LLPS-Mum-a645
Iqsec1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | IQ motif and SEC7 domain-containing protein 1 |
| Gene Name: | Iqsec1, Kiaa0763 |
| Ensembl Gene: | ENSMUSG00000034312.14 |
| Ensembl Protein: | ENSMUSP00000148669.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000212100.1 | ENSMUSP00000148669.1 |
| Ensembl | ENSMUST00000101151.9 | ENSMUSP00000098710.3 |
| Ensembl | ENSMUST00000101153.9 | ENSMUSP00000098712.3 |
| Ensembl | ENSMUST00000156834.1 | ENSMUSP00000118802.1 |
| UniProt | Q8R0S2, IQEC1_MOUSE, Q3TZC3, Q5DU15 | |
| GeneBank | AK157963, BC026481, AK220355, AC121954 | , AAH26481.1, BAE34286.1, BAD90418.1 |
| RefSeq | NM_001134383.1 | NP_001127855.1 |
| Entrez | 232227 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MACRRRYFVE GEAPSSETGT SLDSPSAYHQ GPLVPGSSLS PDHYEHTSVG AYGLYAGPGP 60 61 QQRTRRPRLQ HSTSVLRKQA EEEAIKRSRS LSESYELSSD LQDKQVEMLE RKYGGRLVTR 120 121 HAARTIQTAF RQYQMNKNFE RLRSSMSENR MSRRIVLSNM RMQFSFEGPE KVHSSYFEGK 180 181 QVSVTNDGSQ LGALVPSECG DLSDPALKSP APSSDFADAI TELEDAFSRQ VKSLAESIDD 240 241 ALNCRSLHSE EVPASDTARA RDTEPKPGLH GMDHRKLDEM TASYSDVTLY IDEEELSPPL 300 301 PLSQAGDRPS STESDLRLRS GGAAQDYWAL AHKEDKADTD TSCRSTPSLE RPEPRLRVEH 360 361 LPLLTIEPPS DSSVELSDRS DRSSLKRQSA YERSLGGQQG SPKHGPHGGP PKGLPREEPE 420 421 LRPRPPRPLE SHLAINGSAN RQSKSESDYS DGDNDSINST SNSNDTINCS SESSSRDSLR 480 481 EQTLSKQTYH KETRNSWDSP AFSNDVIRKR HYRIGLNLFN KKPEKGIQYL IERGFVPDTP 540 541 VGVAHFLLQR KGLSRQMIGE FLGNRQKQFN RDVLDCVVDE MDFSAMELDE ALRKFQAHIR 600 601 VQGEAQKVER LIEAFSQRYC VCNPGVVRQF RNPDTIFILA FAIILLNTDM YSPNVKPERK 660 661 MKLEDFVKNL RGVDDGEDIP RETLIGIYER IRKRELKTNE DHVSQVQKVE KLIVGKKPIG 720 721 SLHHGLGCVL SLPHRRLVCY CRLFEVPDPN KPQKLGLHQR EIFLFNDLLV VTKIFQKKKN 780 781 SVTYSFRQSF SLYGMQVLLF ENQYYPNGIR LTSAVPGADI KVLINFNAPN PQDRKKFTDD 840 841 LRESVAEVQE MEKHRIESEL EKQKGVVRPS MSQCSSLKKE SGNGTLSRAC LDDSYASGEG 900 901 LKRSALSSSL RDLSEAGKRG RRSSAGSLES NVEGSIISSP HMRRRATSTR ECPSRPPQPV 960 961 PNSSSLLGSL FGSRRGKPPP QAHPPSAPPP APPHAHHPGP SEGPLHGHHA QYCHAQQNPP 1020 1021 PYHHHHHYHP PPHLQHTHQY HHGPHGGHPP YGAHAHSHPP LPTAHPGHAG HSAHHHGQPP 1080 1081 APPPPTSSKA KPSGISTVV 1099 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGTGCC TGCACTGCAA CTCAGAGAGG ACCCAGTCCT TGCTGGAGCT GGAGCTTGAC 60 61 AGCGGTGTTG AGGGCGAGGC CCCCAGCAGC GAGACTGGCA CATCGCTGGA CAGCCCCTCA 120 121 GCCTACCATC AGGGTCCCCT GGTACCTGGT TCCAGCCTGA GTCCAGACCA CTACGAGCAC 180 181 ACATCAGTGG GCGCCTATGG GCTGTACGCA GGGCCAGGAC CACAACAGCG CACACGGAGG 240 241 CCCCGGCTGC AGCACTCGAC CTCAGTCCTG CGCAAGCAGG CTGAGGAGGA GGCCATCAAG 300 301 CGCTCTCGGT CACTCTCTGA GAGCTATGAG CTCTCTTCAG ATCTGCAAGA CAAGCAGGTG 360 361 GAAATGCTAG AACGCAAGTA TGGGGGACGC CTCGTGACCC GCCATGCAGC CCGCACCATC 420 421 CAGACGGCGT TCCGCCAATA CCAGATGAAC AAGAACTTTG AGCGCCTGCG CAGCTCCATG 480 481 TCGGAGAACC GCATGTCACG TCGCATTGTG CTGTCCAACA TGAGGATGCA GTTCTCCTTT 540 541 GAGGGCCCCG AGAAGGTGCA CAGCTCCTAC TTTGAGGGAA AGCAGGTCTC TGTGACTAAT 600 601 GATGGCTCCC AGCTGGGGGC CCTGGTGCCA TCAGAATGTG GAGACCTTAG TGACCCAGCC 660 661 CTCAAGTCTC CAGCCCCCTC CAGTGACTTT GCAGATGCCA TCACGGAACT GGAGGATGCC 720 721 TTCTCCAGGC AGGTGAAATC CCTGGCTGAA TCCATCGATG ATGCCCTCAA TTGCCGCAGC 780 781 CTACACAGTG AGGAGGTACC AGCCTCAGAC ACGGCCCGGG CTCGGGACAC TGAGCCCAAA 840 841 CCAGGTCTAC ATGGCATGGA CCACCGCAAA CTGGATGAGA TGACAGCCTC GTATAGTGAT 900 901 GTGACCCTCT ACATTGATGA GGAAGAGCTG TCACCACCGC TTCCACTCTC ACAGGCTGGC 960 961 GATCGGCCCT CCAGCACAGA GTCGGACCTG CGGCTGAGGT CTGGGGGTGC AGCCCAGGAC 1020 1021 TACTGGGCCT TGGCCCACAA AGAGGACAAG GCTGACACGG ACACAAGCTG CCGAAGCACA 1080 1081 CCATCACTGG AGCGGCCAGA GCCACGGCTG CGGGTGGAGC ACCTGCCCCT GCTTACCATT 1140 1141 GAGCCACCCA GTGATAGCTC CGTGGAACTC AGTGACCGCT CAGATCGCAG CTCACTCAAG 1200 1201 AGGCAGAGTG CCTATGAGCG CAGCCTCGGT GGGCAGCAGG GCAGCCCCAA GCATGGCCCC 1260 1261 CACGGTGGCC CCCCCAAAGG CCTCCCCAGG GAGGAACCTG AATTGCGGCC TCGGCCCCCC 1320 1321 AGACCTCTTG AGAGTCACCT AGCCATCAAT GGTTCAGCCA ACCGGCAGAG CAAATCTGAG 1380 1381 TCTGACTACT CAGATGGGGA CAATGACAGC ATCAACAGCA CCTCCAACTC CAATGACACC 1440 1441 ATAAACTGCA GCTCTGAGTC CTCATCACGG GACAGCCTGC GGGAACAGAC ACTCAGCAAG 1500 1501 CAGACATACC ACAAGGAGAC CCGCAACAGC TGGGACTCTC CAGCTTTCAG CAACGATGTC 1560 1561 ATCCGTAAGA GGCATTACCG AATTGGCCTA AATCTCTTCA ACAAGAAGCC TGAGAAGGGC 1620 1621 ATCCAGTATC TCATTGAGCG CGGCTTCGTG CCCGACACGC CAGTGGGAGT GGCCCACTTC 1680 1681 CTGCTGCAGC GCAAGGGCCT CAGCCGCCAG ATGATCGGTG AGTTCCTGGG AAACCGGCAG 1740 1741 AAGCAGTTCA ACCGTGATGT GCTCGACTGT GTTGTGGACG AGATGGACTT CTCTGCCATG 1800 1801 GAGCTAGATG AAGCCCTCCG GAAGTTCCAG GCACACATCC GAGTCCAAGG GGAGGCTCAG 1860 1861 AAAGTGGAGC GGCTCATCGA GGCATTCAGC CAGCGGTACT GTGTCTGCAA CCCAGGGGTG 1920 1921 GTGCGACAGT TCCGGAACCC AGACACCATC TTCATCCTGG CCTTCGCCAT CATCCTGCTC 1980 1981 AACACAGACA TGTACAGCCC CAATGTCAAG CCAGAGCGCA AAATGAAGCT GGAGGACTTT 2040 2041 GTCAAGAACC TCCGAGGTGT GGATGACGGT GAAGACATTC CCCGGGAGAC GCTAATTGGG 2100 2101 ATCTATGAGC GAATCCGTAA GCGAGAACTG AAGACCAACG AGGACCACGT GTCCCAGGTG 2160 2161 CAGAAGGTTG AGAAGCTCAT CGTGGGCAAG AAGCCGATTG GATCCCTGCA TCATGGTCTT 2220 2221 GGCTGTGTGC TGTCTCTTCC CCATCGACGA CTAGTCTGCT ACTGCCGGCT TTTTGAAGTT 2280 2281 CCTGACCCCA ACAAACCCCA GAAGCTGGGA CTACACCAGC GAGAGATCTT CCTGTTTAAT 2340 2341 GACCTCCTGG TGGTCACCAA GATCTTCCAG AAGAAGAAGA ACTCGGTGAC ATACAGCTTC 2400 2401 CGGCAGTCCT TCTCCCTCTA CGGCATGCAG GTCCTGCTCT TCGAGAACCA GTACTATCCC 2460 2461 AATGGCATCC GGCTGACGTC TGCTGTCCCT GGAGCAGACA TCAAAGTGCT AATAAACTTC 2520 2521 AACGCTCCCA ATCCTCAGGA CCGGAAGAAG TTCACTGACG ACCTGCGGGA GTCTGTCGCT 2580 2581 GAAGTGCAAG AGATGGAGAA ACACCGAATA GAGTCGGAGC TCGAGAAGCA GAAAGGTGTC 2640 2641 GTGCGGCCCA GCATGTCACA GTGCTCCAGC CTCAAAAAGG AGTCAGGCAA CGGGACACTG 2700 2701 AGCAGGGCTT GCCTGGATGA CAGCTATGCC AGTGGCGAGG GCCTCAAGCG CAGCGCCCTC 2760 2761 AGCAGCTCAC TGAGAGACCT CTCAGAAGCG GGGAAGCGAG GGCGTCGCAG CAGTGCGGGA 2820 2821 TCGCTAGAGA GCAATGTGGA ATTTCAGCCC TTCCAGCCAC CACAGCCTCC AGTGCTGTGC 2880 2881 TCCTAA 2886 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Intracellular membrane-bounded organelle | |
Cellular Component | Nucleolus | |
Cellular Component | Postsynaptic density, intracellular component | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | ARF guanyl-nucleotide exchange factor activity | |
Molecular Function | Lipid binding | |
Molecular Function | Protein kinase binding | |
Biological Process | Actin cytoskeleton organization | |
Biological Process | Positive regulation of adherens junction organization | |
Biological Process | Positive regulation of GTPase activity | |
Biological Process | Positive regulation of keratinocyte migration | |
Biological Process | Regulation of ARF protein signal transduction | |
Biological Process | Regulation of postsynaptic neurotransmitter receptor internalization |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mea-a609 | Mesocricetus auratus | 98.91 | 0.0 | 2233 |
| LLPS-Ran-a637 | Rattus norvegicus | 98.31 | 0.0 | 1899 |
| LLPS-Poa-a633 | Pongo abelii | 95.83 | 0.0 | 1756 |
| LLPS-Orc-a605 | Oryctolagus cuniculus | 95.03 | 0.0 | 1813 |
| LLPS-Loa-a622 | Loxodonta africana | 94.63 | 0.0 | 1709 |
| LLPS-Chs-a629 | Chlorocebus sabaeus | 94.42 | 0.0 | 1749 |
| LLPS-Caf-a628 | Canis familiaris | 93.37 | 0.0 | 1724 |
| LLPS-Caj-a636 | Callithrix jacchus | 92.88 | 0.0 | 1867 |
| LLPS-Maf-a643 | Macaca fascicularis | 92.67 | 0.0 | 1949 |
| LLPS-Eqc-a641 | Equus caballus | 92.62 | 0.0 | 1897 |
| LLPS-Mam-a633 | Macaca mulatta | 92.61 | 0.0 | 1930 |
| LLPS-Man-a646 | Macaca nemestrina | 92.52 | 0.0 | 1927 |
| LLPS-Pap-a400 | Pan paniscus | 92.5 | 0.0 | 1924 |
| LLPS-Pat-a431 | Pan troglodytes | 92.49 | 0.0 | 1948 |
| LLPS-Rhb-a637 | Rhinopithecus bieti | 92.49 | 0.0 | 1935 |
| LLPS-Mup-a624 | Mustela putorius furo | 92.33 | 0.0 | 1950 |
| LLPS-Hos-a651 | Homo sapiens | 92.18 | 0.0 | 1909 |
| LLPS-Aon-a646 | Aotus nancymaae | 92.12 | 0.0 | 1883 |
| LLPS-Cap-a638 | Cavia porcellus | 91.99 | 0.0 | 1879 |
| LLPS-Cea-a647 | Cercocebus atys | 91.44 | 0.0 | 1936 |
| LLPS-Mal-a426 | Mandrillus leucophaeus | 91.41 | 0.0 | 1873 |
| LLPS-Paa-a642 | Papio anubis | 91.35 | 0.0 | 1935 |
| LLPS-Gog-a427 | Gorilla gorilla | 90.88 | 0.0 | 1894 |
| LLPS-Sus-a645 | Sus scrofa | 90.47 | 0.0 | 1830 |
| LLPS-Myl-a597 | Myotis lucifugus | 90.36 | 0.0 | 1886 |
| LLPS-Otg-a637 | Otolemur garnettii | 90.34 | 0.0 | 1754 |
| LLPS-Mod-a612 | Monodelphis domestica | 89.99 | 0.0 | 1649 |
| LLPS-Nol-a396 | Nomascus leucogenys | 89.8 | 0.0 | 1855 |
| LLPS-Aim-a393 | Ailuropoda melanoleuca | 89.61 | 0.0 | 1857 |
| LLPS-Pes-a376 | Pelodiscus sinensis | 89.54 | 0.0 | 1506 |
| LLPS-Ict-a634 | Ictidomys tridecemlineatus | 88.47 | 0.0 | 1550 |
| LLPS-Tag-a377 | Taeniopygia guttata | 88.3 | 0.0 | 1648 |
| LLPS-Bot-a647 | Bos taurus | 87.61 | 0.0 | 1748 |
| LLPS-Gaa-a544 | Gasterosteus aculeatus | 86.99 | 0.0 | 1465 |
| LLPS-Fec-a642 | Felis catus | 86.76 | 0.0 | 1491 |
| LLPS-Sah-a578 | Sarcophilus harrisii | 86.18 | 0.0 | 1874 |
| LLPS-Ora-a344 | Ornithorhynchus anatinus | 85.32 | 0.0 | 850 |
| LLPS-Fia-a379 | Ficedula albicollis | 84.89 | 4e-76 | 257 |
| LLPS-Ten-a530 | Tetraodon nigroviridis | 84.56 | 0.0 | 1502 |
| LLPS-Gaga-a389 | Gallus gallus | 83.32 | 0.0 | 1818 |
| LLPS-Anp-a361 | Anas platyrhynchos | 83.13 | 0.0 | 1746 |
| LLPS-Asm-a553 | Astyanax mexicanus | 82.92 | 0.0 | 1592 |
| LLPS-Meg-a363 | Meleagris gallopavo | 82.83 | 0.0 | 1801 |
| LLPS-Dar-a381 | Danio rerio | 82.14 | 0.0 | 1665 |
| LLPS-Lac-a564 | Latimeria chalumnae | 81.1 | 0.0 | 1754 |
| LLPS-Leo-a384 | Lepisosteus oculatus | 79.96 | 0.0 | 1729 |
| LLPS-Orn-a556 | Oreochromis niloticus | 79.41 | 0.0 | 1629 |
| LLPS-Anc-a594 | Anolis carolinensis | 79.15 | 0.0 | 1664 |
| LLPS-Scm-a540 | Scophthalmus maximus | 78.95 | 0.0 | 1644 |
| LLPS-Pof-a560 | Poecilia formosa | 78.4 | 0.0 | 1551 |
| LLPS-Tar-a364 | Takifugu rubripes | 77.77 | 0.0 | 1537 |
| LLPS-Xim-a566 | Xiphophorus maculatus | 76.48 | 0.0 | 1579 |
| LLPS-Icp-a560 | Ictalurus punctatus | 75.0 | 0.0 | 1552 |
| LLPS-Scf-a540 | Scleropages formosus | 74.67 | 0.0 | 1570 |
| LLPS-Orl-a548 | Oryzias latipes | 73.5 | 0.0 | 1542 |
| LLPS-Urm-a370 | Ursus maritimus | 72.57 | 0.0 | 759 |
| LLPS-Cis-a100 | Ciona savignyi | 62.41 | 1e-115 | 368 |
| LLPS-Dio-a395 | Dipodomys ordii | 60.08 | 0.0 | 1031 |
| LLPS-Xet-a377 | Xenopus tropicalis | 58.44 | 0.0 | 1134 |
| LLPS-Ova-a426 | Ovis aries | 56.36 | 0.0 | 1041 |
| LLPS-Fud-a420 | Fukomys damarensis | 55.11 | 0.0 | 983 |
| LLPS-Drm-a106 | Drosophila melanogaster | 54.41 | 5e-149 | 489 |
| LLPS-Cii-a313 | Ciona intestinalis | 51.57 | 1e-158 | 493 |