LLPS-Mum-a525
Numb

▼ OVERVIEW

Status: Reviewed
Protein Name: Protein numb homolog
Gene Name: Numb
Ensembl Gene: ENSMUSG00000021224.15
Ensembl Protein: ENSMUSP00000119303.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others
PDB: 5YQG (A, E) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNKLRQSFRR  KKDVYVPEAS  RPHQWQTDEE  GVRTGKCSFP  VKYLGHVEVD  ESRGMHICED  60
61    AVKRLKAERK  FFKGFFGKTG  KKAVKAVLWV  SADGLRVVDE  KTKDLIVDQT  IEKVSFCAPD  120
121   RNFDRAFSYI  CRDGTTRRWI  CHCFMAVKDT  GERLSHAVGC  AFAACLERKQ  KREKECGVTA  180
181   TFDASRTTFT  REGSFRVTTA  TEQAEREEIM  KQLQDAKKAE  TDKTVVGPSV  APGNTAPSPS  240
241   SPTSPTPDGT  ASSEMNNPHA  IPRRHAPIEQ  LARQGSFRGF  PALSQKMSPF  KRQLSLRINE  300
301   LPSTMQRKTD  FPIKNTVPEV  EGEAESISSL  CSQITSAFST  PSEDPFSSAP  MTKPVTLVAP  360
361   QSPVLQANGT  DSASHVLTAK  PANTALAHVA  MPVRETNPWA  HVPDAANKEI  AAIHPGTEWG  420
421   QSSGAASPGL  FQAGHRRTPS  EADRWLEEVS  KSVRAQQPQV  SAAPLQPVLQ  PPPPAAIAPP  480
481   APPFQGHAFL  TSQPVPVGVV  PPLQPAFVPT  QSYPVANGMP  YPASNVPVVG  ITPSQMVANV  540
541   FGTAGHPQTT  HPHQSPSLAK  QQTFPQYETS  SATTSPFFKP  PAQHLNGSAA  FNGVDNGGLA  600
601   SGNRHAEVPP  GTCPVDPFEA  QWAALESKSK  QRTNPSPTNP  FSSDLQKTFE  IEL  653
Nucleotide CDS Sequence (FASTA)
1     ATGAACAAAC  TACGGCAAAG  CTTCAGGAGA  AAGAAAGACG  TTTATGTCCC  AGAGGCCAGC  60
61    CGTCCACATC  AGTGGCAGAC  AGATGAAGAA  GGAGTCCGCA  CTGGAAAGTG  TAGCTTCCCA  120
121   GTTAAGTACC  TCGGCCACGT  AGAAGTTGAT  GAGTCAAGAG  GAATGCACAT  CTGTGAAGAT  180
181   GCCGTAAAGA  GATTGAAAGC  TGAAAGGAAG  TTCTTCAAAG  GCTTCTTTGG  AAAAACGGGA  240
241   AAGAAAGCAG  TGAAGGCCGT  TCTGTGGGTG  TCAGCGGATG  GGCTCAGAGT  TGTGGACGAG  300
301   AAAACTAAGG  ACCTCATAGT  TGACCAGACA  ATAGAAAAAG  TTTCCTTCTG  TGCCCCAGAT  360
361   AGGAACTTTG  ACAGAGCCTT  TTCTTACATA  TGTCGTGATG  GCACCACTCG  GCGATGGATC  420
421   TGTCATTGTT  TCATGGCTGT  CAAAGACACG  GGGGAAAGAC  TGAGCCACGC  CGTGGGCTGT  480
481   GCTTTTGCAG  CCTGTTTAGA  GCGTAAACAG  AAGCGGGAGA  AGGAGTGTGG  CGTCACTGCT  540
541   ACTTTTGATG  CCAGTAGAAC  CACTTTCACA  AGAGAAGGAT  CATTCCGTGT  CACAACTGCC  600
601   ACTGAGCAAG  CCGAAAGAGA  GGAGATCATG  AAACAGTTGC  AAGATGCCAA  GAAAGCTGAG  660
661   ACAGACAAGA  CAGTTGTTGG  TCCATCAGTG  GCTCCTGGCA  ACACTGCTCC  ATCCCCATCC  720
721   TCTCCCACCT  CTCCCACTCC  GGATGGCACT  GCATCTTCAG  AGATGAACAA  TCCCCATGCT  780
781   ATCCCACGCC  GGCATGCACC  AATTGAACAG  CTTGCTCGTC  AAGGCTCTTT  CCGGGGATTT  840
841   CCTGCTCTTA  GCCAGAAGAT  GTCACCCTTT  AAACGCCAGC  TGTCCCTACG  CATCAATGAG  900
901   TTGCCTTCCA  CTATGCAGAG  GAAGACCGAT  TTCCCAATAA  AAAACACAGT  GCCCGAGGTG  960
961   GAAGGAGAGG  CCGAGAGCAT  CAGCTCCTTG  TGTTCCCAGA  TCACCAGTGC  CTTCAGCACG  1020
1021  CCCTCTGAGG  ACCCCTTCTC  CTCCGCCCCA  ATGACCAAAC  CAGTGACATT  GGTGGCACCA  1080
1081  CAGTCTCCTG  TGTTACAAGG  GACTGAGTGG  GGTCAGTCTT  CTGGTGCTGC  CTCTCCAGGT  1140
1141  CTCTTCCAGG  CTGGTCACAG  ACGCACTCCC  TCTGAAGCTG  ACCGCTGGTT  AGAAGAAGTG  1200
1201  TCAAAGAGTG  TGCGGGCCCA  GCAGCCTCAG  GTCTCAGCTG  CCCCTCTGCA  GCCAGTTCTC  1260
1261  CAGCCGCCTC  CGCCCGCCGC  CATTGCCCCT  CCAGCACCTC  CTTTCCAAGG  ACATGCCTTC  1320
1321  CTCACGTCCC  AGCCTGTGCC  CGTGGGTGTG  GTCCCACCCC  TACAACCAGC  CTTTGTCCCT  1380
1381  ACCCAGTCCT  ACCCTGTGGC  CAACGGGATG  CCCTACCCAG  CCTCTAATGT  GCCTGTAGTG  1440
1441  GGCATCACCC  CATCCCAGAT  GGTAGCCAAT  GTGTTTGGCA  CTGCAGGCCA  CCCTCAGACA  1500
1501  ACTCATCCAC  ATCAGTCGCC  AAGCCTGGCC  AAGCAGCAGA  CATTCCCTCA  ATATGAGACA  1560
1561  AGTAGTGCTA  CCACCAGTCC  CTTCTTTAAG  CCTCCTGCTC  AGCACCTCAA  TGGTTCTGCA  1620
1621  GCTTTCAATG  GTGTAGACAA  TGGTGGGCTA  GCCTCAGGAA  ACAGGCATGC  AGAAGTCCCT  1680
1681  CCAGGCACCT  GCCCAGTGGA  TCCTTTCGAA  GCTCAGTGGG  CCGCACTAGA  AAGCAAGTCC  1740
1741  AAGCAGCGTA  CAAATCCTTC  TCCTACCAAC  CCTTTCTCCA  GTGACTTACA  GAAAACATTT  1800
1801  GAAATAGAAC  TTTAG  1815

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Complete proteome
Developmental protein
Membrane
Neurogenesis
Phosphoprotein
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical part of cell
Cellular Component
Basolateral plasma membrane
Cellular Component
Clathrin-coated vesicle
Cellular Component
Cytoplasm
Cellular Component
Cytoplasmic vesicle
Cellular Component
Early endosome
Cellular Component
Extrinsic component of plasma membrane
Cellular Component
Glutamatergic synapse
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Postsynaptic density
Molecular Function
Alpha-catenin binding
Molecular Function
Beta-catenin binding
Molecular Function
Cadherin binding
Biological Process
Adherens junction organization
Biological Process
Axonogenesis
Biological Process
Forebrain development
Biological Process
Lateral ventricle development
Biological Process
Negative regulation of protein localization to plasma membrane
Biological Process
Nervous system development
Biological Process
Neuroblast division in subventricular zone
Biological Process
Neuroblast proliferation
Biological Process
Positive regulation of cell migration
Biological Process
Positive regulation of dendrite morphogenesis
Biological Process
Positive regulation of neurogenesis
Biological Process
Regulation of neuron differentiation
Biological Process
Regulation of postsynaptic neurotransmitter receptor internalization
Biological Process
Regulation of postsynaptic specialization assembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a519Rattus norvegicus95.260.01175
LLPS-Ict-a516Ictidomys tridecemlineatus94.180.01195
LLPS-Aon-a524Aotus nancymaae93.720.01202
LLPS-Pap-a518Pan paniscus93.720.01198
LLPS-Gog-a515Gorilla gorilla93.720.01198
LLPS-Pat-a521Pan troglodytes93.570.01197
LLPS-Poa-a513Pongo abelii93.570.01197
LLPS-Hos-a529Homo sapiens93.420.01195
LLPS-Caj-a516Callithrix jacchus93.260.01194
LLPS-Man-a523Macaca nemestrina93.260.01201
LLPS-Chs-a512Chlorocebus sabaeus93.260.01200
LLPS-Mam-a516Macaca mulatta93.260.01202
LLPS-Mup-a512Mustela putorius furo93.110.01167
LLPS-Mal-a511Mandrillus leucophaeus93.110.01201
LLPS-Cea-a525Cercocebus atys93.110.01201
LLPS-Maf-a523Macaca fascicularis93.110.01200
LLPS-Paa-a521Papio anubis93.110.01199
LLPS-Fec-a521Felis catus92.960.01177
LLPS-Rhb-a515Rhinopithecus bieti92.960.01186
LLPS-Eqc-a525Equus caballus92.90.01159
LLPS-Aim-a506Ailuropoda melanoleuca92.660.01143
LLPS-Loa-a503Loxodonta africana92.660.01146
LLPS-Nol-a507Nomascus leucogenys92.650.01182
LLPS-Orc-a494Oryctolagus cuniculus92.50.01199
LLPS-Mea-a487Mesocricetus auratus92.460.01174
LLPS-Bot-a526Bos taurus92.340.01172
LLPS-Fud-a500Fukomys damarensis92.190.01160
LLPS-Sus-a526Sus scrofa91.730.01168
LLPS-Cap-a517Cavia porcellus91.420.01135
LLPS-Ova-a511Ovis aries91.130.01123
LLPS-Otg-a520Otolemur garnettii91.060.01081
LLPS-Myl-a232Myotis lucifugus90.510.01155
LLPS-Cas-a224Carlito syrichta90.050.01138
LLPS-Dio-a505Dipodomys ordii90.050.01142
LLPS-Mod-a500Monodelphis domestica87.920.01084
LLPS-Urm-a225Ursus maritimus87.570.01134
LLPS-Caf-a511Canis familiaris85.870.01059
LLPS-Sah-a1032Sarcophilus harrisii84.30.0991
LLPS-Pes-a217Pelodiscus sinensis84.10.0814
LLPS-Anp-a215Anas platyrhynchos81.430.01018
LLPS-Fia-a215Ficedula albicollis81.420.0887
LLPS-Tag-a215Taeniopygia guttata80.580.0979
LLPS-Meg-a207Meleagris gallopavo79.450.0987
LLPS-Anc-a480Anolis carolinensis79.180.0972
LLPS-Gaga-a221Gallus gallus75.150.0915
LLPS-Scm-a205Scophthalmus maximus73.320.0591
LLPS-Lac-a458Latimeria chalumnae69.620.0835
LLPS-Xet-a454Xenopus tropicalis68.780.0869
LLPS-Tut-a144Tursiops truncatus67.834e-156471
LLPS-Leo-a216Lepisosteus oculatus65.580.0818
LLPS-Xim-a462Xiphophorus maculatus64.360.0748
LLPS-Pof-a458Poecilia formosa64.20.0754
LLPS-Orn-a455Oreochromis niloticus63.820.0774
LLPS-Ten-a434Tetraodon nigroviridis63.560.0750
LLPS-Asm-a451Astyanax mexicanus63.220.0776
LLPS-Orl-a446Oryzias latipes62.240.0745
LLPS-Scf-a435Scleropages formosus60.40.0739
LLPS-Gaa-a441Gasterosteus aculeatus59.680.0715
LLPS-Dar-a457Danio rerio58.860.0701
LLPS-Icp-a457Ictalurus punctatus58.130.0737
LLPS-Drm-a071Drosophila melanogaster56.422e-96316
LLPS-Tar-a209Takifugu rubripes51.220.0567