LLPS-Mum-a362
Fbxo2

▼ OVERVIEW

Status: Reviewed
Protein Name: F-box only protein 2
Gene Name: Fbxo2, Fbs1, Fbx2
Ensembl Gene: ENSMUSG00000041556.8
Ensembl Protein: ENSMUSP00000037377.8
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others
PDB: 2RJ2 (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDGDGDPESV  SHPEEASPEE  QPEEAGAEAS  AEEEQLREAE  EEEEAEAVEY  LAELPEPLLL  60
61    RVLAELPATE  LVQACRLVCL  RWKELVDGAP  LWLLKCQQEG  LVPEGSADEE  RDHWQQFYFL  120
121   SKRRRNLLRN  PCGEEDLEGW  SDVEHGGDGW  RVEELPGDNG  VEFTQDDSVK  KYFASSFEWC  180
181   RKAQVIDLQA  EGYWEELLDT  TQPAIVVKDW  YSGRTDAGSL  YELTVRLLSE  NEDVLAEFAT  240
241   GQVAVPEDGS  WMEISHTFID  YGPGVRFVRF  EHGGQDSVYW  KGWFGARVTN  SSVWVEP  297
Nucleotide CDS Sequence (FASTA)
1     ATGGATGGAG  ATGGTGATCC  AGAGAGTGTG  AGCCACCCCG  AAGAAGCGAG  CCCAGAGGAG  60
61    CAGCCAGAGG  AGGCGGGCGC  CGAGGCGAGT  GCGGAGGAGG  AGCAGCTCCG  GGAGGCGGAG  120
121   GAGGAGGAAG  AGGCGGAGGC  CGTGGAGTAC  CTGGCCGAGC  TGCCGGAGCC  ACTGCTGCTG  180
181   CGCGTGCTGG  CCGAGCTGCC  AGCTACGGAG  CTGGTGCAGG  CCTGCCGCCT  GGTGTGCCTG  240
241   CGCTGGAAGG  AGCTGGTGGA  CGGCGCCCCA  CTGTGGCTGC  TCAAGTGCCA  GCAGGAGGGG  300
301   CTGGTGCCCG  AGGGCAGCGC  TGATGAGGAG  CGGGACCACT  GGCAACAGTT  CTACTTTCTG  360
361   AGCAAGAGGA  GGCGCAACCT  GCTGCGCAAC  CCTTGTGGGG  AAGAGGACTT  GGAGGGCTGG  420
421   AGCGACGTGG  AGCACGGTGG  GGACGGCTGG  AGGGTGGAGG  AACTGCCCGG  AGACAATGGG  480
481   GTGGAATTTA  CCCAAGATGA  CAGCGTTAAG  AAATACTTCG  CCTCCTCCTT  CGAGTGGTGT  540
541   CGCAAAGCGC  AGGTCATTGA  TCTGCAGGCA  GAGGGCTACT  GGGAGGAGCT  ACTGGACACC  600
601   ACCCAGCCCG  CCATCGTGGT  GAAGGACTGG  TACTCGGGTC  GCACTGATGC  GGGCAGCCTG  660
661   TATGAGCTCA  CTGTGAGGCT  GCTGTCGGAG  AACGAAGATG  TGCTGGCGGA  GTTCGCTACA  720
721   GGACAGGTGG  CTGTGCCAGA  GGACGGCAGT  TGGATGGAGA  TCTCCCACAC  CTTCATCGAC  780
781   TACGGGCCAG  GTGTCCGCTT  TGTCCGCTTC  GAGCACGGAG  GGCAGGACTC  GGTCTACTGG  840
841   AAGGGCTGGT  TCGGGGCCCG  GGTGACCAAC  AGTAGCGTGT  GGGTGGAACC  CTGA  894

▼ KEYWORD

ID
Family
3D-structure
Complete proteome
Cytoplasm
Endoplasmic reticulum
Lectin
Membrane
Microsome
Phosphoprotein
Reference proteome
Ubl conjugation pathway

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Dendritic spine
Cellular Component
Endoplasmic reticulum
Cellular Component
Organelle membrane
Cellular Component
SCF ubiquitin ligase complex
Molecular Function
Amyloid-beta binding
Molecular Function
Carbohydrate binding
Biological Process
Glycoprotein catabolic process
Biological Process
Negative regulation of cell population proliferation
Biological Process
Protein ubiquitination
Biological Process
Regulation of protein ubiquitination
Biological Process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process
Ubiquitin-dependent ERAD pathway
Biological Process
Ubiquitin-dependent protein catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a359Rattus norvegicus96.30.0572
LLPS-Mea-a328Mesocricetus auratus90.270.0511
LLPS-Dio-a351Dipodomys ordii90.02e-156448
LLPS-Rhb-a350Rhinopithecus bieti88.01e-173492
LLPS-Cea-a357Cercocebus atys87.331e-171486
LLPS-Paa-a356Papio anubis87.331e-171486
LLPS-Maf-a358Macaca fascicularis87.331e-171486
LLPS-Hos-a362Homo sapiens87.04e-174493
LLPS-Pat-a353Pan troglodytes86.674e-171485
LLPS-Mal-a348Mandrillus leucophaeus86.675e-170483
LLPS-Poa-a351Pongo abelii86.676e-171484
LLPS-Gog-a350Gorilla gorilla86.675e-171485
LLPS-Chs-a354Chlorocebus sabaeus86.672e-170484
LLPS-Aon-a363Aotus nancymaae86.352e-162464
LLPS-Pap-a354Pan paniscus86.331e-170484
LLPS-Man-a356Macaca nemestrina86.11e-164468
LLPS-Caj-a354Callithrix jacchus86.01e-169481
LLPS-Mam-a354Macaca mulatta85.672e-165471
LLPS-Caf-a355Canis familiaris84.721e-164469
LLPS-Eqc-a363Equus caballus84.673e-165470
LLPS-Otg-a360Otolemur garnettii84.03e-165470
LLPS-Fud-a349Fukomys damarensis83.452e-147424
LLPS-Bot-a362Bos taurus83.332e-161461
LLPS-Tut-a211Tursiops truncatus83.02e-153440
LLPS-Fec-a358Felis catus82.946e-154441
LLPS-Sus-a360Sus scrofa82.833e-161461
LLPS-Aim-a347Ailuropoda melanoleuca82.675e-161459
LLPS-Cap-a357Cavia porcellus82.065e-157449
LLPS-Loa-a350Loxodonta africana82.032e-162463
LLPS-Mup-a354Mustela putorius furo81.673e-158452
LLPS-Ict-a355Ictidomys tridecemlineatus79.932e-157450
LLPS-Ova-a352Ovis aries78.742e-167476
LLPS-Nol-a350Nomascus leucogenys78.02e-143414
LLPS-Ere-a092Erinaceus europaeus76.562e-93284
LLPS-Myl-a341Myotis lucifugus73.448e-138400
LLPS-Ora-a303Ornithorhynchus anatinus72.983e-133387
LLPS-Gaga-a319Gallus gallus68.274e-125366
LLPS-Meg-a298Meleagris gallopavo68.272e-125367
LLPS-Fia-a310Ficedula albicollis67.471e-123362
LLPS-Anp-a300Anas platyrhynchos67.474e-123362
LLPS-Tag-a309Taeniopygia guttata67.071e-120355
LLPS-Anc-a333Anolis carolinensis65.061e-115342
LLPS-Pes-a316Pelodiscus sinensis64.343e-120354
LLPS-Mod-a341Monodelphis domestica62.542e-129378
LLPS-Scm-a303Scophthalmus maximus59.439e-64207
LLPS-Orl-a311Oryzias latipes54.61e-57191
LLPS-Lac-a317Latimeria chalumnae51.817e-96292
LLPS-Cas-a324Carlito syrichta50.993e-85266