LLPS-Mum-a388
Rab3gap2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Rab3 GTPase-activating protein non-catalytic subunit; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit |
| Gene Name: | Rab3gap2, Kiaa0839 |
| Ensembl Gene: | ENSMUSG00000039318.12 |
| Ensembl Protein: | ENSMUSP00000066325.6 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000069652.7 | ENSMUSP00000066325.6 |
| Ensembl | ENSMUST00000194740.5 | ENSMUSP00000141608.1 |
| UniProt | Q8BMG7, RBGPR_MOUSE, Q6PEU0, Q80TQ6, Q8BX72 | |
| GeneBank | AC131084, AK048759, AK031191, AC158963, AK122385, AC129195, BC057872 | BAC65667.2, BAC27296.1, AAH57872.1, BAC33447.1 |
| RefSeq | NM_001163754.1 | NP_001157226.1 |
| Entrez | 98732 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MACSIVQFCS FQDLQSARDF LFPHLREETP GALKRDPSKT SSWEDDSWGA WEETEPREPE 60 61 EEGNTSKTQK NSWLQECVLS LSPTSDLMVI AREQKAAFLV PKWKHGDKGK EEMQFAVGWS 120 121 GSVSAEEGEY VTSALCIPLA SQKRSSTGRP DWTCIVVGFT SGYVRFYTES GVLLLAQLLN 180 181 EDKVLQLKCR TYEIPRHPGV TEQNEELSIL YPAAIVTIDG FSLFQSLRAC RNQVAKAAAS 240 241 GNENIQPPPL AYKKWGLQDI DTIIDHASIG IMTLSPFDQM KTASNIGGFN AAIKNSPPAM 300 301 SQYITVGSSP FTGFFYALEG STQPLLSHVA LAVASKLTSA LFSAASGWLG WKSKHEEDTV 360 361 QKQKPKMEPA TPLAVRFGLP DSRRHGESIC LSPCNTLAAV TDDFGRVILL DVARGIAIRM 420 421 WKGYRDAQVG WIQIVEDLHE RVPEKGGFSP FGNTQGPSRV AQFLVIYAPR RGILEVWNTQ 480 481 QGPRVGAFNV GKHCRLLYPG YKIMGLNNVT SQSWQPQTYQ ICLVDPVSAS VKAVNVPFHL 540 541 ALSDKKSERA KDLHLVKKLS ALLRAKSPRP DSFETEIKEL ILDIKYPATK KQALESILAS 600 601 DRLSFSCLRN VTQTLMDTLK NQELESVDEG LLQFCASKLK LLHLYESVSQ LNTLDFHSDT 660 661 PFSDNDLAVL LRLDDKELLK LRALLEKYKQ ENTKATVRFS EDADRVLPVK TFLEYLEYEK 720 721 DALSIRKVGE EECVALGSFF FWKCLHGESS TEEMCHSLES AGLSPQQLLS LLLSVWLSKE 780 781 KDILDKPQSV CCLHTMLSLL SKMKVAIDET WDSQSVSPWW QQMRMACIQS ENSGAALLSA 840 841 HVGHSVAAQM SSGATDKKFS QMVLDADAEA LTDSWEALSL DTEYWKLLLR QLEDCLILQT 900 901 LLHSKLSPPA AKAPSLQSEP LPRLSVKKLL EGGKGGIADS VAKWIFKQDL SPELLKCANK 960 961 ERDVENPDEP REGITRSFPE VSEVEIDLGA VPDLLHLAYE QFPCSLELDV LHAHCCWEYV 1020 1021 VQWNKDPEEA RFLVRSIEHL KHILNPHVQN GIALMMWNTF LVKRFSAATY LMDKVGKSPK 1080 1081 DRLCRRDVGM SDTALTSFLG SCLELLQTSL EADISRDEVQ VPVLDTEDAW LSVEGPISIV 1140 1141 ELALEQKPIH YPLVEHHSVL CSILYASMRF SLKSVKPLAL FDSKGKNAFF KDLTSIQLLP 1200 1201 SGEMDPNFIS VRQQFLLKVV SAAVQAQHSK DKDPSAEAAN THWKDLNWPG LAVDLAHHLQ 1260 1261 VSDDVIRRHY VGELYSHGAD LLGEEAIFQV QDKEVLASQL LVLTGQRLAH ALFHTQTKEG 1320 1321 MELLARLPPT LCTWLKAMNP QDLQNTGVPI AATAKLVHKV MELLPEKHGQ YSLALHLIDA 1380 1381 VEAMATL 1387 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTGCT CCATCGTCCA GTTCTGCTCC TTCCAGGACC TGCAGTCCGC GCGCGACTTC 60 61 CTATTCCCTC ACCTGCGGGA GGAGACCCCC GGCGCCCTGA AGAGGGACCC GAGTAAAACA 120 121 TCAAGCTGGG AAGATGATAG TTGGGGAGCA TGGGAAGAGA CAGAGCCCCG AGAACCTGAA 180 181 GAAGAAGGAA ATACTTCTAA AACACAAAAA AATTCCTGGC TTCAAGAATG TGTTTTATCC 240 241 TTATCTCCAA CCAGTGACCT TATGGTTATA GCTCGGGAGC AGAAGGCCGC ATTCCTAGTG 300 301 CCAAAATGGA AACATGGTGA TAAAGGGAAG GAAGAAATGC AGTTTGCTGT TGGTTGGAGC 360 361 GGCTCCGTAA GTGCAGAGGA AGGGGAGTAT GTAACCAGTG CCCTGTGCAT CCCACTGGCG 420 421 AGTCAGAAGA GGAGTTCCAC TGGGCGCCCT GACTGGACCT GCATTGTGGT GGGCTTCACA 480 481 TCGGGCTATG TGCGCTTCTA CACTGAGAGT GGAGTGCTTT TGCTTGCACA ACTTTTGAAT 540 541 GAGGACAAAG TGCTTCAGCT TAAATGCAGG ACCTATGAAA TCCCAAGACA CCCTGGAGTG 600 601 ACTGAGCAGA ATGAAGAACT GAGCATCTTA TATCCAGCCG CCATTGTGAC GATTGATGGA 660 661 TTTAGTCTCT TTCAGTCTCT TCGAGCCTGT CGAAACCAAG TAGCAAAAGC TGCAGCATCA 720 721 GGCAATGAGA ACATTCAGCC ACCACCATTA GCTTATAAGA AATGGGGTCT TCAAGATATT 780 781 GACACCATCA TCGATCATGC TAGTATTGGT ATTATGACTC TGTCACCATT TGATCAAATG 840 841 AAGACTGCTT CCAATATAGG TGGATTTAAT GCAGCAATTA AAAACAGTCC GCCTGCCATG 900 901 TCTCAGTACA TCACTGTGGG CTCCAGTCCG TTCACTGGCT TCTTCTATGC TCTCGAGGGA 960 961 AGCACGCAGC CTCTGTTGTC TCACGTCGCG CTCGCTGTTG CAAGTAAGCT GACCTCCGCC 1020 1021 CTCTTCAGTG CCGCCAGTGG TTGGCTTGGT TGGAAAAGCA AGCATGAGGA AGACACTGTC 1080 1081 CAGAAGCAGA AGCCCAAGAT GGAGCCGGCC ACCCCACTAG CTGTGAGATT TGGACTTCCG 1140 1141 GATTCTAGAC GCCACGGAGA AAGCATATGC CTGTCTCCTT GTAATACCCT GGCAGCAGTC 1200 1201 ACAGATGATT TTGGCAGGGT TATCTTACTG GACGTAGCCC GAGGAATCGC AATACGGATG 1260 1261 TGGAAAGGGT ATCGGGATGC GCAGGTCGGA TGGATTCAAA TTGTAGAGGA CCTCCATGAA 1320 1321 CGAGTGCCAG AAAAGGGGGG CTTCTCCCCC TTTGGAAATA CTCAAGGGCC CAGTCGGGTC 1380 1381 GCTCAGTTCC TTGTGATCTA TGCACCACGA AGGGGGATTC TGGAAGTGTG GAACACACAG 1440 1441 CAAGGACCTA GAGTGGGAGC TTTCAACGTG GGTAAACACT GCAGGCTACT CTATCCTGGC 1500 1501 TACAAAATCA TGGGCTTAAA CAACGTGACA AGTCAGAGTT GGCAGCCTCA GACTTACCAG 1560 1561 ATCTGTCTTG TTGACCCTGT GTCTGCAAGC GTGAAGGCGG TGAACGTGCC TTTCCATCTA 1620 1621 GCGCTGAGTG ATAAGAAGAG TGAAAGAGCC AAGGACCTGC ACTTAGTGAA GAAACTATCA 1680 1681 GCCCTGCTGA GAGCCAAGTC CCCCAGGCCG GATTCATTTG AAACCGAAAT AAAGGAGTTG 1740 1741 ATTCTTGATA TTAAGTACCC TGCAACCAAG AAACAAGCTC TGGAAAGCAT TTTGGCCAGT 1800 1801 GACCGTTTAT CGTTTTCCTG CCTTAGAAAT GTTACTCAGA CTTTAATGGA CACTTTAAAA 1860 1861 AACCAAGAGC TTGAGTCTGT TGATGAAGGA CTGCTACAGT TTTGTGCCAG TAAATTAAAA 1920 1921 CTACTACATC TTTATGAATC TGTCAGTCAG TTAAATACGC TTGACTTTCA CTCAGACACC 1980 1981 CCGTTCTCTG ATAATGATCT GGCTGTCTTG CTAAGGCTGG ATGATAAGGA ACTCCTGAAA 2040 2041 CTCCGGGCCT TGTTAGAGAA ATATAAACAA GAAAACACCA AAGCCACCGT GCGCTTTTCT 2100 2101 GAGGATGCAG ACAGAGTGCT ACCTGTCAAG ACCTTCCTGG AGTATCTAGA GTATGAGAAG 2160 2161 GATGCACTGA GCATAAGGAA GGTCGGAGAG GAGGAGTGTG TGGCTCTAGG CAGTTTCTTT 2220 2221 TTCTGGAAGT GTTTGCATGG AGAAAGCTCC ACTGAAGAGA TGTGCCACAG CCTGGAGTCG 2280 2281 GCTGGACTCA GCCCTCAGCA GTTACTGTCT CTGCTCCTAA GTGTTTGGCT TTCGAAGGAA 2340 2341 AAAGACATTT TGGACAAACC ACAGTCTGTC TGCTGCCTTC ATACCATGCT GTCCCTGCTG 2400 2401 AGCAAGATGA AAGTGGCCAT CGATGAGACG TGGGATTCTC AGTCTGTGTC CCCCTGGTGG 2460 2461 CAGCAGATGC GCATGGCCTG CATCCAGTCA GAGAACAGCG GCGCTGCCCT GCTGTCTGCA 2520 2521 CATGTGGGGC ATTCTGTGGC CGCACAGATG TCCAGCGGTG CTACAGATAA GAAATTTTCC 2580 2581 CAGATGGTGT TGGATGCAGA TGCCGAAGCC CTCACGGACT CCTGGGAAGC TCTCTCTCTG 2640 2641 GACACGGAGT ACTGGAAGCT CCTGCTGAGA CAGCTGGAGG ACTGCCTCAT ACTCCAGACT 2700 2701 CTGCTGCATA GCAAATTGAG CCCCCCAGCC GCCAAAGCAC CATCTCTGCA GTCGGAGCCA 2760 2761 CTGCCAAGGC TTTCTGTTAA AAAGCTGTTA GAAGGGGGGA AAGGTGGTAT TGCAGACAGT 2820 2821 GTAGCCAAGT GGATATTTAA ACAGGACCTC AGCCCTGAAT TGTTGAAATG TGCCAACAAA 2880 2881 GAGAGAGATG TAGAAAATCC AGACGAACCC AGAGAAGGTA TTACACGAAG TTTCCCTGAG 2940 2941 GTGTCAGAGG TGGAGATAGA CCTAGGAGCC GTACCAGACT TGCTCCACCT GGCCTACGAG 3000 3001 CAGTTCCCTT GTAGCCTTGA GCTTGATGTG CTGCACGCCC ACTGCTGCTG GGAGTATGTG 3060 3061 GTTCAGTGGA ACAAAGACCC GGAGGAAGCT CGCTTTTTGG TTAGATCCAT AGAACACTTG 3120 3121 AAGCACATTC TTAATCCACA CGTTCAAAAT GGTATCGCGC TGATGATGTG GAATACGTTC 3180 3181 TTGGTGAAAA GGTTTTCTGC TGCTACTTAC CTAATGGATA AGGTTGGGAA ATCTCCAAAG 3240 3241 GATAGGTTGT GCCGAAGGGA TGTGGGGATG AGCGACACGG CGCTGACATC CTTCCTCGGC 3300 3301 TCCTGCCTGG AACTTCTTCA GACGTCATTG GAGGCTGACA TTAGCAGGGA TGAAGTCCAG 3360 3361 GTGCCCGTCC TGGACACTGA GGACGCCTGG CTGTCCGTGG AAGGCCCCAT CTCTATAGTG 3420 3421 GAGCTGGCGC TGGAGCAGAA GCCTATCCAC TACCCACTGG TGGAGCACCA TTCCGTCCTG 3480 3481 TGCTCCATCC TGTACGCGTC CATGCGCTTT TCTCTGAAGA GTGTGAAGCC ACTCGCCCTT 3540 3541 TTTGACAGCA AGGGAAAGAA TGCATTTTTT AAGGATTTAA CTTCAATTCA GTTATTACCT 3600 3601 AGTGGGGAAA TGGATCCAAA TTTTATTTCA GTAAGACAAC AGTTCTTACT GAAAGTTGTC 3660 3661 AGTGCAGCTG TCCAGGCTCA GCATTCCAAG GACAAAGATC CCTCTGCAGA AGCAGCAAAC 3720 3721 ACTCATTGGA AAGACCTCAA CTGGCCAGGT TTGGCTGTGG ACTTAGCCCA TCACCTTCAA 3780 3781 GTGAGCGACG ATGTCATTCG AAGGCACTAT GTGGGGGAGC TGTACAGCCA TGGAGCTGAC 3840 3841 CTCTTAGGAG AGGAGGCCAT TTTTCAAGTT CAGGACAAAG AAGTTCTGGC GTCTCAGCTG 3900 3901 CTAGTGCTGA CCGGGCAAAG GCTGGCTCAC GCGCTTTTCC ACACCCAGAC GAAGGAAGGC 3960 3961 ATGGAGCTGC TGGCCAGACT CCCGCCCACA CTCTGCACCT GGCTGAAGGC AATGAACCCT 4020 4021 CAGGATCTTC AGAACACTGG CGTGCCTATT GCAGCAACAG CTAAACTCGT GCATAAAGTG 4080 4081 ATGGAGCTCC TGCCAGAGAA GCACGGGCAG TACAGCCTCG CCTTACACCT CATCGATGCC 4140 4141 GTGGAAGCCA TGGCGACTTT ATGA 4164 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Plasma membrane | |
Cellular Component | Protein-containing complex | |
Molecular Function | Enzyme regulator activity | |
Molecular Function | GTPase activator activity | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Rab GTPase binding | |
Molecular Function | Rab guanyl-nucleotide exchange factor activity | |
Biological Process | Establishment of protein localization to endoplasmic reticulum membrane | |
Biological Process | Positive regulation of autophagosome assembly | |
Biological Process | Positive regulation of endoplasmic reticulum tubular network organization | |
Biological Process | Positive regulation of protein lipidation | |
Biological Process | Regulation of GTPase activity |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a385 | Rattus norvegicus | 95.54 | 0.0 | 2669 |
| LLPS-Mea-a354 | Mesocricetus auratus | 92.73 | 0.0 | 2617 |
| LLPS-Cea-a384 | Cercocebus atys | 89.49 | 0.0 | 2469 |
| LLPS-Eqc-a390 | Equus caballus | 89.28 | 0.0 | 2486 |
| LLPS-Mam-a379 | Macaca mulatta | 89.2 | 0.0 | 2516 |
| LLPS-Chs-a380 | Chlorocebus sabaeus | 89.2 | 0.0 | 2518 |
| LLPS-Maf-a384 | Macaca fascicularis | 89.2 | 0.0 | 2517 |
| LLPS-Rhb-a377 | Rhinopithecus bieti | 89.2 | 0.0 | 2513 |
| LLPS-Pat-a380 | Pan troglodytes | 89.13 | 0.0 | 2513 |
| LLPS-Poa-a378 | Pongo abelii | 89.13 | 0.0 | 2513 |
| LLPS-Mal-a375 | Mandrillus leucophaeus | 89.06 | 0.0 | 2514 |
| LLPS-Man-a383 | Macaca nemestrina | 89.06 | 0.0 | 2514 |
| LLPS-Hos-a389 | Homo sapiens | 88.98 | 0.0 | 2508 |
| LLPS-Pap-a380 | Pan paniscus | 88.98 | 0.0 | 2509 |
| LLPS-Orc-a368 | Oryctolagus cuniculus | 88.95 | 0.0 | 2316 |
| LLPS-Caf-a379 | Canis familiaris | 88.63 | 0.0 | 2489 |
| LLPS-Nol-a377 | Nomascus leucogenys | 88.62 | 0.0 | 2497 |
| LLPS-Mup-a381 | Mustela putorius furo | 88.35 | 0.0 | 2455 |
| LLPS-Aim-a374 | Ailuropoda melanoleuca | 88.33 | 0.0 | 2481 |
| LLPS-Ict-a381 | Ictidomys tridecemlineatus | 88.26 | 0.0 | 2475 |
| LLPS-Cas-a348 | Carlito syrichta | 87.67 | 0.0 | 1714 |
| LLPS-Gog-a377 | Gorilla gorilla | 87.54 | 0.0 | 2467 |
| LLPS-Bot-a389 | Bos taurus | 87.47 | 0.0 | 2458 |
| LLPS-Otg-a387 | Otolemur garnettii | 87.34 | 0.0 | 2427 |
| LLPS-Dio-a378 | Dipodomys ordii | 87.31 | 0.0 | 2469 |
| LLPS-Fec-a385 | Felis catus | 87.15 | 0.0 | 2444 |
| LLPS-Tut-a226 | Tursiops truncatus | 87.11 | 0.0 | 2472 |
| LLPS-Paa-a383 | Papio anubis | 87.07 | 0.0 | 2432 |
| LLPS-Ova-a379 | Ovis aries | 87.01 | 0.0 | 2451 |
| LLPS-Loa-a375 | Loxodonta africana | 86.95 | 0.0 | 2341 |
| LLPS-Caj-a381 | Callithrix jacchus | 86.75 | 0.0 | 2434 |
| LLPS-Sus-a387 | Sus scrofa | 86.06 | 0.0 | 2376 |
| LLPS-Myl-a366 | Myotis lucifugus | 85.84 | 0.0 | 2419 |
| LLPS-Urm-a354 | Ursus maritimus | 85.64 | 0.0 | 2443 |
| LLPS-Sah-a359 | Sarcophilus harrisii | 84.79 | 0.0 | 2122 |
| LLPS-Mod-a368 | Monodelphis domestica | 83.48 | 0.0 | 2370 |
| LLPS-Ora-a327 | Ornithorhynchus anatinus | 80.17 | 0.0 | 2254 |
| LLPS-Pes-a338 | Pelodiscus sinensis | 79.41 | 0.0 | 2192 |
| LLPS-Cap-a383 | Cavia porcellus | 79.06 | 0.0 | 2114 |
| LLPS-Meg-a323 | Meleagris gallopavo | 77.48 | 0.0 | 2127 |
| LLPS-Anc-a359 | Anolis carolinensis | 77.03 | 0.0 | 2166 |
| LLPS-Gaga-a344 | Gallus gallus | 76.77 | 0.0 | 2160 |
| LLPS-Fud-a374 | Fukomys damarensis | 76.64 | 0.0 | 2125 |
| LLPS-Anp-a324 | Anas platyrhynchos | 75.7 | 0.0 | 2099 |
| LLPS-Fia-a334 | Ficedula albicollis | 75.54 | 0.0 | 2129 |
| LLPS-Tag-a335 | Taeniopygia guttata | 75.11 | 0.0 | 2106 |
| LLPS-Lac-a340 | Latimeria chalumnae | 71.83 | 0.0 | 1908 |
| LLPS-Xet-a335 | Xenopus tropicalis | 70.64 | 0.0 | 1942 |
| LLPS-Leo-a340 | Lepisosteus oculatus | 61.32 | 1e-159 | 494 |
| LLPS-Scf-a320 | Scleropages formosus | 61.12 | 0.0 | 1582 |
| LLPS-Orn-a338 | Oreochromis niloticus | 58.49 | 0.0 | 1591 |
| LLPS-Cis-a094 | Ciona savignyi | 57.92 | 1e-68 | 238 |
| LLPS-Dar-a339 | Danio rerio | 57.68 | 0.0 | 1569 |
| LLPS-Gaa-a325 | Gasterosteus aculeatus | 57.46 | 0.0 | 1563 |
| LLPS-Scm-a326 | Scophthalmus maximus | 57.26 | 0.0 | 1529 |
| LLPS-Pof-a340 | Poecilia formosa | 57.07 | 0.0 | 1544 |
| LLPS-Icp-a340 | Ictalurus punctatus | 56.99 | 0.0 | 1583 |
| LLPS-Xim-a344 | Xiphophorus maculatus | 56.63 | 0.0 | 1544 |
| LLPS-Orl-a333 | Oryzias latipes | 56.07 | 0.0 | 1505 |
| LLPS-Asm-a334 | Astyanax mexicanus | 55.72 | 0.0 | 1497 |
| LLPS-Tar-a327 | Takifugu rubripes | 54.59 | 0.0 | 1252 |
| LLPS-Ten-a324 | Tetraodon nigroviridis | 51.75 | 3e-144 | 457 |