LLPS-Mum-a378
Abcd3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | ATP-binding cassette sub-family D member 3; 68 kDa peroxisomal membrane protein; PMP68; 70 kDa peroxisomal membrane protein; PMP70 |
| Gene Name: | Abcd3, Pmp70, Pxmp1 |
| Ensembl Gene: | ENSMUSG00000028127.10 |
| Ensembl Protein: | ENSMUSP00000143487.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000197662.4 | ENSMUSP00000143487.1 |
| Ensembl | ENSMUST00000029770.7 | ENSMUSP00000029770.5 |
| Ensembl | ENSMUST00000197383.4 | ENSMUSP00000142387.1 |
| UniProt | P55096, ABCD3_MOUSE | |
| GeneBank | AC129311, X89569, L28836 | CAA61748.1, AAA39958.1 |
| RefSeq | NM_008991.2 | NP_033017.2 |
| Entrez | 19299 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAFSKYLTA RNTSLAGAAF LLLCLLHKRR RALGLHGKKS GKPPLQNNEK EGKKERAVVD 60 61 KVFLSRLSQI LKIMVPRTFC KETGYLLLIA VMLVSRTYCD VWMIQNGTLI ESGIIGRSSK 120 121 DFKRYLFNFI AAMPLISLVN NFLKYGLNEL KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN 180 181 RIANPDQLLT QDVEKFCNSV VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS 240 241 GLFLTRLRRP IGKMTIMEQK YEGEYRYVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 300 301 EHLHNFIFFR FSMGFIDSII AKYVATVVGY LVVSRPFLDL AHPRHLHSTH SELLEDYYQS 360 361 GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD LNHGRYERTM VSQQEKGIEG 420 421 AQASPLVPGA GEIINTDNII KFDHVPLATP NGDILIQDLS FEVRSGANVL ICGPNGCGKS 480 481 SLFRVLGELW PLFGGRLTKP ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKRGISDQ 540 541 VLKEYLDNVQ LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 600 601 VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI TEDTVEFGS 659 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCCT TCAGCAAGTA CTTGACGGCA CGGAACACCT CGCTGGCGGG GGCCGCGTTC 60 61 CTGCTGCTCT GCCTACTCCA TAAGCGGCGT CGCGCCCTCG GCCTGCACGG TAAGAAAAGT 120 121 GGAAAACCGC CATTACAGAA TAATGAGAAA GAAGGAAAGA AAGAGCGAGC TGTGGTGGAC 180 181 AAAGTGTTTT TATCAAGGCT CTCACAGATC CTAAAAATTA TGGTTCCTAG AACATTTTGT 240 241 AAAGAGACAG GCTACTTGTT ACTTATTGCG GTTATGCTGG TATCTCGAAC ATACTGTGAT 300 301 GTTTGGATGA TTCAGAATGG GACGCTCATT GAGAGTGGCA TCATTGGTCG CAGCAGCAAA 360 361 GATTTCAAGA GATACTTATT CAACTTCATC GCTGCCATGC CTCTTATCTC TCTGGTTAAT 420 421 AACTTCTTGA AGTATGGGTT AAATGAGCTC AAACTGTGCT TCCGAGTCAG GCTCACACGG 480 481 TACCTCTACG AGGAGTATCT CCAAGCTTTC ACCTATTATA AAATGGGCAA CCTGGATAAC 540 541 AGAATAGCAA ATCCAGACCA GCTGCTTACA CAGGATGTAG AAAAATTTTG TAACAGTGTA 600 601 GTCGATCTGT ATTCAAATCT TAGTAAGCCA TTTTTAGACA TAGTTTTATA TATTTTCAAG 660 661 TTAACAAGTG CAATTGGAGC TCAGGGCCCG GCAAGCATGA TGGCCTACTT GCTTGTTTCT 720 721 GGGCTATTCC TAACTCGACT CAGAAGACCC ATTGGTAAGA TGACAATTAT GGAGCAGAAG 780 781 TACGAAGGAG AATACAGATA CGTGAATTCA CGGCTTATCA CTAATAGTGA AGAAATTGCC 840 841 TTTTACAATG GGAATAAACG GGAGAAGCAG ACAATCCACT CAGTCTTCCG AAAACTGGTG 900 901 GAACACCTAC ATAATTTCAT TTTCTTTCGG TTTTCTATGG GTTTCATTGA TAGCATCATT 960 961 GCCAAATATG TTGCCACTGT CGTCGGGTAC CTGGTTGTCA GTCGCCCCTT CCTAGATCTG 1020 1021 GCACACCCTC GCCACCTTCA CAGCACACAC TCAGAGCTGC TGGAGGATTA CTACCAAAGT 1080 1081 GGAAGGATGC TTTTGAGAAT GTCTCAAGCT TTGGGTCGTA TAGTTTTGGC TGGGCGTGAA 1140 1141 ATGACTAGAT TGGCTGGTTT TACGGCTCGG ATTACAGAAT TAATGCAAGT ACTAAAGGAC 1200 1201 TTAAATCATG GCAGATATGA ACGTACAATG GTGTCACAAC AGGAGAAGGG TATTGAAGGA 1260 1261 GCACAAGCTA GTCCCTTGGT CCCTGGTGCT GGAGAAATCA TCAATACAGA CAACATTATA 1320 1321 AAGTTTGATC ATGTTCCTTT AGCAACACCA AATGGTGACA TCTTGATCCA AGACCTTAGT 1380 1381 TTTGAAGTTC GATCTGGGGC CAACGTTCTG ATTTGTGGTC CAAACGGCTG TGGAAAGAGC 1440 1441 TCCCTCTTCC GTGTTCTTGG TGAGTTATGG CCTCTTTTTG GAGGGCGGCT TACTAAACCT 1500 1501 GAGAGAGGAA AGTTATTTTA TGTTCCTCAG CGACCCTATA TGACCCTGGG AACACTGAGA 1560 1561 GACCAAGTCA TATATCCAGA TGGAAAGGAA GATCAGAAGA AGAGGGGGAT CTCTGACCAG 1620 1621 GTGCTGAAGG AGTACTTGGA CAATGTGCAG CTGGGTCACA TCCTTGAGCG AGAAGGCGGC 1680 1681 TGGGACAGTG TTCAGGACTG GATGGATGTA CTCAGCGGAG GAGAGAAACA AAGAATGGCG 1740 1741 ATGGCAAGAC TGTTTTATCA TAAACCCCAG TTTGCCATTT TGGATGAATG CACAAGTGCG 1800 1801 GTCAGTGTGG ATGTGGAGGA CTACATTTAC AGCCACTGTC GAAAGGTTGG CATCACCCTC 1860 1861 TTTACCGTTT CACACAGAAA GTCCCTTTGG AAGCACCACG AGTACTACCT GCATATGGAT 1920 1921 GGGAGAGGCA ATTATGAATT CAAAAAGATC ACAGAAGATA CAGTTGAGTT CGGATCATAG 1980 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Intracellular membrane-bounded organelle | |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrion | |
Cellular Component | Peroxisomal matrix | |
Cellular Component | Peroxisomal membrane | |
Cellular Component | Peroxisome | |
Molecular Function | ATP binding | |
Molecular Function | ATPase activity | |
Molecular Function | ATPase activity, coupled to transmembrane movement of substances | |
Molecular Function | Long-chain fatty acid transporter activity | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Protein self-association | |
Biological Process | Fatty acid beta-oxidation | |
Biological Process | Fatty acid biosynthetic process | |
Biological Process | Long-chain fatty acid import into peroxisome | |
Biological Process | Peroxisome organization | |
Biological Process | Response to drug | |
Biological Process | Response to organic cyclic compound | |
Biological Process | Very long-chain fatty acid catabolic process |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| RaftProt | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a375 | Rattus norvegicus | 98.18 | 0.0 | 1351 |
| LLPS-Mea-a344 | Mesocricetus auratus | 97.88 | 0.0 | 1345 |
| LLPS-Otg-a377 | Otolemur garnettii | 95.5 | 0.0 | 1245 |
| LLPS-Pat-a370 | Pan troglodytes | 95.45 | 0.0 | 1317 |
| LLPS-Hos-a379 | Homo sapiens | 95.45 | 0.0 | 1317 |
| LLPS-Gog-a367 | Gorilla gorilla | 95.45 | 0.0 | 1317 |
| LLPS-Pap-a370 | Pan paniscus | 95.45 | 0.0 | 1317 |
| LLPS-Caj-a371 | Callithrix jacchus | 95.3 | 0.0 | 1318 |
| LLPS-Cea-a374 | Cercocebus atys | 94.99 | 0.0 | 1312 |
| LLPS-Ict-a371 | Ictidomys tridecemlineatus | 94.99 | 0.0 | 1310 |
| LLPS-Maf-a374 | Macaca fascicularis | 94.99 | 0.0 | 1312 |
| LLPS-Man-a373 | Macaca nemestrina | 94.99 | 0.0 | 1312 |
| LLPS-Paa-a373 | Papio anubis | 94.99 | 0.0 | 1312 |
| LLPS-Mal-a365 | Mandrillus leucophaeus | 94.86 | 0.0 | 1239 |
| LLPS-Orc-a358 | Oryctolagus cuniculus | 94.84 | 0.0 | 1257 |
| LLPS-Mod-a358 | Monodelphis domestica | 94.69 | 0.0 | 1239 |
| LLPS-Chs-a370 | Chlorocebus sabaeus | 94.69 | 0.0 | 1309 |
| LLPS-Myl-a357 | Myotis lucifugus | 94.08 | 0.0 | 1299 |
| LLPS-Caf-a371 | Canis familiaris | 94.06 | 0.0 | 1226 |
| LLPS-Sus-a377 | Sus scrofa | 93.93 | 0.0 | 1295 |
| LLPS-Fec-a375 | Felis catus | 93.9 | 0.0 | 1224 |
| LLPS-Mam-a370 | Macaca mulatta | 93.78 | 0.0 | 1294 |
| LLPS-Mup-a371 | Mustela putorius furo | 93.64 | 0.0 | 1271 |
| LLPS-Fud-a364 | Fukomys damarensis | 93.63 | 0.0 | 1277 |
| LLPS-Bot-a379 | Bos taurus | 93.63 | 0.0 | 1289 |
| LLPS-Eqc-a380 | Equus caballus | 93.59 | 0.0 | 1227 |
| LLPS-Cas-a339 | Carlito syrichta | 93.45 | 0.0 | 1252 |
| LLPS-Nol-a367 | Nomascus leucogenys | 93.17 | 0.0 | 1278 |
| LLPS-Ora-a317 | Ornithorhynchus anatinus | 93.09 | 0.0 | 1218 |
| LLPS-Loa-a365 | Loxodonta africana | 93.08 | 0.0 | 1231 |
| LLPS-Aim-a364 | Ailuropoda melanoleuca | 93.03 | 0.0 | 1262 |
| LLPS-Dio-a368 | Dipodomys ordii | 92.6 | 0.0 | 1263 |
| LLPS-Rhb-a367 | Rhinopithecus bieti | 92.55 | 0.0 | 1291 |
| LLPS-Sah-a349 | Sarcophilus harrisii | 92.35 | 0.0 | 1183 |
| LLPS-Aon-a380 | Aotus nancymaae | 91.5 | 0.0 | 1255 |
| LLPS-Poa-a368 | Pongo abelii | 90.5 | 0.0 | 1278 |
| LLPS-Urm-a344 | Ursus maritimus | 90.31 | 0.0 | 1210 |
| LLPS-Pes-a329 | Pelodiscus sinensis | 90.18 | 0.0 | 1181 |
| LLPS-Ova-a369 | Ovis aries | 89.61 | 0.0 | 1187 |
| LLPS-Tag-a326 | Taeniopygia guttata | 89.55 | 0.0 | 1171 |
| LLPS-Fia-a326 | Ficedula albicollis | 89.41 | 0.0 | 1170 |
| LLPS-Leo-a331 | Lepisosteus oculatus | 87.72 | 0.0 | 1077 |
| LLPS-Gaga-a334 | Gallus gallus | 87.44 | 0.0 | 1206 |
| LLPS-Cap-a373 | Cavia porcellus | 87.41 | 0.0 | 1159 |
| LLPS-Meg-a314 | Meleagris gallopavo | 87.35 | 0.0 | 1202 |
| LLPS-Anp-a315 | Anas platyrhynchos | 86.47 | 0.0 | 1181 |
| LLPS-Anc-a350 | Anolis carolinensis | 85.67 | 0.0 | 1157 |
| LLPS-Scf-a312 | Scleropages formosus | 83.76 | 0.0 | 1157 |
| LLPS-Xet-a326 | Xenopus tropicalis | 83.66 | 0.0 | 1162 |
| LLPS-Dar-a331 | Danio rerio | 83.16 | 0.0 | 1156 |
| LLPS-Lac-a330 | Latimeria chalumnae | 83.04 | 0.0 | 1174 |
| LLPS-Icp-a331 | Ictalurus punctatus | 83.0 | 0.0 | 1140 |
| LLPS-Pof-a332 | Poecilia formosa | 82.55 | 0.0 | 1127 |
| LLPS-Gaa-a317 | Gasterosteus aculeatus | 82.25 | 0.0 | 1143 |
| LLPS-Xim-a336 | Xiphophorus maculatus | 82.25 | 0.0 | 1118 |
| LLPS-Scm-a317 | Scophthalmus maximus | 81.64 | 0.0 | 1130 |
| LLPS-Asm-a325 | Astyanax mexicanus | 81.34 | 0.0 | 1112 |
| LLPS-Ten-a315 | Tetraodon nigroviridis | 81.27 | 0.0 | 1130 |
| LLPS-Orl-a324 | Oryzias latipes | 79.82 | 0.0 | 1089 |
| LLPS-Orn-a330 | Oreochromis niloticus | 78.41 | 0.0 | 1120 |
| LLPS-Cii-a107 | Ciona intestinalis | 69.14 | 0.0 | 897 |
| LLPS-Cae-a066 | Caenorhabditis elegans | 61.17 | 0.0 | 794 |
| LLPS-Drm-a100 | Drosophila melanogaster | 58.71 | 0.0 | 786 |