LLPS-Mum-a564
Bin1

▼ OVERVIEW

Status: Reviewed
Protein Name: Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1; SH3 domain-containing protein 9
Gene Name: Bin1, Amphl, Sh3p9
Ensembl Gene: ENSMUSG00000024381.16
Ensembl Protein: ENSMUSP00000157259.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAEMGSKGVT  AGKIASNVQK  KLTRAQEKVL  QKLGKADETK  DEQFEQCVQN  FNKQLTEGTR  60
61    LQKDLRTYLA  SVKAMHEASK  KLSECLQEVY  EPEWPGRDEA  NKIAENNDLL  WMDYHQKLVD  120
121   QALLTMDTYL  GQFPDIKSRI  AKRGRKLVDY  DSARHHYESL  QTAKKKDEAK  IAKPVSLLEK  180
181   AAPQWCQGKL  QAHLVAQTNL  LRNQAEEELI  KAQKVFEEMN  VDLQEELPSL  WNSRVGFYVN  240
241   TFQSIAGLEE  NFHKEMSKLN  QNLNDVLVSL  EKQHGSNTFT  VKAQPSDNAP  EKGNKSPSPP  300
301   PDGSPAATPE  IRVNHEPEPA  SGASPGATIP  KSPSQLRKGP  PVPPPPKHTP  SKEMKQEQIL  360
361   SLFDDAFVPE  ISVTTPSQFE  APGPFSEQAS  LLDLDFEPLP  PVASPVKAPT  PSGQSIPWDL  420
421   WEPTESQAGI  LPSGEPSSAE  GSFAVAWPSQ  TAEPGPAQPA  EASEVVGGAQ  EPGETAASEA  480
481   TSSSLPAVVV  ETFSATVNGA  VEGSAGTGRL  DLPPGFMFKV  QAQHDYTATD  TDELQLKAGD  540
541   VVLVIPFQNP  EEQDEGWLMG  VKESDWNQHK  ELEKCRGVFP  ENFTERVQ  588
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGAGA  TGGGGAGCAA  GGGGGTGACG  GCGGGGAAGA  TCGCCAGCAA  CGTACAGAAG  60
61    AAGCTGACCC  GAGCGCAGGA  GAAGGTCCTG  CAGAAACTGG  GGAAGGCGGA  CGAGACGAAG  120
121   GACGAGCAGT  TTGAGCAGTG  TGTCCAGAAC  TTCAATAAGC  AGCTGACAGA  GGGTACCCGG  180
181   CTGCAGAAGG  ATCTTCGGAC  CTATCTGGCT  TCTGTTAAAG  CGATGCACGA  AGCCTCCAAG  240
241   AAGCTGAGTG  AGTGTCTTCA  GGAGGTGTAT  GAGCCCGAGT  GGCCTGGCAG  GGATGAAGCA  300
301   AACAAGATTG  CAGAGAACAA  TGACCTACTC  TGGATGGACT  ACCACCAGAA  GCTGGTGGAC  360
361   CAGGCTCTGC  TGACCATGGA  CACCTACCTA  GGCCAGTTCC  CTGATATCAA  GTCGCGCATT  420
421   GCCAAGCGGG  GGCGGAAGCT  GGTGGACTAT  GACAGTGCCC  GGCACCACTA  TGAGTCTCTT  480
481   CAAACCGCCA  AAAAGAAGGA  TGAAGCCAAA  ATTGCCAAGC  CTGTCTCGCT  GCTTGAGAAA  540
541   GCCGCCCCCC  AGTGGTGCCA  AGGCAAACTA  CAGGCTCATC  TTGTAGCTCA  AACTAACCTG  600
601   CTCCGAAATC  AGGCAGAAGA  GGAGCTCATC  AAAGCCCAGA  AGGTGTTCGA  GGAGATGAAC  660
661   GTGGATCTGC  AGGAGGAGCT  GCCATCCCTG  TGGAACAGCC  GTGTAGGTTT  CTATGTCAAC  720
721   ACGTTCCAGA  GCATCGCGGG  TCTGGAGGAA  AACTTCCATA  AAGAGATGAG  TAAGCTCAAT  780
781   CAGAACCTCA  ATGATGTCCT  GGTCAGCCTA  GAGAAGCAGC  ACGGGAGCAA  CACCTTCACA  840
841   GTCAAGGCCC  AACCCAGTGA  CAATGCCCCT  GAGAAAGGGA  ACAAGAGCCC  GTCACCTCCT  900
901   CCAGATGGCT  CCCCTGCTGC  TACCCCTGAG  ATCAGAGTGA  ACCATGAGCC  AGAGCCGGCC  960
961   AGTGGGGCCT  CACCCGGGGC  TACCATCCCC  AAGTCCCCAT  CTCAGCTCCG  GAAAGGCCCA  1020
1021  CCTGTCCCTC  CGCCTCCCAA  ACACACCCCA  TCCAAGGAGA  TGAAGCAGGA  GCAGATTCTC  1080
1081  AGCCTTTTTG  ATGACGCATT  TGTCCCTGAG  ATCAGCGTGA  CCACCCCCTC  CCAGTTTGAG  1140
1141  GCCCCTGGGC  CTTTCTCAGA  GCAGGCCAGT  CTACTAGACC  TGGACTTCGA  GCCCCTTCCA  1200
1201  CCAGTGGCGA  GCCCCGTGAA  GGCACCCACA  CCCTCTGGTC  AGTCAATCCC  ATGGGACCTC  1260
1261  TGGGAGCCCA  CAGAGAGTCA  AGCTGGCATC  CTGCCTTCCG  GGGAGCCCAG  TTCTGCTGAG  1320
1321  GGCAGCTTTG  CTGTGGCCTG  GCCCAGCCAG  ACAGCCGAGC  CAGGGCCCGC  CCAACCAGCA  1380
1381  GAGGCCTCCG  AGGTGGTGGG  TGGAGCCCAG  GAGCCAGGGG  AGACAGCAGC  CAGTGAAGCA  1440
1441  ACCTCCAGCT  CTCTTCCGGC  TGTGGTGGTG  GAGACCTTCT  CCGCAACTGT  GAATGGGGCG  1500
1501  GTGGAGGGCA  GCGCTGGGAC  TGGACGCTTG  GACCTGCCCC  CGGGATTCAT  GTTCAAGGTT  1560
1561  CAAGCCCAGC  ATGATTACAC  GGCCACTGAC  ACTGATGAGC  TGCAACTCAA  AGCTGGCGAT  1620
1621  GTGGTGTTGG  TGATTCCTTT  CCAGAACCCA  GAGGAGCAGG  ATGAAGGCTG  GCTCATGGGT  1680
1681  GTGAAGGAGA  GCGACTGGAA  TCAGCACAAG  GAACTGGAGA  AATGCCGCGG  CGTCTTCCCG  1740
1741  GAGAATTTTA  CAGAGCGGGT  GCAGTGA  1767

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Endocytosis
Endosome
Membrane
Nucleus
Phosphoprotein
Reference proteome
SH3 domain

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Axon initial segment
Cellular Component
Axon terminus
Cellular Component
Cerebellar mossy fiber
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Endosome
Cellular Component
Extrinsic component of synaptic vesicle membrane
Cellular Component
Glutamatergic synapse
Cellular Component
I band
Cellular Component
Lipid tube
Cellular Component
Membrane
Cellular Component
Microtubule
Cellular Component
Node of Ranvier
Cellular Component
Nuclear envelope
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Synapse
Cellular Component
Synaptic vesicle
Cellular Component
T-tubule
Cellular Component
Varicosity
Cellular Component
Z disc
Molecular Function
Actin filament binding
Molecular Function
Chaperone binding
Molecular Function
GTPase binding
Molecular Function
Identical protein binding
Molecular Function
Phospholipid binding
Molecular Function
Protease binding
Molecular Function
Protein heterodimerization activity
Molecular Function
Protein-containing complex binding
Molecular Function
RNA polymerase binding
Molecular Function
Tau protein binding
Biological Process
Endosome to lysosome transport
Biological Process
Lipid tube assembly
Biological Process
Muscle cell differentiation
Biological Process
Negative regulation of amyloid-beta formation
Biological Process
Negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Biological Process
Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Process
Negative regulation of potassium ion transmembrane transport
Biological Process
Negative regulation of ventricular cardiac muscle cell action potential
Biological Process
Nucleus localization
Biological Process
Nucleus organization
Biological Process
Positive regulation of actin filament polymerization
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of astrocyte differentiation
Biological Process
Positive regulation of endocytosis
Biological Process
Positive regulation of GTPase activity
Biological Process
Regulation of cell cycle arrest
Biological Process
Regulation of heart rate by cardiac conduction
Biological Process
Regulation of neuron differentiation
Biological Process
Synaptic vesicle endocytosis
Biological Process
T-tubule organization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a558Rattus norvegicus98.980.01190
LLPS-Dio-a543Dipodomys ordii95.910.01106
LLPS-Sus-a565Sus scrofa95.750.01083
LLPS-Rhb-a553Rhinopithecus bieti95.110.01132
LLPS-Mal-a549Mandrillus leucophaeus94.940.01113
LLPS-Hos-a569Homo sapiens94.770.01112
LLPS-Gog-a554Gorilla gorilla94.770.01111
LLPS-Mup-a549Mustela putorius furo94.280.01088
LLPS-Pat-a560Pan troglodytes94.140.01106
LLPS-Fud-a539Fukomys damarensis93.750.01053
LLPS-Eqc-a563Equus caballus92.910.0999
LLPS-Ict-a555Ictidomys tridecemlineatus92.780.01088
LLPS-Cea-a563Cercocebus atys92.60.01105
LLPS-Paa-a560Papio anubis92.60.01105
LLPS-Chs-a552Chlorocebus sabaeus92.430.01104
LLPS-Man-a563Macaca nemestrina92.430.01102
LLPS-Fec-a560Felis catus92.120.01066
LLPS-Cap-a557Cavia porcellus91.250.01034
LLPS-Mam-a553Macaca mulatta89.710.01019
LLPS-Caj-a556Callithrix jacchus89.210.01026
LLPS-Pap-a557Pan paniscus88.550.01028
LLPS-Nol-a546Nomascus leucogenys88.270.01012
LLPS-Aon-a562Aotus nancymaae87.770.01033
LLPS-Bot-a566Bos taurus87.160.0910
LLPS-Leo-a489Lepisosteus oculatus86.211e-139414
LLPS-Aim-a542Ailuropoda melanoleuca85.890.0664
LLPS-Otg-a558Otolemur garnettii85.420.0624
LLPS-Mea-a526Mesocricetus auratus84.510.0954
LLPS-Maf-a563Macaca fascicularis84.040.0636
LLPS-Poa-a552Pongo abelii82.290.0919
LLPS-Urm-a513Ursus maritimus82.12e-169501
LLPS-Orc-a531Oryctolagus cuniculus80.720.0854
LLPS-Tag-a485Taeniopygia guttata79.170.0538
LLPS-Caf-a548Canis familiaris79.060.0667
LLPS-Gaga-a506Gallus gallus78.871e-175514
LLPS-Mod-a534Monodelphis domestica77.010.0849
LLPS-Anp-a456Anas platyrhynchos75.080.0842
LLPS-Pes-a474Pelodiscus sinensis74.710.0832
LLPS-Fia-a488Ficedula albicollis74.560.0866
LLPS-Scm-a470Scophthalmus maximus70.112e-123381
LLPS-Meg-a455Meleagris gallopavo68.818e-45162
LLPS-Anc-a516Anolis carolinensis67.170.0744
LLPS-Tar-a467Takifugu rubripes66.432e-124384
LLPS-Loa-a542Loxodonta africana62.857e-117363
LLPS-Xet-a485Xenopus tropicalis62.350.0640
LLPS-Ora-a464Ornithorhynchus anatinus61.868e-38142
LLPS-Orn-a1007Oreochromis niloticus59.476e-137422
LLPS-Ova-a550Ovis aries58.729e-112350
LLPS-Orl-a1004Oryzias latipes57.74e-134414
LLPS-Xim-a496Xiphophorus maculatus56.742e-146446
LLPS-Pof-a997Poecilia formosa56.443e-145443
LLPS-Scf-a465Scleropages formosus56.220.0568
LLPS-Lac-a488Latimeria chalumnae54.831e-97320
LLPS-Myl-a525Myotis lucifugus54.812e-89295
LLPS-Gaa-a475Gasterosteus aculeatus53.450.0567
LLPS-Icp-a492Ictalurus punctatus53.270.0545
LLPS-Ten-a466Tetraodon nigroviridis52.390.0550
LLPS-Sah-a507Sarcophilus harrisii51.767e-80263
LLPS-Asm-a484Astyanax mexicanus51.090.0559