DrLLPS - Data resource of LLPS

LLPS-Nec-0475
lea-1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U2 small nuclear ribonucleoprotein A'
Gene Name:	lea-1, NCU06622
Ensembl Gene:	NCU06622
Ensembl Protein:	EAA33128
Organism:	Neurospora crassa
Taxa ID:	367110
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Cajal body, Nuclear speckle, Nucleolus, Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-1730	P57784	Client	Nuclear speckle, Nucleolus	41.25	2e-49	169
Homo sapiens	LLPS-Hos-0140	P09661	Client	Cajal body, Nuclear speckle, Nucleolus, Stress granule	41.25	1e-48	167
Drosophila melanogaster	LLPS-Drm-0166	Q9V4Q8	Client	Stress granule	41.67	2e-36	136
Arabidopsis thaliana	LLPS-Art-0780	P43333	Client	Nucleolus	37.25	9e-22	95.5

▼ FUNCTION

Involved in pre-mRNA splicing.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	EAA33128	EAA33128
UniProt		Q7S9P4, RU2A_NEUCR
GeneBank	CM002239	EAA33128.1
RefSeq	XM_957271.2	XP_962364.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRLTADLINN SLSYLNPLKE REIDLRGHRI PAIENLGVAG PHDAIDFTDN DIQVLGNFPL 60 61 SPRIRTLLLA RNRIAQIQST LPNATPNLKN LVLASNNIGE LADLEVLGRF PRLTHLVLTD 120 121 NPVTKKENYR YWVLWLCPQV RFLDYVKVKD AERQKAKELF GTADEPTELA KTIKGIKSKT 180 181 FDVGASSANG AAGSGPSSKL SRLKLTEKEK KKLQDLIKKA DSLEEIIRLE KALNEGRLPP 240 241 GIIAEDDDAM EE 252
Nucleotide CDS Sequence (FASTA)
1 ATGAGGCTGA CGGCAGACCT TATCAACAAC TCCCTTTCCT ATCTCAATCC GCTTAAGGAG 60 61 CGAGAGATAG ACCTCCGAGG ACACAGAATA CCTGCTATTG AGAACTTGGG CGTTGCTGGG 120 121 CCCCACGATG CCATTGATTT CACCGACAAC GATATCCAAG TGCTGGGCAA CTTCCCGCTC 180 181 TCTCCCCGCA TACGCACCCT CCTGCTCGCC CGCAACAGGA TCGCCCAGAT CCAGTCGACC 240 241 CTACCGAATG CGACCCCGAA CCTGAAGAAC CTCGTCCTGG CGTCCAATAA TATTGGCGAG 300 301 CTGGCGGATT TGGAGGTGTT GGGAAGGTTT CCAAGGCTTA CGCACTTGGT CTTGACGGAC 360 361 AACCCCGTTA CCAAGAAGGA GAACTACCGC TACTGGGTCC TCTGGCTGTG CCCTCAGGTT 420 421 CGCTTTCTCG ATTACGTCAA GGTCAAGGAC GCCGAGAGGC AGAAGGCGAA GGAGCTGTTT 480 481 GGAACCGCTG ATGAGCCGAC GGAGTTGGCC AAGACGATAA AGGGAATCAA GAGCAAGACC 540 541 TTTGACGTTG GCGCCAGCTC CGCCAACGGT GCGGCCGGCA GTGGTCCTTC CTCGAAACTT 600 601 TCGCGTCTCA AGCTCACAGA GAAAGAGAAG AAGAAGTTGC AGGATCTGAT CAAGAAGGCC 660 661 GACAGCTTGG AGGAAATCAT CAGATTGGAG AAGGCGCTCA ACGAGGGACG GCTGCCACCT 720 721 GGCATTATCG CCGAGGATGA CGATGCCATG GAGGAGTAA 759

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0433	Leucine-rich repeat
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0677	Repeat
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005681	Cellular Component	Spliceosomal complex
GO:0005686	Cellular Component	U2 snRNP
GO:0030620	Molecular Function	U2 snRNA binding
GO:0000398	Biological Process	MRNA splicing, via spliceosome

▼ KEGG

ncr:NCU06622

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Map-0626	Magnaporthe poae	75.4	3e-109	322
LLPS-Gag-1246	Gaeumannomyces graminis	73.81	1e-106	316
LLPS-Fus-1384	Fusarium solani	73.81	4e-109	322
LLPS-Coo-0054	Colletotrichum orbiculare	73.71	2e-109	323
LLPS-Fuo-0736	Fusarium oxysporum	73.02	7e-110	324
LLPS-Fuv-0223	Fusarium verticillioides	72.62	3e-110	325
LLPS-Trr-0160	Trichoderma reesei	72.62	7e-107	316
LLPS-Cogr-0277	Colletotrichum graminicola	71.83	5e-108	319
LLPS-Trv-0067	Trichoderma virens	71.43	4e-109	322
LLPS-Beb-0780	Beauveria bassiana	70.63	3e-106	314
LLPS-Mao-0050	Magnaporthe oryzae	70.24	5e-102	304
LLPS-Tum-0041	Tuber melanosporum	70.0	8e-11	63.2
LLPS-Ved-0549	Verticillium dahliae	67.17	2e-95	288
LLPS-Blg-1101	Blumeria graminis	66.27	5e-103	306
LLPS-Nef-0839	Neosartorya fischeri	63.49	2e-94	285
LLPS-Asni-0387	Aspergillus niger	63.24	7e-92	278
LLPS-Asfu-1102	Aspergillus fumigatus	63.1	8e-94	283
LLPS-Scs-0501	Sclerotinia sclerotiorum	62.36	2e-96	290
LLPS-Aso-0323	Aspergillus oryzae	62.06	9e-95	285
LLPS-Asf-0593	Aspergillus flavus	61.66	2e-94	285
LLPS-Ast-0066	Aspergillus terreus	60.95	4e-70	221
LLPS-Asc-0684	Aspergillus clavatus	60.0	2e-87	267
LLPS-Pytr-0036	Pyrenophora triticirepentis	56.56	5e-81	250
LLPS-Zyt-0027	Zymoseptoria tritici	55.95	5e-78	243
LLPS-Dos-0566	Dothistroma septosporum	54.76	2e-79	246
LLPS-Asn-0991	Aspergillus nidulans	54.33	3e-70	222
LLPS-Scj-0367	Schizosaccharomyces japonicus	52.69	4e-52	176
LLPS-Pyt-0524	Pyrenophora teres	51.92	2e-58	191
LLPS-Anp-0395	Anas platyrhynchos	48.47	6e-39	141
LLPS-Abg-1246	Absidia glauca	48.39	2e-37	136
LLPS-Drm-0166	Drosophila melanogaster	47.85	2e-44	156
LLPS-Leo-0599	Lepisosteus oculatus	47.8	1e-45	159
LLPS-Meg-0578	Meleagris gallopavo	47.77	4e-36	134
LLPS-Put-0820	Puccinia triticina	47.73	7e-41	147
LLPS-Gaga-0668	Gallus gallus	47.54	7e-46	160
LLPS-Sem-0481	Selaginella moellendorffii	47.33	5e-34	126
LLPS-Anc-0177	Anolis carolinensis	46.99	2e-46	162
LLPS-Fud-0104	Fukomys damarensis	46.79	9e-34	127
LLPS-Usm-0869	Ustilago maydis	46.77	3e-41	148
LLPS-Dar-0886	Danio rerio	46.7	5e-42	150
LLPS-Hea-1056	Helianthus annuus	46.58	2e-35	132
LLPS-Spr-0403	Sporisorium reilianum	46.52	2e-42	151
LLPS-Ova-1470	Ovis aries	46.5	2e-34	129
LLPS-Bot-0693	Bos taurus	46.45	4e-44	155
LLPS-Ran-0656	Rattus norvegicus	46.45	3e-44	155
LLPS-Mup-0440	Mustela putorius furo	46.45	4e-44	155
LLPS-Mal-0158	Mandrillus leucophaeus	46.45	4e-44	155
LLPS-Paa-1048	Papio anubis	46.45	4e-44	155
LLPS-Chs-2542	Chlorocebus sabaeus	46.45	4e-44	155
LLPS-Maf-0478	Macaca fascicularis	46.45	4e-44	155
LLPS-Mum-1730	Mus musculus	46.45	3e-44	155
LLPS-Mea-0669	Mesocricetus auratus	46.45	3e-44	155
LLPS-Sus-1377	Sus scrofa	46.45	4e-44	155
LLPS-Aon-0095	Aotus nancymaae	46.45	4e-44	155
LLPS-Cea-1179	Cercocebus atys	46.45	4e-44	155
LLPS-Sah-1267	Sarcophilus harrisii	46.45	3e-44	155
LLPS-Gog-0147	Gorilla gorilla	46.45	4e-44	155
LLPS-Caj-0158	Callithrix jacchus	46.45	4e-44	155
LLPS-Cap-0670	Cavia porcellus	46.45	4e-44	155
LLPS-Eqc-1328	Equus caballus	46.45	4e-44	155
LLPS-Poa-0158	Pongo abelii	46.45	4e-44	155
LLPS-Caf-1285	Canis familiaris	46.45	4e-44	155
LLPS-Mam-1366	Macaca mulatta	46.45	4e-44	155
LLPS-Nol-0990	Nomascus leucogenys	46.45	4e-44	155
LLPS-Ict-0270	Ictidomys tridecemlineatus	46.45	4e-44	155
LLPS-Mod-1383	Monodelphis domestica	46.45	2e-44	156
LLPS-Fec-0324	Felis catus	46.45	4e-44	155
LLPS-Hos-0140	Homo sapiens	46.45	4e-44	155
LLPS-Pat-1799	Pan troglodytes	46.45	4e-44	155
LLPS-Pap-0094	Pan paniscus	46.45	4e-44	155
LLPS-Urm-0440	Ursus maritimus	46.45	5e-44	155
LLPS-Man-2131	Macaca nemestrina	46.45	4e-44	155
LLPS-Otg-0004	Otolemur garnettii	46.45	4e-44	155
LLPS-Rhb-2181	Rhinopithecus bieti	46.45	4e-44	155
LLPS-Lac-0670	Latimeria chalumnae	46.15	5e-45	158
LLPS-Kop-1033	Komagataella pastoris	46.07	6e-46	159
LLPS-Dio-1598	Dipodomys ordii	45.96	1e-34	130
LLPS-Ora-0423	Ornithorhynchus anatinus	45.9	1e-43	154
LLPS-Cas-1836	Carlito syrichta	45.9	2e-43	153
LLPS-Tag-1412	Taeniopygia guttata	45.9	6e-44	155
LLPS-Fia-0922	Ficedula albicollis	45.9	7e-44	155
LLPS-Scc-1049	Schizosaccharomyces cryophilus	45.79	1e-47	165
LLPS-Tar-1957	Takifugu rubripes	45.65	1e-44	157
LLPS-Gaa-1392	Gasterosteus aculeatus	45.6	2e-41	149
LLPS-Orn-0222	Oreochromis niloticus	45.6	2e-43	154
LLPS-Crn-0342	Cryptococcus neoformans	45.4	8e-38	139
LLPS-Asm-2013	Astyanax mexicanus	45.37	1e-17	83.6
LLPS-Myl-1047	Myotis lucifugus	45.36	5e-39	142
LLPS-Scm-0439	Scophthalmus maximus	45.05	1e-42	153
LLPS-Pof-1227	Poecilia formosa	45.05	3e-40	147
LLPS-Scp-0246	Schizosaccharomyces pombe	45.0	9e-53	177
LLPS-Osl-0228	Ostreococcus lucimarinus	44.83	1e-36	135
LLPS-Dac-1227	Daucus carota	44.72	7e-23	98.2
LLPS-Aim-3038	Ailuropoda melanoleuca	44.44	5e-12	65.9
LLPS-Pug-0418	Puccinia graminis	44.2	2e-39	144
LLPS-Gor-0401	Gossypium raimondii	44.17	6e-34	130
LLPS-Ten-1734	Tetraodon nigroviridis	43.78	3e-37	137
LLPS-Orc-2459	Oryctolagus cuniculus	43.72	5e-39	142
LLPS-Brd-0167	Brachypodium distachyon	43.56	4e-33	127
LLPS-Cae-0565	Caenorhabditis elegans	43.48	2e-37	137
LLPS-Xim-1084	Xiphophorus maculatus	43.41	4e-39	142
LLPS-Scf-1781	Scleropages formosus	43.41	1e-36	138
LLPS-Mel-0782	Melampsora laricipopulina	43.18	5e-37	138
LLPS-Icp-0115	Ictalurus punctatus	43.17	8e-39	142
LLPS-Loa-0360	Loxodonta africana	43.17	2e-39	143
LLPS-Yal-0816	Yarrowia lipolytica	43.12	2e-29	115
LLPS-Tra-0472	Triticum aestivum	42.94	6e-33	127
LLPS-Hov-0978	Hordeum vulgare	42.94	3e-33	127
LLPS-Coc-1562	Corchorus capsularis	42.94	6e-32	124
LLPS-Tru-0227	Triticum urartu	42.94	4e-33	127
LLPS-Sob-1222	Sorghum bicolor	42.86	3e-34	130
LLPS-Gas-0424	Galdieria sulphuraria	42.59	4e-37	137
LLPS-Pes-1699	Pelodiscus sinensis	42.34	2e-18	85.1
LLPS-Zem-1130	Zea mays	42.31	1e-31	127
LLPS-Miv-1046	Microbotryum violaceum	42.13	6e-35	132
LLPS-Chc-0716	Chondrus crispus	40.37	3e-14	71.2
LLPS-Sac-1365	Saccharomyces cerevisiae	39.78	5e-08	57.0
LLPS-Php-0569	Physcomitrella patens	39.68	2e-38	141
LLPS-Asg-0577	Ashbya gossypii	39.68	1e-12	69.3
LLPS-Cii-0033	Ciona intestinalis	39.56	1e-37	139
LLPS-Cis-0151	Ciona savignyi	39.56	3e-38	140
LLPS-Mae-1174	Manihot esculenta	38.75	2e-35	133
LLPS-Pot-1325	Populus trichocarpa	38.71	6e-38	140
LLPS-Met-0625	Medicago truncatula	38.25	2e-37	139
LLPS-Phv-0861	Phaseolus vulgaris	38.15	2e-37	139
LLPS-Glm-0689	Glycine max	37.94	1e-38	142
LLPS-Vir-1329	Vigna radiata	37.75	2e-36	137
LLPS-Chr-0204	Chlamydomonas reinhardtii	37.65	1e-30	120
LLPS-Brn-1817	Brassica napus	37.65	8e-37	137
LLPS-Brr-0665	Brassica rapa	37.65	5e-37	137
LLPS-Ori-1603	Oryza indica	37.5	1e-36	136
LLPS-Mua-0838	Musa acuminata	37.5	6e-38	140
LLPS-Orni-0475	Oryza nivara	37.5	1e-36	136
LLPS-Orr-1287	Oryza rufipogon	37.5	9e-37	137
LLPS-Orm-0150	Oryza meridionalis	37.5	1e-36	136
LLPS-Ors-0406	Oryza sativa	37.5	1e-36	136
LLPS-Orp-0911	Oryza punctata	37.5	3e-36	135
LLPS-Sei-0355	Setaria italica	37.34	7e-35	132
LLPS-Bro-0080	Brassica oleracea	37.25	3e-37	137
LLPS-Arl-1030	Arabidopsis lyrata	37.21	2e-35	132
LLPS-Art-0780	Arabidopsis thaliana	37.21	9e-40	144
LLPS-Prp-0333	Prunus persica	37.2	3e-38	140
LLPS-Orgl-0434	Oryza glumaepatula	37.08	2e-36	135
LLPS-Orb-0912	Oryza barthii	37.08	6e-36	135
LLPS-Org-0084	Oryza glaberrima	37.08	5e-35	132
LLPS-Orbr-0665	Oryza brachyantha	37.08	2e-36	136
LLPS-Via-0796	Vigna angularis	37.05	8e-37	137
LLPS-Sol-1264	Solanum lycopersicum	36.95	1e-36	137
LLPS-Thc-0006	Theobroma cacao	36.8	3e-35	132
LLPS-Viv-1719	Vitis vinifera	36.64	4e-36	135
LLPS-Orl-2633	Oryzias latipes	36.63	6e-09	58.5
LLPS-Amt-0259	Amborella trichopoda	36.55	9e-34	129
LLPS-Nia-0438	Nicotiana attenuata	36.54	5e-35	132
LLPS-Sot-0362	Solanum tuberosum	36.14	1e-36	137
LLPS-Lep-1357	Leersia perrieri	34.36	5e-29	116
LLPS-Cus-0547	Cucumis sativus	32.64	4e-16	78.6

LLPS-Nec-0475lea-1

Protein Sequence

Nucleotide Sequence

LLPS-Nec-0475
lea-1