LLPS-Mum-a807
Vsnl1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Visinin-like protein 1 |
| Gene Name: | Vsnl1, Visl1 |
| Ensembl Gene: | ENSMUSG00000054459.8 |
| Ensembl Protein: | ENSMUSP00000072145.5 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000072299.6 | ENSMUSP00000072145.5 |
| Ensembl | ENSMUST00000220506.1 | ENSMUSP00000152711.1 |
| UniProt | P62761, VISL1_MOUSE, P28677, P29103, P42323, Q9UM20 | |
| GeneBank | AY101375, D21165, BC046226 | AAH46226.1, BAA04701.1, AAM48292.1 |
| RefSeq | NM_012038.4 | NP_036168.1 |
| Entrez | 26950 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD 60 61 ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE 120 121 MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS 180 181 IVLLLQCDIQ K 191 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGAAAC AGAATAGCAA ACTGGCCCCA GAAGTCATGG AGGACCTGGT GAAGAGCACT 60 61 GAGTTCAATG AGCATGAGCT TAAGCAGTGG TACAAGGGCT TCCTCAAGGA CTGTCCGAGC 120 121 GGGAGGCTGA ACCTCGAGGA GTTCCAGCAG CTCTATGTGA AGTTCTTCCC CTATGGAGAT 180 181 GCCTCCAAGT TCGCGCAGCA CGCCTTCCGC ACCTTCGACA AGAACGGTGA TGGCACCATC 240 241 GATTTCCGAG AGTTCATCTG TGCCCTGTCC ATCACCTCCA GAGGTAGCTT TGAGCAGAAA 300 301 CTGAACTGGG CTTTCAACAT GTATGATCTG GACGGTGACG GCAAGATCAC CCGAGTGGAG 360 361 ATGCTGGAGA TTATCGAGGC TATCTACAAA ATGGTGGGCA CCGTGATCAT GATGAAAATG 420 421 AATGAGGATG GCCTGACGCC TGAACAGCGG GTGGACAAGA TTTTCAGCAA GATGGATAAG 480 481 AACAAAGATG ACCAGATTAC ACTGGATGAA TTCAAAGAAG CTGCAAAAAG CGACCCTTCC 540 541 ATTGTATTAC TTCTGCAGTG TGACATTCAG AAATGA 576 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Membrane | |
Molecular Function | Calcium ion binding | |
Biological Process | Negative regulation of insulin secretion | |
Biological Process | Positive regulation of exocytosis | |
Biological Process | Positive regulation of insulin secretion involved in cellular response to glucose stimulus |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mup-a777 | Mustela putorius furo | 100.0 | 2e-139 | 396 |
| LLPS-Pat-a808 | Pan troglodytes | 100.0 | 2e-139 | 396 |
| LLPS-Cas-a691 | Carlito syrichta | 100.0 | 2e-139 | 396 |
| LLPS-Myl-a750 | Myotis lucifugus | 100.0 | 2e-139 | 396 |
| LLPS-Fia-a713 | Ficedula albicollis | 100.0 | 2e-139 | 396 |
| LLPS-Mal-a792 | Mandrillus leucophaeus | 100.0 | 2e-139 | 396 |
| LLPS-Cea-a808 | Cercocebus atys | 100.0 | 2e-139 | 396 |
| LLPS-Aon-a811 | Aotus nancymaae | 100.0 | 2e-139 | 396 |
| LLPS-Otg-a794 | Otolemur garnettii | 100.0 | 6e-130 | 372 |
| LLPS-Fec-a806 | Felis catus | 100.0 | 6e-139 | 396 |
| LLPS-Ere-a195 | Erinaceus europaeus | 100.0 | 3e-89 | 266 |
| LLPS-Sus-a806 | Sus scrofa | 100.0 | 2e-139 | 396 |
| LLPS-Ran-a800 | Rattus norvegicus | 100.0 | 2e-139 | 396 |
| LLPS-Urm-a729 | Ursus maritimus | 100.0 | 2e-139 | 396 |
| LLPS-Hos-a820 | Homo sapiens | 100.0 | 2e-139 | 396 |
| LLPS-Tut-a418 | Tursiops truncatus | 100.0 | 2e-139 | 396 |
| LLPS-Dio-a773 | Dipodomys ordii | 100.0 | 2e-139 | 396 |
| LLPS-Aim-a766 | Ailuropoda melanoleuca | 100.0 | 2e-139 | 396 |
| LLPS-Chs-a794 | Chlorocebus sabaeus | 100.0 | 3e-138 | 396 |
| LLPS-Maf-a805 | Macaca fascicularis | 100.0 | 2e-139 | 396 |
| LLPS-Caj-a801 | Callithrix jacchus | 100.0 | 2e-139 | 396 |
| LLPS-Orc-a754 | Oryctolagus cuniculus | 100.0 | 2e-139 | 396 |
| LLPS-Pap-a789 | Pan paniscus | 100.0 | 2e-139 | 396 |
| LLPS-Cap-a804 | Cavia porcellus | 100.0 | 2e-139 | 396 |
| LLPS-Poa-a784 | Pongo abelii | 100.0 | 2e-139 | 396 |
| LLPS-Eqc-a803 | Equus caballus | 100.0 | 2e-139 | 399 |
| LLPS-Ict-a792 | Ictidomys tridecemlineatus | 100.0 | 2e-139 | 396 |
| LLPS-Gog-a802 | Gorilla gorilla | 100.0 | 2e-139 | 396 |
| LLPS-Loa-a777 | Loxodonta africana | 100.0 | 2e-139 | 396 |
| LLPS-Man-a809 | Macaca nemestrina | 100.0 | 2e-139 | 396 |
| LLPS-Paa-a807 | Papio anubis | 100.0 | 2e-139 | 396 |
| LLPS-Tag-a697 | Taeniopygia guttata | 100.0 | 2e-139 | 396 |
| LLPS-Mam-a794 | Macaca mulatta | 100.0 | 2e-139 | 396 |
| LLPS-Rhb-a796 | Rhinopithecus bieti | 100.0 | 2e-139 | 396 |
| LLPS-Anp-a654 | Anas platyrhynchos | 100.0 | 2e-139 | 396 |
| LLPS-Ova-a777 | Ovis aries | 100.0 | 2e-139 | 396 |
| LLPS-Meg-a650 | Meleagris gallopavo | 100.0 | 2e-139 | 396 |
| LLPS-Bot-a810 | Bos taurus | 100.0 | 2e-139 | 397 |
| LLPS-Mea-a767 | Mesocricetus auratus | 100.0 | 2e-139 | 396 |
| LLPS-Nol-a789 | Nomascus leucogenys | 100.0 | 2e-139 | 396 |
| LLPS-Fud-a777 | Fukomys damarensis | 100.0 | 2e-139 | 396 |
| LLPS-Xet-a693 | Xenopus tropicalis | 99.48 | 9e-139 | 394 |
| LLPS-Pes-a691 | Pelodiscus sinensis | 99.48 | 9e-139 | 394 |
| LLPS-Anc-a735 | Anolis carolinensis | 98.95 | 2e-137 | 392 |
| LLPS-Leo-a698 | Lepisosteus oculatus | 98.95 | 9e-138 | 392 |
| LLPS-Lac-a711 | Latimeria chalumnae | 98.43 | 1e-137 | 391 |
| LLPS-Ora-a663 | Ornithorhynchus anatinus | 97.87 | 2e-96 | 286 |
| LLPS-Sah-a724 | Sarcophilus harrisii | 97.4 | 4e-134 | 383 |
| LLPS-Orn-a705 | Oreochromis niloticus | 97.38 | 2e-136 | 388 |
| LLPS-Dar-a705 | Danio rerio | 96.86 | 1e-135 | 387 |
| LLPS-Pof-a709 | Poecilia formosa | 96.86 | 8e-136 | 387 |
| LLPS-Ten-a666 | Tetraodon nigroviridis | 96.86 | 6e-136 | 387 |
| LLPS-Scf-a683 | Scleropages formosus | 96.86 | 2e-135 | 386 |
| LLPS-Asm-a700 | Astyanax mexicanus | 96.34 | 2e-135 | 385 |
| LLPS-Icp-a707 | Ictalurus punctatus | 96.34 | 2e-135 | 385 |
| LLPS-Xim-a712 | Xiphophorus maculatus | 96.34 | 2e-135 | 386 |
| LLPS-Scm-a675 | Scophthalmus maximus | 95.81 | 1e-134 | 385 |
| LLPS-Orl-a698 | Oryzias latipes | 95.7 | 9e-131 | 374 |
| LLPS-Gaa-a687 | Gasterosteus aculeatus | 95.29 | 4e-134 | 382 |
| LLPS-Tar-a667 | Takifugu rubripes | 91.1 | 5e-128 | 367 |
| LLPS-Mod-a767 | Monodelphis domestica | 90.05 | 4e-127 | 365 |
| LLPS-Caf-a786 | Canis familiaris | 89.53 | 5e-127 | 365 |
| LLPS-Gaga-a728 | Gallus gallus | 86.91 | 1e-123 | 356 |
| LLPS-Cis-a266 | Ciona savignyi | 56.22 | 3e-67 | 214 |
| LLPS-Drm-a181 | Drosophila melanogaster | 56.22 | 2e-68 | 215 |
| LLPS-Cii-a323 | Ciona intestinalis | 53.97 | 2e-66 | 210 |