LLPS-Mum-a492
Mpp1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | 55 kDa erythrocyte membrane protein |
| Gene Name: | Mpp1 |
| Ensembl Gene: | ENSMUSG00000031402.12 |
| Ensembl Protein: | ENSMUSP00000116401.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000155742.1 | ENSMUSP00000116401.1 |
| Ensembl | ENSMUST00000033775.8 | ENSMUSP00000033775.2 |
| Ensembl | ENSMUST00000132501.7 | ENSMUSP00000118693.1 |
| Ensembl | ENSMUST00000153318.7 | ENSMUSP00000116897.1 |
| Ensembl | ENSMUST00000114092.7 | ENSMUSP00000109726.1 |
| Ensembl | ENSMUST00000114091.7 | ENSMUSP00000109725.1 |
| Ensembl | ENSMUST00000127023.1 | ENSMUSP00000117003.1 |
| UniProt | P70290, EM55_MOUSE | |
| GeneBank | U38196, BC013444 | AAH13444.1, AAC52970.1 |
| RefSeq | NM_008621.3 | NP_032647.1 |
| Entrez | 17524 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTLKSSEGEG GNSMRTALSD LYLEHLLQKR NRPETSLNQS NVTTEDMYTN GSPAPGSPAH 60 61 AKGQEARRVR LIQFEKITEE PMGITLKLNE KQSCTVARIL HGGMIHRQGS LHVGDEILEI 120 121 NGTNVTNHSV DQLQKAMKET KGMISLKVIA NQQSRLPALQ MFMRAQFDYD PQKDNLIPCK 180 181 EAGLKFVTGD IIQIINKDDS NWWQGRVEGS SKESAGLIPS PELQEWRVAS VAHSAPSEAP 240 241 SCSPFGKKKK CKDKYLAKHS SIFDQLDVVS YEEVVRLPAF KRKTLVLIGA SGVGRSHIKN 300 301 GLLSHNPEKF AYPAPYTTRP PKKSEEDGKE YHFISTEEMT KNISANEFLE FGSYQGNMFG 360 361 TKFETVHQIH KQDKIAILDI EPQTLKTVRT AELSPFIVFI APTDQGTQTE ALQQLQKDSE 420 421 AIRSQYAHYF DLSLVNNSVD ETLKKLQEAF DQACSSPQWV PVSWVY 466 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACGCTCA AGTCGAGCGA AGGCGAGGGA GGGAACAGCA TGCGCACCGC ACTTTCGGAC 60 61 CTCTACCTGG AGCACTTACT ACAGAAGCGT AACCGACCTG AGACTTCATT GAACCAGTCA 120 121 AATGTTACTA CTGAGGACAT GTACACCAAT GGGTCCCCTG CTCCAGGTAG CCCTGCCCAT 180 181 GCCAAAGGTC AGGAGGCTCG GAGAGTTCGT CTCATACAAT TTGAGAAGAT CACAGAAGAG 240 241 CCCATGGGGA TCACTTTGAA GCTGAATGAA AAACAGTCGT GTACCGTGGC CAGAATTCTC 300 301 CATGGCGGCA TGATTCATAG ACAAGGCTCC CTTCATGTTG GGGATGAGAT CCTAGAAATC 360 361 AATGGCACAA ATGTGACTAA TCACTCAGTA GATCAGTTGC AGAAGGCAAT GAAGGAAACC 420 421 AAAGGAATGA TCTCATTAAA AGTCATTGCT AATCAGCAGA GTCGCCTTCC TGCGCTACAG 480 481 ATGTTCATGA GAGCACAGTT TGACTATGAT CCCCAAAAGG ACAACCTTAT TCCTTGCAAG 540 541 GAGGCAGGAC TGAAGTTTGT TACTGGAGAC ATTATCCAGA TAATCAACAA AGATGACAGC 600 601 AATTGGTGGC AGGGGCGGGT GGAGGGCTCC TCCAAAGAGT CTGCAGGATT AATCCCTTCT 660 661 CCTGAGCTAC AGGAATGGAG AGTGGCAAGC GTGGCTCACT CTGCTCCAAG TGAAGCACCA 720 721 AGTTGCAGTC CCTTTGGGAA GAAGAAGAAG TGTAAAGACA AGTACCTGGC TAAGCACAGT 780 781 TCCATTTTTG ACCAGTTGGA TGTTGTTTCC TATGAGGAAG TTGTTCGGCT CCCTGCATTC 840 841 AAGAGGAAGA CCTTGGTGTT GATCGGAGCC AGTGGGGTGG GTCGTAGCCA TATTAAGAAT 900 901 GGTCTGCTCA GTCACAATCC AGAGAAGTTT GCGTACCCTG CCCCATATAC AACACGGCCA 960 961 CCAAAGAAGA GTGAGGAAGA TGGGAAGGAG TATCATTTCA TCTCAACAGA GGAGATGACG 1020 1021 AAGAACATCT CTGCCAATGA GTTCTTGGAG TTTGGCAGCT ATCAGGGCAA CATGTTTGGC 1080 1081 ACCAAATTTG AAACAGTGCA CCAGATTCAT AAGCAGGACA AGATTGCCAT CCTTGACATT 1140 1141 GAGCCCCAGA CCCTAAAGAC TGTTCGGACA GCTGAGCTTT CACCTTTCAT TGTGTTCATC 1200 1201 GCACCTACTG ACCAGGGCAC TCAGACTGAA GCCCTGCAGC AGCTGCAGAA GGACTCTGAG 1260 1261 GCCATCCGTA GTCAGTATGC TCATTACTTT GACCTCTCTT TGGTGAATAA TAGTGTTGAT 1320 1321 GAAACTCTTA AGAAATTGCA AGAAGCCTTT GACCAGGCTT GCAGTTCTCC ACAGTGGGTG 1380 1381 CCTGTCTCCT GGGTTTACTA A 1401 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cortical cytoskeleton | |
Cellular Component | Cytosol | |
Cellular Component | Membrane | |
Cellular Component | Nuclear speck | |
Cellular Component | Plasma membrane | |
Cellular Component | Stereocilium | |
Biological Process | Regulation of neutrophil chemotaxis |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mea-a455 | Mesocricetus auratus | 95.71 | 0.0 | 916 |
| LLPS-Fud-a469 | Fukomys damarensis | 95.15 | 0.0 | 803 |
| LLPS-Loa-a471 | Loxodonta africana | 94.84 | 0.0 | 822 |
| LLPS-Caf-a479 | Canis familiaris | 94.81 | 0.0 | 749 |
| LLPS-Ict-a484 | Ictidomys tridecemlineatus | 94.64 | 0.0 | 906 |
| LLPS-Orc-a465 | Oryctolagus cuniculus | 93.83 | 0.0 | 872 |
| LLPS-Cas-a432 | Carlito syrichta | 93.56 | 0.0 | 899 |
| LLPS-Eqc-a493 | Equus caballus | 93.56 | 0.0 | 899 |
| LLPS-Aim-a475 | Ailuropoda melanoleuca | 93.47 | 0.0 | 827 |
| LLPS-Mal-a479 | Mandrillus leucophaeus | 93.35 | 0.0 | 894 |
| LLPS-Cea-a490 | Cercocebus atys | 93.35 | 0.0 | 894 |
| LLPS-Maf-a490 | Macaca fascicularis | 93.35 | 0.0 | 894 |
| LLPS-Poa-a481 | Pongo abelii | 93.35 | 0.0 | 893 |
| LLPS-Mam-a484 | Macaca mulatta | 93.35 | 0.0 | 894 |
| LLPS-Man-a490 | Macaca nemestrina | 93.35 | 0.0 | 894 |
| LLPS-Dio-a476 | Dipodomys ordii | 93.13 | 0.0 | 887 |
| LLPS-Pat-a487 | Pan troglodytes | 92.92 | 0.0 | 890 |
| LLPS-Hos-a496 | Homo sapiens | 92.92 | 0.0 | 890 |
| LLPS-Caj-a484 | Callithrix jacchus | 92.92 | 0.0 | 893 |
| LLPS-Pap-a486 | Pan paniscus | 92.92 | 0.0 | 890 |
| LLPS-Cap-a485 | Cavia porcellus | 92.92 | 0.0 | 890 |
| LLPS-Gog-a482 | Gorilla gorilla | 92.92 | 0.0 | 890 |
| LLPS-Mup-a479 | Mustela putorius furo | 92.54 | 0.0 | 819 |
| LLPS-Aon-a493 | Aotus nancymaae | 91.88 | 0.0 | 877 |
| LLPS-Fec-a487 | Felis catus | 91.85 | 0.0 | 884 |
| LLPS-Nol-a475 | Nomascus leucogenys | 91.42 | 0.0 | 871 |
| LLPS-Myl-a461 | Myotis lucifugus | 90.34 | 0.0 | 864 |
| LLPS-Sus-a492 | Sus scrofa | 89.91 | 0.0 | 872 |
| LLPS-Bot-a494 | Bos taurus | 89.74 | 0.0 | 845 |
| LLPS-Ova-a479 | Ovis aries | 89.7 | 0.0 | 859 |
| LLPS-Paa-a488 | Papio anubis | 88.46 | 0.0 | 832 |
| LLPS-Sah-a449 | Sarcophilus harrisii | 88.08 | 0.0 | 696 |
| LLPS-Urm-a446 | Ursus maritimus | 86.7 | 0.0 | 785 |
| LLPS-Ora-a408 | Ornithorhynchus anatinus | 83.97 | 0.0 | 810 |
| LLPS-Fia-a424 | Ficedula albicollis | 83.92 | 0.0 | 748 |
| LLPS-Anp-a401 | Anas platyrhynchos | 83.8 | 0.0 | 759 |
| LLPS-Meg-a398 | Meleagris gallopavo | 83.57 | 0.0 | 751 |
| LLPS-Mod-a469 | Monodelphis domestica | 83.47 | 0.0 | 801 |
| LLPS-Gaga-a436 | Gallus gallus | 82.56 | 0.0 | 786 |
| LLPS-Tag-a419 | Taeniopygia guttata | 81.33 | 0.0 | 791 |
| LLPS-Otg-a488 | Otolemur garnettii | 80.57 | 0.0 | 665 |
| LLPS-Pes-a419 | Pelodiscus sinensis | 80.09 | 0.0 | 721 |
| LLPS-Anc-a450 | Anolis carolinensis | 77.94 | 0.0 | 753 |
| LLPS-Scf-a405 | Scleropages formosus | 69.67 | 0.0 | 606 |
| LLPS-Lac-a431 | Latimeria chalumnae | 68.97 | 0.0 | 685 |
| LLPS-Xet-a425 | Xenopus tropicalis | 67.76 | 0.0 | 622 |
| LLPS-Orl-a415 | Oryzias latipes | 66.81 | 0.0 | 619 |
| LLPS-Xim-a430 | Xiphophorus maculatus | 66.53 | 0.0 | 625 |
| LLPS-Asm-a420 | Astyanax mexicanus | 66.38 | 0.0 | 635 |
| LLPS-Leo-a428 | Lepisosteus oculatus | 66.17 | 0.0 | 635 |
| LLPS-Pof-a427 | Poecilia formosa | 66.04 | 0.0 | 620 |
| LLPS-Icp-a427 | Ictalurus punctatus | 65.89 | 0.0 | 629 |
| LLPS-Dar-a424 | Danio rerio | 65.54 | 0.0 | 632 |
| LLPS-Orn-a423 | Oreochromis niloticus | 65.12 | 0.0 | 617 |
| LLPS-Scm-a407 | Scophthalmus maximus | 64.42 | 0.0 | 633 |
| LLPS-Gaa-a413 | Gasterosteus aculeatus | 64.27 | 0.0 | 613 |
| LLPS-Tar-a407 | Takifugu rubripes | 63.37 | 0.0 | 600 |
| LLPS-Ten-a403 | Tetraodon nigroviridis | 63.14 | 0.0 | 604 |
| LLPS-Ran-a655 | Rattus norvegicus | 60.0 | 6e-138 | 410 |