LLPS-Mum-a576
Rdx

▼ OVERVIEW

Status: Reviewed
Protein Name: Radixin; ESP10
Gene Name: Rdx
Ensembl Gene: ENSMUSG00000032050.17
Ensembl Protein: ENSMUSP00000000590.8
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client
PDB: 2EMT (A, C) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPKPINVRVT  TMDAELEFAI  QPNTTGKQLF  DQVVKTVGLR  EVWFFGLQYV  DSKGYSTWLK  60
61    LNKKVTQQDV  KKENPLQFKF  RAKFFPEDVS  EELIQEITQR  LFFLQVKEAI  LNDEIYCPPE  120
121   TAVLLASYAV  QAKYGDYNKE  IHKPGYLAND  RLLPQRVLEQ  HKLTKEQWEE  RIQNWHEEHR  180
181   GMLREDSMME  YLKIAQDLEM  YGVNYFEIKN  KKGTELWLGV  DALGLNIYEH  DDKLTPKIGF  240
241   PWSEIRNISF  NDKKFVIKPI  DKKAPDFVFY  APRLRINKRI  LALCMGNHEL  YMRRRKPDTI  300
301   EVQQMKAQAR  EEKHQKQLER  AQLENEKKKR  EIAEKEKERI  EREKEELMER  LRQIEEQTVK  360
361   AQKELEEQTR  KALELEQERQ  RAKEEAERLD  RERRAAEEAK  SAIAKQAADQ  MKNQEQLAAE  420
421   LAEFTAKIAL  LEEAKKKKEE  EATEWQHKAF  AAQEDLEKTK  EELKTVMSAP  PPPPPPPVIP  480
481   PTENEHDEQD  ENSAEASAEL  SSEGVMNHRS  EEERVTETQK  NERVKKQLQA  LSSELAQARD  540
541   ETKKTQNDVL  HAENVKAGRD  KYKTLRQIRQ  GNTKQRIDEF  EAM  583
Nucleotide CDS Sequence (FASTA)
1     ATGCCGAAGC  CAATCAATGT  AAGAGTAACT  ACAATGGACG  CTGAGCTAGA  ATTTGCCATC  60
61    CAGCCCAATA  CAACTGGCAA  ACAACTTTTT  GACCAGGTTG  TAAAAACAGT  TGGCTTACGT  120
121   GAGGTCTGGT  TTTTTGGGCT  GCAATATGTA  GACAGCAAAG  GATATTCTAC  ATGGCTTAAA  180
181   TTGAATAAAA  AGGTAACACA  GCAAGATGTT  AAAAAAGAAA  ATCCTTTACA  GTTCAAGTTT  240
241   AGAGCTAAAT  TCTTTCCTGA  AGATGTTTCT  GAGGAATTGA  TTCAAGAAAT  AACACAGAGA  300
301   CTTTTCTTCT  TGCAAGTTAA  AGAAGCCATC  TTAAATGATG  AGATATATTG  CCCACCAGAA  360
361   ACTGCAGTTC  TTTTGGCTTC  GTATGCTGTC  CAAGCCAAGT  ATGGAGATTA  TAATAAAGAG  420
421   ATTCACAAAC  CAGGCTATCT  GGCTAATGAC  AGACTCTTAC  CACAGCGTGT  TTTGGAACAA  480
481   CACAAACTGA  CCAAAGAGCA  GTGGGAGGAG  AGAATACAGA  ACTGGCATGA  GGAACACAGA  540
541   GGGATGCTAA  GGGAAGATTC  GATGATGGAA  TACTTGAAGA  TTGCGCAAGA  TCTAGAGATG  600
601   TATGGTGTCA  ACTACTTTGA  AATCAAGAAT  AAGAAGGGTA  CTGAGCTGTG  GCTAGGTGTT  660
661   GATGCTTTAG  GCCTGAATAT  TTATGAACAT  GATGACAAGT  TAACACCTAA  AATTGGTTTT  720
721   CCCTGGAGTG  AAATCAGAAA  TATTTCATTT  AATGACAAAA  AATTCGTTAT  AAAGCCAATT  780
781   GACAAAAAGG  CACCTGATTT  TGTCTTCTAT  GCACCTCGTC  TGAGAATCAA  TAAACGAATT  840
841   TTGGCCTTAT  GTATGGGAAA  CCATGAACTG  TACATGCGAA  GGAGAAAGCC  TGATACTATT  900
901   GAAGTACAGC  AGATGAAGGC  TCAGGCCCGG  GAGGAAAAGC  ATCAGAAGCA  GCTAGAAAGG  960
961   GCACAATTAG  AGAATGAAAA  GAAGAAACGA  GAAATAGCAG  AAAAGGAAAA  GGAAAGAATA  1020
1021  GAACGTGAAA  AGGAAGAGCT  GATGGAGCGT  CTGAGGCAGA  TCGAAGAGCA  AACAGTGAAA  1080
1081  GCCCAGAAAG  AACTAGAAGA  ACAGACTCGG  AAAGCTCTAG  AACTGGAGCA  GGAGCGCCAG  1140
1141  CGAGCAAAAG  AGGAGGCAGA  GCGGCTAGAC  AGGGAGCGCC  GGGCTGCAGA  AGAAGCCAAG  1200
1201  TCTGCAATCG  CCAAGCAAGC  TGCTGACCAG  ATGAAGAACC  AGGAGCAGCT  GGCAGCAGAA  1260
1261  CTTGCCGAAT  TCACTGCCAA  GATTGCACTT  TTAGAAGAAG  CCAAGAAGAA  AAAGGAAGAG  1320
1321  GAAGCTACTG  AGTGGCAGCA  CAAAGCTTTT  GCAGCTCAGG  AAGACTTGGA  AAAGACCAAA  1380
1381  GAAGAGCTAA  AAACTGTGAT  GTCTGCGCCA  CCTCCACCTC  CCCCTCCTCC  AGTCATCCCT  1440
1441  CCCACGGAGA  ACGAGCATGA  CGAGCAGGAC  GAGAACAGTG  CGGAGGCCAG  CGCCGAGCTG  1500
1501  TCCAGCGAGG  GGGTGATGAA  CCACCGAAGC  GAGGAGGAGC  GGGTCACCGA  AACCCAGAAG  1560
1561  AATGAACGCG  TGAAGAAGCA  GCTCCAGGCA  TTGAGTTCAG  AATTAGCCCA  AGCTAGAGAT  1620
1621  GAAACCAAGA  AGACACAGAA  CGATGTTCTT  CACGCTGAGA  ATGTCAAGGC  CGGCCGTGAT  1680
1681  AAGTACAAGA  CCCTTCGGCA  GATTCGACAA  GGCAATACGA  AGCAGCGCAT  CGATGAGTTT  1740
1741  GAAGCCATGT  GA  1752

▼ KEYWORD

ID
Family
3D-structure
Actin capping
Actin-binding
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Membrane
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical part of cell
Cellular Component
Apical plasma membrane
Cellular Component
Cell periphery
Cellular Component
Cell tip
Cellular Component
Cell-cell adherens junction
Cellular Component
Cleavage furrow
Cellular Component
Cortical actin cytoskeleton
Cellular Component
Filopodium
Cellular Component
Focal adhesion
Cellular Component
Lamellipodium
Cellular Component
Microvillus
Cellular Component
Midbody
Cellular Component
Myelin sheath
Cellular Component
Plasma membrane
Cellular Component
Ruffle
Cellular Component
Stereocilium
Cellular Component
T-tubule
Molecular Function
Actin binding
Molecular Function
ATPase binding
Molecular Function
Protein domain specific binding
Molecular Function
Protein homodimerization activity
Biological Process
Apical protein localization
Biological Process
Barbed-end actin filament capping
Biological Process
Cellular response to platelet-derived growth factor stimulus
Biological Process
Cellular response to thyroid hormone stimulus
Biological Process
Establishment of endothelial barrier
Biological Process
Establishment of protein localization
Biological Process
Microvillus assembly
Biological Process
Negative regulation of adherens junction organization
Biological Process
Negative regulation of cell size
Biological Process
Negative regulation of GTPase activity
Biological Process
Negative regulation of homotypic cell-cell adhesion
Biological Process
Positive regulation of cell migration
Biological Process
Positive regulation of cellular protein catabolic process
Biological Process
Positive regulation of early endosome to late endosome transport
Biological Process
Positive regulation of G1/S transition of mitotic cell cycle
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of protein localization to early endosome
Biological Process
Protein localization to plasma membrane
Biological Process
Regulation of actin filament bundle assembly
Biological Process
Regulation of cell shape
Biological Process
Regulation of cell size
Biological Process
Regulation of GTPase activity
Biological Process
Regulation of organelle assembly
Biological Process
Regulation of ruffle assembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-a538Mesocricetus auratus99.270.01112
LLPS-Sah-a519Sarcophilus harrisii98.90.0749
LLPS-Mam-a565Macaca mulatta98.630.01172
LLPS-Man-a575Macaca nemestrina98.630.01172
LLPS-Caf-4398Canis familiaris98.460.01172
LLPS-Cea-a575Cercocebus atys98.460.01172
LLPS-Urm-1454Ursus maritimus98.460.01172
LLPS-Hos-a581Homo sapiens98.460.01172
LLPS-Maf-a575Macaca fascicularis98.460.01172
LLPS-Orc-3209Oryctolagus cuniculus98.460.01170
LLPS-Poa-a564Pongo abelii98.460.01172
LLPS-Eqc-1544Equus caballus98.460.01169
LLPS-Gog-a566Gorilla gorilla98.460.01172
LLPS-Fud-3411Fukomys damarensis98.460.01172
LLPS-Paa-a572Papio anubis98.460.01172
LLPS-Rhb-a565Rhinopithecus bieti98.460.01172
LLPS-Nol-1202Nomascus leucogenys98.460.01169
LLPS-Aim-3466Ailuropoda melanoleuca98.450.01163
LLPS-Mup-0601Mustela putorius furo98.280.01171
LLPS-Pat-a572Pan troglodytes98.280.01172
LLPS-Sus-3478Sus scrofa98.280.01172
LLPS-Dio-2982Dipodomys ordii98.280.01171
LLPS-Pap-a569Pan paniscus98.280.01172
LLPS-Cas-2518Carlito syrichta98.110.01168
LLPS-Fec-a572Felis catus98.110.01169
LLPS-Caj-a568Callithrix jacchus98.110.01169
LLPS-Cap-3721Cavia porcellus98.110.01167
LLPS-Bot-1864Bos taurus98.110.01169
LLPS-Mal-a562Mandrillus leucophaeus97.610.01163
LLPS-Ict-4661Ictidomys tridecemlineatus97.60.01161
LLPS-Loa-0036Loxodonta africana97.580.01154
LLPS-Chs-a563Chlorocebus sabaeus97.410.01145
LLPS-Gaga-3716Gallus gallus97.260.01162
LLPS-Otg-a570Otolemur garnettii97.260.01156
LLPS-Pes-1815Pelodiscus sinensis97.260.01161
LLPS-Ova-2322Ovis aries97.260.01151
LLPS-Anp-a464Anas platyrhynchos97.070.01149
LLPS-Myl-0405Myotis lucifugus97.060.01151
LLPS-Meg-a464Meleagris gallopavo96.920.01152
LLPS-Fia-a499Ficedula albicollis96.570.01155
LLPS-Tag-a495Taeniopygia guttata96.570.01157
LLPS-Mod-a546Monodelphis domestica96.050.01052
LLPS-Ran-a570Rattus norvegicus94.850.01034
LLPS-Anc-a529Anolis carolinensis94.570.01034
LLPS-Lac-a497Latimeria chalumnae92.990.0982
LLPS-Scf-4010Scleropages formosus92.280.01035
LLPS-Asm-1159Astyanax mexicanus89.470.01018
LLPS-Xim-a153Xiphophorus maculatus89.330.01006
LLPS-Orn-1496Oreochromis niloticus89.060.0996
LLPS-Tar-3176Takifugu rubripes89.020.01019
LLPS-Gaa-0570Gasterosteus aculeatus88.810.0973
LLPS-Pof-3297Poecilia formosa88.740.01036
LLPS-Aon-a574Aotus nancymaae87.990.0910
LLPS-Scm-0277Scophthalmus maximus87.480.01019
LLPS-Orl-a1046Oryzias latipes85.980.0941
LLPS-Ten-3448Tetraodon nigroviridis82.050.0965
LLPS-Leo-3732Lepisosteus oculatus80.520.0930
LLPS-Dar-a500Danio rerio76.50.0915
LLPS-Tut-0412Tursiops truncatus76.330.0875
LLPS-Icp-a152Ictalurus punctatus75.090.0882
LLPS-Xet-a150Xenopus tropicalis74.610.0876
LLPS-Ora-a476Ornithorhynchus anatinus67.590.0695