LLPS-Mum-a725
Dgke

▼ OVERVIEW

Status: Reviewed
Protein Name: Diacylglycerol kinase epsilon
Gene Name: Dgke
Ensembl Gene: ENSMUSG00000000276.11
Ensembl Protein: ENSMUSP00000116277.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEGDQRSGPP  AQSLLPDGHL  VLWTLCSVLL  PVFITLWCSL  QRSRRQLHRR  DIFRKSKHCW  60
61    RDTDLFSHPT  YCCVCAQHIL  QGAFCDCCGL  RVDEGCLKKV  DKRFPCKEIM  LKNDKAADAM  120
121   PHHWIRGNVP  LCSYCVFCRQ  QCGSQPKLCD  YRCIWCQKTV  HDECMRGSLR  SEKCDFGEFR  180
181   NLIIPPSYLT  SINQMRKDKN  TNYEGLASKF  GKQWTPLIIL  ANSRSGTNMG  EGLLGEFKIL  240
241   LNPVQVFDVT  KTPPIKALQL  CTLLPYYSVR  VLVCGGDGTV  GWVLDAIDEM  KIKGQEKYIP  300
301   EVAVLPLGTG  NDLSNTLGWG  TGYAGEIPVA  QVLRNVMEAD  GIKLDRWKVQ  VTNKGYYNLR  360
361   KPKEFTMNNY  FSVGPDALMA  LNFHAHREKA  PSLFSSRILN  KAVYLFYGTK  DCLVQECKDL  420
421   NKKIELELDG  ERVELPNLEG  IIVLNIGYWG  GGCRLWEGMG  DETYPLARHD  DGLLEIVGVY  480
481   GSFHCAQIQV  KLANPFRIGQ  AHTVRLTLKC  SMMPMQVDGE  PWAQGPCTVT  ITHKTHALML  540
541   YFSGEQSDDD  ISSPSDHEDV  KEAE  564
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGGGG  ACCAGCGGTC  CGGCCCACCC  GCCCAGAGCC  TGCTCCCTGA  TGGCCACTTG  60
61    GTCCTATGGA  CGCTGTGCTC  CGTGCTGTTG  CCGGTGTTCA  TCACTTTATG  GTGTAGCCTG  120
121   CAGCGGTCGC  GCCGGCAGCT  GCACCGCAGG  GATATCTTCC  GCAAGAGCAA  GCATTGCTGG  180
181   CGTGACACCG  ACCTGTTCAG  CCACCCCACC  TACTGCTGCG  TGTGCGCGCA  GCACATCCTG  240
241   CAAGGAGCCT  TCTGCGACTG  CTGTGGGCTC  CGCGTGGACG  AGGGCTGCCT  CAAGAAGGTC  300
301   GACAAGCGCT  TCCCGTGCAA  GGAGATCATG  CTCAAGAACG  ACAAGGCCGC  AGATGCCATG  360
361   CCCCACCACT  GGATCCGCGG  CAACGTGCCC  CTGTGCTCTT  ACTGTGTATT  CTGCAGGCAG  420
421   CAGTGTGGCA  GCCAGCCTAA  ACTGTGCGAT  TACAGGTGCA  TTTGGTGCCA  GAAGACAGTC  480
481   CACGACGAGT  GCATGCGAGG  CAGCTTAAGG  AGCGAAAAGT  GTGACTTTGG  AGAATTCAGA  540
541   AACCTCATCA  TCCCGCCAAG  CTACTTAACT  TCTATTAACC  AGATGCGTAA  AGACAAAAAC  600
601   ACAAATTATG  AAGGGCTTGC  TTCTAAGTTT  GGAAAGCAAT  GGACCCCATT  AATAATCCTA  660
661   GCCAACTCTC  GTAGTGGAAC  TAACATGGGA  GAAGGTCTGT  TGGGAGAGTT  TAAGATCCTG  720
721   TTAAATCCAG  TCCAGGTGTT  TGATGTAACT  AAAACTCCCC  CGATCAAAGC  TCTGCAGCTG  780
781   TGCACTCTTC  TTCCTTATTA  CTCAGTTCGA  GTCCTTGTTT  GTGGAGGGGA  CGGGACTGTG  840
841   GGCTGGGTCC  TCGATGCCAT  TGATGAAATG  AAGATTAAGG  GACAAGAAAA  ATACATTCCA  900
901   GAGGTTGCGG  TCTTACCTCT  GGGAACAGGT  AATGATCTGT  CCAATACCCT  GGGTTGGGGT  960
961   ACAGGCTATG  CTGGAGAAAT  TCCGGTTGCA  CAGGTCTTAA  GAAATGTAAT  GGAAGCAGAT  1020
1021  GGAATCAAAC  TAGACAGATG  GAAAGTTCAG  GTAACAAATA  AAGGATACTA  CAATTTAAGA  1080
1081  AAACCCAAGG  AGTTCACAAT  GAACAACTAC  TTCTCTGTTG  GACCTGATGC  CCTCATGGCT  1140
1141  CTCAATTTTC  ACGCTCATCG  TGAGAAGGCA  CCATCTCTGT  TTTCCAGCCG  AATCCTTAAC  1200
1201  AAGGCTGTTT  ATTTATTCTA  TGGAACTAAA  GATTGTTTAG  TGCAAGAATG  TAAAGATTTG  1260
1261  AATAAAAAAA  TTGAGCTAGA  ACTGGATGGT  GAGCGAGTTG  AGCTGCCTAA  CTTGGAGGGC  1320
1321  ATAATTGTTC  TGAACATTGG  ATACTGGGGC  GGTGGCTGCA  GACTGTGGGA  AGGAATGGGA  1380
1381  GATGAGACTT  ACCCTCTAGC  CAGACACGAT  GATGGCTTAC  TGGAAATCGT  TGGCGTCTAT  1440
1441  GGGTCTTTCC  ACTGTGCTCA  AATCCAGGTG  AAACTGGCAA  ATCCTTTTCG  AATAGGACAA  1500
1501  GCGCACACAG  TGCGGCTGAC  TTTGAAGTGC  TCCATGATGC  CGATGCAGGT  GGATGGGGAG  1560
1561  CCGTGGGCCC  AAGGCCCCTG  TACTGTCACC  ATAACGCACA  AGACACACGC  ACTGATGCTG  1620
1621  TACTTCTCTG  GAGAGCAGTC  AGATGACGAC  ATCTCAAGCC  CTTCGGATCA  TGAGGACGTA  1680
1681  AAGGAAGCCG  AGTAA  1695

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Cytoplasm
Kinase
Membrane
Metal-binding
Nucleotide-binding
Reference proteome
Repeat
Transferase
Transmembrane
Transmembrane helix
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Glutamatergic synapse
Cellular Component
Integral component of membrane
Cellular Component
Membrane
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
Diacylglycerol kinase activity
Molecular Function
Kinase activity
Molecular Function
Metal ion binding
Molecular Function
NAD+ kinase activity
Biological Process
Diacylglycerol metabolic process
Biological Process
Glycerolipid metabolic process
Biological Process
Intracellular signal transduction
Biological Process
Lipid phosphorylation
Biological Process
Modulation of chemical synaptic transmission
Biological Process
Protein kinase C-activating G protein-coupled receptor signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a716Rattus norvegicus95.590.01134
LLPS-Nol-a710Nomascus leucogenys93.690.0813
LLPS-Fud-a700Fukomys damarensis92.450.01082
LLPS-Sus-a725Sus scrofa92.390.01088
LLPS-Ova-a703Ovis aries92.210.01094
LLPS-Cas-a627Carlito syrichta92.060.01090
LLPS-Mea-a687Mesocricetus auratus92.060.0785
LLPS-Caf-a706Canis familiaris92.040.01086
LLPS-Tut-a580Tursiops truncatus92.040.01087
LLPS-Urm-a659Ursus maritimus91.960.01082
LLPS-Bot-a728Bos taurus91.680.01091
LLPS-Fec-a725Felis catus91.330.01081
LLPS-Eqc-a723Equus caballus91.270.01071
LLPS-Aon-a727Aotus nancymaae91.180.01085
LLPS-Aim-a693Ailuropoda melanoleuca91.150.01082
LLPS-Loa-a704Loxodonta africana91.150.01083
LLPS-Otg-a714Otolemur garnettii91.010.01086
LLPS-Caj-a716Callithrix jacchus91.010.01086
LLPS-Chs-a711Chlorocebus sabaeus91.010.01087
LLPS-Mup-a701Mustela putorius furo90.970.01080
LLPS-Mal-a713Mandrillus leucophaeus90.830.01084
LLPS-Cea-a727Cercocebus atys90.830.01084
LLPS-Hos-a735Homo sapiens90.830.01085
LLPS-Maf-a722Macaca fascicularis90.830.01084
LLPS-Cap-a720Cavia porcellus90.830.01086
LLPS-Mam-a713Macaca mulatta90.830.01084
LLPS-Pat-a724Pan troglodytes90.650.01083
LLPS-Gog-a719Gorilla gorilla90.650.01085
LLPS-Pap-a712Pan paniscus90.650.01083
LLPS-Man-a727Macaca nemestrina90.650.01082
LLPS-Rhb-a716Rhinopithecus bieti90.650.01078
LLPS-Myl-a675Myotis lucifugus90.060.0919
LLPS-Orc-a678Oryctolagus cuniculus88.540.01056
LLPS-Paa-a725Papio anubis88.360.01048
LLPS-Poa-a712Pongo abelii87.910.0666
LLPS-Dio-a697Dipodomys ordii83.980.0969
LLPS-Ora-a603Ornithorhynchus anatinus81.680.0926
LLPS-Fia-a644Ficedula albicollis81.120.0891
LLPS-Anp-a589Anas platyrhynchos80.990.0943
LLPS-Mod-a690Monodelphis domestica80.610.0944
LLPS-Tag-a630Taeniopygia guttata80.450.0915
LLPS-Pes-a620Pelodiscus sinensis79.360.0955
LLPS-Gaga-a656Gallus gallus78.830.0915
LLPS-Sah-a650Sarcophilus harrisii78.410.0943
LLPS-Anc-a668Anolis carolinensis77.560.0925
LLPS-Meg-a591Meleagris gallopavo77.50.0920
LLPS-Xet-a624Xenopus tropicalis75.80.0852
LLPS-Lac-a639Latimeria chalumnae73.960.0796
LLPS-Dar-a634Danio rerio71.30.0813
LLPS-Scm-a611Scophthalmus maximus71.240.0821
LLPS-Asm-a631Astyanax mexicanus71.210.0791
LLPS-Leo-a631Lepisosteus oculatus70.570.0826
LLPS-Xim-a641Xiphophorus maculatus69.830.0793
LLPS-Orn-a632Oreochromis niloticus69.270.0813
LLPS-Icp-a634Ictalurus punctatus68.460.0776
LLPS-Tar-a601Takifugu rubripes68.10.0798
LLPS-Orl-a624Oryzias latipes68.070.0792
LLPS-Pof-a637Poecilia formosa67.820.0794
LLPS-Gaa-a618Gasterosteus aculeatus67.460.0771
LLPS-Ten-a599Tetraodon nigroviridis67.410.0736
LLPS-Scf-a612Scleropages formosus67.150.0768