LLPS-Mum-a694
Taok2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Serine/threonine-protein kinase TAO2; Thousand and one amino acid protein 2 |
| Gene Name: | Taok2, Kiaa0881 |
| Ensembl Gene: | ENSMUSG00000059981.12 |
| Ensembl Protein: | ENSMUSP00000071246.4 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000071268.10 | ENSMUSP00000071246.4 |
| Ensembl | ENSMUST00000214525.1 | ENSMUSP00000150069.1 |
| Ensembl | ENSMUST00000117394.1 | ENSMUSP00000112963.1 |
| UniProt | Q6ZQ29, TAOK2_MOUSE, Q7TSS8 | |
| GeneBank | AK129235, BC085152, BC052933 | AAH52933.1, BAC98045.1 |
| RefSeq | NM_001163774.1, NM_001163775.1 | NP_001157246.1, NP_001157247.1 |
| Entrez | 381921 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN SEVVAIKKMS 60 61 YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT AWLVMEYCLG SASDLLEVHK 120 121 KPLQEVEIAA VTHGALQGLA YLHSHNMIHR DVKAGNILLS EPGLVKLGDF GSASIMAPAN 180 181 SFVGTPYWMA PEVILAMDEG QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN 240 241 ESPALQSGHW SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA 300 301 VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEELTPCSQE AEPYTHRAGT LTSLESSHSV 360 361 PSMSISASSQ SSSVNSLADA SDNEEEEEEE EEEEEEEEEE GPESREMAMM QEGEHTVTSH 420 421 SSIIHRLPGS DNLYDDPYQP EMTPGPLQPP AAPPTSTSSS ARRRAYCRNR DHFATIRTAS 480 481 LVSRQIQEHE QDSALREQLS GYKRMRRQHQ KQLLALESRL RGEREEHSGR LQRELEAQRA 540 541 GFGTEAEKLA RRHQAIGEKE ARAAQAEERK FQQHILGQQK KELAALLEAQ KRTYKLRKEQ 600 601 LKEELQENPS TPKREKAEWL LRQKEQLQQC QAEEEAGLLR RQRQYFELQC RQYKRKMLLA 660 661 RHSLDQDLLR EDLNKKQTQK DLECALLLRQ HEATRELELR QLQAVQRTRA ELTRLQHQTE 720 721 LGNQLEYNKR REQELRQKHA AQVRQQPKSL KVRAGQLPMG LPATGALGPL STGTPSEEQP 780 781 CSSGQEAILD QRMLGEEEEA VPERRILGKE GTTLEPEEQR ILGEEMGTFS SSPQKHRSLA 840 841 NEEDWDISEE MKEIRVPSLA SQERNIIGQE EAAAWSLWEK EGGNLVDVEF KLGWVQGPVL 900 901 TPVPEEEEEE EEEGGAPIGT HRDPGDGCPS PDIPPEPPPS HLRQYPTSQL PGLLSHGLLA 960 961 GLSFAVGSSS GLLPLLLLLL LPLLAAQGGG GLQAALLALE VGLVGLGASY LFLCTALHLP 1020 1021 PGLFLLLAQG TALLAVLSLS WRRGLMGVPL GLGAAWLLAW PSLALPLAAM AAGGKWVRQQ 1080 1081 GPQMRRGISR LWLRILLRLS PMVFRALQGC GAVGDRGLFA LYPKTNKNGF RSRLPVPWPR 1140 1141 QGNPRTTQHP LAQLTRVWAV CKGWNWRLAR ASHRLASCLP PWAVHILASW GLLKGERPSR 1200 1201 IPRLLPRSQR RLGLSASRQL PPGTVAGRRS QTRRTLPPWR 1240 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCAGCTG GGGGCCGGGC CGGGAGCCTG AAGGACCCTG ATGTGGCTGA GCTCTTCTTC 60 61 AAGGATGACC CTGAGAAGCT CTTCTCTGAC CTCCGGGAGA TCGGCCATGG CAGCTTTGGA 120 121 GCAGTGTACT TTGCCCGGGA TGTCCGGAAC AGTGAGGTGG TGGCCATCAA GAAGATGTCC 180 181 TATAGTGGGA AGCAATCAAA TGAGAAATGG CAGGATATCA TCAAGGAAGT GCGGTTCTTA 240 241 CAGAAGCTAC GGCATCCTAA TACCATTCAG TACCGGGGCT GTTACCTGAG GGAGCACACA 300 301 GCTTGGCTGG TGATGGAGTA TTGCCTGGGC TCAGCTTCTG ATCTTCTAGA AGTGCACAAG 360 361 AAACCCCTGC AGGAGGTAGA GATTGCAGCT GTGACCCATG GGGCTCTTCA GGGCCTGGCA 420 421 TATCTACACT CACACAACAT GATCCATAGA GATGTGAAGG CTGGAAACAT CTTGCTGTCA 480 481 GAACCAGGCT TGGTAAAACT GGGGGACTTT GGCTCTGCGT CAATCATGGC ACCTGCCAAC 540 541 TCTTTTGTGG GTACTCCATA CTGGATGGCT CCAGAGGTGA TCCTAGCCAT GGATGAGGGA 600 601 CAATATGATG GCAAAGTGGA TGTCTGGTCC TTGGGGATAA CCTGTATTGA GCTAGCGGAG 660 661 CGGAAGCCAC CACTGTTCAA CATGAATGCA ATGAGTGCCT TATACCACAT TGCACAGAAT 720 721 GAATCTCCTG CTCTCCAGTC AGGACACTGG TCTGAGTACT TCCGGAATTT TGTTGACTCC 780 781 TGTCTTCAGA AAATCCCTCA AGACAGACCA ACCTCAGAGG TTCTTTTGAA GCACCGCTTT 840 841 GTGCTCCGGG AGCGACCGCC CACAGTCATC ATGGACCTAA TCCAGAGGAC CAAGGATGCT 900 901 GTACGGGAAC TGGATAACCT GCAGTACCGA AAGATGAAGA AGATACTGTT CCAAGAGGCA 960 961 CCCAATGGCC CTGGTGCTGA GGCCCCAGAG GAAGAGGAGC TCACACCCTG TTCCCAGGAG 1020 1021 GCAGAACCTT ACACGCACCG TGCAGGGACA CTGACCAGTC TAGAGAGCAG CCATTCAGTG 1080 1081 CCCAGCATGT CCATCAGCGC CTCCAGCCAG AGCAGCTCAG TCAACAGCCT AGCAGATGCC 1140 1141 TCAGATAATG AAGAAGAGGA GGAAGAAGAA GAGGAAGAGG AGGAGGAGGA GGAGGAAGAA 1200 1201 GGCCCTGAAT CCAGAGAGAT GGCCATGATG CAGGAGGGGG AGCATACAGT CACTTCCCAC 1260 1261 AGCTCCATCA TCCACCGGCT GCCGGGCTCA GACAACCTAT ATGATGATCC CTACCAGCCA 1320 1321 GAGATGACCC CAGGTCCACT CCAGCCACCT GCAGCCCCTC CCACCTCCAC CTCCTCTTCT 1380 1381 GCTCGCCGCA GAGCTTATTG CCGCAACCGA GACCACTTTG CTACCATTCG TACTGCCTCC 1440 1441 CTGGTCAGCC GTCAGATCCA GGAGCATGAG CAGGACTCAG CCCTGCGAGA GCAGCTGAGT 1500 1501 GGCTACAAGC GGATGCGACG TCAGCACCAG AAGCAACTGC TGGCCCTGGA GTCCCGTCTG 1560 1561 AGGGGTGAAC GTGAGGAGCA CAGTGGGCGG TTACAGCGGG AGCTCGAGGC ACAGCGGGCT 1620 1621 GGCTTTGGGA CCGAGGCTGA GAAGCTGGCC CGGAGGCACC AGGCCATTGG TGAGAAGGAG 1680 1681 GCACGGGCTG CTCAGGCGGA GGAGCGGAAG TTCCAGCAGC ACATCCTGGG GCAGCAGAAG 1740 1741 AAGGAGCTGG CCGCCCTGCT GGAGGCGCAG AAGCGAACCT ACAAGCTGCG GAAGGAGCAG 1800 1801 TTGAAAGAGG AGCTCCAGGA GAACCCTAGC ACACCCAAAC GAGAGAAGGC TGAGTGGCTG 1860 1861 TTGAGGCAAA AGGAGCAGTT GCAACAGTGC CAGGCAGAAG AGGAAGCGGG GCTGCTGCGG 1920 1921 AGGCAGCGCC AGTACTTTGA ACTTCAGTGT CGCCAATACA AGCGCAAGAT GCTACTGGCT 1980 1981 CGGCACAGCC TAGATCAGGA CCTGCTTCGA GAGGACTTGA ATAAGAAACA GACACAGAAG 2040 2041 GACTTGGAGT GTGCTCTGCT GTTACGGCAG CATGAGGCTA CCCGAGAGCT GGAGCTAAGA 2100 2101 CAGCTCCAGG CTGTCCAGCG CACACGTGCT GAACTTACCC GCCTTCAGCA CCAGACAGAA 2160 2161 CTAGGCAACC AGCTGGAGTA CAACAAGCGA CGGGAGCAAG AATTACGGCA GAAGCACGCG 2220 2221 GCCCAGGTTC GCCAGCAGCC CAAGAGCCTC AAATCAAAGG AGCTGCAGAT CAAGAAGCAG 2280 2281 TTCCAGGAGA CGTGTAAGAT CCAGACGCGG CAATACAAGG CTCTTCGGGC ACACTTGCTG 2340 2341 GAGACCACAC CCAAAGCTCA GCACAAGAGC CTTCTTAAGC GGCTCAAGGA GGAGCAGACC 2400 2401 CGCAAGCTGG CGATCCTGGC TGAGCAGTAT GACCAGTCCA TTTCAGAGAT GCTCAGCTCG 2460 2461 CAGGCGCTCC GGCTTGATGA GACCCAAGAG GCAGAGTTTC AGGCCCTGCG GCAGCAGCTC 2520 2521 CAGCAGGAGC TGGAGCTCCT CAACGCTTAC CAGAGCAAGA TCAAGATCCG CACAGAGAGC 2580 2581 CAGCATGAGC GGGAGCTGAG GGAGCTGGAG CAGAGAGTAG CTCTGAGGCG GGCACTGCTA 2640 2641 GAGCAACGGG TGGAAGAAGA GCTGCTGGCC CTACAGACAG GCCGTTCGGA ACGTATCCGG 2700 2701 AGTTTGCTTG AGCGGCAGGC CCGTGAGATC GAGGCCTTCG ATGCTGAGAG CATGAGACTG 2760 2761 GGCTTCTCCA GCATGGCTCT GGGGGGCATT CCAGCTGAAG CTGCGGCCCA GGGCTATCCT 2820 2821 GCTCCACCCC CCGCCCCTGC CTGGCCCTCC CGTCCAGTTC CCCGTTCAGG GGCCCATTGG 2880 2881 AGCCATGGCC CTCCTCCACC AGGCATGCCC CCACCAGCTT GGCGTCAGCC AGCTCTGCTG 2940 2941 GCTCCCCCAG GGCCTCCAAA CTGGTTAGGG CCCCCAACAC AGAGTGGAAC ACCCCGTGGA 3000 3001 GGGGCTCTGC TGCTGCTAAG AAACAGTCCT CAACCCCTAA GGCGGGCAGC GTCAGGGGGC 3060 3061 AGCAGTGGTG AGAACGTCGG CCCACCTGCT GCAGTGCCAG GGCCGCTGAG CCGAAGCACC 3120 3121 AGTGTTGCTT CCCACATCCT CAACGGCTCC TCCCACTTCT ATTCCTGA 3168 |
▼ KEYWORD
ID | Family |
Alternative splicing | |
ATP-binding | |
Cell projection | |
Coiled coil | |
Complete proteome | |
Cytoplasm | |
Cytoplasmic vesicle | |
Cytoskeleton | |
Kinase | |
Magnesium | |
Membrane | |
Methylation | |
Nucleotide-binding | |
Phosphoprotein | |
Reference proteome | |
Serine/threonine-protein kinase | |
Transferase | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axon | |
Cellular Component | Axonal growth cone | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Cytoplasmic vesicle membrane | |
Cellular Component | Cytoskeleton | |
Cellular Component | Cytosol | |
Cellular Component | Dendritic growth cone | |
Cellular Component | Integral component of membrane | |
Cellular Component | Neuron projection | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Cellular Component | Receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | Mitogen-activated protein kinase kinase binding | |
Molecular Function | Neuropilin binding | |
Molecular Function | Protein serine/threonine kinase activity | |
Biological Process | Actin cytoskeleton organization | |
Biological Process | Activation of MAPKK activity | |
Biological Process | Activation of protein kinase activity | |
Biological Process | Axonogenesis | |
Biological Process | Basal dendrite arborization | |
Biological Process | Basal dendrite morphogenesis | |
Biological Process | Cellular response to DNA damage stimulus | |
Biological Process | Focal adhesion assembly | |
Biological Process | Mitotic G2 DNA damage checkpoint | |
Biological Process | Positive regulation of JNK cascade | |
Biological Process | Positive regulation of stress-activated MAPK cascade | |
Biological Process | Regulation of actin cytoskeleton organization | |
Biological Process | Regulation of cell shape | |
Biological Process | Signal transduction by protein phosphorylation | |
Biological Process | Stress-activated MAPK cascade | |
Biological Process | Stress-activated protein kinase signaling cascade |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Dio-a665 | Dipodomys ordii | 97.76 | 0.0 | 1500 |
| LLPS-Ran-a686 | Rattus norvegicus | 97.74 | 0.0 | 2444 |
| LLPS-Mea-a653 | Mesocricetus auratus | 97.18 | 0.0 | 2444 |
| LLPS-Poa-a683 | Pongo abelii | 97.1 | 0.0 | 1484 |
| LLPS-Bot-a695 | Bos taurus | 97.1 | 0.0 | 1484 |
| LLPS-Ova-a674 | Ovis aries | 96.31 | 0.0 | 1466 |
| LLPS-Mup-a669 | Mustela putorius furo | 96.17 | 0.0 | 1470 |
| LLPS-Aon-a694 | Aotus nancymaae | 95.23 | 0.0 | 1334 |
| LLPS-Ict-a683 | Ictidomys tridecemlineatus | 92.6 | 0.0 | 2065 |
| LLPS-Cas-a598 | Carlito syrichta | 91.49 | 0.0 | 2026 |
| LLPS-Cap-a688 | Cavia porcellus | 91.48 | 0.0 | 2030 |
| LLPS-Loa-a672 | Loxodonta africana | 91.41 | 0.0 | 2020 |
| LLPS-Fud-a667 | Fukomys damarensis | 91.16 | 0.0 | 2019 |
| LLPS-Mod-a659 | Monodelphis domestica | 90.69 | 0.0 | 1341 |
| LLPS-Caf-a674 | Canis familiaris | 90.37 | 0.0 | 1990 |
| LLPS-Caj-a683 | Callithrix jacchus | 90.21 | 0.0 | 2017 |
| LLPS-Pat-a690 | Pan troglodytes | 90.2 | 0.0 | 2019 |
| LLPS-Hos-a701 | Homo sapiens | 90.12 | 0.0 | 2016 |
| LLPS-Fec-a692 | Felis catus | 90.06 | 0.0 | 1977 |
| LLPS-Sus-a693 | Sus scrofa | 90.05 | 0.0 | 2026 |
| LLPS-Pap-a681 | Pan paniscus | 89.96 | 0.0 | 2006 |
| LLPS-Gog-a685 | Gorilla gorilla | 89.96 | 0.0 | 2013 |
| LLPS-Rhb-a683 | Rhinopithecus bieti | 89.89 | 0.0 | 2011 |
| LLPS-Myl-a643 | Myotis lucifugus | 89.81 | 0.0 | 2046 |
| LLPS-Cea-a694 | Cercocebus atys | 89.81 | 0.0 | 2016 |
| LLPS-Otg-a683 | Otolemur garnettii | 89.75 | 0.0 | 1966 |
| LLPS-Mal-a679 | Mandrillus leucophaeus | 89.65 | 0.0 | 2005 |
| LLPS-Aim-a662 | Ailuropoda melanoleuca | 89.64 | 0.0 | 2009 |
| LLPS-Maf-a692 | Macaca fascicularis | 89.57 | 0.0 | 2005 |
| LLPS-Orc-a650 | Oryctolagus cuniculus | 89.57 | 0.0 | 2008 |
| LLPS-Mam-a681 | Macaca mulatta | 89.57 | 0.0 | 2005 |
| LLPS-Man-a695 | Macaca nemestrina | 89.57 | 0.0 | 2005 |
| LLPS-Nol-a679 | Nomascus leucogenys | 89.01 | 0.0 | 1996 |
| LLPS-Eqc-a690 | Equus caballus | 87.83 | 0.0 | 1982 |
| LLPS-Paa-a691 | Papio anubis | 85.63 | 0.0 | 1874 |
| LLPS-Anc-a635 | Anolis carolinensis | 81.23 | 0.0 | 1200 |
| LLPS-Sah-a621 | Sarcophilus harrisii | 79.43 | 0.0 | 1732 |
| LLPS-Icp-a604 | Ictalurus punctatus | 78.47 | 0.0 | 1178 |
| LLPS-Asm-a599 | Astyanax mexicanus | 78.07 | 0.0 | 1168 |
| LLPS-Orn-a599 | Oreochromis niloticus | 76.95 | 0.0 | 1159 |
| LLPS-Ten-a569 | Tetraodon nigroviridis | 76.72 | 0.0 | 1161 |
| LLPS-Xim-a608 | Xiphophorus maculatus | 75.86 | 0.0 | 1125 |
| LLPS-Dar-a1091 | Danio rerio | 75.62 | 0.0 | 1136 |
| LLPS-Lac-a692 | Latimeria chalumnae | 75.38 | 0.0 | 896 |
| LLPS-Pof-a604 | Poecilia formosa | 74.9 | 0.0 | 1114 |
| LLPS-Gaa-a586 | Gasterosteus aculeatus | 74.58 | 0.0 | 1133 |
| LLPS-Tar-a1055 | Takifugu rubripes | 74.51 | 0.0 | 1105 |
| LLPS-Scf-a667 | Scleropages formosus | 70.84 | 0.0 | 1026 |
| LLPS-Scm-a579 | Scophthalmus maximus | 64.1 | 0.0 | 1113 |
| LLPS-Gaga-a711 | Gallus gallus | 62.34 | 0.0 | 922 |
| LLPS-Fia-a696 | Ficedula albicollis | 62.2 | 0.0 | 912 |
| LLPS-Anp-a639 | Anas platyrhynchos | 61.99 | 0.0 | 927 |
| LLPS-Meg-a635 | Meleagris gallopavo | 61.94 | 0.0 | 925 |
| LLPS-Xet-a676 | Xenopus tropicalis | 61.67 | 0.0 | 887 |
| LLPS-Chs-a773 | Chlorocebus sabaeus | 61.65 | 0.0 | 938 |
| LLPS-Leo-a682 | Lepisosteus oculatus | 61.62 | 0.0 | 927 |
| LLPS-Pes-a671 | Pelodiscus sinensis | 61.4 | 0.0 | 926 |
| LLPS-Urm-a710 | Ursus maritimus | 59.32 | 0.0 | 831 |
| LLPS-Orl-a1087 | Oryzias latipes | 56.12 | 0.0 | 1172 |
| LLPS-Tag-a680 | Taeniopygia guttata | 54.11 | 0.0 | 734 |