LLPS-Mum-a967
B3galt6

▼ OVERVIEW

Status: Reviewed
Protein Name: Beta-1,3-galactosyltransferase 6
Gene Name: B3galt6
Ensembl Gene: ENSMUSG00000050796.4
Ensembl Protein: ENSMUSP00000057521.3
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKVFRRAWRH  RVALGLGGLA  FCGTTLLYLA  RCASEGETPS  ASGAARPRAK  AFLAVLVASA  60
61    PRAVERRTAV  RSTWLAPERR  GGPEDVWARF  AVGTGGLGSE  ERRALELEQA  QHGDLLLLPA  120
121   LRDAYENLTA  KVLAMLTWLD  ERVDFEFVLK  ADDDSFARLD  AILVDLRARE  PARRRRLYWG  180
181   FFSGRGRVKP  GGRWREAAWQ  LCDYYLPYAL  GGGYVLSADL  VHYLRLSREY  LRAWHSEDVS  240
241   LGTWLAPVDV  QREHDPRFDT  EYKSRGCNNQ  YLVTHKQSPE  DMLEKQQMLL  HEGRLCKHEV  300
301   QLRLSYVYDW  SAPPSQCCQR  KEGVP  325
Nucleotide CDS Sequence (FASTA)
1     ATGAAGGTAT  TCCGGCGCGC  TTGGCGGCAC  CGGGTGGCGC  TGGGCCTAGG  CGGCCTGGCG  60
61    TTCTGCGGCA  CCACTCTGTT  GTACCTGGCG  CGCTGCGCTT  CCGAGGGCGA  GACGCCCTCC  120
121   GCTTCCGGAG  CCGCTCGGCC  CCGCGCTAAG  GCCTTCCTGG  CGGTGCTGGT  GGCCAGTGCG  180
181   CCCCGCGCGG  TCGAGCGCCG  CACCGCAGTG  CGCAGCACGT  GGCTGGCACC  GGAGAGGCGT  240
241   GGCGGACCCG  AGGACGTGTG  GGCGCGCTTC  GCCGTGGGCA  CTGGCGGCTT  AGGCTCGGAG  300
301   GAGCGGCGCG  CTCTTGAGCT  CGAGCAGGCG  CAGCACGGGG  ACCTGCTGCT  GCTGCCCGCC  360
361   CTGCGCGACG  CCTACGAGAA  CCTCACGGCC  AAGGTCCTGG  CCATGCTGAC  CTGGCTGGAT  420
421   GAGCGCGTGG  ACTTCGAGTT  CGTGCTCAAG  GCGGACGACG  ACTCCTTTGC  GCGCCTGGAC  480
481   GCTATCCTGG  TGGACCTACG  CGCACGGGAG  CCCGCACGCC  GCCGGCGCCT  CTACTGGGGC  540
541   TTCTTTTCCG  GGCGCGGGCG  CGTCAAGCCG  GGAGGTCGCT  GGCGAGAAGC  AGCCTGGCAA  600
601   CTCTGCGACT  ACTACCTGCC  CTACGCGTTG  GGCGGTGGCT  ATGTCCTTTC  TGCGGACCTG  660
661   GTGCATTACC  TGCGCCTCAG  CCGCGAGTAC  CTGCGCGCGT  GGCACAGTGA  AGACGTATCG  720
721   CTGGGCACCT  GGCTGGCACC  AGTGGATGTG  CAACGGGAGC  ACGACCCACG  CTTCGACACG  780
781   GAGTACAAAT  CTCGAGGCTG  CAACAATCAG  TATCTGGTGA  CACACAAGCA  AAGCCCAGAG  840
841   GACATGTTGG  AGAAGCAACA  GATGTTGCTG  CATGAGGGCC  GGTTGTGCAA  GCATGAGGTG  900
901   CAGTTGCGCC  TTTCCTATGT  CTATGACTGG  TCAGCTCCAC  CCTCCCAGTG  CTGCCAGCGC  960
961   AAGGAGGGCG  TTCCCTGA  978

▼ KEYWORD

ID
Family
Complete proteome
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Membrane
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum
Cellular Component
Golgi apparatus
Cellular Component
Golgi medial cisterna
Cellular Component
Golgi membrane
Cellular Component
Integral component of membrane
Molecular Function
Galactosyltransferase activity
Molecular Function
Galactosylxylosylprotein 3-beta-galactosyltransferase activity
Molecular Function
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Molecular Function
UDP-galactosyltransferase activity
Biological Process
Chondroitin sulfate biosynthetic process
Biological Process
Glycosaminoglycan biosynthetic process
Biological Process
Heparan sulfate proteoglycan biosynthetic process
Biological Process
Protein glycosylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a962Rattus norvegicus96.00.0613
LLPS-Aim-a918Ailuropoda melanoleuca91.987e-114337
LLPS-Mea-a922Mesocricetus auratus90.80.0577
LLPS-Ova-a928Ovis aries89.511e-150436
LLPS-Rhb-a957Rhinopithecus bieti89.331e-134392
LLPS-Ict-a951Ictidomys tridecemlineatus88.161e-171489
LLPS-Paa-a969Papio anubis87.642e-158455
LLPS-Mam-a950Macaca mulatta87.62e-152439
LLPS-Loa-a934Loxodonta africana87.222e-136395
LLPS-Dio-a928Dipodomys ordii86.52e-150435
LLPS-Otg-a951Otolemur garnettii85.082e-160460
LLPS-Eqc-a962Equus caballus84.190.0518
LLPS-Sus-a966Sus scrofa84.05e-159457
LLPS-Cap-a963Cavia porcellus83.692e-173493
LLPS-Bot-a966Bos taurus83.642e-158456
LLPS-Hos-a982Homo sapiens83.63e-168480
LLPS-Pat-a969Pan troglodytes83.395e-164469
LLPS-Fec-a966Felis catus82.980.0513
LLPS-Caj-a958Callithrix jacchus82.338e-174494
LLPS-Chs-a955Chlorocebus sabaeus80.761e-166476
LLPS-Fia-a843Ficedula albicollis74.485e-131382
LLPS-Anp-a771Anas platyrhynchos72.669e-148427
LLPS-Mod-a924Monodelphis domestica71.438e-142412
LLPS-Meg-a766Meleagris gallopavo71.272e-145421
LLPS-Aon-a972Aotus nancymaae69.01e-94290
LLPS-Tag-a826Taeniopygia guttata65.964e-155447
LLPS-Leo-a826Lepisosteus oculatus63.314e-148429
LLPS-Pes-a825Pelodiscus sinensis62.769e-148429
LLPS-Scf-a812Scleropages formosus61.729e-146423
LLPS-Icp-a841Ictalurus punctatus60.881e-136400
LLPS-Orn-a836Oreochromis niloticus60.46e-137401
LLPS-Xet-a818Xenopus tropicalis60.175e-133391
LLPS-Dar-a843Danio rerio59.537e-129380
LLPS-Lac-a844Latimeria chalumnae59.413e-141412
LLPS-Pof-a832Poecilia formosa58.387e-133391
LLPS-Gaa-a812Gasterosteus aculeatus57.643e-141412
LLPS-Scm-a799Scophthalmus maximus57.644e-132389
LLPS-Asm-a831Astyanax mexicanus56.881e-116349
LLPS-Xim-a841Xiphophorus maculatus56.02e-114343