LLPS-Mum-a754
Slc6a1

▼ OVERVIEW

Status: Reviewed
Protein Name: Sodium- and chloride-dependent GABA transporter 1
Gene Name: Slc6a1, Gabt1, Gat-1, Gat1
Ensembl Gene: ENSMUSG00000030310.10
Ensembl Protein: ENSMUSP00000032454.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATDNSKVAD  GQISTEVSEA  PVASDKPKTL  VVKVQKKAGD  LPDRDTWKGR  FDFLMSCVGY  60
61    AIGLGNVWRF  PYLCGKNGGG  AFLIPYFLTL  IFAGVPLFLL  ECSLGQYTSI  GGLGVWKLAP  120
121   MFKGVGLAAA  VLSFWLNIYY  IVIISWAIYY  LYNSFTTTLP  WKQCDNPWNT  DRCFSNYSLV  180
181   NTTNMTSAVV  EFWERNMHQM  TDGLDKPGQI  RWPLAITLAI  AWVLVYFCIW  KGVGWTGKVV  240
241   YFSATYPYIM  LIILFFRGVT  LPGAKEGILF  YITPNFRKLS  DSEVWLDAAT  QIFFSYGLGL  300
301   GSLIALGSYN  SFHNNVYRDS  IIVCCINSCT  SMFAGFVIFS  IVGFMAHVTK  RSIADVAASG  360
361   PGLAFLAYPE  AVTQLPISPL  WAILFFSMLL  MLGIDSQFCT  VEGFITALVD  EYPRLLRNRR  420
421   ELFIAAVCIV  SYLIGLSNIT  QGGIYVFKLF  DYYSASGMSL  LFLVFFECVS  ISWFYGVNRF  480
481   YDNIQEMVGS  RPCIWWKLCW  SFFTPIIVAG  VFLFSAVQMT  PLTMGSYVFP  KWGQGVGWLM  540
541   ALSSMVLIPG  YMAYMFLTLK  GSLKQRLQVM  IQPSEDIVRP  ENGPEQPQAG  SSASKEAYI  599
Nucleotide CDS Sequence (FASTA)
1     ATGGCGACTG  ACAACAGCAA  GGTGGCTGAT  GGGCAGATCT  CTACTGAGGT  CAGCGAGGCC  60
61    CCTGTGGCCA  GCGACAAGCC  CAAAACCCTG  GTAGTCAAGG  TGCAGAAGAA  GGCCGGGGAC  120
121   CTCCCTGACC  GGGACACATG  GAAGGGACGC  TTCGACTTCC  TCATGTCCTG  CGTGGGCTAT  180
181   GCCATCGGCC  TGGGCAATGT  GTGGAGGTTC  CCTTACCTCT  GTGGGAAAAA  CGGTGGCGGG  240
241   GCCTTCCTAA  TCCCATATTT  CCTGACGCTC  ATCTTTGCGG  GTGTTCCTCT  CTTCCTTTTG  300
301   GAGTGCTCCC  TAGGCCAGTA  CACCTCCATT  GGGGGCCTGG  GCGTATGGAA  GCTGGCGCCC  360
361   ATGTTCAAGG  GTGTGGGCCT  CGCGGCAGCT  GTGCTGTCCT  TCTGGCTGAA  CATCTACTAC  420
421   ATCGTCATCA  TCTCCTGGGC  CATCTACTAC  CTGTACAACT  CCTTCACCAC  GACCCTGCCA  480
481   TGGAAACAGT  GTGACAACCC  GTGGAACACT  GACCGCTGCT  TCTCCAACTA  CAGCCTGGTC  540
541   AATACCACCA  ACATGACCAG  CGCCGTGGTG  GAGTTCTGGG  AGCGCAACAT  GCACCAGATG  600
601   ACAGATGGAC  TGGACAAGCC  AGGACAGATC  CGCTGGCCTC  TGGCCATCAC  ACTGGCCATT  660
661   GCCTGGGTGC  TCGTGTATTT  CTGCATCTGG  AAGGGTGTTG  GTTGGACTGG  AAAGGTGGTC  720
721   TACTTCTCAG  CCACGTACCC  CTACATCATG  CTTATCATCC  TGTTCTTCCG  TGGAGTGACG  780
781   CTTCCCGGGG  CCAAGGAGGG  GATCCTCTTC  TACATCACAC  CCAACTTCCG  AAAGCTGTCT  840
841   GATTCTGAGG  TGTGGCTTGA  CGCCGCCACC  CAGATCTTCT  TCTCCTACGG  GCTGGGCCTG  900
901   GGGTCCCTGA  TTGCTCTGGG  AAGCTACAAC  TCTTTCCACA  ACAATGTGTA  CAGGGACTCC  960
961   ATCATCGTTT  GCTGCATCAA  CTCCTGCACC  AGCATGTTTG  CCGGATTCGT  CATCTTCTCC  1020
1021  ATCGTGGGCT  TCATGGCTCA  TGTCACCAAG  AGGTCCATAG  CTGATGTGGC  AGCCTCAGGC  1080
1081  CCGGGGCTGG  CATTCTTGGC  GTACCCTGAG  GCTGTGACAC  AGCTACCCAT  CTCTCCCCTC  1140
1141  TGGGCTATCC  TCTTCTTCTC  CATGCTGCTG  ATGCTGGGCA  TTGACAGCCA  GTTCTGTACC  1200
1201  GTGGAGGGCT  TCATCACTGC  CCTGGTGGAC  GAGTACCCCA  GACTTCTCCG  CAATCGCCGT  1260
1261  GAACTCTTCA  TTGCTGCCGT  GTGCATCGTG  TCCTACCTGA  TTGGCCTGTC  TAACATCACC  1320
1321  CAGGGTGGCA  TTTATGTCTT  CAAACTGTTT  GATTATTACT  CTGCCAGCGG  CATGAGCTTG  1380
1381  CTGTTCCTGG  TTTTCTTCGA  GTGTGTCTCC  ATTTCCTGGT  TTTATGGTGT  CAACCGGTTC  1440
1441  TATGACAACA  TCCAGGAGAT  GGTTGGCTCC  AGGCCCTGCA  TCTGGTGGAA  GCTGTGCTGG  1500
1501  TCCTTTTTCA  CACCCATCAT  TGTGGCGGGC  GTGTTTCTCT  TCAGTGCTGT  GCAGATGACA  1560
1561  CCACTCACCA  TGGGAAGCTA  TGTTTTCCCC  AAGTGGGGCC  AGGGCGTGGG  CTGGCTCATG  1620
1621  GCTCTGTCCT  CCATGGTGCT  CATCCCCGGG  TACATGGCTT  ACATGTTCCT  CACCCTGAAG  1680
1681  GGCTCCCTGA  AGCAGCGTCT  CCAGGTCATG  ATTCAGCCCA  GTGAAGATAT  TGTGCGCCCT  1740
1741  GAGAATGGCC  CTGAGCAGCC  GCAGGCTGGC  AGCTCAGCCA  GCAAGGAGGC  CTACATCTAG  1800

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Metal-binding
Neurotransmitter transport
Phosphoprotein
Reference proteome
Sodium
Symport
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cell surface
Cellular Component
GABA-ergic synapse
Cellular Component
Integral component of postsynaptic membrane
Cellular Component
Integral component of presynaptic membrane
Cellular Component
Neuron projection
Cellular Component
Plasma membrane
Molecular Function
Gamma-aminobutyric acid:sodium symporter activity
Molecular Function
Metal ion binding
Molecular Function
Neurotransmitter binding
Biological Process
Gamma-aminobutyric acid import
Biological Process
Learning
Biological Process
Negative regulation of synaptic transmission, GABAergic
Biological Process
Neurotransmitter reuptake
Biological Process
Positive regulation of gamma-aminobutyric acid secretion
Biological Process
Protein homooligomerization
Biological Process
Response to calcium ion
Biological Process
Response to cocaine
Biological Process
Response to estradiol
Biological Process
Response to lead ion
Biological Process
Response to organic substance
Biological Process
Response to purine-containing compound
Biological Process
Response to sucrose
Biological Process
Response to toxic substance

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a747Rattus norvegicus100.00.01221
LLPS-Mea-a717Mesocricetus auratus99.330.01215
LLPS-Cas-a651Carlito syrichta98.660.01211
LLPS-Aon-a759Aotus nancymaae98.580.01138
LLPS-Caf-a735Canis familiaris98.160.01206
LLPS-Fec-a754Felis catus98.160.01206
LLPS-Sus-a755Sus scrofa98.160.01206
LLPS-Dio-a725Dipodomys ordii98.160.01209
LLPS-Caj-a748Callithrix jacchus98.160.01208
LLPS-Ict-a742Ictidomys tridecemlineatus98.160.01209
LLPS-Otg-a743Otolemur garnettii98.010.01204
LLPS-Pat-a755Pan troglodytes98.00.01207
LLPS-Mal-a744Mandrillus leucophaeus98.00.01207
LLPS-Poa-a738Pongo abelii98.00.01207
LLPS-Maf-a754Macaca fascicularis98.00.01207
LLPS-Pap-a741Pan paniscus98.00.01207
LLPS-Gog-a751Gorilla gorilla98.00.01207
LLPS-Paa-a756Papio anubis98.00.01207
LLPS-Chs-a742Chlorocebus sabaeus98.00.01207
LLPS-Mam-a744Macaca mulatta98.00.01207
LLPS-Mup-a730Mustela putorius furo97.830.01203
LLPS-Urm-a686Ursus maritimus97.830.01202
LLPS-Loa-a731Loxodonta africana97.810.01194
LLPS-Fud-a727Fukomys damarensis97.660.01203
LLPS-Bot-a758Bos taurus97.50.01196
LLPS-Hos-a767Homo sapiens96.550.01200
LLPS-Cea-a758Cercocebus atys96.390.01142
LLPS-Man-a758Macaca nemestrina96.390.01142
LLPS-Anp-a616Anas platyrhynchos95.540.01055
LLPS-Myl-a703Myotis lucifugus95.510.01176
LLPS-Ova-a732Ovis aries95.210.01172
LLPS-Rhb-a746Rhinopithecus bieti95.170.01157
LLPS-Mod-a719Monodelphis domestica94.330.01162
LLPS-Sah-a677Sarcophilus harrisii94.170.01158
LLPS-Meg-a613Meleagris gallopavo94.040.01007
LLPS-Eqc-a753Equus caballus93.030.01184
LLPS-Cap-a750Cavia porcellus93.010.01127
LLPS-Gaga-a684Gallus gallus92.990.01148
LLPS-Fia-a671Ficedula albicollis92.820.01147
LLPS-Tag-a657Taeniopygia guttata91.820.01128
LLPS-Pes-a647Pelodiscus sinensis91.490.01135
LLPS-Anc-a693Anolis carolinensis90.980.01134
LLPS-Nol-a741Nomascus leucogenys90.650.01099
LLPS-Leo-a658Lepisosteus oculatus87.830.01072
LLPS-Xet-a650Xenopus tropicalis86.350.0917
LLPS-Orc-a708Oryctolagus cuniculus85.130.0951
LLPS-Dar-a662Danio rerio85.020.01055
LLPS-Icp-a662Ictalurus punctatus84.330.01058
LLPS-Scf-a641Scleropages formosus84.030.01045
LLPS-Xim-a669Xiphophorus maculatus81.980.01025
LLPS-Scm-a638Scophthalmus maximus81.680.01016
LLPS-Lac-a665Latimeria chalumnae81.40.01025
LLPS-Pof-a1023Poecilia formosa81.320.01020
LLPS-Gaa-a646Gasterosteus aculeatus81.210.01007
LLPS-Ten-a626Tetraodon nigroviridis80.770.0991
LLPS-Asm-a658Astyanax mexicanus80.440.0962
LLPS-Orn-a660Oreochromis niloticus80.330.01013
LLPS-Orl-a652Oryzias latipes80.330.01010
LLPS-Ora-a627Ornithorhynchus anatinus74.430.0799
LLPS-Tar-a626Takifugu rubripes73.310.0883
LLPS-Drm-a172Drosophila melanogaster56.770.0697
LLPS-Cii-a193Ciona intestinalis52.820.0609
LLPS-Aim-a721Ailuropoda melanoleuca52.190.0619
LLPS-Tut-a645Tursiops truncatus50.080.0600