LLPS-Mum-a372
Adgrl2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Adhesion G protein-coupled receptor L2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Latrophilin-2 |
| Gene Name: | Adgrl2, Kiaa0786, Lphn2 |
| Ensembl Gene: | ENSMUSG00000028184.12 |
| Ensembl Protein: | ENSMUSP00000143511.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVSSGCRMRS LWFIIIISFS PSTEGFSRAA LPFGLVRREL SCEGYSIDLR CPGSDVIMIE 60 61 SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR TQCIVVTGSD VFPDPCPGTY 120 121 KYLEVQYECV PYSKMLVFVC PGTLKAIVDS PCIYEAEQKS GAWCKDPLQA ADKIYFMPWT 180 181 PYRTDTLIEY ASLEDFQNSR QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKFDLRT 240 241 RIKSGEAIIN YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL 300 301 RFEATWETAY DKRAASNAFM ICGVLYVVRS VYQDNESEAG KNTIDYIYNT RLSRGEYVDV 360 361 PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD PAQVPTTAVT ITSSAELFKT 420 421 TISTTSSASQ RGPVSSTAAG PQDGSRGTKP PPAVSTTKIP PVTNIFPLPE RFCEALDWKG 480 481 IKWPQTQRGM MVERPCPKGT RGTASYLCMA STGTWNPKGP DLSNCTSHWV NQLAQKIRSG 540 541 ENAASLANEL AKHTKGHVFA GDVSSSVRLM EQLVDILDAQ LQELKPSEKD SAGRSYNKLQ 600 601 KREKTCRAYL KAIVDTVDNL LRAEALESWK HMNSSEQAHT ATMLLDTLEE GAFVLADNLL 660 661 EPTRVSMPTE NIVLEVAVLS TEGQVQDFKF PLGLKGLGSS IQLSANTVKQ NSRNGLAKLV 720 721 FIIYRSLGQF LSTENATIKL GADLMGRNST IAVNSPVISV SINKESSRVY LTDPVLFTLP 780 781 HIDPDNYFNA NCSFWNYSER TMMGYWSTQG CKLVDTNKTR TTCACSHLTN FAILMAHREI 840 841 AYKDGVHHLL LTVITWVGIV VSLVCLAICI FTFCFFRGLQ SDRNTIHKNL CINLFIAEFI 900 901 FLIGIDKTKY TIACPVFAGL LHFFFLAAFS WMCLEGVQLY LMLVEVFESE YSRKKYYYVA 960 961 GYLFPATVVG VSAAIDYKSY GTVQACWLHV DNYFIWSFIG PVTFIILLNI IFLVITLCKM 1020 1021 VKHSNTLKPD SSRLENINNY RVCDGYYNTD LPGYEDNKPF IKSWVLGAFA LLCLLGLTWS 1080 1081 FGLLFVNEET VVMAYLFTAF NAFQGLFIFI FHCALQKKVR KEYGKCFRHW YCCGGLPTES 1140 1141 PHSSVKASTT RTSARYSSGT QSRIRRMWND TVRKQSESSF ISGDINSTST LNQGMTGNYL 1200 1201 LTNPLLRPHG TNNPYNTLLA ETVVCNAPSA PAFNSPGHSL NNARDTSAMD TLPLNGNFNN 1260 1261 SYSLRKADYH DGVQVVDCGL SLNDTAFEKM IISELVHNNL RGGNKTHNLE LKLPVKPVIG 1320 1321 GSSSEDDAIV ADASSLMHGD NPGLEFRHKE LEAPLIPQRT HSLLYQPQKK VKPEATDSYV 1380 1381 SQLTAEADDH LQSPNRDSLY TSMPNLRDSP YPESSPDMAE DLSPSRRSEN EDIYYKSMPN 1440 1441 LGAGRHLHMC YQISRGNSDG YIIPINKEGC IPEGDVREGQ MQLVTSL 1487 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTGTCTT CTGGCTGCAG AATGCGAAGT CTGTGGTTTA TCATTATAAT CAGTTTCTCA 60 61 CCGAGTACAG AAGGTTTCAG CAGAGCAGCC TTACCATTCG GGTTAGTTAG ACGAGAGCTA 120 121 TCCTGTGAGG GTTATTCTAT AGACCTGCGA TGTCCGGGCA GTGACGTCAT CATGATCGAG 180 181 AGTGCGAACT ACGGTCGGAC GGACGACAAG ATCTGCGATG CAGACCCCTT TCAAATGGAG 240 241 AACACAGACT GCTACCTCCC TGATGCCTTC AAAATCATGA CTCAAAGGTA G 291 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Integral component of postsynaptic membrane | |
Cellular Component | Neuron projection | |
Molecular Function | Carbohydrate binding | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | PDZ domain binding | |
Biological Process | Adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | Brain development | |
Biological Process | Cell surface receptor signaling pathway | |
Biological Process | Positive regulation of synapse assembly | |
Biological Process | Response to bacterium | |
Biological Process | Synapse organization |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mea-a338 | Mesocricetus auratus | 96.77 | 0.0 | 3021 |
| LLPS-Ran-a369 | Rattus norvegicus | 96.7 | 0.0 | 3013 |
| LLPS-Ict-a365 | Ictidomys tridecemlineatus | 96.03 | 0.0 | 2982 |
| LLPS-Fec-a369 | Felis catus | 95.63 | 0.0 | 2988 |
| LLPS-Chs-a364 | Chlorocebus sabaeus | 95.56 | 0.0 | 2481 |
| LLPS-Loa-a360 | Loxodonta africana | 95.5 | 0.0 | 2964 |
| LLPS-Bot-a373 | Bos taurus | 95.43 | 0.0 | 2965 |
| LLPS-Pat-a364 | Pan troglodytes | 95.16 | 0.0 | 2949 |
| LLPS-Aon-a374 | Aotus nancymaae | 95.16 | 0.0 | 2950 |
| LLPS-Dio-a362 | Dipodomys ordii | 95.16 | 0.0 | 2963 |
| LLPS-Caj-a365 | Callithrix jacchus | 95.16 | 0.0 | 2949 |
| LLPS-Pap-a365 | Pan paniscus | 95.16 | 0.0 | 2949 |
| LLPS-Gog-a361 | Gorilla gorilla | 95.16 | 0.0 | 2948 |
| LLPS-Mal-a359 | Mandrillus leucophaeus | 95.1 | 0.0 | 2945 |
| LLPS-Cea-a368 | Cercocebus atys | 95.1 | 0.0 | 2945 |
| LLPS-Paa-a367 | Papio anubis | 95.1 | 0.0 | 2945 |
| LLPS-Rhb-a361 | Rhinopithecus bieti | 95.1 | 0.0 | 2945 |
| LLPS-Hos-a373 | Homo sapiens | 95.09 | 0.0 | 2946 |
| LLPS-Sus-a371 | Sus scrofa | 95.03 | 0.0 | 2944 |
| LLPS-Maf-a369 | Macaca fascicularis | 95.03 | 0.0 | 2944 |
| LLPS-Man-a367 | Macaca nemestrina | 95.03 | 0.0 | 2944 |
| LLPS-Nol-a361 | Nomascus leucogenys | 95.02 | 0.0 | 2946 |
| LLPS-Fud-a359 | Fukomys damarensis | 94.96 | 0.0 | 2961 |
| LLPS-Ova-a099 | Ovis aries | 94.86 | 0.0 | 2924 |
| LLPS-Otg-a371 | Otolemur garnettii | 94.8 | 0.0 | 2917 |
| LLPS-Eqc-a374 | Equus caballus | 94.57 | 0.0 | 2934 |
| LLPS-Myl-a351 | Myotis lucifugus | 94.33 | 0.0 | 2892 |
| LLPS-Aim-a358 | Ailuropoda melanoleuca | 94.31 | 0.0 | 2890 |
| LLPS-Mam-a364 | Macaca mulatta | 94.27 | 0.0 | 2937 |
| LLPS-Poa-a362 | Pongo abelii | 94.1 | 0.0 | 2432 |
| LLPS-Cas-a334 | Carlito syrichta | 93.92 | 0.0 | 2860 |
| LLPS-Cap-a367 | Cavia porcellus | 93.45 | 0.0 | 2875 |
| LLPS-Mod-a352 | Monodelphis domestica | 93.35 | 0.0 | 2892 |
| LLPS-Mup-a365 | Mustela putorius furo | 92.88 | 0.0 | 2291 |
| LLPS-Ora-a312 | Ornithorhynchus anatinus | 91.81 | 0.0 | 2357 |
| LLPS-Orc-a352 | Oryctolagus cuniculus | 91.47 | 0.0 | 2804 |
| LLPS-Caf-a366 | Canis familiaris | 91.26 | 0.0 | 2786 |
| LLPS-Sah-a344 | Sarcophilus harrisii | 87.43 | 0.0 | 2659 |
| LLPS-Anc-a344 | Anolis carolinensis | 85.34 | 0.0 | 2628 |
| LLPS-Xet-a321 | Xenopus tropicalis | 83.3 | 0.0 | 2554 |
| LLPS-Leo-a326 | Lepisosteus oculatus | 81.73 | 0.0 | 2513 |
| LLPS-Orn-a324 | Oreochromis niloticus | 79.7 | 0.0 | 2428 |
| LLPS-Scm-a311 | Scophthalmus maximus | 79.14 | 0.0 | 2457 |
| LLPS-Scf-a307 | Scleropages formosus | 76.11 | 0.0 | 2306 |
| LLPS-Xim-a331 | Xiphophorus maculatus | 76.0 | 0.0 | 2395 |
| LLPS-Asm-a319 | Astyanax mexicanus | 75.43 | 0.0 | 2354 |
| LLPS-Pof-a327 | Poecilia formosa | 75.05 | 0.0 | 2336 |
| LLPS-Gaa-a311 | Gasterosteus aculeatus | 74.83 | 0.0 | 2266 |
| LLPS-Orl-a318 | Oryzias latipes | 73.28 | 0.0 | 2249 |
| LLPS-Dar-a325 | Danio rerio | 72.82 | 0.0 | 2218 |
| LLPS-Icp-a325 | Ictalurus punctatus | 72.67 | 0.0 | 2184 |
| LLPS-Tar-a313 | Takifugu rubripes | 72.59 | 0.0 | 2131 |
| LLPS-Ten-a311 | Tetraodon nigroviridis | 68.54 | 0.0 | 2048 |
| LLPS-Urm-a339 | Ursus maritimus | 60.33 | 0.0 | 1844 |
| LLPS-Gaga-a329 | Gallus gallus | 59.79 | 0.0 | 1851 |
| LLPS-Fia-a321 | Ficedula albicollis | 59.36 | 0.0 | 1712 |
| LLPS-Lac-a325 | Latimeria chalumnae | 58.25 | 0.0 | 1732 |
| LLPS-Tag-a320 | Taeniopygia guttata | 57.39 | 0.0 | 891 |
| LLPS-Anp-a310 | Anas platyrhynchos | 56.07 | 0.0 | 1213 |
| LLPS-Meg-a309 | Meleagris gallopavo | 51.89 | 0.0 | 1103 |