LLPS-Mum-a984
Cox5a

▼ OVERVIEW

Status: Reviewed
Protein Name: Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va
Gene Name: Cox5a
Ensembl Gene: ENSMUSG00000000088.7
Ensembl Protein: ENSMUSP00000000090.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLAAALRRCT  AAAAARGLLH  PASAPSPAAA  VCSIRCYSHG  SHETDEEFDA  RWVTYFNKPD  60
61    IDAWELRKGM  NTLVGYDLVP  EPKIIDAALR  ACRRLNDFAS  AVRILEVVKD  KAGPHKEIYP  120
121   YVIQELRPTL  NELGISTPEE  LGLDKV  146
Nucleotide CDS Sequence (FASTA)
1     ATGCTCGCCG  CTGCCCTCCG  TCGCTGTACC  GCAGCCGCGG  CTGCCCGAGG  CCTCCTGCAC  60
61    CCCGCCTCGG  CTCCCAGCCC  CGCCGCCGCT  GTCTGTTCCA  TTCGCTGCTA  TTCTCATGGG  120
121   TCACACGAGA  CAGATGAGGA  GTTTGATGCT  CGCTGGGTGA  CATATTTCAA  CAAGCCAGAC  180
181   ATTGATGCCT  GGGAATTGCG  TAAAGGGATG  AATACACTTG  TTGGCTATGA  TCTGGTTCCT  240
241   GAGCCCAAAA  TCATTGATGC  TGCATTGCGA  GCATGTAGAC  GGTTAAATGA  TTTTGCTAGT  300
301   GCTGTTCGCA  TCTTGGAGGT  TGTTAAGGAC  AAAGCAGGAC  CTCATAAGGA  AATCTATCCC  360
361   TATGTCATCC  AGGAACTTAG  ACCAACTTTA  AATGAATTGG  GAATCTCCAC  TCCAGAGGAG  420
421   CTGGGCCTTG  ACAAAGTGTA  A  441

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Direct protein sequencing
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein
Reference proteome
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial respiratory chain complex IV
Cellular Component
Mitochondrion
Cellular Component
Myelin sheath
Molecular Function
Cytochrome-c oxidase activity
Molecular Function
Metal ion binding
Biological Process
Mitochondrial electron transport, cytochrome c to oxygen

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a980Rattus norvegicus99.321e-102299
LLPS-Urm-a880Ursus maritimus99.126e-79239
LLPS-Ora-a806Ornithorhynchus anatinus99.17e-78236
LLPS-Dio-a943Dipodomys ordii98.73e-47156
LLPS-Eqc-a979Equus caballus98.292e-80243
LLPS-Fud-a941Fukomys damarensis98.283e-78236
LLPS-Ict-a967Ictidomys tridecemlineatus97.711e-80244
LLPS-Loa-a950Loxodonta africana96.581e-79240
LLPS-Mea-a938Mesocricetus auratus96.332e-70217
LLPS-Ova-a943Ovis aries95.879e-81243
LLPS-Myl-a910Myotis lucifugus95.381e-81246
LLPS-Orc-a916Oryctolagus cuniculus95.121e-81245
LLPS-Mod-a940Monodelphis domestica94.925e-79238
LLPS-Gaga-a880Gallus gallus93.977e-75228
LLPS-Anp-a784Anas platyrhynchos93.972e-75230
LLPS-Meg-a780Meleagris gallopavo93.973e-75229
LLPS-Fec-a981Felis catus93.238e-87259
LLPS-Aim-a934Ailuropoda melanoleuca93.239e-87259
LLPS-Tag-a840Taeniopygia guttata93.168e-76230
LLPS-Sah-a884Sarcophilus harrisii93.11e-76232
LLPS-Mal-a967Mandrillus leucophaeus92.58e-77234
LLPS-Pes-a841Pelodiscus sinensis92.444e-77233
LLPS-Mup-a943Mustela putorius furo91.732e-85255
LLPS-Cea-a1137Cercocebus atys91.673e-75230
LLPS-Pap-a1095Pan paniscus91.454e-76231
LLPS-Tut-a515Tursiops truncatus89.474e-88263
LLPS-Otg-a968Otolemur garnettii89.335e-93275
LLPS-Caf-a962Canis familiaris88.742e-83250
LLPS-Anc-a887Anolis carolinensis88.443e-85255
LLPS-Sus-a984Sus scrofa88.162e-91271
LLPS-Bot-a984Bos taurus88.161e-90269
LLPS-Cap-a980Cavia porcellus87.332e-89265
LLPS-Orl-a837Oryzias latipes87.298e-73224
LLPS-Chs-a973Chlorocebus sabaeus86.02e-89265
LLPS-Poa-a1102Pongo abelii85.331e-88264
LLPS-Fia-a858Ficedula albicollis85.197e-77234
LLPS-Caj-a1126Callithrix jacchus84.672e-85256
LLPS-Rhb-a1120Rhinopithecus bieti84.674e-88262
LLPS-Aon-a1139Aotus nancymaae84.561e-85256
LLPS-Gaa-a941Gasterosteus aculeatus83.936e-68211
LLPS-Cas-a952Carlito syrichta83.451e-80243
LLPS-Xet-a834Xenopus tropicalis81.213e-79239
LLPS-Nol-a1097Nomascus leucogenys80.823e-80242
LLPS-Hos-a1000Homo sapiens80.535e-59188
LLPS-Lac-a855Latimeria chalumnae79.178e-77233
LLPS-Paa-a1136Papio anubis78.526e-74226
LLPS-Pat-a1142Pan troglodytes77.72e-72222
LLPS-Mam-a1111Macaca mulatta77.182e-72222
LLPS-Asm-a846Astyanax mexicanus76.553e-74227
LLPS-Man-a1138Macaca nemestrina75.841e-69215
LLPS-Gog-a1121Gorilla gorilla75.684e-69214
LLPS-Icp-a857Ictalurus punctatus75.177e-72222
LLPS-Scf-a825Scleropages formosus75.174e-70218
LLPS-Dar-a856Danio rerio74.262e-72222
LLPS-Orn-a849Oreochromis niloticus73.971e-74228
LLPS-Xim-a855Xiphophorus maculatus73.974e-72221
LLPS-Leo-a842Lepisosteus oculatus73.791e-73225
LLPS-Maf-a1127Macaca fascicularis73.58e-55176
LLPS-Pof-a962Poecilia formosa73.292e-71219
LLPS-Tar-a808Takifugu rubripes72.61e-72223
LLPS-Ten-a807Tetraodon nigroviridis72.62e-72222
LLPS-Scm-a814Scophthalmus maximus70.551e-68212
LLPS-Cis-a219Ciona savignyi54.295e-1983.6
LLPS-Cae-a126Caenorhabditis elegans51.02e-31118
LLPS-Drm-a204Drosophila melanogaster50.345e-40140