LLPS-Mum-a381
Marc2

▼ OVERVIEW

Status: Reviewed
Protein Name: Mitochondrial amidoxime reducing component 2
Gene Name: Marc2, Mg87, Mosc2
Ensembl Gene: ENSMUSG00000073481.9
Ensembl Protein: ENSMUSP00000125374.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGSSSSTALA  RLGLPGQPRS  TWLGVAALGL  AAVALGTVAW  RRTRPRRRRQ  LQQVGTVSKV  60
61    WIYPIKSCKG  VSVCETECTD  MGLRCGKVRD  RFWMVVKEDG  HMVTARQEPR  LVLVSITLEN  120
121   NYLTLEAPGM  EQIVLPIKLP  SSNKIHNCRL  FGLDIKGRDC  GDEVAQWFTN  YLKTQAYRLV  180
181   QFDTSMKGRT  TKKLYPSESY  LQNYEVAYPD  CSPVHLISEA  SLVDLNTRLK  KKVKMEYFRP  240
241   NIVVSGCEAF  EEDTWDELLI  GDVEMKRVLS  CPRCVLTTVD  PDTGIIDRKE  PLETLKSYRL  300
301   CDPSVKSIYQ  SSPLFGMYFS  VEKLGSLRVG  DPVYRMVD  338
Nucleotide CDS Sequence (FASTA)
1     ATGGGTTCCT  CCAGCTCTAC  GGCTCTGGCT  CGCCTCGGCC  TCCCTGGGCA  GCCGCGGTCC  60
61    ACCTGGCTCG  GCGTCGCCGC  GCTGGGGCTG  GCTGCGGTGG  CGCTGGGGAC  CGTAGCTTGG  120
121   CGTCGCACGC  GTCCCCGGCG  GCGCCGGCAG  CTGCAGCAGG  TGGGCACGGT  GTCGAAGGTT  180
181   TGGATCTACC  CGATCAAGTC  CTGCAAGGGG  GTGTCGGTGT  GTGAGACCGA  GTGCACGGAC  240
241   ATGGGGCTGC  GCTGTGGCAA  AGTGCGCGAC  AGGTTCTGGA  TGGTGGTGAA  GGAGGACGGA  300
301   CACATGGTCA  CTGCCCGCCA  GGAGCCTCGC  CTTGTGCTGG  TCTCCATCAC  CCTGGAGAAC  360
361   AATTACCTGA  CGCTGGAAGC  TCCAGGCATG  GAGCAGATAG  TTCTGCCAAT  CAAGCTCCCT  420
421   TCTTCGAATA  AGATCCACAA  CTGCAGGCTG  TTTGGTCTCG  ACATCAAAGG  CAGAGATTGT  480
481   GGCGATGAGG  TAGCTCAGTG  GTTCACCAAC  TACCTGAAGA  CGCAAGCCTA  CAGGTTGGTT  540
541   CAGTTTGATA  CCAGCATGAA  AGGAAGAACA  ACGAAGAAAC  TTTACCCTTC  TGAAAGTTAC  600
601   CTTCAGAACT  ATGAGGTAGC  CTACCCGGAC  TGCAGCCCTG  TCCACCTGAT  TTCTGAAGCC  660
661   TCCTTAGTCG  ATCTCAACAC  CAGGCTGAAG  AAGAAAGTGA  AGATGGAATA  TTTCAGGCCA  720
721   AACATCGTGG  TGTCAGGCTG  TGAGGCTTTC  GAGGAGGATA  CTTGGGATGA  ACTCCTGATT  780
781   GGTGACGTGG  AGATGAAAAG  GGTGTTGAGC  TGTCCCAGGT  GCGTTCTGAC  TACAGTGGAC  840
841   CCAGACACCG  GCATCATAGA  CAGGAAGGAG  CCACTGGAGA  CCCTGAAGAG  CTATCGCCTG  900
901   TGTGATCCTT  CTGTGAAGAG  TATATACCAG  TCATCTCCAC  TTTTTGGGAT  GTATTTCTCG  960
961   GTGGAGAAGC  TTGGGAGCCT  GAGAGTGGGT  GACCCTGTGT  ACCGGATGGT  GGATTAG  1017

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion outer membrane
Molybdenum
Oxidoreductase
Peroxisome
Reference proteome
Transit peptide
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial outer membrane
Cellular Component
Mitochondrion
Cellular Component
Peroxisome
Molecular Function
Molybdenum ion binding
Molecular Function
Molybdopterin cofactor binding
Molecular Function
Nitrate reductase activity
Molecular Function
Pyridoxal phosphate binding
Biological Process
Nitrate metabolic process
Biological Process
Oxidation-reduction process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a378Rattus norvegicus99.70.0695
LLPS-Mea-a347Mesocricetus auratus94.080.0618
LLPS-Ict-a374Ictidomys tridecemlineatus78.640.0528
LLPS-Caf-a372Canis familiaris77.789e-107319
LLPS-Fud-a367Fukomys damarensis76.335e-162463
LLPS-Mal-a368Mandrillus leucophaeus76.262e-176502
LLPS-Chs-a373Chlorocebus sabaeus76.261e-175500
LLPS-Cea-a377Cercocebus atys75.962e-175499
LLPS-Maf-a377Macaca fascicularis75.962e-175499
LLPS-Man-a376Macaca nemestrina75.968e-175498
LLPS-Paa-a376Papio anubis75.962e-175499
LLPS-Nol-a370Nomascus leucogenys75.965e-173493
LLPS-Rhb-a370Rhinopithecus bieti75.373e-177504
LLPS-Poa-a371Pongo abelii75.21e-139406
LLPS-Otg-a380Otolemur garnettii75.150.0515
LLPS-Orc-a361Oryctolagus cuniculus75.154e-172491
LLPS-Urm-a347Ursus maritimus75.07e-140408
LLPS-Pat-a373Pan troglodytes74.781e-170487
LLPS-Hos-a382Homo sapiens74.782e-171489
LLPS-Aon-a383Aotus nancymaae74.79e-169483
LLPS-Ere-a098Erinaceus europaeus74.694e-140406
LLPS-Eqc-a383Equus caballus74.564e-173493
LLPS-Gog-a370Gorilla gorilla74.485e-170486
LLPS-Fec-a378Felis catus74.270.0528
LLPS-Bot-a382Bos taurus74.181e-170487
LLPS-Dio-a371Dipodomys ordii73.689e-139402
LLPS-Cap-a376Cavia porcellus73.376e-163468
LLPS-Caj-a374Callithrix jacchus73.216e-178506
LLPS-Tut-a221Tursiops truncatus72.781e-155449
LLPS-Myl-a359Myotis lucifugus72.621e-132387
LLPS-Cas-a341Carlito syrichta72.512e-168481
LLPS-Mup-a374Mustela putorius furo69.876e-160459
LLPS-Sus-a380Sus scrofa69.551e-139408
LLPS-Ova-a372Ovis aries69.251e-167479
LLPS-Ora-a320Ornithorhynchus anatinus68.292e-145422
LLPS-Aim-a367Ailuropoda melanoleuca67.668e-164470
LLPS-Sah-a352Sarcophilus harrisii67.457e-158455
LLPS-Mam-a372Macaca mulatta67.398e-39142
LLPS-Anp-a318Anas platyrhynchos67.29e-88271
LLPS-Mod-a361Monodelphis domestica67.062e-158456
LLPS-Gaga-a337Gallus gallus64.935e-137402
LLPS-Meg-a317Meleagris gallopavo64.749e-87268
LLPS-Tag-a329Taeniopygia guttata63.884e-133390
LLPS-Fia-a328Ficedula albicollis63.285e-117348
LLPS-Loa-a368Loxodonta africana61.089e-132388
LLPS-Pes-a332Pelodiscus sinensis60.826e-114340
LLPS-Pap-a373Pan paniscus59.643e-143418
LLPS-Anc-a353Anolis carolinensis59.69e-129380
LLPS-Gaa-a1068Gasterosteus aculeatus53.332e-102313
LLPS-Tar-a320Takifugu rubripes53.081e-106326
LLPS-Ten-a318Tetraodon nigroviridis52.749e-103314
LLPS-Orl-a327Oryzias latipes52.192e-106323
LLPS-Leo-a334Lepisosteus oculatus51.722e-113341
LLPS-Scf-a315Scleropages formosus51.382e-106323
LLPS-Pof-a1087Poecilia formosa50.681e-99306
LLPS-Orn-a1092Oreochromis niloticus50.627e-107325
LLPS-Lac-a333Latimeria chalumnae50.37e-117350
LLPS-Icp-a1089Ictalurus punctatus50.167e-105319