LLPS-Mum-a813
Nfasc
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Neurofascin |
| Gene Name: | Nfasc |
| Ensembl Gene: | ENSMUSG00000026442.14 |
| Ensembl Protein: | ENSMUSP00000132979.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000163770.7 | ENSMUSP00000132979.1 |
| Ensembl | ENSMUST00000188307.1 | ENSMUSP00000139520.1 |
| Ensembl | ENSMUST00000043189.13 | ENSMUSP00000035454.7 |
| Ensembl | ENSMUST00000186389.6 | ENSMUSP00000140480.1 |
| Ensembl | ENSMUST00000187861.6 | ENSMUSP00000139955.1 |
| Ensembl | ENSMUST00000094569.10 | ENSMUSP00000092148.4 |
| UniProt | Q810U3, NFASC_MOUSE | |
| GeneBank | AJ543322 | CAD65849.1 |
| RefSeq | NM_182716.4 | NP_874385.1 |
| Entrez | 269116 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MARQQAPPWV HIALILFLLS LGGAIEIPMD PSIQNELTQP PTITKQSVKD HIVDPRDNIL 60 61 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 120 121 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 180 181 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 240 241 ERTPSFMYPQ GTSSSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSN KAKFENFNKA 300 301 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 360 361 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 420 421 AFVSVLDVPP RMLSARNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 480 481 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVAKRGTTVQ 540 541 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCMASTELDQ 600 601 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDDNNSPITD 660 661 YVVQFEEDQF QPGVWHDHSR FPGSVNSAVL HLSPYVNYQF RVIAVNEVGS SHPSLPSERY 720 721 RTSGAPPESN PSDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETRETWNNVT 780 781 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPDTIIGYS GEDYPRAAPT EVKIRVLNST 840 841 AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR PRGVVARLFP 900 901 YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG 960 961 ILIGYILRYV PFNGTKLGKQ MVENFSPNQT KFSVQRADPV SRYRFSLSAR TQVGSGEAAT 1020 1021 EESPAPPNEA TPTAAPPTLP PTTVGTTGLV SSTDATALAA TSEATTVPII PTVVPTTVAT 1080 1081 TIATTTTTTA ATTTTTTTES PPTTTAGTKI HETAPDEQSI WNVTVLPNSK WANITWKHNF 1140 1141 RPGTDFVVEY IDSNHTKKTV PVKAQAQPIQ LTDLFPGMTY TLRVYSRDNE GISSTVITFM 1200 1201 TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE KKDVPLGPED 1260 1261 PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD YGEGGEGQFN EDGSFIGQYT 1320 1321 VKKDKEETEG NESSEATSPV NAIYSLA 1347 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCAGGC AGCAGGCGCC ACCCTGGGTC CACATAGCCC TCATCCTCTT CCTCCTCAGC 60 61 CTCGGAGGGG CCATCGAGAT TCCGATGGAC CTGACCCAAC CCCCAACTAT CACCAAGCAG 120 121 TCCGTGAAGG ACCACATCGT GGACCCTCGA GATAACATCC TGATTGAATG TGAAGCTAAA 180 181 GGCAACCCCG CCCCCAGTTT TCACTGGACT CGCAACAGCA GATTCTTCAA CATTGCCAAG 240 241 GACCCACGGG TGTCCATGAG GAGGAGATCT GGGACCTTGG TGATCGACTT CCGCAGTGGT 300 301 GGGCGGCCTG AGGAATACGA AGGGGAGTAC CAGTGCTTTG CCCGGAACAA ATTTGGCACT 360 361 GCACTTAGCA ACCGCATCCG CCTGCAGGTG TCCAAATCTC CCCTGTGGCC CAAGGAAAAC 420 421 CTAGACCCCG TCGTGGTTCA AGAGGGTGCC CCCTTGACAC TACAGTGCAA CCCCCCACCC 480 481 GGCCTCCCGT CCCCCGTCAT CTTCTGGATG AGCAGCTCCA TGGAGCCCAT CACCCAGGAC 540 541 AAGCGTGTCT CCCAGGGTCA CAACGGGGAC CTGTACTTCT CCAACGTCAT GCTGCAGGAC 600 601 ATGCAGACCG ACTACAGCTG CAACGCGCGC TTTCACTTCA CCCACACCAT TCAGCAGAAG 660 661 AACCCCTTCA CCCTCAAGGT CCTCACCACC CGAGGAGTTG CAGAAAGAAC GCCCAGCTTC 720 721 ATGTATCCCC AGGGCACATC GAGCAGTCAG ATGGTTCTCC GTGGCATGGA CCTGCTGCTG 780 781 GAATGCATTG CCTCTGGCGT CCCAACACCA GACATTGCAT GGTACAAGAA AGGTGGGGAC 840 841 CTCCCATCTA ACAAGGCCAA GTTCGAGAAC TTTAATAAGG CTCTGCGCAT CACCAATGTC 900 901 TCTGAAGAGG ACTCTGGGGA GTATTTCTGC CTGGCCTCCA ACAAGATGGG CAGCATCCGG 960 961 CACACGATCT CGGTGAGAGT AAAGGCTGCT CCATACTGGC TGGATGAGCC CAAGAACCTG 1020 1021 ATCCTGGCTC CTGGGGAAGA TGGGAGGCTG GTATGCCGAG CCAATGGGAA CCCGAAGCCG 1080 1081 ACCGTGCAGT GGATGGTGAA TGGAGAGCCT TTACAATCGG CACCACCCAA TCCCAACCGT 1140 1141 GAGGTAGCTG GAGACACTAT CATCTTCCGG GATACTCAGA TCAGCAGCAG GGCAGTGTAC 1200 1201 CAATGTAATA CATCCAATGA ACATGGCTAC CTGCTGGCCA ATGCCTTCGT CAGCGTGTTA 1260 1261 GATGTACCCC CTCGGATGCT GTCTGCCCGC AACCAGCTCA TCAGGGTGAT CCTTTATAAC 1320 1321 CGGACACGGC TGGACTGTCC GTTCTTTGGG TCTCCCATCC CAACACTCCG ATGGTTTAAG 1380 1381 AATGGGCAAG GAAGCAACCT GGATGGCGGT AACTACCACG TCTACGAAAA CGGCAGTCTA 1440 1441 GAAATCAAGA TGATTCGCAA AGAGGACCAA GGCATCTACA CCTGTGTGGC CACCAACATC 1500 1501 CTGGGCAAAG CCGAAAATCA AGTCCGCCTG GAGGTCAAAG ACCCCACCAG GATCTACAGG 1560 1561 ATGCCCGAGG ACCAGGTGGC CAAGAGGGGC ACCACGGTGC AGCTGGAGTG CCGCGTGAAA 1620 1621 CATGACCCCT CCTTGAAGCT CACAGTCTCC TGGCTGAAGG ACGATGAGCC ACTCTACATT 1680 1681 GGAAACAGGA TGAAGAAGGA AGATGACTCC CTGACGATCT TCGGAGTGGC AGAGCGGGAC 1740 1741 CAGGGCAGTT ACACGTGTAT GGCCAGCACC GAGCTGGACC AGGACCTGGC AAAGGCCTAC 1800 1801 CTCACTGTTC TAGGGCGACC AGACCGACCC AGGGACCTGG AGCTCACTGA CCTGGCTGAG 1860 1861 AGGAGTGTGA GGCTGACCTG GATCCCAGGG GATGACAACA ACAGCCCTAT CACAGACTAC 1920 1921 GTCGTTCAGT TTGAAGAGGA CCAGTTCCAA CCAGGGGTGT GGCATGACCA CTCCAGGTTC 1980 1981 CCAGGCAGCG TCAACTCAGC CGTCCTCCAT CTGTCCCCAT ATGTCAACTA CCAATTCAGA 2040 2041 GTCATCGCTG TCAACGAGGT TGGGAGCAGC CACCCCAGCC TTCCATCCGA GCGGTACCGA 2100 2101 ACCAGTGGGG CACCCCCTGA ATCTAATCCC AGTGATGTGA AGGGCGAAGG GACAAGAAAG 2160 2161 AACAATATGG AGATCACGTG GACGCCTATG AATGCTACCT CTGCCTTTGG CCCCAACCTA 2220 2221 CGCTACATTG TCAAGTGGCG ACGGAGAGAG ACCCGAGAGA CTTGGAACAA TGTCACAGTG 2280 2281 TGGGGCTCTC GCTACGTGGT GGGGCAGACG CCTGTCTACG TTCCCTATGA GATCCGAGTC 2340 2341 CAGGCTGAAA ATGACTTTGG GAAAGGCCCC GAGCCTGACA CCATCATTGG GTACTCCGGA 2400 2401 GAAGATTATC CCAGGGCTGC GCCCACTGAA GTTAAAATCC GAGTCCTGAA CAGCACAGCC 2460 2461 ATCAGCCTTC AGTGGAACCG AGTCTACTCT GACACGGTCC AGGGCCAGCT CAGAGAGTAT 2520 2521 CGAGCTTACT ACTGGAGGGA AAGCAGTTTG CTGAAGAACC TGTGGGTGTC TCAGAAGAGA 2580 2581 CAGCAGGCCA GCTTCCCTGG TGACCGTCCC CGGGGCGTGG TGGCCCGCCT GTTCCCCTAC 2640 2641 AGTAACTACA AGCTGGAGAT GGTGGTGGTC AATGGGAGAG GTGACGGGCC TCGAAGTGAA 2700 2701 ACCAAGGAAT TCACCACCCC AGAAGGAGTA CCCAGTGCCC CCAGGCGGTT CAGAGTCCGA 2760 2761 CAGCCCAACC TGGAGACCAT CAACCTGGAG TGGGACCACC CAGAGCACCC CAACGGAATC 2820 2821 CTGATTGGAT ACATCCTCAG ATACGTGCCC TTTAATGGAA CCAAACTGGG AAAGCAGATG 2880 2881 GTGGAAAACT TCTCTCCCAA TCAGACCAAG TTCTCTGTGC AGAGAGCAGA CCCAGTGTCG 2940 2941 CGTTACCGCT TCTCCCTCAG TGCCAGGACA CAGGTGGGCT CTGGAGAAGC AGCCACAGAG 3000 3001 GAGTCCCCAG CACCTCCAAA TGAAGCTACT CCAACTGCAG CTTACACCAA TAACCAGGCA 3060 3061 GACATCGCCA CCCAGGGCTG GTTCATCGGG CTCATGTGTG CCATTGCCCT TCTGGTGCTG 3120 3121 ATCCTTCTCA TCGTCTGCTT CATCAAGAGG AGTCGAGGTG GCAAGTACCC AGTGCGGGAA 3180 3181 AAGAAGGATG TCCCCTTGGG TCCTGAAGAC CCCAAAGAAG AAGATGGCTC ATTTGACTAC 3240 3241 AGTGATGAGG ACAACAAGCC CCTGCAGGGC AGCCAGACAT CTCTGGATGG CACCATCAAG 3300 3301 CAGCAGGAGA GCGATGACAG CCTGGTGGAC TATGGCGAAG GCGGCGAGGG CCAGTTCAAT 3360 3361 GAAGATGGCT CCTTTATTGG CCAGTACACT GTCAAAAAGG ACAAGGAGGA AACGGAGGGC 3420 3421 AATGAGAGCT CAGAGGCCAC ATCACCAGTC AATGCCATCT ATTCCCTTGC CTGA 3474 |
▼ KEYWORD
ID | Family |
Cell adhesion | |
Cell membrane | |
Complete proteome | |
Direct protein sequencing | |
Disulfide bond | |
Glycoprotein | |
Immunoglobulin domain | |
Membrane | |
Phosphoprotein | |
Reference proteome | |
Repeat | |
Signal | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axon | |
Cellular Component | Axon initial segment | |
Cellular Component | Dendrite | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Myelin sheath | |
Cellular Component | Node of Ranvier | |
Cellular Component | Paranodal junction | |
Cellular Component | Paranode region of axon | |
Cellular Component | Plasma membrane | |
Cellular Component | Schwann cell microvillus | |
Cellular Component | Septate junction | |
Molecular Function | Protein binding involved in heterotypic cell-cell adhesion | |
Molecular Function | Protein domain specific binding | |
Biological Process | Axon guidance | |
Biological Process | Clustering of voltage-gated sodium channels | |
Biological Process | Paranodal junction assembly | |
Biological Process | Peripheral nervous system development | |
Biological Process | Protein localization to juxtaparanode region of axon | |
Biological Process | Protein localization to paranode region of axon | |
Biological Process | Protein localization to plasma membrane | |
Biological Process | Synapse organization | |
Biological Process | Transmission of nerve impulse |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ict-a799 | Ictidomys tridecemlineatus | 96.46 | 0.0 | 1721 |
| LLPS-Dio-a780 | Dipodomys ordii | 96.36 | 0.0 | 2706 |
| LLPS-Paa-a814 | Papio anubis | 96.22 | 0.0 | 2702 |
| LLPS-Mal-a799 | Mandrillus leucophaeus | 96.08 | 0.0 | 2548 |
| LLPS-Poa-a791 | Pongo abelii | 95.63 | 0.0 | 1705 |
| LLPS-Otg-a800 | Otolemur garnettii | 95.55 | 0.0 | 2543 |
| LLPS-Hos-a826 | Homo sapiens | 95.4 | 0.0 | 1704 |
| LLPS-Cea-a815 | Cercocebus atys | 95.33 | 0.0 | 2569 |
| LLPS-Cas-a697 | Carlito syrichta | 95.11 | 0.0 | 2568 |
| LLPS-Mup-a784 | Mustela putorius furo | 95.1 | 0.0 | 2550 |
| LLPS-Aon-a817 | Aotus nancymaae | 95.03 | 0.0 | 2567 |
| LLPS-Gog-a808 | Gorilla gorilla | 95.03 | 0.0 | 2558 |
| LLPS-Pap-a796 | Pan paniscus | 94.95 | 0.0 | 2558 |
| LLPS-Pat-a814 | Pan troglodytes | 94.88 | 0.0 | 2557 |
| LLPS-Nol-a796 | Nomascus leucogenys | 94.74 | 0.0 | 2548 |
| LLPS-Caj-a807 | Callithrix jacchus | 94.72 | 0.0 | 2545 |
| LLPS-Chs-a801 | Chlorocebus sabaeus | 94.65 | 0.0 | 2548 |
| LLPS-Aim-a772 | Ailuropoda melanoleuca | 94.6 | 0.0 | 2540 |
| LLPS-Maf-a811 | Macaca fascicularis | 94.57 | 0.0 | 2548 |
| LLPS-Mam-a800 | Macaca mulatta | 94.57 | 0.0 | 2544 |
| LLPS-Cap-a811 | Cavia porcellus | 94.51 | 0.0 | 2507 |
| LLPS-Eqc-a810 | Equus caballus | 94.43 | 0.0 | 2533 |
| LLPS-Fec-a812 | Felis catus | 94.01 | 0.0 | 2556 |
| LLPS-Man-a815 | Macaca nemestrina | 93.98 | 0.0 | 1698 |
| LLPS-Caf-a793 | Canis familiaris | 93.91 | 0.0 | 2557 |
| LLPS-Loa-a784 | Loxodonta africana | 93.91 | 0.0 | 2035 |
| LLPS-Sus-a813 | Sus scrofa | 93.78 | 0.0 | 2529 |
| LLPS-Bot-a816 | Bos taurus | 93.38 | 0.0 | 2507 |
| LLPS-Fud-a784 | Fukomys damarensis | 92.87 | 0.0 | 2508 |
| LLPS-Orc-a760 | Oryctolagus cuniculus | 91.52 | 0.0 | 2496 |
| LLPS-Ran-a807 | Rattus norvegicus | 90.54 | 0.0 | 1734 |
| LLPS-Myl-a757 | Myotis lucifugus | 90.16 | 0.0 | 2408 |
| LLPS-Rhb-a802 | Rhinopithecus bieti | 88.78 | 0.0 | 1709 |
| LLPS-Ova-a782 | Ovis aries | 87.91 | 0.0 | 1904 |
| LLPS-Urm-a733 | Ursus maritimus | 87.19 | 0.0 | 1678 |
| LLPS-Mod-a774 | Monodelphis domestica | 85.09 | 0.0 | 2293 |
| LLPS-Ora-a665 | Ornithorhynchus anatinus | 81.46 | 0.0 | 1736 |
| LLPS-Sah-a730 | Sarcophilus harrisii | 81.43 | 0.0 | 2195 |
| LLPS-Tag-a699 | Taeniopygia guttata | 80.75 | 0.0 | 1701 |
| LLPS-Mea-a773 | Mesocricetus auratus | 75.6 | 0.0 | 1251 |
| LLPS-Gaga-a731 | Gallus gallus | 75.09 | 0.0 | 2024 |
| LLPS-Fia-a716 | Ficedula albicollis | 73.45 | 0.0 | 2026 |
| LLPS-Anp-a658 | Anas platyrhynchos | 73.26 | 0.0 | 1998 |
| LLPS-Pes-a694 | Pelodiscus sinensis | 72.82 | 0.0 | 1743 |
| LLPS-Meg-a652 | Meleagris gallopavo | 72.73 | 0.0 | 1041 |
| LLPS-Anc-a739 | Anolis carolinensis | 72.51 | 0.0 | 1932 |
| LLPS-Xet-a696 | Xenopus tropicalis | 70.17 | 0.0 | 1775 |
| LLPS-Lac-a715 | Latimeria chalumnae | 68.39 | 0.0 | 1856 |
| LLPS-Scf-a688 | Scleropages formosus | 62.17 | 0.0 | 1299 |
| LLPS-Leo-a701 | Lepisosteus oculatus | 62.04 | 0.0 | 1679 |
| LLPS-Asm-a705 | Astyanax mexicanus | 60.8 | 0.0 | 1278 |
| LLPS-Dar-a710 | Danio rerio | 60.14 | 0.0 | 1287 |
| LLPS-Orn-a710 | Oreochromis niloticus | 60.03 | 0.0 | 1555 |
| LLPS-Xim-a716 | Xiphophorus maculatus | 59.62 | 0.0 | 1507 |
| LLPS-Scm-a679 | Scophthalmus maximus | 59.34 | 0.0 | 1254 |
| LLPS-Ten-a670 | Tetraodon nigroviridis | 59.11 | 0.0 | 1513 |
| LLPS-Tar-a671 | Takifugu rubripes | 58.53 | 0.0 | 1211 |
| LLPS-Icp-a712 | Ictalurus punctatus | 58.02 | 0.0 | 1259 |
| LLPS-Gaa-a691 | Gasterosteus aculeatus | 57.76 | 0.0 | 1495 |
| LLPS-Orl-a703 | Oryzias latipes | 57.6 | 0.0 | 1377 |
| LLPS-Pof-a713 | Poecilia formosa | 56.97 | 0.0 | 1408 |