LLPS-Mum-a609
Vps53
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Vacuolar protein sorting-associated protein 53 homolog |
| Gene Name: | Vps53 |
| Ensembl Gene: | ENSMUSG00000017288.15 |
| Ensembl Protein: | ENSMUSP00000130499.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000169734.7 | ENSMUSP00000130499.1 |
| Ensembl | ENSMUST00000167114.7 | ENSMUSP00000131663.1 |
| Ensembl | ENSMUST00000108419.8 | ENSMUSP00000104057.2 |
| Ensembl | ENSMUST00000166752.7 | ENSMUSP00000129159.1 |
| Ensembl | ENSMUST00000170730.2 | ENSMUSP00000127364.1 |
| Ensembl | ENSMUST00000163878.1 | ENSMUSP00000128856.1 |
| Ensembl | ENSMUST00000056601.10 | ENSMUSP00000061317.4 |
| Ensembl | ENSMUST00000166436.7 | ENSMUSP00000131387.1 |
| Ensembl | ENSMUST00000094015.10 | ENSMUSP00000091554.4 |
| Ensembl | ENSMUST00000129256.1 | ENSMUSP00000126125.1 |
| UniProt | Q8CCB4, VPS53_MOUSE, Q8C7U0, Q8CIA1, Q9CX82, Q9D6T7 | |
| GeneBank | AK019408, AK033495, BC034371, AL591129, AK049259, AK009970 | BAB26620.1, BAC28318.1, AAH34371.1, BAB31707.1, BAC33641.1 |
| RefSeq | NM_026664.3 | NP_080940.2 |
| Entrez | 68299 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDQA DFNAVEYINT LFPTEQSLAN 60 61 IDDVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQALEEA QKAIQQLFGK IKDIKDKAEK 120 121 SEQMVKEITR DIKQLDHAKR HLTTSITTLN HLHMLAGGVD SLEAMTRRRQ YGEVANLLQG 180 181 VMNVLEHFHK YMGIPQIRQL SERVKAAQTE LGQQILADFE EAFPSQGTKR PGGPSNVLRD 240 241 ACLVANILDP RIKQEIIKKF IKQHLSEYLV LFQENQDVAW LDKIDRRYAW VKRQLVDYEE 300 301 KYGRMFPREW CMTERISVEF CHVTRAELSK IMRARAKEIE VKLLLFAIQR TTNFEGFLAK 360 361 RFSGCTLTDG TLKKLESPPP STNPFLEDET TPEMEELALE KGELEQPKKP KAPDNPFHGI 420 421 VSKCFEPHLY VYIESQDKNL SELIDRFVAD FKAQGPPKPN TDEGGAVLPS CADLFVYYKK 480 481 CMVQCSQLST GEPMIALTTI FQKYLREYAW KILSGNLPKT SSSSGGLTIS SLLKEKEGSE 540 541 VARFTLEELC LICSILSTAE YCLATTQQLE EKLKEKVDVS LTERINLTGE MDTFSTVISS 600 601 SIQLLVQDLD AACDPALIAM SKMPWQNVEH VGDQSPYVTS VILHIKQNVP IIRDNLASTR 660 661 KYFTQFCIKF ANSFIPKFIT HLFKCKPISM VGAEQLLLDT HSLKMVLLDL PSIGSQVVRK 720 721 APASYTKIVV KGMTRAEMIL KVVMAPHEPL VVFVDNYIKL LTDCNSETFQ KILDMKGLKR 780 781 SEQSSMLELL RQRLPAPPSG TEGSSTLSLI APTPEQESSR IRKLEKLIKK RL 832 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG 60 61 CCAGAGGTGC AACTCGCCAT CGAGCAGGTA TTCCCAAGCC AGGATCCTCT TGATCAAGCT 120 121 GACTTCAATG CCGTTGAGTA TATCAATACT CTGTTCCCAA CAGAGCAATC TCTGGCAAAC 180 181 ATTGACGATG TTGTGAACAA AATTAGACTG AAAATAAGGA GACTGGATGA CAATATCCGG 240 241 ACTGTCGTAA GAGGTCAGAC AAATGTGGGG CAGGATGGAA GGCAAGCACT TGAAGAGGCC 300 301 CAGAAAGCCA TTCAGCAACT CTTTGGCAAA ATCAAGGATA TCAAAGACAA AGCAGAAAAG 360 361 TCAGAACAAA TGGTGAAAGA GATCACCCGA GATATTAAGC AGTTAGATCA CGCCAAGCGC 420 421 CACCTGACCA CCTCAATCAC GACCCTGAAC CACCTGCACA TGCTGGCAGG CGGGGTGGAC 480 481 TCCCTGGAAG CCATGACCAG GCGCAGACAG TATGGAGAAG TTGCTAATCT CCTTCAGGGT 540 541 GTAATGAATG TTCTGGAGCA CTTTCACAAA TACATGGGAA TCCCACAGAT CCGACAGCTT 600 601 TCTGAAAGGG TGAAGGCTGC ACAGACAGAG TTAGGACAGC AAATCCTGGC TGACTTTGAA 660 661 GAAGCATTTC CTTCGCAGGG TACCAAGAGG CCGGGAGGAC CCAGCAATGT CCTGAGAGAT 720 721 GCGTGCCTGG TGGCTAATAT TTTGGACCCC AGAATCAAAC AAGAAATCAT CAAAAAGTTT 780 781 ATTAAACAGC ATCTATCAGA GTATCTAGTA CTTTTTCAAG AAAACCAAGA TGTCGCCTGG 840 841 CTGGACAAAA TTGACAGACG TTATGCTTGG GTGAAACGCC AGCTTGTGGA CTATGAAGAG 900 901 AAGTATGGCC GGATGTTTCC TCGGGAGTGG TGCATGACGG AGAGGATCTC AGTAGAGTTT 960 961 TGCCACGTGA CGAGGGCAGA ACTTTCCAAA ATCATGCGTG CCAGAGCTAA GGAAATTGAA 1020 1021 GTGAAATTGC TTCTTTTTGC GATCCAGAGA ACAACCAACT TTGAGGGGTT TCTTGCAAAA 1080 1081 CGCTTCTCCG GTTGCACCCT GACAGATGGA ACCCTGAAAA AGCTGGAGTC CCCACCACCA 1140 1141 TCTACCAATC CTTTCCTGGA AGATGAGACA ACACCAGAGA TGGAGGAGCT GGCTCTGGAG 1200 1201 AAAGGAGAGT TAGAGCAACC GAAGAAGCCC AAGGCCCCGG ACAACCCGTT CCACGGCATC 1260 1261 GTTTCCAAGT GTTTTGAGCC TCATCTCTAC GTGTACATTG AGTCCCAGGA CAAAAACCTC 1320 1321 AGCGAGCTGA TAGACCGGTT TGTGGCAGAT TTCAAAGCCC AGGGCCCACC CAAGCCCAAC 1380 1381 ACTGACGAAG GGGGTGCTGT GCTCCCCAGC TGCGCTGACC TCTTTGTCTA CTACAAGAAG 1440 1441 TGCATGGTGC AGTGCTCACA GCTCAGCACA GGCGAGCCCA TGATCGCCCT GACTACCATC 1500 1501 TTCCAGAAGT ACCTCCGAGA ATACGCCTGG AAAATCCTCT CTGGCAACCT GCCTAAAACC 1560 1561 AGCAGCAGCA GTGGGGGGCT GACCATCAGC AGCCTCCTCA AAGAGAAGGA GGGCTCAGAA 1620 1621 GTGGCCAGGT TCACTCTGGA GGAGCTGTGT CTCATCTGCA GCATCCTGAG CACAGCCGAG 1680 1681 TATTGTCTGG CTACCACCCA GCAGCTAGAA GAAAAACTCA AAGAAAAAGT TGATGTGAGC 1740 1741 CTGACTGAAC GAATTAATCT CACAGGAGAA ATGGACACAT TCAGCACTGT CATCTCCAGC 1800 1801 AGCATCCAGC TGTTGGTTCA AGATCTGGAT GCAGCCTGTG ACCCTGCCCT GATTGCCATG 1860 1861 AGCAAGATGC CTTGGCAGAA CGTGGAGCAT GTTGGTGACC AGAGCCCTTA TGTCACTTCT 1920 1921 GTTATTCTTC ACATTAAGCA AAACGTCCCC ATCATCCGTG ACAACCTGGC TTCCACACGG 1980 1981 AAATACTTCA CACAGTTCTG CATTAAATTT GCAAATTCGT TCATTCCCAA ATTCATCACC 2040 2041 CACCTCTTCA AGTGTAAGCC GATCAGCATG GTGGGAGCAG AGCAGCTTCT GCTGGACACC 2100 2101 CACTCCCTGA AGATGGTCCT GCTCGACCTT CCGTCCATTG GCTCCCAGGT GGTGAGGAAG 2160 2161 GCCCCTGCCA GTTACACTAA GATTGTCGTG AAAGGCATGA CCCGGGCTGA AATGATCCTT 2220 2221 AAGGTGGTGA TGGCCCCTCA TGAACCGTTG GTGGTATTTG TTGACAACTA CATCAAACTC 2280 2281 CTTACGGACT GCAACTCAGA AACCTTCCAG AAAATACTGG ATATGAAGGG GCTGAAGAGG 2340 2341 AGTGAGCAGA GCAGCATGCT GGAACTTTTG CGGCAGAGGC TCCCTGCCCC GCCCTCGGGG 2400 2401 ACAGAAGGTT CCAGCACCCT GTCGCTGATT GCCCCAACAC CGGAGCAGGA GTCATCCCGA 2460 2461 ATCCGCAAAC TGGAGAAACT GATTAAAAAG AGACTGTAA 2499 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | EARP complex | |
Cellular Component | Endosome membrane | |
Cellular Component | GARP complex | |
Cellular Component | Golgi apparatus | |
Cellular Component | Membrane | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Recycling endosome | |
Cellular Component | Trans-Golgi network | |
Biological Process | Endocytic recycling | |
Biological Process | Lysosomal transport | |
Biological Process | Protein transport | |
Biological Process | Retrograde transport, endosome to Golgi |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | SEA | microRNA.org | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a603 | Rattus norvegicus | 99.16 | 0.0 | 1705 |
| LLPS-Mea-a573 | Mesocricetus auratus | 98.68 | 0.0 | 1690 |
| LLPS-Fud-a583 | Fukomys damarensis | 97.23 | 0.0 | 1672 |
| LLPS-Ict-a597 | Ictidomys tridecemlineatus | 97.12 | 0.0 | 1680 |
| LLPS-Mup-a591 | Mustela putorius furo | 97.12 | 0.0 | 1677 |
| LLPS-Cap-a602 | Cavia porcellus | 97.11 | 0.0 | 1672 |
| LLPS-Gog-a601 | Gorilla gorilla | 96.88 | 0.0 | 1676 |
| LLPS-Chs-a593 | Chlorocebus sabaeus | 96.88 | 0.0 | 1674 |
| LLPS-Otg-a602 | Otolemur garnettii | 96.79 | 0.0 | 1254 |
| LLPS-Pat-a606 | Pan troglodytes | 96.75 | 0.0 | 1674 |
| LLPS-Hos-a614 | Homo sapiens | 96.75 | 0.0 | 1673 |
| LLPS-Dio-a586 | Dipodomys ordii | 96.72 | 0.0 | 862 |
| LLPS-Urm-a557 | Ursus maritimus | 96.63 | 0.0 | 1670 |
| LLPS-Fec-a604 | Felis catus | 96.63 | 0.0 | 1669 |
| LLPS-Caf-a593 | Canis familiaris | 96.51 | 0.0 | 1667 |
| LLPS-Cas-a524 | Carlito syrichta | 96.51 | 0.0 | 1666 |
| LLPS-Paa-a606 | Papio anubis | 96.51 | 0.0 | 1668 |
| LLPS-Bot-a609 | Bos taurus | 96.51 | 0.0 | 1666 |
| LLPS-Loa-a586 | Loxodonta africana | 96.4 | 0.0 | 1660 |
| LLPS-Ova-a592 | Ovis aries | 96.39 | 0.0 | 1659 |
| LLPS-Eqc-a606 | Equus caballus | 96.39 | 0.0 | 1666 |
| LLPS-Aim-a586 | Ailuropoda melanoleuca | 96.27 | 0.0 | 1659 |
| LLPS-Mam-a598 | Macaca mulatta | 96.16 | 0.0 | 1661 |
| LLPS-Caj-a600 | Callithrix jacchus | 96.14 | 0.0 | 1604 |
| LLPS-Maf-a608 | Macaca fascicularis | 96.09 | 0.0 | 1634 |
| LLPS-Pap-a603 | Pan paniscus | 96.05 | 0.0 | 1661 |
| LLPS-Myl-a566 | Myotis lucifugus | 95.72 | 0.0 | 1637 |
| LLPS-Mal-a596 | Mandrillus leucophaeus | 95.69 | 0.0 | 1583 |
| LLPS-Sus-a608 | Sus scrofa | 95.48 | 0.0 | 1628 |
| LLPS-Rhb-a600 | Rhinopithecus bieti | 94.38 | 0.0 | 1592 |
| LLPS-Aon-a608 | Aotus nancymaae | 94.26 | 0.0 | 1630 |
| LLPS-Orc-a570 | Oryctolagus cuniculus | 94.13 | 0.0 | 1601 |
| LLPS-Mod-a578 | Monodelphis domestica | 93.52 | 0.0 | 1600 |
| LLPS-Nol-a592 | Nomascus leucogenys | 93.4 | 0.0 | 1577 |
| LLPS-Tag-a527 | Taeniopygia guttata | 92.91 | 0.0 | 1560 |
| LLPS-Anp-a493 | Anas platyrhynchos | 92.8 | 0.0 | 1557 |
| LLPS-Cea-a609 | Cercocebus atys | 92.54 | 0.0 | 1542 |
| LLPS-Fia-a533 | Ficedula albicollis | 92.29 | 0.0 | 1534 |
| LLPS-Gaga-a547 | Gallus gallus | 92.18 | 0.0 | 1600 |
| LLPS-Meg-a493 | Meleagris gallopavo | 91.95 | 0.0 | 801 |
| LLPS-Anc-a561 | Anolis carolinensis | 91.53 | 0.0 | 1568 |
| LLPS-Man-a608 | Macaca nemestrina | 91.45 | 0.0 | 1521 |
| LLPS-Pes-a515 | Pelodiscus sinensis | 91.11 | 0.0 | 1361 |
| LLPS-Leo-a527 | Lepisosteus oculatus | 90.75 | 0.0 | 1537 |
| LLPS-Lac-a529 | Latimeria chalumnae | 90.6 | 0.0 | 1516 |
| LLPS-Ora-a507 | Ornithorhynchus anatinus | 90.37 | 0.0 | 1558 |
| LLPS-Poa-a598 | Pongo abelii | 89.98 | 0.0 | 1505 |
| LLPS-Scm-a510 | Scophthalmus maximus | 89.69 | 0.0 | 1533 |
| LLPS-Orn-a527 | Oreochromis niloticus | 89.45 | 0.0 | 1527 |
| LLPS-Dar-a532 | Danio rerio | 89.33 | 0.0 | 1541 |
| LLPS-Gaa-a517 | Gasterosteus aculeatus | 89.13 | 0.0 | 1515 |
| LLPS-Ten-a502 | Tetraodon nigroviridis | 88.96 | 0.0 | 1372 |
| LLPS-Icp-a530 | Ictalurus punctatus | 88.72 | 0.0 | 1528 |
| LLPS-Tar-a504 | Takifugu rubripes | 88.61 | 0.0 | 1522 |
| LLPS-Xim-a534 | Xiphophorus maculatus | 88.5 | 0.0 | 1516 |
| LLPS-Pof-a530 | Poecilia formosa | 88.38 | 0.0 | 1514 |
| LLPS-Xet-a524 | Xenopus tropicalis | 86.43 | 0.0 | 1451 |
| LLPS-Asm-a524 | Astyanax mexicanus | 85.37 | 0.0 | 1499 |
| LLPS-Scf-a508 | Scleropages formosus | 84.27 | 0.0 | 1441 |
| LLPS-Orl-a517 | Oryzias latipes | 82.89 | 0.0 | 1377 |
| LLPS-Sah-a551 | Sarcophilus harrisii | 77.64 | 0.0 | 1258 |
| LLPS-Cis-a143 | Ciona savignyi | 57.44 | 0.0 | 900 |