LLPS-Mum-a806
Fbxo41
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | F-box only protein 41 |
| Gene Name: | Fbxo41, D6Ertd538e, Kiaa1940 |
| Ensembl Gene: | ENSMUSG00000047013.15 |
| Ensembl Protein: | ENSMUSP00000125671.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000159062.7 | ENSMUSP00000125671.1 |
| Ensembl | ENSMUST00000161546.1 | ENSMUSP00000124754.1 |
| Ensembl | ENSMUST00000161078.7 | ENSMUSP00000124524.1 |
| UniProt | Q6NS60, FBX41_MOUSE, Q6P7W4, Q6ZPG1 | |
| GeneBank | AK129466, BC061475, BC070445 | AAH61475.1, BAC98276.1, AAH70445.1 |
| RefSeq | NM_001001160.3, NM_001289674.1, NM_001289675.1 | NP_001001160.1, NP_001276603.1, NP_001276604.1 |
| Entrez | 330369 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG AAAAAAAAAA 60 61 ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQATGPSP AGPHLLHHHH HHAPLAHFPA 120 121 DLVPASLPCE ELAEPGLVPA ARYALREIEI PLGELFARKS VASSACSTPP PGPGPGPCSG 180 181 PSSASPASPS PADVAYEEGL ARLKIRALEK LEVDRRLERL SEEVEQKIAG QVGRLQAELE 240 241 RKAAELETAR QESARLGREK EELEERASEL SRQVDVSVEL LASLKQDLVH KEQELSRKQQ 300 301 EVVQIDQFLK ETAAREASAK LRLQQFIEEL LERADRAERQ LQVISSSCGS TPSASLGRGG 360 361 GGSASGPGVR GPGRMREHHA GSAVPSTYAV SRHGSSPSTG ASSRVPAASQ SSGCYDSDSL 420 421 ELPRPEEGPS EDSGPGGLGS RAQATNGGSE RSQAPRSSGL RRQAIQNWQR RPRRHSTEGE 480 481 EGDVSDVGSR TTESEAEGPS DVPRPGPAVA GPLNSCRLSA RPEGGSGRGR RVERGSPSRS 540 541 NEVISPEILK MRAALFCIFT YLDTRTLLHA AEVCRDWRFV ARHPAVWTRV LLENARVCSK 600 601 FLAMLAQWCT QAHSLTLQNL KPRQRGKKES KEEYARSTRG CLEAGLESLL KAAGGNLLIL 660 661 RISHCPNILT DRSLWLASCY CRALQAVTYR SATDPVGHEV IWALGAGCRD IVSLQVAPLH 720 721 PCQQPTRFSN RCLQMIGRCW PHLRALGVGG AGCGVQGLAS LARNCMRLQV LELDHVSEIT 780 781 QEVAAEVCRE GLKGLEMLVL TATPVTPKAL LHFNSICRNL KSIVVQIGIA DYFKEPSSPE 840 841 AQKLFEDMVT KLQALRRRPG FSKILHIKVE GGC 873 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTCGC TGGACCTACC GTACCGCTGC CCGCGCTGCG GGGAGCATAA GCGCTTCCGG 60 61 AGCCTATCGT CGCTGCGCGC GCACCTGGAG TACAGCCACA CCTACGAGAC GCTCTACATC 120 121 CTTTCCAAGA CCAACAGCAT CTGCGACGGC GCGGCCGCCG CTGCAGCCGC TGCCGCCGCA 180 181 GCCTCTGGAT TCCCGCTGGC GCCTGAGCCC GCCGCCTTGC TGGCTGTCCC CGGGGCCCGG 240 241 CGTGAGGTCT TTGAGAGCAC GTCCTTCCAG GGCAAGGAAC AGGCGACCGG GCCCTCGCCC 300 301 GCGGGGCCGC ACCTGCTGCA CCATCATCAC CACCACGCGC CACTGGCGCA CTTTCCCGCT 360 361 GACCTGGTGC CCGCTAGCCT GCCCTGCGAG GAGCTGGCTG AGCCGGGGCT CGTGCCCGCT 420 421 GCGCGCTATG CGCTACGCGA AATCGAAATC CCACTCGGCG AGCTGTTTGC GCGCAAGTCC 480 481 GTGGCATCCT CTGCCTGCTC GACGCCGCCA CCCGGACCTG GCCCTGGTCC TTGTTCCGGG 540 541 CCCTCCTCTG CATCGCCGGC GTCGCCATCA CCTGCGGACG TCGCCTACGA AGAGGGCCTG 600 601 GCACGCCTTA AGATCCGCGC CCTGGAGAAG CTGGAGGTGG ACCGGAGACT AGAGCGGCTG 660 661 AGCGAGGAGG TGGAGCAGAA GATCGCGGGC CAGGTGGGTC GGCTACAGGC GGAGCTGGAG 720 721 CGCAAGGCAG CAGAGCTAGA AACTGCAAGA CAGGAGAGCG CGCGCCTGGG ACGCGAGAAG 780 781 GAGGAGCTGG AGGAGCGCGC CTCTGAGCTC TCACGCCAAG TGGACGTGAG CGTGGAACTG 840 841 CTGGCTTCAC TCAAGCAGGA CCTGGTGCAT AAGGAACAGG AGCTGAGCCG CAAGCAGCAG 900 901 GAGGTGGTGC AGATCGACCA GTTCCTGAAG GAGACGGCAG CTCGGGAGGC CAGTGCCAAG 960 961 CTGCGGCTGC AACAGTTCAT CGAGGAGCTC CTGGAGCGTG CAGACAGGGC CGAGCGCCAG 1020 1021 TTGCAGGTCA TCAGCAGCAG CTGTGGCAGC ACACCCAGTG CCAGCCTGGG CAGAGGAGGT 1080 1081 GGGGGCAGTG CCTCGGGGCC TGGGGTGAGA GGCCCCGGCA GAATGCGAGA ACATCATGCA 1140 1141 GGCTCAGCTG TGCCAAGCAC ATACGCCGTA TCACGGCATG GCTCCTCTCC CAGCACAGGG 1200 1201 GCCTCCAGTC GTGTGCCAGC TGCATCCCAG AGCTCAGGCT GCTATGACAG TGACAGTCTG 1260 1261 GAGCTGCCCC GGCCAGAGGA AGGGCCCTCG GAGGACAGTG GCCCTGGGGG CTTGGGTTCA 1320 1321 CGGGCCCAGG CTACCAACGG TGGTTCAGAG CGGTCCCAGG CCCCTCGTAG TTCAGGCCTA 1380 1381 AGACGACAGG CCATCCAGAA CTGGCAACGC CGACCTCGTC GTCACAGCAC CGAGGGGGAG 1440 1441 GAGGGTGACG TTTCGGATGT GGGCTCCCGA ACTACTGAGT CAGAGGCTGA AGGACCCTCA 1500 1501 GATGTCCCAC GCCCTGGACC TGCTGTGGCT GGCCCCTTGA ACAGCTGCCG GCTCTCTGCA 1560 1561 CGTCCTGAAG GAGGCAGCGG GCGAGGCCGT CGGGTGGAGA GAGGTAGCCC CTCACGCTCC 1620 1621 AATGAGGTCA TCAGCCCAGA AATCCTCAAG ATGCGAGCTG CCCTCTTCTG TATCTTCACC 1680 1681 TACCTGGATA CCCGGACACT GCTCCATGCA GCAGAGGTCT GTCGGGACTG GCGCTTTGTG 1740 1741 GCCCGCCATC CCGCTGTCTG GACGAGAGTG CTACTTGAGA ATGCCCGAGT CTGTTCCAAG 1800 1801 TTCCTGGCGA TGTTGGCTCA GTGGTGCACC CAGGCTCACT CGTTAACATT ACAGAACCTG 1860 1861 AAGCCCCGGC AGCGGGGGAA GAAGGAAAGC AAGGAGGAGT ATGCCCGCAG CACCCGGGGC 1920 1921 TGCCTTGAAG CAGGGCTGGA GTCCCTGCTG AAGGCAGCTG GTGGGAACCT GCTGATCCTG 1980 1981 CGAATCTCCC ACTGCCCCAA CATCCTCACT GACCGGTCCC TCTGGCTGGC CAGCTGCTAC 2040 2041 TGCCGTGCCC TGCAGGCTGT CACCTACAGG AGTGCCACGG ACCCCGTCGG CCATGAGGTG 2100 2101 ATCTGGGCCC TGGGTGCAGG CTGCAGAGAC ATTGTCTCCC TCCAGGTGGC GCCACTTCAC 2160 2161 CCCTGCCAGC AGCCCACCCG GTTCAGCAAC CGTTGCCTGC AGATGATTGG ACGCTGTTGG 2220 2221 CCCCACCTCC GGGCCCTGGG CGTAGGTGGT GCCGGCTGTG GGGTACAGGG CCTGGCATCA 2280 2281 CTTGCAAGAA ACTGTATGCG GCTGCAGGTC CTGGAGCTGG ACCACGTGTC AGAGATTACC 2340 2341 CAGGAGGTGG CGGCTGAGGT CTGCCGGGAA GGCCTGAAGG GACTGGAGAT GCTGGTGCTC 2400 2401 ACAGCCACCC CTGTCACCCC TAAGGCCCTG CTTCATTTTA ACAGCATCTG CCGGAACCTT 2460 2461 AAATCCATTG TGGTGCAGAT TGGGATTGCA GATTACTTCA AAGAGCCCAG CAGTCCCGAG 2520 2521 GCCCAGAAGC TGTTTGAGGA CATGGTGACA AAACTCCAGG CCCTGCGTCG GAGGCCTGGC 2580 2581 TTCTCGAAGA TTCTGCACAT CAAGGTAGAA GGTGGTTGCT AA 2622 |
▼ KEYWORD
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mea-a766 | Mesocricetus auratus | 98.51 | 0.0 | 1731 |
| LLPS-Poa-a783 | Pongo abelii | 97.68 | 0.0 | 575 |
| LLPS-Fud-a776 | Fukomys damarensis | 97.4 | 0.0 | 1281 |
| LLPS-Maf-a804 | Macaca fascicularis | 97.37 | 0.0 | 1709 |
| LLPS-Chs-a793 | Chlorocebus sabaeus | 97.26 | 0.0 | 1708 |
| LLPS-Rhb-a795 | Rhinopithecus bieti | 97.21 | 0.0 | 997 |
| LLPS-Mal-a791 | Mandrillus leucophaeus | 97.03 | 0.0 | 1133 |
| LLPS-Aon-a810 | Aotus nancymaae | 97.03 | 0.0 | 1706 |
| LLPS-Caj-a800 | Callithrix jacchus | 97.03 | 0.0 | 1701 |
| LLPS-Ict-a791 | Ictidomys tridecemlineatus | 97.03 | 0.0 | 1696 |
| LLPS-Hos-a819 | Homo sapiens | 96.91 | 0.0 | 1701 |
| LLPS-Sus-a805 | Sus scrofa | 96.69 | 0.0 | 1696 |
| LLPS-Dio-a772 | Dipodomys ordii | 96.69 | 0.0 | 1692 |
| LLPS-Cap-a803 | Cavia porcellus | 96.57 | 0.0 | 1692 |
| LLPS-Fec-a805 | Felis catus | 96.34 | 0.0 | 1686 |
| LLPS-Eqc-a802 | Equus caballus | 96.34 | 0.0 | 1684 |
| LLPS-Caf-a785 | Canis familiaris | 96.11 | 0.0 | 1679 |
| LLPS-Mam-a793 | Macaca mulatta | 95.84 | 0.0 | 1698 |
| LLPS-Man-a808 | Macaca nemestrina | 95.67 | 0.0 | 1524 |
| LLPS-Aim-a765 | Ailuropoda melanoleuca | 95.63 | 0.0 | 1348 |
| LLPS-Cea-a807 | Cercocebus atys | 95.56 | 0.0 | 1524 |
| LLPS-Bot-a809 | Bos taurus | 95.41 | 0.0 | 1553 |
| LLPS-Pat-a807 | Pan troglodytes | 95.34 | 0.0 | 1520 |
| LLPS-Pap-a788 | Pan paniscus | 94.83 | 0.0 | 1333 |
| LLPS-Loa-a776 | Loxodonta africana | 94.73 | 0.0 | 1519 |
| LLPS-Myl-a749 | Myotis lucifugus | 94.63 | 0.0 | 1541 |
| LLPS-Paa-a806 | Papio anubis | 92.79 | 0.0 | 1448 |
| LLPS-Ran-a799 | Rattus norvegicus | 92.44 | 0.0 | 1456 |
| LLPS-Gog-a801 | Gorilla gorilla | 91.28 | 0.0 | 1395 |
| LLPS-Ova-a776 | Ovis aries | 86.89 | 0.0 | 1170 |
| LLPS-Orc-a753 | Oryctolagus cuniculus | 86.38 | 0.0 | 1447 |
| LLPS-Ten-a665 | Tetraodon nigroviridis | 86.38 | 0.0 | 606 |
| LLPS-Mod-a766 | Monodelphis domestica | 84.34 | 0.0 | 1366 |
| LLPS-Pes-a690 | Pelodiscus sinensis | 79.27 | 0.0 | 903 |
| LLPS-Fia-a712 | Ficedula albicollis | 78.71 | 0.0 | 1038 |
| LLPS-Sah-a723 | Sarcophilus harrisii | 74.07 | 0.0 | 1129 |
| LLPS-Gaga-a727 | Gallus gallus | 71.89 | 0.0 | 1183 |
| LLPS-Meg-a649 | Meleagris gallopavo | 71.69 | 0.0 | 1173 |
| LLPS-Anc-a734 | Anolis carolinensis | 70.57 | 0.0 | 1191 |
| LLPS-Xet-a692 | Xenopus tropicalis | 69.16 | 0.0 | 1152 |
| LLPS-Leo-a697 | Lepisosteus oculatus | 67.38 | 0.0 | 1117 |
| LLPS-Pof-a708 | Poecilia formosa | 65.66 | 0.0 | 1089 |
| LLPS-Xim-a711 | Xiphophorus maculatus | 65.62 | 0.0 | 1089 |
| LLPS-Tag-a696 | Taeniopygia guttata | 65.11 | 0.0 | 981 |
| LLPS-Dar-a704 | Danio rerio | 65.11 | 0.0 | 1060 |
| LLPS-Asm-a699 | Astyanax mexicanus | 64.45 | 0.0 | 1059 |
| LLPS-Icp-a706 | Ictalurus punctatus | 64.36 | 0.0 | 1047 |
| LLPS-Lac-a710 | Latimeria chalumnae | 61.94 | 0.0 | 948 |
| LLPS-Orl-a697 | Oryzias latipes | 60.45 | 2e-128 | 408 |