LLPS-Mum-a514
Wasf3

▼ OVERVIEW

Status: Reviewed
Protein Name: Wiskott-Aldrich syndrome protein family member 3
Gene Name: Wasf3, Wave3
Ensembl Gene: ENSMUSG00000029636.10
Ensembl Protein: ENSMUSP00000016143.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPLVKRNIEP  RHLCRGALPE  GVTSELECVT  NSTLAAIIRQ  LSSLSKHAED  IFGELFNEAN  60
61    NFYIRANSLQ  DRIDRLAVKV  TQLDSTVEEV  SLQDINMKKA  FKSSTIQDQQ  VVSKNSIPNP  120
121   VADIYNQSDK  PPPLSILTPY  RDDKKDGLKF  YTDPSYFFDL  WKEKMLQDTE  DKRKEKRRQK  180
181   EQKRVDGTTR  EVKKVRKARN  RRQEWNMMAY  DKELRPDNRL  SQSVHHGASS  EGSLSPDTRS  240
241   HTSDVTDYSY  PATPNHALQA  QPATPSYTAG  DAPLHGTTNQ  GAEHEYRPSS  ASARHMALNR  300
301   PQQPPPPPPP  QAPEGSQAST  SVAPADYGML  PAQIIEYYSP  SGPPPPPPPP  MIPSAQTAFV  360
361   SPLQMPTQPP  FPASAVSTYP  TPPHQPSTGL  LATAPPPPGP  PPPPPGPPGP  SSLSSSPMHG  420
421   PPVAEAKRPE  PAQPPISDAR  SDLLAAIRMG  IQLKKVQEQR  EQEAKREPVG  NDVATILSRR  480
481   IAVEYSDSDD  DSEFDENDWS  D  501
Nucleotide CDS Sequence (FASTA)
1     ATGCCTTTAG  TGAAGAGAAA  CATCGAACCC  CGGCACCTGT  GCCGGGGCGC  CCTGCCGGAA  60
61    GGAGTCACCA  GTGAGCTGGA  ATGCGTGACC  AACAGCACGC  TCGCTGCAAT  CATCCGCCAG  120
121   CTGAGCAGTC  TGAGTAAACA  TGCAGAAGAC  ATATTTGGTG  AGTTATTTAA  TGAGGCTAAC  180
181   AACTTCTACA  TCAGAGCAAA  TTCCCTTCAA  GACAGAATCG  ATCGGCTTGC  TGTCAAAGTC  240
241   ACCCAGCTGG  ACTCCACGGT  GGAGGAGGTC  TCACTACAGG  ATATCAACAT  GAAGAAAGCA  300
301   TTCAAAAGCT  CTACCATCCA  AGACCAGCAG  GTGGTCTCCA  AGAACAGCAT  TCCCAACCCT  360
361   GTTGCTGACA  TTTATAATCA  GAGTGACAAA  CCCCCGCCGC  TGAGCATTCT  GACACCGTAC  420
421   AGAGATGACA  AGAAGGATGG  GCTGAAGTTC  TACACGGATC  CCTCTTACTT  CTTTGACCTC  480
481   TGGAAAGAAA  AGATGCTGCA  GGACACAGAA  GACAAGAGGA  AAGAGAAACG  ACGTCAGAAG  540
541   GAACAAAAGC  GTGTAGATGG  CACCACCCGA  GAGGTGAAAA  AGGTTAGAAA  AGCCAGAAAC  600
601   AGGCGCCAGG  AGTGGAATAT  GATGGCGTAT  GACAAGGAGC  TTAGGCCCGA  CAACAGGTTG  660
661   TCTCAGAGTG  TGCACCACGG  AGCATCCTCC  GAGGGATCTC  TGTCCCCAGA  TACTAGGTCT  720
721   CACACATCCG  ATGTCACCGA  TTATTCTTAT  CCTGCTACTC  CCAACCATGC  TTTGCAAGCA  780
781   CAGCCGGCGA  CACCCTCCTA  CACAGCTGGC  GATGCACCAC  TGCATGGGAC  CACAAACCAA  840
841   GGCGCTGAGC  ACGAGTACCG  ACCGTCGTCT  GCCTCGGCAA  GGCACATGGC  CCTGAACAGA  900
901   CCTCAGCAGC  CACCGCCACC  GCCTCCTCCC  CAGGCGCCGG  AGGGGTCCCA  GGCCTCTACG  960
961   TCAGTGGCTC  CAGCCGACTA  TGGGATGCTT  CCAGCACAGA  TAATTGAATA  CTACAGCCCC  1020
1021  TCAGGACCGC  CACCACCTCC  CCCTCCACCC  ATGATTCCCT  CAGCACAAAC  TGCCTTCGTC  1080
1081  AGCCCTCTCC  AGATGCCCAC  ACAGCCCCCG  TTCCCTGCCT  CAGCCGTCTC  CACATACCCC  1140
1141  ACTCCTCCTC  ACCAGCCCTC  CACTGGGCTC  CTGGCCACAG  CACCACCACC  CCCAGGTCCC  1200
1201  CCACCTCCTC  CACCTGGTCC  TCCTGGCCCC  TCCTCCCTAT  CATCGTCCCC  AATGCATGGT  1260
1261  CCCCCTGTGG  CTGAGGCAAA  GCGCCCAGAG  CCTGCACAGC  CACCCATAAG  TGATGCGAGA  1320
1321  AGTGACCTCT  TGGCTGCCAT  CCGGATGGGA  ATCCAACTGA  AAAAGGTGCA  GGAGCAACGC  1380
1381  GAGCAGGAAG  CCAAGCGGGA  GCCTGTCGGG  AATGACGTGG  CCACCATCTT  GTCTAGACGC  1440
1441  ATTGCTGTGG  AGTACAGCGA  CTCAGACGAC  GACTCTGAGT  TTGATGAGAA  TGACTGGTCT  1500
1501  GACTGA  1506

▼ KEYWORD

ID
Family
Actin-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytoskeleton
Cellular Component
Glutamatergic synapse
Cellular Component
Lamellipodium
Cellular Component
Postsynapse
Molecular Function
Actin binding
Biological Process
Actin cytoskeleton organization
Biological Process
Cytoskeleton organization
Biological Process
Lamellipodium assembly
Biological Process
Modification of postsynaptic actin cytoskeleton
Biological Process
Oligodendrocyte development
Biological Process
Positive regulation of myelination
Biological Process
Regulation of cell shape

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-a506Ictidomys tridecemlineatus93.030.0825
LLPS-Man-a512Macaca nemestrina92.830.0822
LLPS-Mam-a505Macaca mulatta92.830.0822
LLPS-Maf-a512Macaca fascicularis92.830.0822
LLPS-Rhb-a504Rhinopithecus bieti92.830.0822
LLPS-Cea-a513Cercocebus atys92.630.0820
LLPS-Hos-a518Homo sapiens92.630.0821
LLPS-Pap-a508Pan paniscus92.630.0821
LLPS-Nol-a495Nomascus leucogenys92.630.0820
LLPS-Pat-a510Pan troglodytes92.430.0819
LLPS-Mal-a500Mandrillus leucophaeus92.430.0818
LLPS-Gog-a504Gorilla gorilla92.430.0821
LLPS-Paa-a510Papio anubis92.430.0820
LLPS-Chs-a503Chlorocebus sabaeus92.430.0819
LLPS-Cap-a506Cavia porcellus92.230.0816
LLPS-Caj-a505Callithrix jacchus92.030.0815
LLPS-Aon-a514Aotus nancymaae91.830.0813
LLPS-Otg-a510Otolemur garnettii91.480.0782
LLPS-Ran-a508Rattus norvegicus91.430.0914
LLPS-Caf-a500Canis familiaris91.240.0825
LLPS-Fec-a509Felis catus91.040.0812
LLPS-Eqc-a515Equus caballus90.840.0806
LLPS-Urm-a464Ursus maritimus90.460.0817
LLPS-Myl-a482Myotis lucifugus90.260.0805
LLPS-Aim-a496Ailuropoda melanoleuca89.920.0819
LLPS-Mup-a501Mustela putorius furo89.660.0623
LLPS-Bot-a516Bos taurus89.240.0780
LLPS-Loa-a492Loxodonta africana88.450.0782
LLPS-Sah-a467Sarcophilus harrisii88.120.0786
LLPS-Sus-a514Sus scrofa88.070.0773
LLPS-Tut-a287Tursiops truncatus87.530.0704
LLPS-Pes-a435Pelodiscus sinensis84.10.0780
LLPS-Meg-a418Meleagris gallopavo83.830.0742
LLPS-Gaga-a457Gallus gallus83.230.0739
LLPS-Tag-a437Taeniopygia guttata82.940.0743
LLPS-Anc-a472Anolis carolinensis82.830.0780
LLPS-Orc-a485Oryctolagus cuniculus81.980.0659
LLPS-Poa-a501Pongo abelii81.750.0683
LLPS-Anp-a416Anas platyrhynchos78.730.0648
LLPS-Scf-a424Scleropages formosus78.521e-139412
LLPS-Ova-a502Ovis aries77.670.0690
LLPS-Cas-a447Carlito syrichta74.110.0615
LLPS-Mod-a1123Monodelphis domestica72.999e-157462
LLPS-Xet-a444Xenopus tropicalis72.670.0678
LLPS-Tar-a635Takifugu rubripes71.541e-126379
LLPS-Mea-a728Mesocricetus auratus71.431e-1481.6
LLPS-Lac-a447Latimeria chalumnae69.090.0639
LLPS-Leo-a447Lepisosteus oculatus66.80.0573
LLPS-Pof-a447Poecilia formosa65.423e-171501
LLPS-Xim-a452Xiphophorus maculatus64.961e-175514
LLPS-Orn-a444Oreochromis niloticus64.592e-175512
LLPS-Dar-a445Danio rerio64.190.0563
LLPS-Scm-a427Scophthalmus maximus63.743e-172504
LLPS-Gaa-a432Gasterosteus aculeatus63.169e-171500
LLPS-Ten-a423Tetraodon nigroviridis62.964e-178519
LLPS-Asm-a439Astyanax mexicanus62.780.0565
LLPS-Ora-a990Ornithorhynchus anatinus62.22e-1271.2
LLPS-Dio-a736Dipodomys ordii61.211e-76258
LLPS-Fia-a1018Ficedula albicollis60.232e-123379
LLPS-Icp-a447Ictalurus punctatus60.040.0536
LLPS-Orl-a1029Oryzias latipes55.039e-152450