LLPS-Mum-a604
Uqcrc2

▼ OVERVIEW

Status: Reviewed
Protein Name: Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2
Gene Name: Uqcrc2
Ensembl Gene: ENSMUSG00000030884.12
Ensembl Protein: ENSMUSP00000146732.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKLLSRAGSF  SRFYSLKVAP  KVKTSAAPGG  VPLQPQDLEF  TKLPNGLVIA  SLENYAPLSR  60
61    IGLFVKAGSR  YEDSNNLGTS  HLLRLASSLT  TKGASSFKIT  RGIEAVGGKL  SVTATRENMA  120
121   YTVEGIRSDI  EILMEFLLNV  TTAPEFRRWE  VAALRSQLKI  DKAVAFQNSQ  TRIIENLHDV  180
181   AYKNALANPL  YCPDYRMGKI  TSEELHYFVQ  NHFTSARMAL  VGLGVSHSVL  KQVAEQFLNM  240
241   RGGLGLAGAK  AKYRGGEIRE  QNGDNLVHAA  IVAESAAIGN  AEANAFSVLQ  HLLGAGPHIK  300
301   RGNNTTSLLS  QSVAKGSHQP  FDVSAFNASY  SDSGLFGIYT  ISQAAAAGEV  INAAYNQVKA  360
361   VAQGNLSSAD  VQAAKNKLKA  GYLMSVETSE  GFLSEIGSQA  LAAGSYMPPS  TVLQQIDSVA  420
421   DADVVKAAKK  FVSGKKSMAA  SGNLGHTPFL  DEL  453
Nucleotide CDS Sequence (FASTA)
1     ATGAAGCTCC  TCAGCAGGGC  CGGGTCCTTC  TCGAGATTTT  ATTCCCTCAA  AGTTGCCCCG  60
61    AAGGTTAAAA  CTTCAGCAGC  CCCTGGAGGA  GTGCCTCTGC  AGCCTCAGGA  TCTTGAGTTT  120
121   ACCAAATTAC  CAAATGGTTT  GGTGATTGCT  TCTCTGGAAA  ACTATGCTCC  TCTGTCAAGA  180
181   ATCGGCTTGT  TCGTTAAAGC  AGGCAGTAGA  TATGAGGACT  CCAACAACTT  GGGAACCTCA  240
241   CATTTACTAC  GTCTTGCATC  TAGTTTGACT  ACCAAAGGAG  CTTCATCTTT  CAAGATAACC  300
301   CGTGGGATTG  AAGCAGTTGG  TGGTAAATTA  AGTGTGACTG  CAACAAGGGA  AAACATGGCG  360
361   TACACTGTAG  AAGGCATTCG  GAGTGATATT  GAGATCCTCA  TGGAGTTCCT  GCTCAATGTC  420
421   ACCACAGCAC  CCGAGTTTCG  CCGTTGGGAA  GTAGCTGCCC  TGCGGTCTCA  GCTAAAGATT  480
481   GACAAAGCTG  TTGCCTTTCA  GAATTCACAG  ACCCGTATCA  TTGAGAACTT  GCATGATGTT  540
541   GCCTACAAGA  ATGCCTTGGC  TAATCCTTTG  TACTGTCCTG  ACTATAGGAT  GGGGAAGATA  600
601   ACATCAGAGG  AATTACATTA  CTTTGTTCAG  AACCACTTCA  CAAGTGCAAG  AATGGCTCTG  660
661   GTTGGACTTG  GTGTGAGTCA  TTCTGTCTTA  AAGCAGGTGG  CTGAACAATT  TCTCAACATG  720
721   AGGGGTGGCC  TTGGTTTAGC  TGGTGCAAAA  GCCAAATACC  GTGGAGGTGA  AATTAGAGAG  780
781   CAGAATGGAG  ACAACCTGGT  CCATGCTGCT  ATTGTTGCAG  AAAGTGCTGC  CATTGGAAAT  840
841   GCAGAGGCAA  ATGCATTCAG  TGTACTTCAG  CATCTTCTTG  GTGCTGGACC  ACATATCAAA  900
901   AGGGGCAACA  ACACCACCAG  CCTCCTGAGC  CAGAGTGTTG  CCAAAGGAAG  TCACCAGCCT  960
961   TTTGATGTTT  CTGCATTTAA  TGCCAGTTAC  TCAGACTCTG  GGCTCTTTGG  AATTTACACT  1020
1021  ATTTCCCAGG  CTGCAGCTGC  TGGAGAGGTT  ATCAATGCTG  CCTACAACCA  AGTCAAAGCA  1080
1081  GTTGCTCAAG  GAAACCTTTC  CAGTGCAGAT  GTCCAAGCTG  CCAAGAACAA  GCTAAAAGCT  1140
1141  GGATATCTAA  TGTCTGTGGA  GACGTCAGAG  GGCTTCCTGA  GTGAAATTGG  GTCACAGGCT  1200
1201  CTAGCTGCAG  GTTCTTATAT  GCCACCTTCT  ACCGTCCTTC  AACAGATTGA  CTCCGTGGCT  1260
1261  GATGCTGATG  TTGTAAAGGC  TGCAAAAAAG  TTTGTTTCTG  GCAAGAAGTC  AATGGCAGCG  1320
1321  AGTGGAAACT  TGGGACATAC  GCCTTTTCTC  GACGAGTTAT  AA  1362

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Direct protein sequencing
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein
Reference proteome
Respiratory chain
Transit peptide
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial processing peptidase complex
Cellular Component
Mitochondrial respiratory chain complex III
Cellular Component
Mitochondrial respiratory chain complex IV
Cellular Component
Mitochondrion
Cellular Component
Myelin sheath
Cellular Component
Nucleoplasm
Molecular Function
Metal ion binding
Molecular Function
Metalloendopeptidase activity
Molecular Function
Protein-containing complex binding
Biological Process
Oxidation-reduction process
Biological Process
Protein processing involved in protein targeting to mitochondrion
Biological Process
Response to drug

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a598Rattus norvegicus95.580.0884
LLPS-Mea-a568Mesocricetus auratus92.720.0868
LLPS-Cas-a520Carlito syrichta90.992e-54186
LLPS-Orc-a567Oryctolagus cuniculus87.20.0827
LLPS-Cap-a597Cavia porcellus86.750.0821
LLPS-Nol-a587Nomascus leucogenys86.530.0769
LLPS-Fud-a578Fukomys damarensis86.310.0800
LLPS-Myl-a561Myotis lucifugus86.180.0807
LLPS-Poa-a593Pongo abelii86.090.0820
LLPS-Eqc-a601Equus caballus85.990.0744
LLPS-Gog-a596Gorilla gorilla85.870.0817
LLPS-Chs-a589Chlorocebus sabaeus85.870.0790
LLPS-Maf-a603Macaca fascicularis85.870.0791
LLPS-Rhb-a595Rhinopithecus bieti85.870.0794
LLPS-Pat-a601Pan troglodytes85.650.0792
LLPS-Fec-a599Felis catus85.650.0806
LLPS-Hos-a609Homo sapiens85.650.0791
LLPS-Pap-a598Pan paniscus85.650.0792
LLPS-Man-a603Macaca nemestrina85.650.0810
LLPS-Mal-a591Mandrillus leucophaeus85.430.0790
LLPS-Cea-a604Cercocebus atys85.430.0790
LLPS-Urm-a552Ursus maritimus85.430.0807
LLPS-Caj-a595Callithrix jacchus85.430.0760
LLPS-Paa-a601Papio anubis85.430.0790
LLPS-Aon-a603Aotus nancymaae85.210.0758
LLPS-Caf-a588Canis familiaris85.030.0666
LLPS-Sus-a603Sus scrofa84.990.0808
LLPS-Ova-a588Ovis aries84.770.0784
LLPS-Bot-a604Bos taurus84.770.0801
LLPS-Mam-a593Macaca mulatta84.730.0776
LLPS-Aim-a581Ailuropoda melanoleuca84.340.0776
LLPS-Otg-a597Otolemur garnettii84.110.0786
LLPS-Ict-a592Ictidomys tridecemlineatus83.440.0792
LLPS-Dio-a581Dipodomys ordii82.120.0782
LLPS-Mod-a573Monodelphis domestica79.960.0729
LLPS-Loa-a581Loxodonta africana79.690.0715
LLPS-Ora-a502Ornithorhynchus anatinus79.070.0715
LLPS-Mup-a586Mustela putorius furo78.38e-55187
LLPS-Sah-a546Sarcophilus harrisii77.360.0704
LLPS-Meg-a488Meleagris gallopavo72.731e-115347
LLPS-Anp-a488Anas platyrhynchos72.30.0664
LLPS-Gaga-a542Gallus gallus72.070.0650
LLPS-Tag-a522Taeniopygia guttata71.650.0665
LLPS-Pes-a511Pelodiscus sinensis70.720.0647
LLPS-Fia-a528Ficedula albicollis70.290.0654
LLPS-Leo-a522Lepisosteus oculatus69.790.0591
LLPS-Xet-a519Xenopus tropicalis69.60.0650
LLPS-Anc-a556Anolis carolinensis69.00.0652
LLPS-Scf-a503Scleropages formosus64.780.0581
LLPS-Asm-a519Astyanax mexicanus64.110.0572
LLPS-Tar-a500Takifugu rubripes64.110.0577
LLPS-Ten-a498Tetraodon nigroviridis63.660.0590
LLPS-Lac-a524Latimeria chalumnae63.290.0573
LLPS-Orn-a1034Oreochromis niloticus63.210.0566
LLPS-Icp-a525Ictalurus punctatus62.670.0556
LLPS-Scm-a1011Scophthalmus maximus62.530.0556
LLPS-Pof-a1029Poecilia formosa61.850.0551
LLPS-Gaa-a513Gasterosteus aculeatus61.020.0545
LLPS-Orl-a512Oryzias latipes60.90.0541
LLPS-Xim-a529Xiphophorus maculatus60.90.0546
LLPS-Dar-a527Danio rerio60.360.0540