LLPS-Myl-a160
JPH4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Junctophilin |
| Gene Name: | JPH4 |
| Ensembl Gene: | ENSMLUG00000029547.1 |
| Ensembl Protein: | ENSMLUP00000022337.1 |
| Organism: | Myotis lucifugus |
| Taxa ID: | 59463 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLUT00000027577.1 | ENSMLUP00000022337.1 |
| UniProt | G1QF54, G1QF54_MYOLU | |
| GeneBank | AAPE02039905, AAPE02039906, AAPE02039907 | |
| Entrez | 102440222 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSPGGKFDFD DGGCYVGGWE AGRAHGYGVC TGPGAQGEYS GCWAHGFESL GVFTGPGGHS 60 61 YQGHWQQGKR EGLGVERKSR WTYRGEWLGG LKGRSGVWES ASGLRYAGLW KDGFQDGYGT 120 121 ETYSDGGTYQ GQWQAGKRHG YGVRQSVPYH QAALLRSPRR TSLDSGHSDP PTPPPPLPLL 180 181 GDEGGSPASG SRGGFVLAGP GDADRASSRK RTPVAGGFFR RSLLLSGLRA GGRRSSLGSK 240 241 RGSLRSEVSS EVGSTGPPGS EASGSLAPAP PALIEGSATE VYAGEWRADR RSGYGVSQRS 300 301 NGLRYEGEWL GNRRHGYGRT TRPDGSREEG KYKRNRLVHG GRVRSLLPLA LRRGKVKEKV 360 361 DRAVEGARRA VSAARQRQEI AAARAADALL KAVAASSVAE KAVEAARMAK LIAQDLQPML 420 421 EAPAVPAPGR RPRQDSEGSD TEPLDEDSPG VYENGLTPSE GSPELPSSPA SCRQPWRPPA 480 481 CRNPLPPGGD RGPFSSPKTW PEEWGGPGER AEELAGYEAE DEAGIQGPGP RDGSPLLGRC 540 541 SDSSGSLREE EGEDEEPLPL IRTLGASEPE PLATPVLRGS SSRGPEAGCL MEEREEPAAT 600 601 ERPAQPGAAN PLVVGAVALL DLSLAFLFSQ LLT 633 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCCCCG GGGGCAAGTT CGACTTTGAC GACGGGGGCT GCTACGTGGG GGGCTGGGAG 60 61 GCGGGGCGGG CACATGGCTA CGGCGTGTGC ACCGGGCCCG GCGCCCAGGG CGAGTACAGC 120 121 GGCTGCTGGG CGCACGGCTT CGAGTCACTG GGCGTCTTCA CGGGGCCCGG CGGACACAGC 180 181 TACCAGGGCC ACTGGCAGCA GGGCAAGCGT GAAGGGCTGG GCGTGGAGCG CAAGAGCCGC 240 241 TGGACGTACC GCGGCGAGTG GCTGGGCGGG CTGAAGGGGC GCAGCGGCGT GTGGGAGAGC 300 301 GCGTCCGGCC TGCGCTACGC CGGGCTCTGG AAGGACGGCT TCCAGGACGG CTACGGCACC 360 361 GAGACCTACT CCGACGGAGG CACCTACCAG GGCCAGTGGC AGGCCGGGAA GCGCCACGGC 420 421 TACGGGGTGC GCCAGAGCGT ACCCTACCAT CAGGCGGCGC TGCTGCGCTC ACCCCGCCGC 480 481 ACCTCTCTGG ACTCCGGCCA CAGCGACCCC CCGACGCCGC CCCCGCCCCT GCCCCTGCTC 540 541 GGCGACGAGG GAGGCAGCCC GGCCTCCGGC TCTCGGGGCG GCTTCGTGCT AGCCGGGCCG 600 601 GGGGACGCTG ACCGCGCGTC CTCCCGCAAG CGCACCCCCG TGGCCGGCGG CTTCTTCCGC 660 661 CGCTCGCTGC TGCTTAGCGG GCTCCGCGCG GGCGGGCGCC GCAGCTCCTT GGGCAGCAAG 720 721 CGAGGGTCCC TGCGTAGCGA GGTGAGCAGC GAGGTGGGCA GTACAGGGCC CCCCGGCTCT 780 781 GAGGCCAGCG GGTCCCTGGC CCCCGCGCCG CCCGCCCTCA TCGAGGGCTC GGCCACCGAG 840 841 GTGTATGCGG GCGAATGGCG CGCGGACCGT CGCAGCGGCT ACGGCGTGAG CCAGCGCTCC 900 901 AACGGGCTTC GCTACGAGGG CGAGTGGCTG GGCAACCGGC GGCACGGCTA CGGGCGCACC 960 961 ACCCGCCCCG ACGGCTCGCG TGAAGAGGGC AAGTACAAGC GCAACAGGCT GGTGCACGGG 1020 1021 GGGCGCGTGC GCAGCCTCCT GCCTCTGGCC CTTCGGCGGG GCAAAGTCAA GGAGAAGGTG 1080 1081 GACCGGGCCG TCGAGGGCGC CCGTCGAGCA GTGAGTGCTG CCCGCCAGCG CCAGGAGATT 1140 1141 GCCGCTGCCA GGGCAGCAGA CGCCCTTCTC AAGGCAGTAG CAGCCAGCAG CGTTGCTGAG 1200 1201 AAGGCTGTGG AGGCTGCTCG AATGGCCAAA CTGATAGCCC AGGACCTGCA ACCCATGTTA 1260 1261 GAGGCCCCAG CTGTCCCTGC CCCAGGCCGC AGACCCAGGC AGGACTCAGA AGGTTCCGAC 1320 1321 ACAGAGCCCT TGGATGAGGA CAGCCCTGGG GTGTACGAGA ACGGACTGAC CCCCTCAGAG 1380 1381 GGCTCCCCTG AACTGCCCAG CAGTCCTGCC TCCTGCCGCC AACCCTGGCG ACCCCCAGCC 1440 1441 TGCCGGAACC CACTGCCTCC TGGAGGGGAC CGGGGTCCCT TCTCCAGCCC TAAAACTTGG 1500 1501 CCTGAGGAGT GGGGGGGCCC GGGTGAGCGG GCAGAGGAAC TAGCTGGCTA TGAGGCCGAG 1560 1561 GATGAGGCTG GGATCCAGGG CCCAGGACCC CGAGATGGTT CCCCACTCCT TGGACGCTGC 1620 1621 AGTGACAGTT CCGGAAGTCT TCGCGAGGAG GAGGGGGAAG ATGAAGAGCC CCTGCCCCTC 1680 1681 ATAAGGACCC TAGGGGCCTC GGAGCCTGAG CCCCTGGCCA CACCAGTCCT GAGGGGCTCC 1740 1741 TCCTCAAGGG GTCCTGAAGC TGGGTGCCTG ATGGAAGAGC GTGAGGAGCC AGCTGCCACC 1800 1801 GAGAGGCCAG CCCAGCCGGG AGCTGCCAAC CCCCTGGTGG TGGGAGCCGT GGCCCTCCTG 1860 1861 GACCTCAGCC TGGCGTTCCT GTTCTCCCAG CTCCTCACCT AA 1902 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Dendritic shaft | |
Cellular Component | Junctional membrane complex | |
Cellular Component | Smooth endoplasmic reticulum | |
Biological Process | Learning | |
Biological Process | Neuromuscular process controlling balance | |
Biological Process | Regulation of cytokine production | |
Biological Process | Regulation of store-operated calcium entry | |
Biological Process | Regulation of synaptic plasticity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a168 | Homo sapiens | 0.0 | 1081 | undefined |
| LLPS-Mum-a169 | Mus musculus | 0.0 | 1083 | undefined |