqc-1592Equus caballus41.676e-164 496
LLPS-Sei-2122Setaria italica41.62e-79 278
LLPS-Mam-1463Macaca mulatta41.592e-164 497
LLPS-Paa-2272Papio anubis41.593e-164 496
LLPS-Mal-1833Mandrillus leucophaeus41.592e-164 497
LLPS-Maf-2511Macaca fascicularis41.599e-165 498
LLPS-Chs-2575Chlorocebus sabaeus41.596e-164 496
LLPS-Caj-4545Callithrix jacchus41.597e-165 498
LLPS-Cea-3530Cercocebus atys41.561e-164 497
LLPS-Fia-1502Ficedula albicollis41.533e-167 505
LLPS-Bro-2857Brassica oleracea41.511e-164 498
LLPS-Hos-3746Homo sapiens41.451e-164 498
LLPS-Loa-4145Loxodonta africana41.451e-157 479
LLPS-Brr-2567Brassica rapa41.41e-165 500
LLPS-Anp-3208Anas platyrhynchos41.47e-164 496
LLPS-Brn-1511Brassica napus41.41e-165 500
LLPS-Php-1516Physcomitrella patens41.46e-163 493
LLPS-Orc-0146Oryctolagus cuniculus41.391e-162 492
LLPS-Sus-3113Sus scrofa41.314e-163 494
LLPS-Ict-0922Ictidomys tridecemlineatus41.251e-163 496
LLPS-Pat-1347Pan troglodytes41.251e-164 498
LLPS-Pap-4045Pan paniscus41.251e-164 498
LLPS-Orn-2918Oreochromis niloticus41.253e-169 510
LLPS-Miv-0117Microbotryum violaceum41.191e-170 513
LLPS-Gog-4138Gorilla gorilla41.111e-163 495
LLPS-Tag-0285Taeniopygia guttata41.063e-164 496
LLPS-Otg-3525Otolemur garnettii41.063e-156 474
LLPS-Tut-1316Tursiops truncatus41.034e-160 486
LLPS-Scc-1276Schizosaccharomyces cryophilus41.06e-160 484
LLPS-Amt-0608Amborella trichopoda40.961e-159 484
LLPS-Sah-3890Sarcophilus harrisii40.951e-156 477
LLPS-Nia-1737Nicotiana attenuata40.898e-161 488
LLPS-Orl-2033Oryzias latipes40.884e-157 479
LLPS-Pof-3407Poecilia formosa40.874e-163 494
LLPS-Scm-1821Scophthalmus maximus40.871e-165 500
LLPS-Xim-0624Xiphophorus maculatus40.871e-162 493
LLPS-Met-1227Medicago truncatula40.765e-158 480
LLPS-Gaa-3244Gasterosteus aculeatus40.76e-164 496
LLPS-Dio-2848Dipodomys ordii40.683e-155 473
LLPS-Art-2313Arabidopsis thaliana40.635e-167 503
LLPS-Hov-0586Hordeum vulgare40.623e-73 262
LLPS-Drm-2257Drosophila melanogaster40.527e-144 443
LLPS-Scf-2782Scleropages formosus40.494e-161 491
LLPS-Mod-3985Monodelphis domestica40.423e-161 489
LLPS-Ten-0015Tetraodon nigroviridis40.361e-144 444
LLPS-Arl-2358Arabidopsis lyrata40.293e-165 499
LLPS-Pug-0092Puccinia graminis40.254e-168 508
LLPS-Tar-1924Takifugu rubripes40.175e-148 454
LLPS-Glm-2669Glycine max40.144e-162 490
LLPS-Asm-3832Astyanax mexicanus40.035e-164 496
LLPS-Ora-0398Ornithorhynchus anatinus40.01e-106 341
LLPS-Bot-0746Bos taurus39.923e-160 486
LLPS-Sol-1911Solanum lycopersicum39.923e-160 487
LLPS-Scj-1296Schizosaccharomyces japonicus39.881e-151 462
LLPS-Sot-2033Solanum tuberosum39.834e-161 489
LLPS-Cus-1835Cucumis sativus39.834e-156 476
LLPS-Mel-1323Melampsora laricipopulina39.811e-169 511
LLPS-Hea-1576Helianthus annuus39.755e-155 473
LLPS-Ova-4218Ovis aries39.71e-160 488
LLPS-Mua-2511Musa acuminata39.611e-146 453
LLPS-Nol-3862Nomascus leucogenys39.365e-147 451
LLPS-Phv-2344Phaseolus vulgaris39.364e-158 481
LLPS-Gor-1402Gossypium raimondii39.324e-155 473
LLPS-Pot-0917Populus trichocarpa39.292e-153 469
LLPS-Vir-0935Vigna radiata39.194e-148 454
LLPS-Dac-1870Daucus carota39.156e-146 449
LLPS-Put-1080Puccinia triticina39.088e-170 511
LLPS-Prp-2545Prunus persica38.862e-146 451
LLPS-Thc-0546Theobroma cacao38.81e-155 474
LLPS-Brd-2162Brachypodium distachyon38.642e-75 268
LLPS-Sem-2442Selaginella moellendorffii38.641e-141 438
LLPS-Viv-1414Vitis vinifera38.495e-156 478
LLPS-Osl-0936Ostreococcus lucimarinus38.464e-137 425
LLPS-Rhb-3377Rhinopithecus bieti38.163e-140 432
LLPS-Dar-2169Danio rerio37.779e-138 428
LLPS-Cae-2011Caenorhabditis elegans36.422e-112 360
LLPS-Xet-3931Xenopus tropicalis34.535e-95 315